WO2008062424A3 - Substituted 4,5-dihydro-1h-pyrazole derivatives as cannabinoid modulators - Google Patents

Substituted 4,5-dihydro-1h-pyrazole derivatives as cannabinoid modulators Download PDF

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Publication number
WO2008062424A3
WO2008062424A3 PCT/IN2007/000320 IN2007000320W WO2008062424A3 WO 2008062424 A3 WO2008062424 A3 WO 2008062424A3 IN 2007000320 W IN2007000320 W IN 2007000320W WO 2008062424 A3 WO2008062424 A3 WO 2008062424A3
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WO
WIPO (PCT)
Prior art keywords
pharmaceutically acceptable
dihydro
substituted
pyrazole derivatives
cannabinoid modulators
Prior art date
Application number
PCT/IN2007/000320
Other languages
French (fr)
Other versions
WO2008062424A2 (en
Inventor
Brijesh K Srivastava
Braj Bhushan Lohray
Vidya Bhushan Lohray
Pankaj Ramanbhai Patel
Original Assignee
Cadila Healthcare Ltd
Brijesh K Srivastava
Braj Bhushan Lohray
Vidya Bhushan Lohray
Pankaj Ramanbhai Patel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd, Brijesh K Srivastava, Braj Bhushan Lohray, Vidya Bhushan Lohray, Pankaj Ramanbhai Patel filed Critical Cadila Healthcare Ltd
Publication of WO2008062424A2 publication Critical patent/WO2008062424A2/en
Publication of WO2008062424A3 publication Critical patent/WO2008062424A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Disclosed herein in the embodiment of the invention are compounds of general formula (I), their stereoisomers, regioisomers, tautomeric forms and novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The present invention also discloses process of preparing compounds of general formula (I), their stereoisomers, regioisomers, their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.
PCT/IN2007/000320 2006-07-31 2007-07-27 Substituted 4,5-dihydro-1h-pyrazole derivatives as cannabinoid modulators WO2008062424A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1214MU2006 2006-07-31
IN1214/MUM/2006 2006-07-31

Publications (2)

Publication Number Publication Date
WO2008062424A2 WO2008062424A2 (en) 2008-05-29
WO2008062424A3 true WO2008062424A3 (en) 2008-07-31

Family

ID=39323933

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000320 WO2008062424A2 (en) 2006-07-31 2007-07-27 Substituted 4,5-dihydro-1h-pyrazole derivatives as cannabinoid modulators

Country Status (1)

Country Link
WO (1) WO2008062424A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2864958A1 (en) * 2004-01-12 2005-07-15 Sanofi Synthelabo New 1,5-diphenyl-3-sulfonamidomethyl-1H-pyrazole derivatives are cannabinoid receptor antagonists used for treating e.g. eating disorders, gastrointestinal disorders, inflammation and immunological disorders
WO2005077911A1 (en) * 2004-02-17 2005-08-25 Laboratorios Del Dr. Esteve S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
EP1602656A1 (en) * 2004-05-24 2005-12-07 NEUROSCIENZE PHARMANESS S.C. a R.L. Pyrazole derivatives having affinity for cb1 and/or cb2 receptors
WO2008043544A1 (en) * 2006-10-11 2008-04-17 Laboratorios Del Dr. Esteve, S.A. Sulfonamide substituted pyrazoline compounds, their preparation and use as cb1 modulators

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2864958A1 (en) * 2004-01-12 2005-07-15 Sanofi Synthelabo New 1,5-diphenyl-3-sulfonamidomethyl-1H-pyrazole derivatives are cannabinoid receptor antagonists used for treating e.g. eating disorders, gastrointestinal disorders, inflammation and immunological disorders
WO2005077911A1 (en) * 2004-02-17 2005-08-25 Laboratorios Del Dr. Esteve S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
EP1602656A1 (en) * 2004-05-24 2005-12-07 NEUROSCIENZE PHARMANESS S.C. a R.L. Pyrazole derivatives having affinity for cb1 and/or cb2 receptors
WO2008043544A1 (en) * 2006-10-11 2008-04-17 Laboratorios Del Dr. Esteve, S.A. Sulfonamide substituted pyrazoline compounds, their preparation and use as cb1 modulators

Also Published As

Publication number Publication date
WO2008062424A2 (en) 2008-05-29

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