WO2009108223A2 - Détection d’agents pathogènes par mesure simultanée de la taille/de la fluorescence - Google Patents

Détection d’agents pathogènes par mesure simultanée de la taille/de la fluorescence Download PDF

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Publication number
WO2009108223A2
WO2009108223A2 PCT/US2008/083052 US2008083052W WO2009108223A2 WO 2009108223 A2 WO2009108223 A2 WO 2009108223A2 US 2008083052 W US2008083052 W US 2008083052W WO 2009108223 A2 WO2009108223 A2 WO 2009108223A2
Authority
WO
WIPO (PCT)
Prior art keywords
particle
particles
fluorescence
threshold
cross
Prior art date
Application number
PCT/US2008/083052
Other languages
English (en)
Other versions
WO2009108223A3 (fr
Inventor
Michael Morrell
Gregory Scott Morris
Jien-Ping Jiang
Original Assignee
Biovigilant Systems, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovigilant Systems, Inc. filed Critical Biovigilant Systems, Inc.
Publication of WO2009108223A2 publication Critical patent/WO2009108223A2/fr
Publication of WO2009108223A3 publication Critical patent/WO2009108223A3/fr

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6486Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N15/1456Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G01N2015/019
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1493Particle size

Abstract

La présente invention concerne un procédé et un appareil permettant de détecter des agents pathogènes et des particules dans un fluide. Dans ledit procédé et ledit appareil, il est possible de déterminer la taille particulaire et la fluorescence intrinsèque d’une particule. La présente invention concerne la classification de particules en tant que particules biologiques ou inertes au moyen d’un ou de plusieurs seuils.
PCT/US2008/083052 2007-11-09 2008-11-10 Détection d’agents pathogènes par mesure simultanée de la taille/de la fluorescence WO2009108223A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US269207P 2007-11-09 2007-11-09
US61/002,692 2007-11-09

Publications (2)

Publication Number Publication Date
WO2009108223A2 true WO2009108223A2 (fr) 2009-09-03
WO2009108223A3 WO2009108223A3 (fr) 2010-01-21

Family

ID=41016636

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/083052 WO2009108223A2 (fr) 2007-11-09 2008-11-10 Détection d’agents pathogènes par mesure simultanée de la taille/de la fluorescence

Country Status (1)

Country Link
WO (1) WO2009108223A2 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130030715A1 (en) * 2011-07-29 2013-01-31 Honeywell Asca Inc. Apparatus and method for monitoring autotroph cultivation
EP2610832A3 (fr) * 2011-12-27 2014-03-12 Agency For Defense Development Procédé de génération d'alarme dynamique de surveillance de particules biologiques
EP2960640A1 (fr) * 2014-06-26 2015-12-30 Azbil Corporation Dispositif de detection de particules et procede de detection de particules
CN105203445A (zh) * 2014-06-26 2015-12-30 阿自倍尔株式会社 粒子检测装置及粒子检测方法
WO2017056592A1 (fr) * 2015-10-01 2017-04-06 シャープ株式会社 Dispositif de détection de fluorescence
CN109074033A (zh) * 2016-04-01 2018-12-21 凯米罗总公司 用于优化水处理过程中的凝聚和/或絮凝的方法和系统

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US5290707A (en) * 1991-11-25 1994-03-01 The United States Of America As Represented By The Secretary Of The Army Method for detection of microorganisms
US5540494A (en) * 1994-06-03 1996-07-30 Purvis, Jr.; Norman B. Method and apparatus for determining absolute particle size, surface area and volume normalized fluorescence using forward angle light scatter intensity in flow cytometry
WO2005033283A2 (fr) * 2003-09-30 2005-04-14 Singulex, Inc. Procedes pour ameliorer l'analyse de detection de particules
US20050221497A1 (en) * 1992-02-24 2005-10-06 Carole Young Quality control method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5290707A (en) * 1991-11-25 1994-03-01 The United States Of America As Represented By The Secretary Of The Army Method for detection of microorganisms
US20050221497A1 (en) * 1992-02-24 2005-10-06 Carole Young Quality control method
US5540494A (en) * 1994-06-03 1996-07-30 Purvis, Jr.; Norman B. Method and apparatus for determining absolute particle size, surface area and volume normalized fluorescence using forward angle light scatter intensity in flow cytometry
WO2005033283A2 (fr) * 2003-09-30 2005-04-14 Singulex, Inc. Procedes pour ameliorer l'analyse de detection de particules

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HAIRSTON ET AL.: 'Design of an Instrument for Real-Time Detection of Bioaerosols Using Simultaneous Measurement of Particle Aerodynamic Size and Intrinsic Fluorescence.' JOURNAL OF AEROSOL SCIENCE vol. 28, no. 3, 1997, pages 471 - 482 *
'Searched for http://www.biovigilant.com/PDFs/Why Simultaneous Sizing and Fluorescence is Necessary for Microbial Detection 9-8-05-c.pdf.' WAYBACK MACHINE INTERNET ARCHIVE., [Online] 10 July 2009, Retrieved from the Internet: <URL:http://web.archive.org/web/"/http://ww w.biovigilant.com/PDFs/Why%20Simultaneous%2 0Sizing %20and%20Fluorescence%20is%20Necessary%20fo r%20Microbial%20Detection%209-8-05- c.pdf> [retrieved on 2009-07-10] *
WEICHERT ET AL.: 'Determination of Fluorescence Cross-Sections of Biological Aerosols.' PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION vol. 19, no. ISS.3, 01 July 2002, pages 216 - 222 *
'Why Simultaneous Sizing and Fluorescence is Necessary in Order to Do Microbial Detection.' BIOVIGILANT.COM BIOVIGILANT WHITE PAPER, [Online] 21 October 2006, Retrieved from the Internet: <URL:http://www.biovigilant.com/PDFs/Why%20 Simultaneous%20Sizing%20and%20Fluorescence% 20is%20Necessary%20for%20Microbial%20Detect ion%209-8-05-c.pdf> [retrieved on 2009-07-06] *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130030715A1 (en) * 2011-07-29 2013-01-31 Honeywell Asca Inc. Apparatus and method for monitoring autotroph cultivation
US9540604B2 (en) * 2011-07-29 2017-01-10 Honeywell Limited Apparatus and method for monitoring autotroph cultivation
EP2610832A3 (fr) * 2011-12-27 2014-03-12 Agency For Defense Development Procédé de génération d'alarme dynamique de surveillance de particules biologiques
CN105203445A (zh) * 2014-06-26 2015-12-30 阿自倍尔株式会社 粒子检测装置及粒子检测方法
CN105223112A (zh) * 2014-06-26 2016-01-06 阿自倍尔株式会社 粒子检测装置及粒子检测方法
JP2016008957A (ja) * 2014-06-26 2016-01-18 アズビル株式会社 粒子検出装置及び粒子の検出方法
EP2960640A1 (fr) * 2014-06-26 2015-12-30 Azbil Corporation Dispositif de detection de particules et procede de detection de particules
US9671346B2 (en) 2014-06-26 2017-06-06 Azbil Corporation Particle detecting and discriminating device and method
CN105203445B (zh) * 2014-06-26 2019-08-06 阿自倍尔株式会社 粒子检测装置及粒子检测方法
WO2017056592A1 (fr) * 2015-10-01 2017-04-06 シャープ株式会社 Dispositif de détection de fluorescence
CN109074033A (zh) * 2016-04-01 2018-12-21 凯米罗总公司 用于优化水处理过程中的凝聚和/或絮凝的方法和系统
US10988392B2 (en) 2016-04-01 2021-04-27 Kemira Oyj Method and system for optimization of coagulation and/or flocculation in a water treatment process
CN109074033B (zh) * 2016-04-01 2022-04-19 凯米罗总公司 用于优化水处理过程中的凝聚和/或絮凝的方法和系统

Also Published As

Publication number Publication date
WO2009108223A3 (fr) 2010-01-21

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