WO2009116074A3 - Substituted benzimidazoles as cannabinoid modulator - Google Patents

Substituted benzimidazoles as cannabinoid modulator Download PDF

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Publication number
WO2009116074A3
WO2009116074A3 PCT/IN2009/000099 IN2009000099W WO2009116074A3 WO 2009116074 A3 WO2009116074 A3 WO 2009116074A3 IN 2009000099 W IN2009000099 W IN 2009000099W WO 2009116074 A3 WO2009116074 A3 WO 2009116074A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutically acceptable
substituted benzimidazoles
regioisomers
stereoisomers
synthesis
Prior art date
Application number
PCT/IN2009/000099
Other languages
French (fr)
Other versions
WO2009116074A2 (en
Inventor
Harikishore Pingali
Mukul R. Jain
Pankaj M. Makadia
Original Assignee
Cadila Healthcare Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Limited filed Critical Cadila Healthcare Limited
Publication of WO2009116074A2 publication Critical patent/WO2009116074A2/en
Publication of WO2009116074A3 publication Critical patent/WO2009116074A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel compounds of general formula (I), their stereoisomers, regioisomers, tautomeric forms and novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The present invention also relates to a process of preparing novel compounds of general formula (I), their stereoisomers, regioisomers, their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.
PCT/IN2009/000099 2008-02-13 2009-02-12 Substituted benzimidazoles as cannabinoid modulator WO2009116074A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN313/MUM/2008 2008-02-13
IN313MU2008 2008-02-13

Publications (2)

Publication Number Publication Date
WO2009116074A2 WO2009116074A2 (en) 2009-09-24
WO2009116074A3 true WO2009116074A3 (en) 2009-11-12

Family

ID=41057444

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000099 WO2009116074A2 (en) 2008-02-13 2009-02-12 Substituted benzimidazoles as cannabinoid modulator

Country Status (1)

Country Link
WO (1) WO2009116074A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2536285B1 (en) 2010-02-18 2018-04-25 vTv Therapeutics LLC Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
US8759535B2 (en) 2010-02-18 2014-06-24 High Point Pharmaceuticals, Llc Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
PE20170143A1 (en) 2014-02-11 2017-03-19 Bayer Pharma AG BENZIMIDAZOLE-2-AMINES AS MIDH1 INHIBITORS
ES2732902T3 (en) 2014-02-11 2019-11-26 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts Benzimidazol-2-amines as MIDH1 inhibitors
ES2814151T3 (en) 2014-10-23 2021-03-26 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts 1-Cyclohexyl-2-phenylaminobenzimidazoles as MIDH1 inhibitors for the treatment of tumors
US10138226B2 (en) 2014-10-23 2018-11-27 Bayer Pharma Aktiengesellschaft Benzimidazol-2-amines as MIDH1 inhibitors
WO2016089648A1 (en) 2014-12-01 2016-06-09 Vtv Therapeutics Llc Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof
WO2016198322A1 (en) 2015-06-08 2016-12-15 Bayer Pharma Aktiengesellschaft N-menthylbenzimidazoles as midh1 inhibitors
US10414734B2 (en) 2015-07-16 2019-09-17 Bayer Pharma Aktiengesellschaft 5-hydroxyalkylbenzimidazoles as mIDH1 inhibitors
ES2899114T3 (en) * 2016-07-25 2022-03-10 Nerviano Medical Sciences Srl Purine and 3-deazapurine analogs as choline kinase inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002085866A1 (en) * 2001-04-20 2002-10-31 Astrazeneca Ab Novel compounds
WO2008153701A1 (en) * 2007-05-24 2008-12-18 Schering Corporation Compounds for inhibiting ksp kinesin activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002085866A1 (en) * 2001-04-20 2002-10-31 Astrazeneca Ab Novel compounds
WO2008153701A1 (en) * 2007-05-24 2008-12-18 Schering Corporation Compounds for inhibiting ksp kinesin activity

Also Published As

Publication number Publication date
WO2009116074A2 (en) 2009-09-24

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