WO2009119987A3 - 피라졸 유도체를 포함하는 골다공증 예방 및 치료용 조성물 - Google Patents

피라졸 유도체를 포함하는 골다공증 예방 및 치료용 조성물 Download PDF

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Publication number
WO2009119987A3
WO2009119987A3 PCT/KR2009/001315 KR2009001315W WO2009119987A3 WO 2009119987 A3 WO2009119987 A3 WO 2009119987A3 KR 2009001315 W KR2009001315 W KR 2009001315W WO 2009119987 A3 WO2009119987 A3 WO 2009119987A3
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WO
WIPO (PCT)
Prior art keywords
preventing
pyrazole derivatives
treating osteoporosis
composition
pharmaceutically acceptable
Prior art date
Application number
PCT/KR2009/001315
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English (en)
French (fr)
Other versions
WO2009119987A2 (ko
Inventor
배윤수
이기인
이수영
최선
이지현
Original Assignee
이화여자대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 이화여자대학교 산학협력단 filed Critical 이화여자대학교 산학협력단
Publication of WO2009119987A2 publication Critical patent/WO2009119987A2/ko
Publication of WO2009119987A3 publication Critical patent/WO2009119987A3/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/306—Foods, ingredients or supplements having a functional effect on health having an effect on bone mass, e.g. osteoporosis prevention

Abstract

본 발명은 피라졸 유도체, 또는 이들의 약제학적으로 허용되는 염을 포함하는 골다공증 예방 및 치료용 조성물과, 상기 조성물을 개체에 투여하는 단계를 포함하는 골다공증의 예방 및 치료 방법에 관한 것으로서, 구체적으로는 본 발명에 따른 피라졸 유도체, 또는 이들의 약제학적으로 허용되는 염은 NADPH 옥시다아제 및 RANKL 억제 활성이 우수함으로 인해 파골세포 분화 억제 효과가 뛰어나 골다공증 치료 및 예방에 사용될 수 있다.
PCT/KR2009/001315 2008-03-25 2009-03-17 피라졸 유도체를 포함하는 골다공증 예방 및 치료용 조성물 WO2009119987A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0027414 2008-03-25
KR1020080027414A KR100942382B1 (ko) 2008-03-25 2008-03-25 피라졸 유도체를 포함하는 골다공증 예방 및 치료용 조성물

Publications (2)

Publication Number Publication Date
WO2009119987A2 WO2009119987A2 (ko) 2009-10-01
WO2009119987A3 true WO2009119987A3 (ko) 2009-12-03

Family

ID=41114438

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/001315 WO2009119987A2 (ko) 2008-03-25 2009-03-17 피라졸 유도체를 포함하는 골다공증 예방 및 치료용 조성물

Country Status (2)

Country Link
KR (1) KR100942382B1 (ko)
WO (1) WO2009119987A2 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101252520B1 (ko) * 2010-09-20 2013-04-09 서울대학교산학협력단 Ｒａｎｋｌ－유도 파골세포형성을 억제하는 벤조피라닐 테트라사이클
KR20120098489A (ko) * 2011-02-28 2012-09-05 이화여자대학교 산학협력단 피라졸 유도체를 포함하는 심혈관 질환 예방 및 치료용 조성물
KR20120098462A (ko) * 2011-02-28 2012-09-05 이화여자대학교 산학협력단 피라졸 유도체, 이의 제조방법 및 이를 포함하는 골다공증 예방 및 치료용 조성물
KR101633957B1 (ko) * 2012-08-27 2016-06-27 이화여자대학교 산학협력단 피라졸 유도체를 포함하는 신장질환 예방 또는 치료용 조성물
KR101395658B1 (ko) 2012-09-20 2014-05-16 서울대학교산학협력단 4-(5-(2-메톡시페닐)-3-(ｐ-톨릴)-4,5-디하이드로-1Ｈ-피라졸-1-일)-4-옥소부탄산을 포함하는 골대사성 질환의 예방 및 치료용 조성물
KR101840702B1 (ko) * 2017-11-01 2018-03-22 압타바이오 주식회사 간질환 치료제

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0469357A1 (de) * 1990-07-24 1992-02-05 Bayer Ag 1-[Pyri(mi)dyl-(2)]-5-hydroxy-pyrazol-Mikrobizide
US20060084695A1 (en) * 2004-04-29 2006-04-20 John Griffin Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US20060194861A1 (en) * 2002-06-27 2006-08-31 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0469357A1 (de) * 1990-07-24 1992-02-05 Bayer Ag 1-[Pyri(mi)dyl-(2)]-5-hydroxy-pyrazol-Mikrobizide
US20060194861A1 (en) * 2002-06-27 2006-08-31 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
US20060084695A1 (en) * 2004-04-29 2006-04-20 John Griffin Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KHAN, MISBAHUL A. ET AL.: "'Synthesis of heterocyclic compounds. IV., Pyrazol-1'-yl-pyridines'", MONATSHEFTE FUER CHEMIE, vol. 111, no. 4, 1980, pages 883 - 888 *

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Publication number Publication date
KR100942382B1 (ko) 2010-02-12
KR20090102145A (ko) 2009-09-30
WO2009119987A2 (ko) 2009-10-01

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