WO2009137691A3 - 1,3-diol synthesis via controlled, radical-mediated c-h functionalization - Google Patents
1,3-diol synthesis via controlled, radical-mediated c-h functionalization Download PDFInfo
- Publication number
- WO2009137691A3 WO2009137691A3 PCT/US2009/043163 US2009043163W WO2009137691A3 WO 2009137691 A3 WO2009137691 A3 WO 2009137691A3 US 2009043163 W US2009043163 W US 2009043163W WO 2009137691 A3 WO2009137691 A3 WO 2009137691A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- functionalization
- mediated
- radical
- via controlled
- synthesis via
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
- C07C29/095—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of organic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B41/00—Formation or introduction of functional groups containing oxygen
- C07B41/02—Formation or introduction of functional groups containing oxygen of hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The conversion of an alcohol into a 1,3- diol via controlled, radical-mediated C-H functionalization has been demonstrated. The method entails nearly quantitative conversion of an alcohol to the corresponding N-substitutedcarbamate, followed by a variant of the Hofffman-Lδffler-Freytag reaction, cyclization, and hydrolysis to provide a 1,3-diol.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5202708P | 2008-05-09 | 2008-05-09 | |
US61/052,027 | 2008-05-09 | ||
US5238908P | 2008-05-12 | 2008-05-12 | |
US61/052,389 | 2008-05-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009137691A2 WO2009137691A2 (en) | 2009-11-12 |
WO2009137691A3 true WO2009137691A3 (en) | 2009-12-23 |
Family
ID=41265408
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/043163 WO2009137691A2 (en) | 2008-05-09 | 2009-05-07 | 1,3-diol synthesis via controlled, radical-mediated c-h functionalization |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009137691A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104803840B (en) * | 2014-01-29 | 2016-08-17 | 中国科学院海洋研究所 | Antibacterium monoterpene and its production and use |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4873379A (en) * | 1988-05-25 | 1989-10-10 | Hoechst Celanese Corporation | Process for making 1,3-diols from epoxides |
US20020161021A1 (en) * | 1997-12-19 | 2002-10-31 | Bosch Robert Lee | Process for the synthesis of 1,3-diols |
US6545190B2 (en) * | 2001-03-15 | 2003-04-08 | Shell Oil Company | One step process for preparing a 1,3-diol |
US6548716B1 (en) * | 2000-03-22 | 2003-04-15 | Shell Oil Company | Process for preparing a 1,3-diol |
-
2009
- 2009-05-07 WO PCT/US2009/043163 patent/WO2009137691A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4873379A (en) * | 1988-05-25 | 1989-10-10 | Hoechst Celanese Corporation | Process for making 1,3-diols from epoxides |
US20020161021A1 (en) * | 1997-12-19 | 2002-10-31 | Bosch Robert Lee | Process for the synthesis of 1,3-diols |
US6548716B1 (en) * | 2000-03-22 | 2003-04-15 | Shell Oil Company | Process for preparing a 1,3-diol |
US6545190B2 (en) * | 2001-03-15 | 2003-04-08 | Shell Oil Company | One step process for preparing a 1,3-diol |
Also Published As
Publication number | Publication date |
---|---|
WO2009137691A2 (en) | 2009-11-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2009036281A3 (en) | Bortezomib and process for producing same | |
WO2010080407A3 (en) | Methods for increasing hydrolysis of cellulosic material | |
WO2009061740A3 (en) | Process of producing ethanol using cellulose with enzymes generated through solid state culture | |
WO2009054373A1 (en) | Method for producing cellulose ether derivative | |
WO2009086303A3 (en) | Method for altering the lifespan of eukaryotic organisms | |
WO2009092752A3 (en) | Polyolefins having isotactic structural elements, method for producing the same and use thereof | |
WO2010031720A3 (en) | Novel antibody formulation | |
WO2010001137A3 (en) | Microwave torrefaction of biomass | |
WO2009079213A3 (en) | Renewable compositions | |
WO2007144424A3 (en) | Processes for production of a starch hydrolysate | |
WO2007093627A3 (en) | Biocidal composition | |
WO2008136394A1 (en) | Method for production of lactam compound, and intermediate for the production method | |
WO2008083950A3 (en) | Spirocyclic tetronic acid derivatives | |
WO2008006902A3 (en) | Modified biomass comprising synthetically grown carbon fibers | |
WO2009081012A3 (en) | Method for producing succinic acid | |
WO2010009879A3 (en) | Methods for producing paricalcitol | |
WO2010015657A3 (en) | Alkoxypyrazoles and the process for their preparation | |
WO2009135898A3 (en) | Fermentation of a lignocellulose-containing material | |
WO2010004575A3 (en) | Preparation of escitalopram, its salts and intermediates | |
WO2009066735A1 (en) | Method for producing 2-azaadamantane | |
WO2009092702A3 (en) | ((2s,4r)-4,6-dihydroxytetrahydro-2h-pyran-2-yl)methyl carboxylate and process for the production employing a 2-deoxyribose-5-phosphate aldolase | |
WO2006061215A3 (en) | 2-alkyl-cycloalk(en)yl-carboxamides | |
BR112012018694A2 (en) | "Methods for ethanol production and harvesting and apparatus for ethanol production and harvesting." | |
WO2010027323A3 (en) | Corrosion inhibition | |
WO2010011990A3 (en) | Isolation of novel bacteria contributing to soilborne disease suppression |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 09743677 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 09743677 Country of ref document: EP Kind code of ref document: A2 |