WO2009127398A3 - Conjugated linoleic acid derivatives - Google Patents

Conjugated linoleic acid derivatives Download PDF

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Publication number
WO2009127398A3
WO2009127398A3 PCT/EP2009/002746 EP2009002746W WO2009127398A3 WO 2009127398 A3 WO2009127398 A3 WO 2009127398A3 EP 2009002746 W EP2009002746 W EP 2009002746W WO 2009127398 A3 WO2009127398 A3 WO 2009127398A3
Authority
WO
WIPO (PCT)
Prior art keywords
linoleic acid
conjugated linoleic
acid derivatives
positions
single bond
Prior art date
Application number
PCT/EP2009/002746
Other languages
French (fr)
Other versions
WO2009127398A2 (en
Inventor
Orina Belton
Desmond Fitzgerald
Marc Devocelle
Clare Cox
Nicolas ARDÈS-GUISOT
Original Assignee
University College Dublin, National University Of Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College Dublin, National University Of Ireland filed Critical University College Dublin, National University Of Ireland
Publication of WO2009127398A2 publication Critical patent/WO2009127398A2/en
Publication of WO2009127398A3 publication Critical patent/WO2009127398A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Fats And Perfumes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A conjugated linoleic acid (CLA) derivative having the structure (I) wherein n is an integer from 1 to 10; and wherein the broken lines at positions 9 and 11, or at positions 10 and 12, are each double bonds separated by a single bond, and wherein the remaining broken line is a single bond.
PCT/EP2009/002746 2008-04-15 2009-04-15 Conjugated linoleic acid derivatives WO2009127398A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0806802.5 2008-04-15
GBGB0806802.5A GB0806802D0 (en) 2008-04-15 2008-04-15 Conjugated linoleic acid derivatives

Publications (2)

Publication Number Publication Date
WO2009127398A2 WO2009127398A2 (en) 2009-10-22
WO2009127398A3 true WO2009127398A3 (en) 2010-02-18

Family

ID=39433656

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/002746 WO2009127398A2 (en) 2008-04-15 2009-04-15 Conjugated linoleic acid derivatives

Country Status (2)

Country Link
GB (1) GB0806802D0 (en)
WO (1) WO2009127398A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8809560B2 (en) 2011-05-17 2014-08-19 Board Of Trustees Of The University Of Arkansas Trans-, trans-conjugated linoleic acid compositions and use thereof
US9062276B2 (en) 2012-12-03 2015-06-23 Board Of Trustees Of The University Of Arkansas Conjugated linoleic acid rich vegetable oil production from linoleic rich oils by heterogeneous catalysis
WO2020221805A1 (en) * 2019-04-30 2020-11-05 Dsm Ip Assets B.V. Novel fatty acid esters

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BUCCELLATI CAROLA ET AL: "Pharmacological characterization of 2NTX-99 [4-methoxy-N '(4-trans-nitrooxycyclohexyl)-N-3-(3-pyridinylmethyl)-1,3-benzenedica rboxamide], a potential antiatherothrombotic agent with antithromboxane and nitric oxide donor activity in platelet and vascular preparations", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 317, no. 2, May 2006 (2006-05-01), pages 830 - 837 URL, XP002559646, ISSN: 0022-3565 *
DECKER M ET AL: "Synthesis and vasorelaxant properties of hybrid molecules out of NO-donors and the beta-receptor blocking drug propranolol", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 14, no. 19, 4 October 2004 (2004-10-04), pages 4995 - 4997, XP004548804, ISSN: 0960-894X *
LAZZARATO LORETTA ET AL: "Searching for new NO-donor aspirin-like molecules: A new class of nitrooxy-acyl derivatives of salicylic acid", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 6, March 2008 (2008-03-01), pages 1894 - 1903, XP002559647, ISSN: 0022-2623 *
MOMI ET AL: "NCX 6560, a nitric oxide-releasing derivative of atorvastatin, inhibits cholesterol biosynthesis and shows anti-inflammatory and anti-thrombotic properties", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER BV, NL, vol. 570, no. 1-3, 16 August 2007 (2007-08-16), pages 115 - 124, XP022202431, ISSN: 0014-2999 *
PAUL-CLAR M ET AL: "21-NO-prednisolone is a novel nitric oxide-releasing derivative of prednisolone with enhanced anti-inflammatory properties", BRITISH JOURNAL OF PHARMACOLOGY, NATURE PUBLISHING GROUP, BASINGSTOKE, HANTS, vol. 131, 1 December 2000 (2000-12-01), pages 1345 - 1354, XP002953774, ISSN: 0007-1188 *
TOOMEY S ET AL: "Profound resolution of early atherosclerosis with conjugated linoleic acid", ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, IE, vol. 187, no. 1, 1 July 2006 (2006-07-01), pages 40 - 49, XP025242588, ISSN: 0021-9150, [retrieved on 20060701] *
TOOMEY S ET AL: "Regression of pre-established atherosclerosis in the apoE-/- mouse by conjugated linoleic acid.", BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 31, no. 5, October 2003 (2003-10-01), pages 1075 - 1079, XP002559645, ISSN: 0300-5127 *

Also Published As

Publication number Publication date
WO2009127398A2 (en) 2009-10-22
GB0806802D0 (en) 2008-05-14

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