WO2009105507A3 - Béloxépine, ses énantiomères et certains de leurs analogues convenant au traitement de la douleur - Google Patents

Béloxépine, ses énantiomères et certains de leurs analogues convenant au traitement de la douleur Download PDF

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Publication number
WO2009105507A3
WO2009105507A3 PCT/US2009/034461 US2009034461W WO2009105507A3 WO 2009105507 A3 WO2009105507 A3 WO 2009105507A3 US 2009034461 W US2009034461 W US 2009034461W WO 2009105507 A3 WO2009105507 A3 WO 2009105507A3
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WO
WIPO (PCT)
Prior art keywords
beloxepin
enantiomers
analogs
pain
treatment
Prior art date
Application number
PCT/US2009/034461
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English (en)
Other versions
WO2009105507A2 (fr
Inventor
Bertrand Le Bourdonnec
Roland Dolle
Original Assignee
Adolor Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ594937A priority Critical patent/NZ594937A/xx
Priority to JP2010547737A priority patent/JP2011512414A/ja
Priority to EP09712730A priority patent/EP2285818A4/fr
Priority to BRPI0908098-8A priority patent/BRPI0908098A2/pt
Priority to AU2009215541A priority patent/AU2009215541A1/en
Priority to CN2009801138213A priority patent/CN102007139A/zh
Application filed by Adolor Corporation filed Critical Adolor Corporation
Priority to NZ587896A priority patent/NZ587896A/en
Priority to MX2010009110A priority patent/MX2010009110A/es
Priority to CA2715192A priority patent/CA2715192A1/fr
Publication of WO2009105507A2 publication Critical patent/WO2009105507A2/fr
Publication of WO2009105507A3 publication Critical patent/WO2009105507A3/fr
Priority to IL207668A priority patent/IL207668A0/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des procédés destinés au traitement de la douleur au moyen de béloxépine, d'énantiomères de béloxépine, et de certains de leurs analogues.
PCT/US2009/034461 2008-02-19 2009-02-19 Béloxépine, ses énantiomères et certains de leurs analogues convenant au traitement de la douleur WO2009105507A2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP2010547737A JP2011512414A (ja) 2008-02-19 2009-02-19 疼痛を処置するための、ベロキセピン、その鏡像異性体および類似体
EP09712730A EP2285818A4 (fr) 2008-02-19 2009-02-19 Béloxépine, ses énantiomères et certains de leurs analogues convenant au traitement de la douleur
BRPI0908098-8A BRPI0908098A2 (pt) 2008-02-19 2009-02-19 Beloxepina, composição, métodos para tratar dor em um mamífero, para inibir a recaptação de ne, para antagonizar um receptor de 5ht2 e para tratar um distúrbio em um paciente que é responsivo ao tratamento com um composto nri e com um composto antagonista de 5ht2
AU2009215541A AU2009215541A1 (en) 2008-02-19 2009-02-19 Beloxepin, its enantiomers, and analogs thereof for the treatment of pain
CN2009801138213A CN102007139A (zh) 2008-02-19 2009-02-19 用于治疗疼痛的贝洛塞平、its对映体及其类似物
NZ594937A NZ594937A (en) 2008-02-19 2009-02-19 Beloxepin, its enantiomers, and analogs thereof for the treatment of pain
NZ587896A NZ587896A (en) 2008-02-19 2009-02-19 Enantiomers of beloxepin, and the use of beloxepin and its enantiomers to treat pain and other disorders
MX2010009110A MX2010009110A (es) 2008-02-19 2009-02-19 Beloxepina, sus enantiomeros, y analogos de la misma para el tratamiento de dolor.
CA2715192A CA2715192A1 (fr) 2008-02-19 2009-02-19 Beloxepine, ses enantiomeres et certains de leurs analogues convenant au traitement de la douleur
IL207668A IL207668A0 (en) 2008-02-19 2010-08-18 Beloxepin, its enantiomers, and analogs thereof for the treatment of pain

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US2991308P 2008-02-19 2008-02-19
US2991508P 2008-02-19 2008-02-19
US2991608P 2008-02-19 2008-02-19
US61/029,915 2008-02-19
US61/029,913 2008-02-19
US61/029,916 2008-02-19
US5092108P 2008-05-06 2008-05-06
US61/050,921 2008-05-06

Publications (2)

Publication Number Publication Date
WO2009105507A2 WO2009105507A2 (fr) 2009-08-27
WO2009105507A3 true WO2009105507A3 (fr) 2010-01-14

Family

ID=40986169

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/034461 WO2009105507A2 (fr) 2008-02-19 2009-02-19 Béloxépine, ses énantiomères et certains de leurs analogues convenant au traitement de la douleur

Country Status (11)

Country Link
EP (1) EP2285818A4 (fr)
JP (1) JP2011512414A (fr)
KR (1) KR20100137473A (fr)
CN (1) CN102007139A (fr)
AU (1) AU2009215541A1 (fr)
BR (1) BRPI0908098A2 (fr)
CA (1) CA2715192A1 (fr)
IL (1) IL207668A0 (fr)
MX (1) MX2010009110A (fr)
NZ (2) NZ587896A (fr)
WO (1) WO2009105507A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090233959A1 (en) 2008-02-19 2009-09-17 Adolor Corporation Beloxepin and analogs for the treatment of pain
EA201992474A3 (ru) 2015-02-25 2020-05-31 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорниа Агонисты 5ht для лечения нарушений
CN106243096B (zh) * 2016-07-29 2019-11-29 上海璃道医药科技有限公司 三环类药物的新用途
US10966938B2 (en) 2019-01-04 2021-04-06 Jonand4, Llc Composition and method for preventing or treating hangover symptoms

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997044326A1 (fr) * 1996-05-23 1997-11-27 F. Hoffmann-La Roche Ag Derives d'aryl pyrimidine
WO2001062341A2 (fr) * 2000-02-22 2001-08-30 Knoll Gmbh Agents therapeutiques
WO2004052461A1 (fr) * 2002-12-11 2004-06-24 Pharmacia & Upjohn Company Llc Traitement combine de troubles deficitaires de l'attention avec hyperactivite
WO2005042501A1 (fr) * 2003-11-03 2005-05-12 Warner-Lambert Company Llc Nouveaux inhibiteurs du recaptage de la norepinephrine pour le traitement des troubles du systeme nerveux central
WO2006065600A2 (fr) * 2004-12-13 2006-06-22 Arena Pharmaceuticals, Inc. Derives de n-biaryl et de n-arylheteroaryl piperazine servant de modulateurs du recepteur 5ht2c utilises pour le traitement de troubles associes a celui-ci
WO2006079637A1 (fr) * 2005-01-27 2006-08-03 Janssen Pharmaceutica N.V. Derives heterocycliques tetracycliques de tetrahydrofuranne en tant qu'inhibiteurs de 5ht2 dans le traitement de troubles du systeme nerveux central
US20060293309A1 (en) * 2005-03-28 2006-12-28 Dynogen Pharmaceuticals, Inc. Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors
WO2007041258A1 (fr) * 2005-09-29 2007-04-12 Wyeth Derives de benzothiadiazolyphenylalkylamine utilises dans le traitement d'etats pathologiques ameliores par le recaptage de la monoamine
WO2007112453A2 (fr) * 2006-03-28 2007-10-04 Neopro Labs, Llc Méthodes et compositions pour traiter des conditions
WO2007129111A1 (fr) * 2006-05-03 2007-11-15 Merck Sharp & Dohme Limited Dérivés de diazépine en tant qu'antagonistes de 5-ht2a
WO2007142923A1 (fr) * 2006-05-31 2007-12-13 Avigen, Inc. Inhibiteurs mif destinés au traitement d'une douleur névropathique et des syndromes associés

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE62754B1 (en) * 1988-08-26 1995-02-22 Akzo Nv Tetracyclic antidepressants
US5663178A (en) 1995-02-06 1997-09-02 Eli Lilly And Company Tetrahydro-beta carbolines
US5952331A (en) 1996-05-23 1999-09-14 Syntex (Usa) Inc. Aryl pyrimidine derivatives
GB0019950D0 (en) 2000-08-12 2000-09-27 Smithkline Beecham Plc Compounds

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997044326A1 (fr) * 1996-05-23 1997-11-27 F. Hoffmann-La Roche Ag Derives d'aryl pyrimidine
WO2001062341A2 (fr) * 2000-02-22 2001-08-30 Knoll Gmbh Agents therapeutiques
WO2004052461A1 (fr) * 2002-12-11 2004-06-24 Pharmacia & Upjohn Company Llc Traitement combine de troubles deficitaires de l'attention avec hyperactivite
WO2005042501A1 (fr) * 2003-11-03 2005-05-12 Warner-Lambert Company Llc Nouveaux inhibiteurs du recaptage de la norepinephrine pour le traitement des troubles du systeme nerveux central
WO2006065600A2 (fr) * 2004-12-13 2006-06-22 Arena Pharmaceuticals, Inc. Derives de n-biaryl et de n-arylheteroaryl piperazine servant de modulateurs du recepteur 5ht2c utilises pour le traitement de troubles associes a celui-ci
WO2006079637A1 (fr) * 2005-01-27 2006-08-03 Janssen Pharmaceutica N.V. Derives heterocycliques tetracycliques de tetrahydrofuranne en tant qu'inhibiteurs de 5ht2 dans le traitement de troubles du systeme nerveux central
US20060293309A1 (en) * 2005-03-28 2006-12-28 Dynogen Pharmaceuticals, Inc. Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors
WO2007041258A1 (fr) * 2005-09-29 2007-04-12 Wyeth Derives de benzothiadiazolyphenylalkylamine utilises dans le traitement d'etats pathologiques ameliores par le recaptage de la monoamine
WO2007112453A2 (fr) * 2006-03-28 2007-10-04 Neopro Labs, Llc Méthodes et compositions pour traiter des conditions
WO2007129111A1 (fr) * 2006-05-03 2007-11-15 Merck Sharp & Dohme Limited Dérivés de diazépine en tant qu'antagonistes de 5-ht2a
WO2007142923A1 (fr) * 2006-05-31 2007-12-13 Avigen, Inc. Inhibiteurs mif destinés au traitement d'une douleur névropathique et des syndromes associés

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PAANAKKER, J.E. ET AL.: "Validation of an LC-MS assay for the quantification of the enantiomers of Org 4428 in human plasma", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS., vol. 16, 28 October 1998 (1998-10-28), pages 981 - 989 *

Also Published As

Publication number Publication date
NZ594937A (en) 2013-03-28
JP2011512414A (ja) 2011-04-21
CN102007139A (zh) 2011-04-06
KR20100137473A (ko) 2010-12-30
BRPI0908098A2 (pt) 2015-08-18
IL207668A0 (en) 2010-12-30
MX2010009110A (es) 2010-11-30
CA2715192A1 (fr) 2009-08-27
AU2009215541A1 (en) 2009-08-27
NZ587896A (en) 2011-09-30
EP2285818A2 (fr) 2011-02-23
EP2285818A4 (fr) 2011-08-17
WO2009105507A2 (fr) 2009-08-27

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