WO2009103790A3 - Procédé et trousse de détection des gènes associés à la mutation du pik3ca et impliqués dans l’activation de la voie pi3k/akt dans les sous-types er-positifs et her2-positifs avec des implications cliniques. - Google Patents

Procédé et trousse de détection des gènes associés à la mutation du pik3ca et impliqués dans l’activation de la voie pi3k/akt dans les sous-types er-positifs et her2-positifs avec des implications cliniques. Download PDF

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Publication number
WO2009103790A3
WO2009103790A3 PCT/EP2009/052043 EP2009052043W WO2009103790A3 WO 2009103790 A3 WO2009103790 A3 WO 2009103790A3 EP 2009052043 W EP2009052043 W EP 2009052043W WO 2009103790 A3 WO2009103790 A3 WO 2009103790A3
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WIPO (PCT)
Prior art keywords
positive
pi3k
her2
kit
involved
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PCT/EP2009/052043
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WO2009103790A2 (fr
Inventor
Christos Sotiriou
Sherene Loi
Grant Mc Arthur
Benjamin Haibe-Kains
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Universite Libre De Bruxelles
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Priority to EP09712209A priority Critical patent/EP2247756A2/fr
Publication of WO2009103790A2 publication Critical patent/WO2009103790A2/fr
Publication of WO2009103790A3 publication Critical patent/WO2009103790A3/fr
Priority to US12/860,638 priority patent/US8580496B2/en
Priority to US14/032,984 priority patent/US20140056881A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

L’invention concerne un procédé pour déterminer le résultat clinique d’une tumeur du sein qui touche une patiente si elle est traitée avec un agent antitumoral contre la tumeur du sein, ledit procédé comprenant l’étape d’analyse d’un échantillon d’une tumeur du sein provenant de ladite patiente pour un taux d’expression des gènes sélectionnés, en mettant les séquences d’ARNm provenant des cellules de cette tumeur du sein en contact avec un ensemble de plus de trois séquences de nucléotides liées au PIK3CA humain muté.
PCT/EP2009/052043 2008-02-21 2009-02-20 Procédé et trousse de détection des gènes associés à la mutation du pik3ca et impliqués dans l’activation de la voie pi3k/akt dans les sous-types er-positifs et her2-positifs avec des implications cliniques. WO2009103790A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP09712209A EP2247756A2 (fr) 2008-02-21 2009-02-20 Procédé et trousse de détection des gènes associés à la mutation du pik3ca et impliqués dans l activation de la voie pi3k/akt dans les sous-types er-positifs et her2-positifs avec des implications cliniques.
US12/860,638 US8580496B2 (en) 2008-02-21 2010-08-20 Method and kit for the detection of genes associated with PIK3CA mutation and involved in PI3K/AKT pathway activation in the ER-postitive and HER2-positive subtypes with clinical implications
US14/032,984 US20140056881A1 (en) 2008-02-21 2013-09-20 Method and kit for the detection of genes associated with pik3ca mutation and involved in pi3k/akt pathway activation in the er-postitive and her2-positive subtypes with clinical implications

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3045008P 2008-02-21 2008-02-21
US61/030,450 2008-02-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/860,638 Continuation-In-Part US8580496B2 (en) 2008-02-21 2010-08-20 Method and kit for the detection of genes associated with PIK3CA mutation and involved in PI3K/AKT pathway activation in the ER-postitive and HER2-positive subtypes with clinical implications

Publications (2)

Publication Number Publication Date
WO2009103790A2 WO2009103790A2 (fr) 2009-08-27
WO2009103790A3 true WO2009103790A3 (fr) 2009-11-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/052043 WO2009103790A2 (fr) 2008-02-21 2009-02-20 Procédé et trousse de détection des gènes associés à la mutation du pik3ca et impliqués dans l’activation de la voie pi3k/akt dans les sous-types er-positifs et her2-positifs avec des implications cliniques.

Country Status (3)

Country Link
US (2) US8580496B2 (fr)
EP (1) EP2247756A2 (fr)
WO (1) WO2009103790A2 (fr)

Cited By (3)

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US7897356B2 (en) 2008-11-12 2011-03-01 Caris Life Sciences Methods and systems of using exosomes for determining phenotypes
US8700335B2 (en) 2006-05-18 2014-04-15 Caris Mpi, Inc. System and method for determining individualized medical intervention for a disease state
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors

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CN103237901B (zh) 2010-03-01 2016-08-03 卡里斯生命科学瑞士控股有限责任公司 用于治疗诊断的生物标志物
WO2011127219A1 (fr) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Biomarqueurs circulants pour une maladie
US20130295571A1 (en) * 2010-10-29 2013-11-07 Institut National De La Santee Et De La Recherche Medicale ( Inserm) Marker of breast tumors from the luminal-b subtype
EP2663652B1 (fr) * 2011-01-11 2018-11-14 Roche Diagniostics GmbH Analyse haute résolution des courbes de fusion à titre d'outil de précriblage
WO2012130720A2 (fr) * 2011-03-28 2012-10-04 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Prédiction de la sensibilité vis-à-vis d'inhibiteurs de pi3k/mtor
KR102165122B1 (ko) * 2011-04-01 2020-10-13 제넨테크, 인크. 암 치료에 대한 감수성을 예측하기 위한 바이오마커
FR2976294B1 (fr) * 2011-06-10 2018-02-16 Universite De Nice Sophia Antipolis Methode de prediction de la reponse a un traitement avec un agent bloquant her2
GB201114051D0 (en) * 2011-08-15 2011-09-28 Domainex Ltd Compounds and their uses
MX2014014831A (es) 2012-06-08 2015-02-12 Hoffmann La Roche Selectividad de mutante y combinaciones de un compuesto inhibidor de fosfoinositida 3 cinasa y agentes quimioterapeuticos para el tratamiento de cancer.
RU2015140573A (ru) 2013-02-25 2017-03-30 Дженентек, Инк. Способы и композиции для обнаружения и лечения устойчивого к лекарственным средствам мутанта акт
WO2015164238A1 (fr) * 2014-04-21 2015-10-29 Mayo Foundation For Medical Education And Research Matériels et méthodes pour identifier et traiter des mammifères ayant un cancer du sein her2-positif
CN112941187A (zh) * 2021-04-02 2021-06-11 无锡市第五人民医院 一种乳腺癌相关基因pik3ca-q928h突变体及其特异性引物

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8700335B2 (en) 2006-05-18 2014-04-15 Caris Mpi, Inc. System and method for determining individualized medical intervention for a disease state
US7897356B2 (en) 2008-11-12 2011-03-01 Caris Life Sciences Methods and systems of using exosomes for determining phenotypes
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors

Also Published As

Publication number Publication date
EP2247756A2 (fr) 2010-11-10
US8580496B2 (en) 2013-11-12
US20140056881A1 (en) 2014-02-27
US20110038862A1 (en) 2011-02-17
WO2009103790A2 (fr) 2009-08-27

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