WO2009106532A3 - Use of prokaryotic tir-domain containing proteins as therapeutic and diagnostic agents - Google Patents

Use of prokaryotic tir-domain containing proteins as therapeutic and diagnostic agents Download PDF

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Publication number
WO2009106532A3
WO2009106532A3 PCT/EP2009/052203 EP2009052203W WO2009106532A3 WO 2009106532 A3 WO2009106532 A3 WO 2009106532A3 EP 2009052203 W EP2009052203 W EP 2009052203W WO 2009106532 A3 WO2009106532 A3 WO 2009106532A3
Authority
WO
WIPO (PCT)
Prior art keywords
tir
prokaryotic
domain containing
therapeutic
diagnostic agents
Prior art date
Application number
PCT/EP2009/052203
Other languages
French (fr)
Other versions
WO2009106532A2 (en
Inventor
Hermann Wagner
Christine Cirl
Thomas Miethke
Original Assignee
Technische Universität München
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technische Universität München filed Critical Technische Universität München
Priority to EP09714809A priority Critical patent/EP2271355A2/en
Publication of WO2009106532A2 publication Critical patent/WO2009106532A2/en
Publication of WO2009106532A3 publication Critical patent/WO2009106532A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/23—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Brucella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates inter alia to nucleic acid molecules encoding prokaryotic TIR-domain containing polypeptides as well as fragments and functional homologues thereof for diagnostic and therapeutic purposes.
PCT/EP2009/052203 2008-02-27 2009-02-25 Use of prokaryotic tir-domain containing proteins as therapeutic and diagnostic agents WO2009106532A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09714809A EP2271355A2 (en) 2008-02-27 2009-02-25 Use of prokaryotic tir-domain containing proteins as therapeutic and diagnostic agents

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3178708P 2008-02-27 2008-02-27
EP08152029.8 2008-02-27
US61/031,787 2008-02-27
EP08152029 2008-02-27

Publications (2)

Publication Number Publication Date
WO2009106532A2 WO2009106532A2 (en) 2009-09-03
WO2009106532A3 true WO2009106532A3 (en) 2009-12-17

Family

ID=40566089

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/052203 WO2009106532A2 (en) 2008-02-27 2009-02-25 Use of prokaryotic tir-domain containing proteins as therapeutic and diagnostic agents

Country Status (2)

Country Link
EP (1) EP2271355A2 (en)
WO (1) WO2009106532A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105936935B (en) * 2016-06-22 2020-01-07 扬州大学 PCR detection kit for rapidly identifying specific serotype salmonella
CN106755294A (en) * 2016-11-10 2017-05-31 浙江大学城市学院 A kind of tcpC real-time quantitative PCR detection methods and purposes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006091517A2 (en) * 2005-02-18 2006-08-31 Novartis Vaccines And Diagnostics Inc. Immunogens from uropathogenic escherichia coli

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006091517A2 (en) * 2005-02-18 2006-08-31 Novartis Vaccines And Diagnostics Inc. Immunogens from uropathogenic escherichia coli

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
"Hypothetical protein c2398 [Escherichia coli CFT073]", PROTEIN HOST- PROTEIN, 20 April 2006 (2006-04-20), XP002537072 *
CIRL CHRISTINE ET AL: "Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins.", NATURE MEDICINE APR 2008, vol. 14, no. 4, April 2008 (2008-04-01), pages 399 - 406, XP002536697, ISSN: 1546-170X *
DATABASE EMBL [online] 20 March 2003 (2003-03-20), "Brucella melitensis 16M chromosome I, section 159 of 195 of the complete sequence.", XP002548351, retrieved from EBI accession no. EMBL:AE009602 Database accession no. AE009602 *
DATABASE NCBI [online] 20 April 2006 (2006-04-20), "Escherichia coli CFT073, complete genome", Database accession no. AAN80857 *
NEWMAN RUCHI M ET AL: "Identification and characterization of a novel bacterial virulence factor that shares homology with mammalian Toll/interleukin-1 receptor family proteins.", INFECTION AND IMMUNITY JAN 2006, vol. 74, no. 1, January 2006 (2006-01-01), pages 594 - 601, XP002536696, ISSN: 0019-9567 *
SALCEDO SUZANA P ET AL: "Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1.", PLOS PATHOGENS 8 FEB 2008, vol. 4, no. 2, 8 February 2008 (2008-02-08), pages e21, XP002536699, ISSN: 1553-7374 *
TURNER JONATHAN D: "A bioinformatic approach to the identification of bacterial proteins interacting with Toll-interleukin 1 receptor-resistance (TIR) homology domains", FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY 10 JUN 2003,, vol. 37, no. 1, 10 June 2003 (2003-06-10), pages 13 - 21, XP002536706 *
WELCH R A ET AL: "Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 99, no. 26, 24 December 2002 (2002-12-24), pages 17020 - 17024, XP002283177, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2009106532A2 (en) 2009-09-03
EP2271355A2 (en) 2011-01-12

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