WO2009113090A3 - Process for preparing an oral formulation of an acid-sensitive benzimidazole drug - Google Patents
Process for preparing an oral formulation of an acid-sensitive benzimidazole drug Download PDFInfo
- Publication number
- WO2009113090A3 WO2009113090A3 PCT/IN2009/000033 IN2009000033W WO2009113090A3 WO 2009113090 A3 WO2009113090 A3 WO 2009113090A3 IN 2009000033 W IN2009000033 W IN 2009000033W WO 2009113090 A3 WO2009113090 A3 WO 2009113090A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- drug
- layer
- depositing
- preparing
- acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to A process for preparing an oral formulation comprising an acid-sensitive benzimidazole drug comprising depositing a stabilizer layer, free of the said drug and comprising an alkaline material on a core made from one or more excipients; or depositing a drug layer, free of an alkaline material and comprising the said drug, on a core made from one or more excipients; depositing one or more of the said stabilizer layer(s) on the said drug layer(s); depositing one or more of the said drug layer(s) on the said stabilizer layer(s); depositing one or more sub-coating layer(s) on the core achieved and depositing an enteric coating layer on the sub-coating layer(s) achieved.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN115MU2008 | 2008-01-17 | ||
IN115/MUM/2008 | 2008-01-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009113090A2 WO2009113090A2 (en) | 2009-09-17 |
WO2009113090A3 true WO2009113090A3 (en) | 2009-11-05 |
Family
ID=41065635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2009/000033 WO2009113090A2 (en) | 2008-01-17 | 2009-01-12 | Process for preparing an oral formulation of an acid-sensitive benzimidazole drug |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009113090A2 (en) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994002140A1 (en) * | 1992-07-17 | 1994-02-03 | Astra Aktiebolag | Pharmaceutical composition containing antiulcer agent |
US5690960A (en) * | 1993-07-09 | 1997-11-25 | Astra Aktiebolag | Pharmaceutical formulation of omeprazole |
WO1998019668A1 (en) * | 1996-11-06 | 1998-05-14 | Sharmatek, Inc. | Delayed delivery system for acid-sensitive drugs |
US20050214371A1 (en) * | 2004-03-03 | 2005-09-29 | Simona Di Capua | Stable pharmaceutical composition comprising an acid labile drug |
WO2006011159A2 (en) * | 2004-06-21 | 2006-02-02 | Torrent Pharmaceuticals Limited | Stabilized pharmaceutical composition containing rabeprazole sodium with improved bioavailability |
WO2007075980A2 (en) * | 2005-12-20 | 2007-07-05 | Teva Pharmaceutical Industries Ltd. | Lansoprazole orally disintegrating tablets |
-
2009
- 2009-01-12 WO PCT/IN2009/000033 patent/WO2009113090A2/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994002140A1 (en) * | 1992-07-17 | 1994-02-03 | Astra Aktiebolag | Pharmaceutical composition containing antiulcer agent |
US5690960A (en) * | 1993-07-09 | 1997-11-25 | Astra Aktiebolag | Pharmaceutical formulation of omeprazole |
WO1998019668A1 (en) * | 1996-11-06 | 1998-05-14 | Sharmatek, Inc. | Delayed delivery system for acid-sensitive drugs |
US20050214371A1 (en) * | 2004-03-03 | 2005-09-29 | Simona Di Capua | Stable pharmaceutical composition comprising an acid labile drug |
WO2006011159A2 (en) * | 2004-06-21 | 2006-02-02 | Torrent Pharmaceuticals Limited | Stabilized pharmaceutical composition containing rabeprazole sodium with improved bioavailability |
WO2007075980A2 (en) * | 2005-12-20 | 2007-07-05 | Teva Pharmaceutical Industries Ltd. | Lansoprazole orally disintegrating tablets |
Also Published As
Publication number | Publication date |
---|---|
WO2009113090A2 (en) | 2009-09-17 |
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