WO2009139731A1 - Mécanisme comprenant une bande alvéolée thermoformée - Google Patents

Mécanisme comprenant une bande alvéolée thermoformée Download PDF

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Publication number
WO2009139731A1
WO2009139731A1 PCT/TR2009/000061 TR2009000061W WO2009139731A1 WO 2009139731 A1 WO2009139731 A1 WO 2009139731A1 TR 2009000061 W TR2009000061 W TR 2009000061W WO 2009139731 A1 WO2009139731 A1 WO 2009139731A1
Authority
WO
WIPO (PCT)
Prior art keywords
gear
trigger
inhalation
drug
rim
Prior art date
Application number
PCT/TR2009/000061
Other languages
English (en)
Inventor
Bilgic Mahmut
Original Assignee
Bilgic Mahmut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bilgic Mahmut filed Critical Bilgic Mahmut
Publication of WO2009139731A1 publication Critical patent/WO2009139731A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0043—Non-destructive separation of the package, e.g. peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0053—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
    • A61M15/0055—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being coiled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Definitions

  • compositions which can be used by inhalation are generally used to treat asthma or chronic bronchitis in bronchial or pulmonary region.
  • One of the devices used for inhalation is a breath actuated device providing the dry powder drug to the air passage.
  • the blister strip comprising separable layers and housings for keeping powdered chemicals, is intended to be opened in a single movement and made ready for the inhalation.
  • opening of the blister strip making up of the device ready for inhalation of drug and running of dosage counter, are all performed with a single movement of the user.
  • the mechanism according to the invention operates as the drug blister strip is winded from one place to another. During this movement, drug blisters are opened at a specified point and become ready for inspiration in an ideal air flow by a patient. There is also a counter working in the provided mechanism in order to allow the follow up how many blisters are inspired.
  • the mechanism conceals the piece contacting the mouth by a cap. After the use of each drug blister, the blister strip is separated and pulls the split for separating and opening a new drug blister to be ready for a new inhalation.
  • the strips of used blisters are winded and compressed via the mechanical effect of the invented mechanism to little bobbins found in special divisions in the device.
  • the movement of the blister strip is provided by bobbins and gear systems.
  • the mechanism according to the invention which fulfills several jobs at the same time, it is aimed to make the manual use of the device easier, than the known examples of the prior art, since the patient population of the device comprising the mechanism includes the children and elderly.
  • a sliding mechanism actuates the mechanism and the drug cannot be inhaled until the slide is pulled completely. It is possible to pull half of the slide and wrongfully think that the drug is ready to use during daily use or while using during attack.
  • the actuated mechanism makes clear that the device is ready for inhalation by revealing the mouthpiece by opening the cap or that it needs triggering and the device is not ready to use by concealing the mouthpiece entirely. When the device is not ready for use, a mouth contact with the device cannot be possible. This mechanism that conceals the mouthpiece also renders the system more hygienic since the device can be carried around in a pocket and it is used manually.
  • Figure 1 is an explosive view of the device according to the invention
  • FIG. 1 is front and top views of the device according to the invention are given.
  • the mechanism according to the invention consists of twenty one components that are listed below and depicted in figure- 1 and figure-2 in detail:
  • the proposed mechanism is encapsulated within two main caps in order to protect the mechanism, ensure proper action and facilitate handheld usage (01 and 18)
  • the mouth piece (19) that goes on top of 01 and 18 is designed as compatible to the mouth shape for the sucking and is related to the jacket (10) .
  • Movable cap (20) reveals or conceals the mouthpiece by sliding over 01 and 18.
  • Trigger (15) is grouped between 10 and 18 in order to easily allow the actuation of the device by finger motion.
  • Winding gear (02), Counter Gear (03), Inner Gear (04), Tension Gear (05), Stretch Gear (06), Drive Gear (07), Pinion (08), Inner Gear (09), Rim (14), Bottom Gear (17) and Motion Gear (21) compose the mechanism that is actuated by pressing the trigger (15) All of these parts and the blister strip comprising the dry powder drug are mounted on parts 01, 10 and 18. They are rendered functional by 01 and 18 being grouped together.
  • the winding spring (01) that compresses the rim causes the rim to act as a bed for the pressure spring (16) while being pushed by the trigger.
  • the work string enables the rim to withstand the tension caused by the pressure spring and to be released upon second actuation of the trigger.
  • the mechanism is actuated by pressing the trigger (15).
  • the mechanism pulls the drug containing blister strip from one compartment to the other compartment on the jacket (10).
  • the layers that compose the strip begin to separate.
  • the movable cap (20) is detached from the mouthpiece (19) and reveals it.
  • the counter gear (03) advances by a step and increments the number by one that is visible through the window (01) found on the bottom cap.
  • the pressure spring (16) between the trigger (15) and rim (14) gets loaded.
  • the string (13) locks the rim as the trigger is fully depressed. When the locking operation is over, the drug containing blister strip is fully advanced to the proper position with the revealed drug.
  • the drug blister on the strip now resides in front of the mouth piece and the dry powder is ready for inhalation.
  • the movable cap (20) is now fully detached from the mouthpiece (19), residing in a position that cannot interfere with the inhalation process..
  • the drug is then inhaled.
  • the patient actuates the trigger a second time solely for releasing the work string (13) and the rim (14). Since the work string's (13) restriction is over, pressure spring (16) is released at the opposite direction of the trigger action.
  • the trigger (15) rapidly slides back to its original place.
  • the mechanism attached to the trigger closes the movable cap (20) and enables the mouthpiece (19) to be concealed.
  • the system is now ready and safe for the next inhalation cycle.
  • the device having the mechanism according to the invention is preferably used for inhalation of drugs such as beta-2agonists, corticosteroids, anti-cholinergic agents, antimuscarinics, antiallergics and antibiotics, for the treatment of pulmonary diseases or local treatment of pulmonary diseases like asthma and chronic obstructive pulmonary diseases.
  • drugs such as beta-2agonists, corticosteroids, anti-cholinergic agents, antimuscarinics, antiallergics and antibiotics, for the treatment of pulmonary diseases or local treatment of pulmonary diseases like asthma and chronic obstructive pulmonary diseases.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne un mécanisme dans lequel une bande alvéolée thermoformée, comprenant des couches séparables et des logements destinés à contenir des produits chimiques en poudre, est ouverte et prête pour une inhalation par des patients.
PCT/TR2009/000061 2008-05-16 2009-05-15 Mécanisme comprenant une bande alvéolée thermoformée WO2009139731A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2008/03523A TR200803523A1 (tr) 2008-05-16 2008-05-16 Şerit ambalaj içeren düzenek
TR2008/03523 2008-05-16

Publications (1)

Publication Number Publication Date
WO2009139731A1 true WO2009139731A1 (fr) 2009-11-19

Family

ID=40942493

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2009/000061 WO2009139731A1 (fr) 2008-05-16 2009-05-15 Mécanisme comprenant une bande alvéolée thermoformée

Country Status (2)

Country Link
TR (1) TR200803523A1 (fr)
WO (1) WO2009139731A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011129788A1 (fr) * 2010-04-13 2011-10-20 Mahmut Bilgic Inhalateur à poudre sèche d'utilisation facile
JP2013523380A (ja) * 2010-04-13 2013-06-17 ビルギチ，マフムト 乾燥粉末吸入器のマウスピースボタン
US9179691B2 (en) 2007-12-14 2015-11-10 Aerodesigns, Inc. Delivering aerosolizable food products
USD744087S1 (en) 2013-10-01 2015-11-24 Mahmut Bilgic Dry powder inhaler
US9345848B2 (en) 2009-10-20 2016-05-24 Sima Patent Ve Lisanslama Hizmetleri Ltd. Sti. Dry powder inhaler
US9849255B2 (en) 2011-11-25 2017-12-26 Mahmut Bilgic Inhalation device

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011093810A2 (fr) 2010-01-28 2011-08-04 Bilgic Mahmut Composition pharmaceutique de poudre sèche comprenant du tiotropium et de la mométasone
WO2011093813A1 (fr) 2010-01-28 2011-08-04 Mahmut Bilgic Composition pharmaceutique de poudre sèche comprenant le tiotropium et le fluticasone
WO2011093809A2 (fr) 2010-01-28 2011-08-04 Mahmut Bilgic Composition pharmaceutique en poudre sèche comprenant du tiotropium et du ciclésonide
WO2011093814A2 (fr) 2010-01-29 2011-08-04 Mahmut Bilgic Compositions pharmaceutiques combinées comprenant du formotérol et du ciclésonide

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005002654A2 (fr) * 2003-07-02 2005-01-13 Pfizer Limited Dispositif de distribution
GB2407042A (en) * 2003-10-17 2005-04-20 Vectura Ltd Pocket blister inhaler with piercing actuator
WO2007012871A1 (fr) * 2005-07-28 2007-02-01 Glaxo Group Limited Distributeur de médicaments

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005002654A2 (fr) * 2003-07-02 2005-01-13 Pfizer Limited Dispositif de distribution
GB2407042A (en) * 2003-10-17 2005-04-20 Vectura Ltd Pocket blister inhaler with piercing actuator
WO2007012871A1 (fr) * 2005-07-28 2007-02-01 Glaxo Group Limited Distributeur de médicaments

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9179691B2 (en) 2007-12-14 2015-11-10 Aerodesigns, Inc. Delivering aerosolizable food products
US9345848B2 (en) 2009-10-20 2016-05-24 Sima Patent Ve Lisanslama Hizmetleri Ltd. Sti. Dry powder inhaler
US9795751B2 (en) 2009-10-20 2017-10-24 Sima Patent Ve Lisanslama Hizmetleri Ltd. Sti. Dry powder inhaler
US9795750B2 (en) 2009-10-20 2017-10-24 Sima Patent Ve Lisanslama Hizmetleri Ltd. Sti. Dry powder inhaler
US10842952B2 (en) 2009-10-20 2020-11-24 Sima Patent Ve Lisanslama Hizmetleri Ltd. Sti. Dry powder inhaler
WO2011129788A1 (fr) * 2010-04-13 2011-10-20 Mahmut Bilgic Inhalateur à poudre sèche d'utilisation facile
JP2013523380A (ja) * 2010-04-13 2013-06-17 ビルギチ，マフムト 乾燥粉末吸入器のマウスピースボタン
US9849255B2 (en) 2011-11-25 2017-12-26 Mahmut Bilgic Inhalation device
USD744087S1 (en) 2013-10-01 2015-11-24 Mahmut Bilgic Dry powder inhaler

Also Published As

Publication number Publication date
TR200803523A1 (tr) 2009-12-21

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