WO2009107859A3 - Polymer nanoparticle and contrast agent for optical molecular imaging - Google Patents

Polymer nanoparticle and contrast agent for optical molecular imaging Download PDF

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Publication number
WO2009107859A3
WO2009107859A3 PCT/JP2009/054108 JP2009054108W WO2009107859A3 WO 2009107859 A3 WO2009107859 A3 WO 2009107859A3 JP 2009054108 W JP2009054108 W JP 2009054108W WO 2009107859 A3 WO2009107859 A3 WO 2009107859A3
Authority
WO
WIPO (PCT)
Prior art keywords
contrast agent
molecular imaging
optical molecular
polymer nanoparticle
polymer
Prior art date
Application number
PCT/JP2009/054108
Other languages
French (fr)
Other versions
WO2009107859A2 (en
Inventor
Shinzaburo Ito
Satoshi Nitahara
Hiroyuki Aoki
Masato Minami
Yoshinori Tomida
Tetsuya Yano
Kimihiro Yoshimura
Original Assignee
Kyoto University
Canon Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto University, Canon Kabushiki Kaisha filed Critical Kyoto University
Publication of WO2009107859A2 publication Critical patent/WO2009107859A2/en
Publication of WO2009107859A3 publication Critical patent/WO2009107859A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0097—Dye preparations of special physical nature; Tablets, films, extrusion, microcapsules, sheets, pads, bags with dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/105—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing a methine or polymethine dye

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Provided are polymer nanoparticles each having a fluorescent dye dispersed in the matrix of a fluorescent polymer, characterized in that the surface of the nanoparticles is protected by a surfactant and fluorescence is emitted via FRET between the fluorescent polymer and the fluorescent dye, and a contrast agent for optical molecular imaging using the polymer nanoparticles.
PCT/JP2009/054108 2008-02-29 2009-02-26 Polymer nanoparticle and contrast agent for optical molecular imaging WO2009107859A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2008-050395 2008-02-29
JP2008050395 2008-02-29
JP2008120603 2008-05-02
JP2008-120603 2008-05-02
JP2008230140 2008-09-08
JP2008-230140 2008-09-08

Publications (2)

Publication Number Publication Date
WO2009107859A2 WO2009107859A2 (en) 2009-09-03
WO2009107859A3 true WO2009107859A3 (en) 2010-08-05

Family

ID=41016556

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2009/054108 WO2009107859A2 (en) 2008-02-29 2009-02-26 Polymer nanoparticle and contrast agent for optical molecular imaging

Country Status (2)

Country Link
JP (1) JP2010083860A (en)
WO (1) WO2009107859A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2935001B1 (en) * 2008-08-14 2011-12-30 Commissariat Energie Atomique FLUORESCENT EMULSION
KR101065241B1 (en) * 2009-05-13 2011-09-19 한국과학기술연구원 Nanoparticles of emissive polymers and preparation method thereof
EP3483610A1 (en) * 2009-11-09 2019-05-15 University Of Washington Center For Commercialization Functionalized chromophoric polymer dots and bioconjugates thereof
US8547533B2 (en) * 2009-12-28 2013-10-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Composite probes and use thereof in super resolution methods
JP6279902B2 (en) 2010-10-18 2018-02-14 ユニバーシティ オブ ワシントン センター フォー コマーシャライゼーション Chromophore polymer dot
JP5887823B2 (en) * 2011-10-19 2016-03-16 コニカミノルタ株式会社 Organization evaluation method
US9797840B2 (en) 2011-11-28 2017-10-24 University Of Washington Through Its Center For Commercialization Highly fluorescent polymer nanoparticle
US10150841B2 (en) 2011-12-30 2018-12-11 University Of Washington Through Its Center For Commercialization Chromophoric polymer dots with narrow-band emission
US10067139B2 (en) 2012-02-03 2018-09-04 University Of Washington Through Its Center For Commercialization Polyelectrolyte-coated polymer dots and related methods
US8974830B2 (en) 2012-02-23 2015-03-10 Canon Kabushiki Kaisha Particles and contrast agent including the same for optical imaging
WO2013125232A1 (en) * 2012-02-23 2013-08-29 キヤノン株式会社 Dye-containing nanoparticle for photoacoustic contrast agent
US10514381B2 (en) 2013-03-14 2019-12-24 University Of Washington Through Its Center For Commercialization Polymer dot compositions and related methods
US20150037255A1 (en) * 2013-07-30 2015-02-05 Canon Kabushiki Kaisha Phthalocyanine dye-containing contrast agent for photoacoustic imaging
US20150037254A1 (en) * 2013-07-30 2015-02-05 Canon Kabushiki Kaisha Contrast agent for photoacoustic imaging
EP3521399B1 (en) 2013-11-27 2021-01-27 University of Washington through its Center for Commercialization Encoded chromophoric polymer particles
GB201412824D0 (en) * 2014-07-18 2014-09-03 Univ Manchester Nanoparticles
WO2016161325A1 (en) 2015-04-02 2016-10-06 University Of Washington Optical painting and fluorescence-activated sorting of adherent cells
JP6769992B2 (en) * 2015-04-20 2020-10-14 オレゴン ステート ユニヴァーシティ Compositions Containing Photosensitive Compounds in Polymer Nanoparticles and Methods of Using the Compositions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040142102A1 (en) * 2003-01-21 2004-07-22 Bioarray Solutions, Ltd. Method for controlling solute loading of polymer microparticles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9815270D0 (en) * 1998-07-14 1998-09-09 Cambridge Display Tech Ltd Particles and devices comprising particles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040142102A1 (en) * 2003-01-21 2004-07-22 Bioarray Solutions, Ltd. Method for controlling solute loading of polymer microparticles

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GRIGALEVIUS: "excitation energy transfer from semi-conducting polymer nanoparticles to surface-bound fluorescent dyes", MACROMOLECULAR RAPID COMMUNICATIONS, vol. 27, 2006, pages 200 - 202, XP002562261 *
KIETZKE: "novel approaches to polymer blends based on polymer nanoparticles", NATURE MATERIALS, vol. 2, 2003, pages 408 - 412, XP002562262 *
LANDFESTER: "semiconducting polymer nanospheres in aqueous dispersion prepared by a miniemulsion process", ADVANCED MATERIALS, vol. 14, no. 9, 2002, XP002562263 *

Also Published As

Publication number Publication date
WO2009107859A2 (en) 2009-09-03
JP2010083860A (en) 2010-04-15

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