WO2009100313A1 - Dispositif pour prévenir un reflux gastro-œsophagien - Google Patents

Dispositif pour prévenir un reflux gastro-œsophagien Download PDF

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Publication number
WO2009100313A1
WO2009100313A1 PCT/US2009/033362 US2009033362W WO2009100313A1 WO 2009100313 A1 WO2009100313 A1 WO 2009100313A1 US 2009033362 W US2009033362 W US 2009033362W WO 2009100313 A1 WO2009100313 A1 WO 2009100313A1
Authority
WO
WIPO (PCT)
Prior art keywords
conduit
esophagus
stomach
proximal
diaphragm
Prior art date
Application number
PCT/US2009/033362
Other languages
English (en)
Inventor
Joseph Friedberg
Original Assignee
The Trustees Of The University Of Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Trustees Of The University Of Pennsylvania filed Critical The Trustees Of The University Of Pennsylvania
Publication of WO2009100313A1 publication Critical patent/WO2009100313A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2002/044—Oesophagi or esophagi or gullets

Definitions

  • This invention relates to apparatus and methods for inhibiting or preventing or otherwise managing gastro-esophageal reflux.
  • Gastroesophageal reflux affects millions of people. The significance of this condition ranges from none to minor intermittent "heartburn” to fatal aspiration pneumonia to causation of terminal esophageal cancer. It is possible to reestablish an anatomic configuration that prevents reflux, but this requires an operation with the attendant risks and failure rate. As a result, medical antacid therapy remains the prevalent treatment for symptomatic gastro-esophageal reflux. These medications do not, however, address the underlying anatomic defect responsible for reflux, but they do neutralize stomach acid and relieve the symptoms resulting from acidic irritation of the esophagus during reflux. In short, reflux can be prevented, but typically requires an operation.
  • the outlet opening is proximal to the inlet opening and is positioned within the esophagus.
  • the conduit is collapsible in the extended condition, with the portion that resides below or distal to the diaphragm being exposed to positive pressure, to at least partially restrict flow through the flow passage from the outlet opening that is positioned within the stomach to the inlet opening that is positioned in the esophagus.
  • the flow passage of the conduit in the everted condition allows flow through the flow passage and outlet opening.
  • the apparatus also includes means for inhibiting distal migration of the inlet opening of the conduit with respect to the esophagus.
  • a method of inhibiting gastro-esophageal reflux from a stomach to an esophagus includes the step of positioning a flexible conduit such that in an extended condition of the conduit, an inlet opening of the conduit is proximal to an outlet opening of the conduit and positive pressure within the stomach at least partially collapses a portion of the conduit that is positioned distal to the diaphragm.
  • an everted condition such as it exists during vomiting
  • the portion of the conduit that is positioned distal to the diaphragm everts on itself from the stomach back into the esophagus so the outlet opening of the conduit is proximal to the inlet opening and vomiting opens the flexible conduit to allow egress of stomach contents.
  • the flexible conduit is engaged to a portion of the esophagus at or proximal to the diaphragm to inhibit distal migration of at least a portion of the conduit with respect to the esophagus.
  • a method of inhibiting gastro-esophageal reflux from a stomach to an esophagus includes the step of defining a passage through a flexible conduit for flow from the esophagus into the stomach.
  • the flexible conduit is collapsed under influence of pressure in the stomach to at least partially block flow from the stomach into the esophagus.
  • the flexible conduit is everted under the influence of the vomiting reflex for flow from the stomach into the esophagus.
  • FIG. IA is a schematic anatomical view of a human body showing placement of an embodiment of an apparatus for preventing gastro-esophageal reflux with a portion of the apparatus being shown asymmetrically collapsed according to an exemplary aspect of this invention
  • FIG. IB is a schematic anatomical view of a human body showing flow through the apparatus in FIG. IA during eating or drinking according to an exemplary aspect of this invention
  • FIG. 1C is a schematic anatomical view of a human body showing the apparatus s in FIG. IA in an everted condition during vomiting according to an exemplary aspect of this invention
  • FIG. ID is a schematic anatomical view of a human body showing the apparatus in FIG. 1C collapsing asymmetrically upon itself after vomiting according to an exemplary aspect of this invention
  • FIG. 2A is a schematic view of an apparatus for preventing gastro-esophageal reflux in the position shown in FIG. IA, according to an exemplary aspect of this invention
  • FIG. 2B is a schematic view of the apparatus shown in FIG. 2A with a portion of the apparatus being symmetrically collapsed according to an exemplary aspect of thiss invention
  • FIG. 2C is a schematic view of an apparatus for preventing gastro-esophageal reflux in the position shown in FIG. IB, according to an exemplary aspect of this invention
  • FIG. 2D is a schematic view of an apparatus for preventing gastro-esophageal0 reflux in the position shown in FIG. 1C, according to an exemplary aspect of this invention
  • FIG. 2E is a schematic view of an apparatus for preventing gastro-esophageal reflux in the position shown in FIG. ID, according to an exemplary aspect of this invention.
  • FIG. 3 is a perspective view of an apparatus for preventing gastro-esophageal reflux according to another embodiment of the present invention.
  • Apparatus 100, 200 includes a flexible conduit 20, 20a having an inlet opening 21, 21a configured to be positioned within the esophagus 10, an outlet opening 22, 22a configured to extend into a portion of the stomach 50 distal to the diaphragm 16 where there is positive pressure, and a flow passage 23 defined between inlet opening 21, 21a and outlet opening 22, 22a.
  • Conduit 20, 20a is eversibleS between an extended condition (FIGs. IA, IB, 2A, 2B, 2C) and an everted condition
  • inlet opening 21, 21a is proximal to the outlet opening 22, 22a such that inlet opening 21, 21a is positioned within a portion of the esophagus 10 and outlet opening 22, 22a is positioned within a portion of the stomach 50 that extends distal to the diaphragm 16.
  • the flexible conduit functionally extends the esophagus 10 distal to the diaphragm 16.
  • the conduit 20, 20a is collapsible in at least the extended condition to partially restrict flow F up from the outlet opening 22, 22a through flow passage 23.
  • outlet opening 22, 22a is proximal to the inlet opening 21, 21a and is positioned within a portion of the esophagus 10 proximal to the diaphragm 16 (e.g., in the chest cavity 12 where there is negative pressure).
  • Apparatus 100, 200 also includes a means for inhibiting distal migration 30, 30a of the inlet opening 21, 21a of the conduit 20, 20a with respect to the esophagus 10.
  • a method for preventing gastro-esophageal reflux includes the step of positioning a flexible conduit 20, 20a in an extended condition such that inlet opening 21, 21a of conduit 23 is proximal to outlet opening 22, 22a. Flexible conduit 20, 20a is then engaged to a portion of the esophagus 10 at or proximal to the diaphragm 16 to inhibit distal migration of at least a portion of the conduit with respect to the esophagus 10.
  • a valve can be inserted in the gastro-esophageal junction.
  • a one way valve is optionally inserted to allow food to enter into the stomach.
  • this option is sometimes less preferred because such a valve does not allow acids and other gastro intestinal fluids to flow back into the esophagus so as to permit a patient to vomit.
  • FIG. IA illustrates schematically an anatomical view of a human body torso having an apparatus 100 for preventing gastro-esophageal reflux attached to a bottom portion of esophagus 10.
  • Apparatus 100 may be attached, for example, at the gastroesophageal junction into stomach 50 such that portion of apparatus 100 extends distal to the diaphragm 16 between the chest cavity 12 and abdominal cavity 14.
  • apparatus 100 may be attached to the esophagus 10 at a location above or proximal to the diaphragm 16 which separates the chest cavity 12 and abdominal cavity 14, so a portion of apparatus 100 extends below or distal to the diaphragm 16 and into the stomach 50.
  • chest cavity 12 is typically under negative pressure and abdominal cavity 14 is under positive pressure. The pressure differential between the negative pressure in the chest cavity 12 and the positive pressure in the abdominal cavity 14 is used for the normal functioning of apparatus 100.
  • patients with acid reflux may be diagnosed with hiatal hernia, meaning that the gastroesophageal junction of the stomach 50 (e.g., the junction between the esophagus and entrance into the stomach) extends proximal to the diaphragm 16 and into the chest 12.
  • a proximal portion of apparatus 100 may be attached to the esophagus 10 at a location sufficiently proximal to the diaphragm 16 and a distal portion of apparatus 100 extends distal to the diaphragm 16, thereby functionally extending and restoring the distal portion of the esophagus to an intra-abdominal location where there is positive pressure.
  • apparatus 100 during normal conditions, when one is not vomiting, apparatus 100 extends down into the stomach 50.
  • the positive pressure from the abdomen collapses apparatus 100, either asymmetrically as shown or symmetrically, thereby substantially or completely "sealing" itself and restricting stomach 50 contents from moving back up into the esophagus 10.
  • the apparatus 100 opens to allow flow into stomach 50.
  • apparatus 100 upon the sudden and severe pressure increase associated with vomiting, apparatus 100 everts and is expelled up into the esophagus 10 along with any contents that may be in the stomach 50.
  • apparatus 100 may protect the esophageal tissue lining and minimize tissue damage from the acidic contents of the stomach 50.
  • apparatus 100 may collapse upon itself and "slide" back down into the stomach 50, once again sealing the esophagus 10 from contents of the stomach 50. For example, normal peristaltic waves in the esophagus and simply swallowing saliva may be sufficient to cause apparatus 100 to return to it's normal position.
  • Apparatus 100 includes a flexible conduit 20 having an inlet opening 21 and an outlet opening 22.
  • Flow passage 23 provides a passageway through which fluid or food may pass through inlet opening 21 and outlet opening 22.
  • conduit 20 is constructed of a thin flexible material that is thin enough and/or long enough to enable it to collapse upon itself as it extends down into the stomach 50.
  • the thin material may be formed, for example, in a substantially cylindrical or tubular shape that may be collapsible under positive pressure from the abdominal cavity 14.
  • conduit 20 is illustrated as a substantially asymmetrical "duckbill" shape when collapsed, other shapes and dimensions may be used as long as conduit 20 is elastic enough to fold back into itself.
  • conduit 20 may collapse symmetrically upon itself due to positive pressure in stomach 50 under normal non-vomiting conditions.
  • the distal opening 22 is collapsed under positive pressure of the abdominal cavity under normal conditions, such that flow F is s substantially or completely prevented from traveling up into the flow passage 23 and into esophagus 10.
  • Conduit 20 may be made of flexible polymers such as polypropylene, silicone, or other biocompatible materials.
  • conduit 20 may be made of a tissue engineered material such as from the patient's own tissue or othero biocompatible tissue.
  • the thickness of the material used for conduit 20 may depend on the type and strength of the material.
  • conduit 20 which is made of a material with high strength may be thinner than a conduit 20 made of a material with lower strength so that conduit 20 is flexible and collapsible.
  • conduit 20 may be stretchable or distensible so the diameter of conduits 20 may accommodate boluses of food that pass down the esophagus 10. Since conduit 20 is aperistaltic, in order to avoid food impaction, conduit 20 may be stretchable to a diameter greater than the esophagus 10 to allow food to enter stomach 50.
  • Conduit 20 may have various lengths and diameters depending on factors such as the type and thickness of the material and the size of the patient, the patient's0 stomach 50, and/or size of the patient's esophagus 10.
  • conduit 20 may have a length that ranges from about 25 mm to about 100 mm, and in some cases from about 40 mm to about 60 mm. Other lengths and diameters may be used to accommodate different patients so that in the extended position, a portion of conduit 20 extends distal to the diaphragm 16 and into the region of positive pressure.5 Additionally, conduit 20 extends into stomach 50 at a sufficient length so the conduit 20 may evert upon itself during vomiting.
  • apparatus 100 may by coupled to the bottom or near the bottom of esophagus 10 such that a portion of conduit 20 remains fixed in the esophagus 10 when one vomits.
  • apparatus 100 may include means foro inhibiting distal migration 30 of at least a portion of conduit 20 with respect to esophagus 10.
  • Attaching apparatus 100 to the esophagus 10 or to the gastroesophageal junction may be accomplished by any means known or developed in the art.
  • apparatus may be attached by a ring, a cuff, or a stent placed inside esophagus 10. Other possibilities include endoscopically clipping, stapling, gluing, or5 sewing a portion of apparatus 100 to esophagus 10.
  • FIG. 2C a schematic view of apparatus 100 shown in FIG. IB is illustrated.
  • inlet opening 21 of conduit 20 is proximal to outlet opening 22 and is attached at or near the bottom of esophagus 10 so that outlet opening 21 extends downward into stomach 50.
  • flow F passes through the inlet opening 21 and into flow passage 23.
  • Force of the food or fluid flow F downwards towards the stomach 50 opens the outlet opening 22 of flexible conduit 20.
  • positive pressure of the abdominal cavity 14 and/or positive pressure in the stomach 50 collapses conduit 20 back into the configuration shown in FIGs. 2A, 2B.
  • conduit 20 may be collapsed symmetrically or asymmetrically.
  • FIG. 2D a schematic view of apparatus 100 shown in FIG. 1C is illustrated.
  • the sudden and severe pressure increase causes flow F of stomach contents to evert flexible conduit 20 into esophagus 10.
  • outlet opening 22 of conduit 20 is proximal to inlet opening 21 so that outlet opening 22 is positioned in the esophagus 10 proximal to the diaphragm 16. Accordingly, in the everted condition, a substantial portion of conduit 20 protects esophagus 10 from damage.
  • FIG. 2E a schematic view of apparatus 100 shown in FIG. ID is illustrated.
  • flexible conduit 20 collapses and "slides” back down in the direction of flow F into the stomach 50. Accordingly, apparatus 100 reverts back to the extended condition to at least partially restrict flow F through the flow passage 23 from the outlet opening 22 to the inlet opening 21.
  • apparatus 200 includes conduit 20a having an inlet opening 21a and an outlet opening 22a.
  • Apparatus 200 also includes means for inhibiting distal migration of at least a portion of conduit 20a with respect to esophagus 10.
  • apparatus may be attached by a stent 30a placed inside esophagus 10.
  • Stent 30a may be made of a polymer material or any biocompatible material known or developed in the art.
  • stent 30a may be made from silicone, nitinol, a metal or a combination of metals such as a nickel- titanium alloy, etc.
  • stent 30a may also be made of a bioabsorbable material.
  • Stent 30a is not limited to any one particular structure and can include a mesh or mesh-like structure.
  • Other fixation devices for inhibiting distal migration of at least a portion of conduit 20a may include a suspension system similar to aortic stents which have prongs or hooks to keep the stent 30a in place.
  • Another way to fix apparatus 200 near the base of the esophagus 10 includes scarifying a ring in the distal portion of esophagus 10 and placing an absorbable ring or teflon cuff into which tissue would grow and serve as an infection barrier and as a fixation device.
  • the entire apparatus 200 may be made of an absorbable scaffolding that would employ tissue engineering technology and capitalize on the fact that the esophagus is lined with high turnover simple squamous cell mucosa and could be used to make a "skin" valve, instead of a prosthetic.
  • the entire conduit 20a including a stent suspension system, from absorbable polymer. This could be used to prevent reflux for a temporary period of time. Applications for this may include patients who have a condition causing obesity that is expected to reverse - like someone being treated for morbid obesity. Or someone with esophageal cancer who is being treated preoperatively with chemotherapy and/or radiation in preparation for esophagectomy.
  • Another application for an absorbable apparatus 200 might be for a diagnostic test to consider an operation or in situations where it is unclear that reflux is the cause of a symptom - as with some cases of adult onset asthma that can be caused by reflux and aspiration into the lungs. In these cases, using an absorbable apparatus 200 could be like a diagnostic test to see if eliminating reflux eliminates the symptoms.
  • apparatus 100, 200 has been described for preventing gastroesophageal reflux
  • apparatus 100, 200 may be used in other embodiments in which a flexible two way valve is needed.
  • apparatus 100, 200 may be used for urethral reflux, stool continence, heart valves, etc. While the invention has been described in detail and with reference to specific examples thereof, it will be apparent to one skilled in the art that various changes and modifications can be made therein without departing from the spirit and scope thereof.

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  • Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Prostheses (AREA)

Abstract

L’invention concerne un appareil et un procédé pour inhiber le reflux gastro-œsophagien. Le dispositif inclut un conduit flexible ayant une ouverture d’entrée, une ouverture de sortie et un passage d’écoulement défini entre eux. Le conduit peut être inversé entre un état étendu et un état inversé. Dans l’état étendu, l’ouverture d’entrée est proximale de l’ouverture de sortie de telle sorte que l’ouverture d’entrée est positionnée dans une partie de l’œsophage à proximité d’un diaphragme et l’ouverture de sortie est positionnée dans une partie de l’estomac distale du diaphragme. Le conduit peut être affaissé dans l’état étendu pour restreindre partiellement l’écoulement vers le haut provenant de l’ouverture de sortie. Dans l’état inversé, tel que lorsqu’une personne vomit, l’ouverture de sortie est proximale de l’ouverture d’entrée et est positionnée dans l’œsophage proximal du diaphragme. L’appareil inclut également un moyen pour inhiber une migration distale de l’ouverture d’entrée du conduit par rapport à l’œsophage.
PCT/US2009/033362 2008-02-06 2009-02-06 Dispositif pour prévenir un reflux gastro-œsophagien WO2009100313A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2659808P 2008-02-06 2008-02-06
US61/026,598 2008-02-06

Publications (1)

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WO2009100313A1 true WO2009100313A1 (fr) 2009-08-13

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2957267A1 (fr) * 2014-06-20 2015-12-23 Ethicon Endo-Surgery, Inc. Sphincter artificiel
WO2015195252A1 (fr) * 2014-06-20 2015-12-23 Ethicon Endo-Surgery, Inc. Sphincter oesophagien artificiel
WO2015195253A1 (fr) * 2014-06-20 2015-12-23 Ethicon Endo-Surgery, Inc. Sphincter œsophagien artificiel
WO2019155284A1 (fr) * 2018-02-12 2019-08-15 Biomedix, S.A. Protection thérapeutique et son procédé d'utilisation
US11364030B2 (en) 2019-02-15 2022-06-21 Boston Scientific Scimed, Inc. Medical device for treating esophageal atresia
US11389286B2 (en) 2018-12-05 2022-07-19 Boston Scientific Scimed, Inc. Esophageal atresia bridge device

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4846836A (en) * 1988-10-03 1989-07-11 Reich Jonathan D Artificial lower gastrointestinal valve
US5993427A (en) * 1996-12-03 1999-11-30 Laborie Medical Technologies Corp. Everting tube structure
US20020032487A1 (en) * 1998-08-31 2002-03-14 Wilson-Cook Medical Incorporated Prosthesis having a sleeve valve

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4846836A (en) * 1988-10-03 1989-07-11 Reich Jonathan D Artificial lower gastrointestinal valve
US5993427A (en) * 1996-12-03 1999-11-30 Laborie Medical Technologies Corp. Everting tube structure
US20020032487A1 (en) * 1998-08-31 2002-03-14 Wilson-Cook Medical Incorporated Prosthesis having a sleeve valve

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2957267A1 (fr) * 2014-06-20 2015-12-23 Ethicon Endo-Surgery, Inc. Sphincter artificiel
EP2957261A1 (fr) * 2014-06-20 2015-12-23 Ethicon Endo-Surgery, Inc. Sphincter artificiel
WO2015195252A1 (fr) * 2014-06-20 2015-12-23 Ethicon Endo-Surgery, Inc. Sphincter oesophagien artificiel
WO2015195253A1 (fr) * 2014-06-20 2015-12-23 Ethicon Endo-Surgery, Inc. Sphincter œsophagien artificiel
EP2957256A1 (fr) * 2014-06-20 2015-12-23 Ethicon Endo-Surgery, Inc. Sphincter artificiel et dispositif de placement de celui-ci
WO2019155284A1 (fr) * 2018-02-12 2019-08-15 Biomedix, S.A. Protection thérapeutique et son procédé d'utilisation
US11980539B2 (en) 2018-02-12 2024-05-14 Biomedix, S.A. Therapeutic-GARD and method of use thereof
US11389286B2 (en) 2018-12-05 2022-07-19 Boston Scientific Scimed, Inc. Esophageal atresia bridge device
US12016765B2 (en) 2018-12-05 2024-06-25 Boston Scientific Scimed, Inc. Esophageal atresia bridge device and methods of treating esophageal atresia
US11364030B2 (en) 2019-02-15 2022-06-21 Boston Scientific Scimed, Inc. Medical device for treating esophageal atresia

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