WO2009130515A3 - Method and system for recording and promoting peripheral nerve regeneration - Google Patents

Method and system for recording and promoting peripheral nerve regeneration Download PDF

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Publication number
WO2009130515A3
WO2009130515A3 PCT/GR2009/000024 GR2009000024W WO2009130515A3 WO 2009130515 A3 WO2009130515 A3 WO 2009130515A3 GR 2009000024 W GR2009000024 W GR 2009000024W WO 2009130515 A3 WO2009130515 A3 WO 2009130515A3
Authority
WO
WIPO (PCT)
Prior art keywords
nerve
stimulating
recording
electronic unit
distal segment
Prior art date
Application number
PCT/GR2009/000024
Other languages
French (fr)
Other versions
WO2009130515A2 (en
Inventor
Alexandros Beris
Original Assignee
Alexandros Beris
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexandros Beris filed Critical Alexandros Beris
Priority to EP09734126A priority Critical patent/EP2307090A2/en
Publication of WO2009130515A2 publication Critical patent/WO2009130515A2/en
Publication of WO2009130515A3 publication Critical patent/WO2009130515A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A61N1/0556—Cuff electrodes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cell Biology (AREA)
  • Electrotherapy Devices (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Prostheses (AREA)

Abstract

Method and system for recording and promoting the regeneration of peripheral nerves after injury that comprise one stimulating electrode that is implanted at the proximal segment of the nerve, at least one recording electrode that is implanted at the distal segment of the nerve, an implantable electronic unit, an implantable device releasing agents for stimulating nerve regeneration, such as a micro-pump, and a computing unit that is preferably placed extracorporeally for the communication of data and transfer of power to the electronic unit. The electrical signals that are produced by the distal segment of the injured nerves after appropriate electrical excitation of the distal segment of said injured nerve are recorded at various time instances. The analysis of the recorded electric signals is used to assess the state and progress of the regenerating neuroaxons; this assessment is used for determining various control parameters. Said control parameters are used by the electronic unit so as to control the release of stimulating agents in such a way that treatment is effective while keeping the administration of stimulating agents at safe levels.
PCT/GR2009/000024 2008-04-22 2009-04-15 Method and system for recording and promoting peripheral nerve regeneration WO2009130515A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09734126A EP2307090A2 (en) 2008-04-22 2009-04-15 Method and system for recording and promoting peripheral nerve regeneration

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GR20080100282A GR1006568B (en) 2008-04-22 2008-04-22 Method and system for recording of, and aiding in, the regeneration of a peripheral nerve.
GR20080100282 2008-04-22

Publications (2)

Publication Number Publication Date
WO2009130515A2 WO2009130515A2 (en) 2009-10-29
WO2009130515A3 true WO2009130515A3 (en) 2010-04-01

Family

ID=40585045

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GR2009/000024 WO2009130515A2 (en) 2008-04-22 2009-04-15 Method and system for recording and promoting peripheral nerve regeneration

Country Status (3)

Country Link
EP (1) EP2307090A2 (en)
GR (1) GR1006568B (en)
WO (1) WO2009130515A2 (en)

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US11554265B2 (en) 2011-05-13 2023-01-17 Saluda Medical Pty Ltd Method and apparatus for application of a neural stimulus

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CA2835486C (en) 2011-05-13 2022-07-19 Saluda Medical Pty Limited Method and apparatus for measurement of neural response - a
DK2707095T3 (en) 2011-05-13 2018-12-17 Saluda Medical Pty Ltd DEVICE FOR APPLYING A NEURAL STIMULUS
EP4159273A1 (en) 2011-05-13 2023-04-05 Saluda Medical Pty Ltd Implantable device for controlling a neural stimulus
US10568559B2 (en) 2011-05-13 2020-02-25 Saluda Medical Pty Ltd Method and apparatus for measurement of neural response
WO2012155184A1 (en) * 2011-05-13 2012-11-22 National Ict Australia Ltd Method and apparatus for measurement of neural response - c
US9974455B2 (en) 2011-05-13 2018-05-22 Saluda Medical Pty Ltd. Method and apparatus for estimating neural recruitment
AU2013344311B2 (en) 2012-11-06 2017-11-30 Saluda Medical Pty Ltd Method and system for controlling electrical conditions of tissue
EP3068296A4 (en) 2013-11-15 2017-07-19 Saluda Medical Pty Limited Monitoring brain neural potentials
JP6671021B2 (en) 2013-11-22 2020-03-25 サルーダ・メディカル・ピーティーワイ・リミテッド Method and device for detecting a neural response in a neural measurement
JP6674385B2 (en) 2014-05-05 2020-04-01 サルーダ・メディカル・ピーティーワイ・リミテッド Improve neurometry
EP3838331B1 (en) 2014-07-25 2024-05-22 Saluda Medical Pty Limited Neural stimulation dosing
US10597636B2 (en) 2014-09-19 2020-03-24 University Of Florida Research Foundation, Inc. Electroactive polymeric scaffolds and method for delivering nerve growth factor to nerve tissue
US11006846B2 (en) 2014-11-17 2021-05-18 Saluda Medical Pty Ltd Method and device for detecting a neural response in neural measurements
WO2016090420A1 (en) 2014-12-11 2016-06-16 Saluda Medical Pty Ltd Implantable electrode positioning
AU2015362091B2 (en) 2014-12-11 2020-11-26 Saluda Medical Pty Ltd Method and device for feedback control of neural stimulation
US10918872B2 (en) 2015-01-19 2021-02-16 Saluda Medical Pty Ltd Method and device for neural implant communication
US10894158B2 (en) 2015-04-09 2021-01-19 Saluda Medical Pty Ltd Electrode to nerve distance estimation
US11110270B2 (en) 2015-05-31 2021-09-07 Closed Loop Medical Pty Ltd Brain neurostimulator electrode fitting
JP2018516150A (en) 2015-05-31 2018-06-21 サルーダ・メディカル・ピーティーワイ・リミテッド Cranial nerve activity monitoring
CA2980482C (en) 2015-06-01 2023-09-26 Saluda Medical Pty Ltd Motor fibre neuromodulation
WO2017173493A1 (en) 2016-04-05 2017-10-12 Saluda Medical Pty Ltd Improved feedback control of neuromodulation
US11179091B2 (en) 2016-06-24 2021-11-23 Saluda Medical Pty Ltd Neural stimulation for reduced artefact
WO2018232145A1 (en) * 2017-06-14 2018-12-20 Wichita State University Apparatus and method for neural regeneration
US10589089B2 (en) 2017-10-25 2020-03-17 Epineuron Technologies Inc. Systems and methods for delivering neuroregenerative therapy
AU2018354250A1 (en) 2017-10-25 2020-06-11 Epineuron Technologies Inc. Systems and methods for delivering neuroregenerative therapy
EP3784338A4 (en) 2018-04-27 2022-01-19 Saluda Medical Pty Ltd Neurostimulation of mixed nerves
US11247043B2 (en) 2019-10-01 2022-02-15 Epineuron Technologies Inc. Electrode interface devices for delivery of neuroregenerative therapy

Citations (4)

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Publication number Priority date Publication date Assignee Title
US20060089751A1 (en) * 1997-01-27 2006-04-27 Ewa Herbst Electronic delivery systems and methods with feedback
US20060194724A1 (en) * 2005-02-25 2006-08-31 Whitehurst Todd K Methods and systems for nerve regeneration
WO2006108262A2 (en) * 2005-04-15 2006-10-19 Lozano Andres M Regulation of neurotrophins
WO2008005843A2 (en) * 2006-06-30 2008-01-10 Cyberkinetics Neurotechnology Systems, Inc. Nerve regeneration system and lead devices associated therewith

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060089751A1 (en) * 1997-01-27 2006-04-27 Ewa Herbst Electronic delivery systems and methods with feedback
US20060194724A1 (en) * 2005-02-25 2006-08-31 Whitehurst Todd K Methods and systems for nerve regeneration
WO2006108262A2 (en) * 2005-04-15 2006-10-19 Lozano Andres M Regulation of neurotrophins
WO2008005843A2 (en) * 2006-06-30 2008-01-10 Cyberkinetics Neurotechnology Systems, Inc. Nerve regeneration system and lead devices associated therewith

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11554265B2 (en) 2011-05-13 2023-01-17 Saluda Medical Pty Ltd Method and apparatus for application of a neural stimulus

Also Published As

Publication number Publication date
WO2009130515A2 (en) 2009-10-29
EP2307090A2 (en) 2011-04-13
GR1006568B (en) 2009-10-13

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