WO2009097968A2 - Couche de surface biocompatible à pores ouverts pour un implant, procédé de fabrication de ladite couche et son utilisation - Google Patents

Couche de surface biocompatible à pores ouverts pour un implant, procédé de fabrication de ladite couche et son utilisation Download PDF

Info

Publication number
WO2009097968A2
WO2009097968A2 PCT/EP2009/000386 EP2009000386W WO2009097968A2 WO 2009097968 A2 WO2009097968 A2 WO 2009097968A2 EP 2009000386 W EP2009000386 W EP 2009000386W WO 2009097968 A2 WO2009097968 A2 WO 2009097968A2
Authority
WO
WIPO (PCT)
Prior art keywords
surface layer
implant
range
framework structure
pore
Prior art date
Application number
PCT/EP2009/000386
Other languages
German (de)
English (en)
Other versions
WO2009097968A3 (fr
Inventor
Hans Schmotzer
Susanne KÖNIG
Original Assignee
Smith & Nephew Orthopaedics Ag
König, Inge
Friedrich, Martin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith & Nephew Orthopaedics Ag, König, Inge, Friedrich, Martin filed Critical Smith & Nephew Orthopaedics Ag
Priority to EP09707895A priority Critical patent/EP2237808A2/fr
Publication of WO2009097968A2 publication Critical patent/WO2009097968A2/fr
Publication of WO2009097968A3 publication Critical patent/WO2009097968A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A61F2/34—Acetabular cups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A61F2/36—Femoral heads ; Femoral endoprostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/38—Joints for elbows or knees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/42—Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes
    • A61F2/4225—Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes for feet, e.g. toes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/42—Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes
    • A61F2/4241—Joints for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes for hands, e.g. fingers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30011—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in porosity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A61F2002/30064—Coating or prosthesis-covering structure made of biodegradable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30065—Properties of materials and coating materials thermoplastic, i.e. softening or fusing when heated, and hardening and becoming rigid again when cooled
    • A61F2002/30067—Coating or prosthesis-covering structure made of thermoplastic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30838—Microstructures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/3084—Nanostructures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30907—Nets or sleeves applied to surface of prostheses or in cement
    • A61F2002/30909—Nets
    • A61F2002/30911—Nets having a honeycomb structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/3092—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having an open-celled or open-pored structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/30929—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having at least two superposed coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/3093—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth for promoting ingrowth of bone tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30968—Sintering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30971—Laminates, i.e. layered products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0023—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A61F2310/00401—Coating made of iron, of stainless steel or of other Fe-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A61F2310/00407—Coating made of titanium or of Ti-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A61F2310/00413—Coating made of cobalt or of Co-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A61F2310/00419—Other metals
    • A61F2310/00425—Coating made of magnesium or of Mg-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A61F2310/00419—Other metals
    • A61F2310/00437—Coating made of silicon or Si-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A61F2310/00419—Other metals
    • A61F2310/00485—Coating made of zirconium or Zr-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A61F2310/00419—Other metals
    • A61F2310/00544—Coating made of tantalum or Ta-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A61F2310/00419—Other metals
    • A61F2310/00562—Coating made of platinum or Pt-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00598—Coating or prosthesis-covering structure made of compounds based on metal oxides or hydroxides
    • A61F2310/00604—Coating made of aluminium oxide or hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00598—Coating or prosthesis-covering structure made of compounds based on metal oxides or hydroxides
    • A61F2310/0061—Coating made of silicon oxide or hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00598—Coating or prosthesis-covering structure made of compounds based on metal oxides or hydroxides
    • A61F2310/00634—Coating made of zirconium oxide or hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00856—Coating or prosthesis-covering structure made of compounds based on metal nitrides
    • A61F2310/00874—Coating made of silicon nitride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/0097—Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00976—Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
    • A61F2310/00982—Coating made of collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00976—Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
    • A61F2310/00994—Coating made of gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors

Definitions

  • the invention relates to an open-pore biocompatible surface layer for an implant according to the preamble of patent claim 1, an implant according to the preamble of patent claim 2 and a method for producing an open-pore biocompatible surface layer for or as an implant according to the preamble of patent claim 18, an implant with or from such a surface layer according to the preamble of patent claim 23 and a use of the surface layer for implants according to the preamble of patent claim 24.
  • Implants and especially joint and bone replacement implants are becoming increasingly important in restorative and curative medicine.
  • joint or bone replacement implants these are cemented cementlessly in the bone according to the current state of the art.
  • a key factor in the success of such cementless anchoring of a metallic orthopedic implant to or in a bone is the rate at which bone tissue bonds to the implant. This speed is critically dependent on the type and structuring of the surface of the metallic implant. For this reason, such surfaces have in the past been provided with a predefined surface roughness, optionally additionally having a bioactive coating applied to the metal substrate of the metallic orthopedic implant.
  • Porous layers, in particular open-porous structures, which have a pore size which allows ingrowth of bone tissue into these, usually metallic, structures have hitherto proven suitable for producing such surface layers which promote the growth of bone cells.
  • porous structures have a thickness in the range of 1 mm or more in current joint and bone replacement implants. Such a thickness is necessary and useful with regard to a good and stable connection between bone and implant, but is problematic in that a good connection between implant and bone is only guaranteed if the porous structure is at least predominantly, but preferably completely, is crossed by ingrown bone tissue. Due to the high thickness of the porous structure, it is therefore essential in terms of achieving a good and stable connection between implant and bone that a ingrowth of bone tissue in the porous structure as quickly as possible take place so that contact between bone cells and porous structure possible forms quickly and comprehensively and stabilizes the connection between implant and bone in this way.
  • the ingrowth of bone into an open-porous structure represents a multi-step process in which bone cells together with blood vessels for nutrient and oxygen supply to the bone cells and the later bone in the pores of the open-porous structure must immigrate to the largest possible and stable connection of the bone cells and the later bone with the pores, respectively, to ensure the particular inner surface of the open-pore structure and thus the implant.
  • an important aspect of ingrowing bone cells into a porous structure is the fact that bone cells can not migrate directly into an empty cavity, but always require a surface in the form of a substrate or matrix to which they adhere and along which they are divide and "move" in this way.
  • bone tissue ingrowth-promoting surfaces have been provided in the form of porous surfaces which were either uncoated or provided with a thin surface coating which typically contained calcium phosphate.
  • the pores were so large in relation to bone cells that, although a lengthening of the bone cells along the pore matrix, ie their inner surface, took place, but the pores over a geraumen period hollow and vacancies that were not filled with bone tissue, since the bone was very slowly from the wall regions of the pores in the direction of pore cavity.
  • this had the disadvantage that the bone on the implant or pore surface formed only a thin layer whose, in particular mechanical, stability was low, so that the connection between the implant and bone was not allowed or only extremely cautious , Only with complete ingrowth of the bone into the entire pore cavities, the latter being filled up with bone tissue, a stable and reliable connection between bone and implant was formed.
  • a coating of the implant with hydroxyapatite which was preferably applied by means of plasma spraying, was often performed.
  • a disadvantage of this method is that the pores of the implant layer starting only from the implant surface and only superficially can be coated with hydroxyapatite and the coating often does not reach to the bottom of the pore. Rather, there is the risk that the pores are clogged at the opening side when using this method, so that the pore bottom is no longer accessible for a coating.
  • such a hydroxyapatite coating has a low solubility under physiological conditions so that bone cells can not penetrate into deeper layers of the coating and can not fully penetrate into the hydroxyapatite coating.
  • a significant disadvantage of the method there is, inter alia, that only a coating of pores is possible, which extends from the implant surface substantially perpendicular to this extend.
  • a coating of transverse pores in a three-dimensional pore network is not possible with this plasma spray coating method, so that a further disadvantage of the local method is that at best a bone growth to a joint replacement implant, but no actual bone ingrowth into a three-dimensional pore structure of an implant , as described for example in WO 2007/051519, is possible.
  • the object of the invention is to provide an open-pore biocompatible surface layer having a three-dimensional pore structure into which a rapid and space-filling ingrowth of osteoblasts is possible, as well as the provision of a method for producing such an open-pored biocompatible surface layer. Furthermore, it is the object of the invention to provide an implant with or consisting of such a surface layer as well as its use for implants.
  • the object is achieved by an open-pored biocompatible surface layer, wherein pores of the surface layer are at least partially, preferably at least 30% and particularly preferably completely filled with a filling material.
  • this open-pored biocompatible surface layer is arranged on a raw surface of a substrate that is present as an implant or as an implant blank.
  • the open-pore biocompatible surface layer is self-supporting and forms the implant itself without the need for a substrate.
  • the latter variant is particularly advantageous when the implant is not intended to carry out any essential supporting function but, for example, a filling and / or stabilizing and / or connecting function.
  • the open-pored surface layer can be formed entirely from a metal foam or have a metal foam.
  • Such an embodiment is particularly advantageous in the case of a self-supporting structure of the open-pore biocompatible surface layer.
  • the filling material is soluble under physiological conditions and / or, in particular by migrating osteoblasts, resorbable and preferably bioactive.
  • the essential essence of the invention is that by a filling of, in an open-pore biocompatible surface layer of an implant, existing pores with a filling material, the free pore volume of the pores in the surface layer is reduced, wherein the filler in turn preferably has a bioactivity and preferably by ingrowing osteoblasts and from these resulting bone tissue at least partially, preferably for the most part, can be absorbed.
  • the filling material in turn has a micro- and nano-pore structure and / or a three-dimensional matrix structure into which ingrowth and migration of osteoblasts is possible.
  • micro- and nano-pores The free cross-section of these micro- and nano-pores is reduced by a factor in the range of 100 to 10,000 compared to the cross-section of the pores of the surface layer, so that in these micro- and nanopores ingrowing cells, for example osteoblasts, which receive the filler present there and / or Due to the small internal volume and the larger inner surface of the micro- and nanopores, these micro- and nanopores can be filled almost completely within a few days to weeks.
  • micropores and nanopores in the context of this invention, a three-dimensional matrix, for example in the form of a gel or in the form of a preferably surface-rich leaf, mesh or honeycomb structure, such as this example in a Silica gel, a pebble xerogel or silica sol as well as in silica hydrosols present.
  • the osteoblasts can migrate into this three-dimensional matrix or into the micropore space of the filling material and adhere and grow to solid constituents of the filling material.
  • a filling of the pore space of the surface layer emanates not only from a wall of pores of the surface layer, but also from the first empty according to the prior art space within the originally free, respectively empty pore volume of the surface layer pores, now However, according to the invention filled with the aforementioned bioactive and preferably resorbable filling material.
  • the pores of the open-pored surface layer are connected to form a coherent three-dimensional pore network, wherein the surface layer is formed as a framework structure and at least a plurality of pores via at least one lateral opening formed in a lateral boundary of the pore is, channel and / or tunnel-like communicate with each other in communication.
  • Such a framework structure has proven to be particularly advantageous, since a particularly firm connection between the bone tissue and the framework structure and thus also the implant on which the framework structure is formed can be achieved by ingrowth of bone tissue into such a framework structure.
  • a particularly firm connection between the bone tissue and the framework structure and thus also the implant on which the framework structure is formed can be achieved by ingrowth of bone tissue into such a framework structure.
  • tunnel-like interconnected pores takes place a mutual enclosure of skeletal structure material and bone tissue, so that such a compound can be claimed not only on pressure, but excellently on train without the bone cells detach from the implant surface, as a in the surface layer of ingrown bone tissue can completely penetrate the pore network and in this way builds up a bone structure which extends through the pore network and also runs within the surface layer or the framework structure.
  • the ingrowing bone tissue traverses and undermines the surface of the surface layer or the contiguous pore network in a manner which ensures an intimate connection of the surface layer with the bone tissue and prevents detachment of the bone tissue from the surface layer, for example under tensile load.
  • the thickness of the surface layer or the framework structure according to the invention is in the range of 0.1 mm to 2.5 mm, preferably in the range of 0.3 mm to 1.9 mm and particularly preferably in the range of 0.5 mm to 1.5 mm.
  • the porosity of the surface layer, or framework structure is in the range of 20% to 70%, preferably in the range of 30% to 60%, and more preferably in the range of 40% to 50%, it being understood that the porosity is within the Surface layer is formed substantially homogeneously, so that takes place within the entire surface layer, a uniform intergrowth of bone tissue with the framework structure of the surface layer.
  • the maximum cross section of the pores of the surface layer is in the range from 10 .mu.m to 800 .mu.m, preferably in the range from 50 .mu.m to 600 .mu.m and more preferably in the range from 100 .mu.m to 300 .mu.m, the size of the pore cross section or the respective free volume of a pore according to an embodiment of the invention is approximately equally distributed within the surface layer.
  • a pore volume gradient can also be provided in the opposite direction.
  • the surface layer namely the framework structure, consists of a material that is not absorbable or absorbs slowly under physiological conditions, namely a metal and / or a ceramic and / or a polymer.
  • the implant can be adapted to the respective intended use, for example with regard to the type of implant.
  • a femoral component which is usually subjected to a very high load, have a framework structure made of a metal
  • a finger joint replacement may have a framework structure of ceramic and a component for a disc replacement a framework structure of a polymer.
  • an implant can be individually adapted to a purpose, wherein a metal, for example, has a very high stability and toughness, while a ceramic can be lightweight, but very hard, and a framework structure of a polymer can have some flexibility.
  • the framework structure or the surface layer is formed of preferably edged metal particles, titanium being the preferred material.
  • titanium particles are coated or bonded according to the invention with silicon particles, wherein silicon particles, for example by a superficial melting of the titanium particles may be compounded with these.
  • the amount of silicon particles used for coating ranges from 0.5% to 8.5% by weight ⁇ 1.5% by weight, preferably 0.5% to 3.0% Wt .-% and particularly preferably 1.0 wt .-% ⁇ 0.5 wt .-%.
  • a titanium powder whose particles have a particle size in the range from 90 ⁇ m to ⁇ 500 ⁇ m, preferably in the range from 150 ⁇ m to ⁇ 300 ⁇ m, is preferably used as the titanium particle.
  • the silicon particles used are preferably silicon powder having a particle size of ⁇ 80 ⁇ m, preferably ⁇ 40 ⁇ m and particularly preferably ⁇ 20 ⁇ m, so that titanium particles coated with silicon particles are present as compound particles having an axial ratio of ⁇ 5: 2.
  • a particle size distribution measured in percent by volume with respect to particle size in accordance with ISO / DIS 13322-1 is given in the following table:
  • coated with silicon particles titanium particles which are present as compound particles, have a particle size of ⁇ 90 microns, preferably ⁇ 150 microns, wherein the above-defined particle size distribution is maintained.
  • an intermediate layer is provided between the raw surface of the implant and the surface layer.
  • Such an intermediate layer is useful, for example, if the base material of the substrate to be coated is not suitable directly for a coating by means of vacuum plasma spraying, such as a polymer or a ceramic, or an extremely high strength is required, depending on the respective Can apply application.
  • the raw surface of the implant can first be coated with a dense base layer, which preferably consists of a bio-inert material, which is preferably a metal.
  • a metal is due to its bioinert properties and its very high strength and its low specific gravity titanium preferred. However, it is also silicon or compounded with silicon titanium into consideration.
  • Other bioinert metals, such as tantalum, platinum, or other biocompatible metals are also useful as basecoat materials, as in the following for the preparation of frameworks called metals.
  • the metal used to make the framework structure may be titanium alloys.
  • the metal used to make the framework structure may be titanium alloys.
  • stainless steel in particular stainless steel, magnesium and / or alloys thereof, zirconium and / or alloys thereof, tantalum and / or alloys thereof, and mixtures and alloys of all of the aforementioned metals into consideration ,
  • the framework structure is to be made of a ceramic, it is preferably selected from the group comprising alumina and zirconia, alumina-reinforced zirconia, zirconia-reinforced alumina and silicon nitride being materials suitable according to the invention. Further, additives may be added to these metal oxides. In addition, the ceramic can also be made of a mixture of these oxides.
  • the framework structure is made of a polymer, this is selected from the group comprising polyetheretherketone (s) (PEEK), polyaryletherketone (s) (PAEK), polyimide (s) (PI), polyurethane (s) (PU), polycarbonate urethane (e) (PCU), polyetherimide (s) (PEI), polyethylene, especially ultra-high molecular weight polyethylene (UHMWPE), preferably crosslinked UHMWPE, polypropylene, and mixtures of these polymers.
  • PEEK polyetheretherketone
  • PAEK polyaryletherketone
  • PI polyimide
  • PU polyurethane
  • PCU polycarbonate urethane
  • PEI polyetherimide
  • polyethylene especially ultra-high molecular weight polyethylene (UHMWPE), preferably crosslinked UHMWPE, polypropylene, and mixtures of these polymers.
  • UHMWPE ultra-high molecular weight polyethylene
  • an intermediate layer is provided which is provided between the raw surface of the implant and the surface layer, ie the framework structure.
  • the intermediate layer is preferably made of titanium and has silicon; However, it can also consist of all other aforementioned metals or their alloys.
  • the intermediate layer has a layer thickness of ⁇ 200 .mu.m, preferably of ⁇ 100 .mu.m and particularly preferably in the range of 30 .mu.m to 50 .mu.m.
  • the implant blank consists of one of the abovementioned metals, wherein, in particular, the raw surface of the implant blank has titanium and / or zirconium and / or alloys of these two metals.
  • Another alloy from which the raw surface of the implant can be made is a biocompatible cobalt-based alloy.
  • the materials mentioned in the last section are characterized by a very high stability and good biocompatibility, so that they are predestined for use under physiological conditions.
  • the following substances are provided according to the invention as filling material for filling in the pores of the surface layer or the framework structure: calcium phosphate, in particular hydroxylapatite and / or tricalcium phosphate, creschite (CaHPO 4 .2H 2 O), calcium sulfate, silicon oxide, in particular in the form of silica gel, preferably pebble xerogel, titanium oxide, gelatin, collagen, extracellular matrix proteins, growth factor (s), bone-forming protein (s), hydrogel (s), substance (s) having antibiotic activity and mixtures of the aforementioned substances.
  • the particle size of the optionally crystalline substances used as filling material is in the range of 0.005 ⁇ m to 50 ⁇ m, preferably in the range of 0.01 ⁇ m to 5 ⁇ m and particularly preferably in the range of 30 nm to 100 nm.
  • these substances can preferably be applied to the framework structure by precipitation or by electrophoresis using a sol-gel process with a water-based and / or silicate-based binder, preferably also in the form of a dip bath, and, if desired, into the pores of the framework structure are filled, with respect to the type of application is no restriction, as long as a filling of the pores at least partially, preferably at least 80% and particularly preferably completely guaranteed.
  • the filling material introduced into the pores of the framework structure has micropores having an average free micropore cross section in the range of 0.1 nm to 100 ⁇ m, preferably in the range of 0.3 nm to 30 nm.
  • the surface layer or the framework structure can be produced in different ways; it should be emphasized, however, that depositing titanium particles by means of a vacuum plasma spraying method on a raw surface of the implant is preferred for generating the framework structure on the implant. Since the framework structure in this case is composed of individual interconnected metal particles, a variation of the type and size or dimensioning of the metal particles to each desired properties of the implant is well adaptable, since the particles are applied in layers and over a thermal process in regions, in particular pointwise, be connected to each other.
  • the object is achieved by a method for producing an open-pored biocompatible surface layer for an implant, in particular joint and / or Bone replacement implant, as well as solved by a method for producing an implant consisting of such an open-pore biocompatible surface layer, wherein the following steps are carried out:
  • step a) that is to say the production of an open-pored biocompatible surface layer in the form of a framework structure
  • step a is carried out by means of a vacuum plasma spraying method in which metal particles, preferably titanium particles, are applied to the raw surface of an implant blank, optionally directly above the raw surface of the implant
  • an intermediate layer preferably from one of the aforementioned metals, such as titanium, which is optionally provided with silicon, may be applied and thus not directly the raw surface of the implant blank, but the intermediate layer attached thereto is coated with the titanium particles.
  • These metal particles used for producing the skeleton structure preferably have a sintering aid which forms an alloy with the respective metal which melts at a lower temperature than the pure metal used in each case.
  • These metal particles are then applied, preferably by means of a vacuum plasma spraying method, to the raw surface of the implant or to the intermediate layer arranged on the raw surface of the implant for producing the framework structure.
  • a PVD (physical vapor deposition) method and / or a CVD (chemical vapor deposition) method can also be used to produce the framework structure, preferably metallic substances on the raw surface of the implant blank or on the intermediate layer applied thereon deposit.
  • the latter two methods are particularly suitable for deposition of metallic substances on an existing framework made of a ceramic or a plastic.
  • these two methods are also suitable to coat a framework of a metal structure.
  • the open-pore biocompatible surface layer is treated in the form of a scaffold structure by means of an arc which occurs between the raw surface of the implant blank and / or an intermediate layer on the implant blank and / or the framework structure on the implant blank, and a counter electrode is generated during and / or after application of metal, in particular titanium and / or compound particles.
  • the arc between the raw surface of the implant, or a surface layer located on the implant and a counter electrode can be applied directly to the implant during the application of the titanium and / or compound particles; Alternatively, however, the arc can also be applied after application of the titanium or compound particles. Another alternative is to use the arc process during and after application of the titanium and / or compound particles.
  • a second circuit between a Plasmatron, respectively the plasma gun, and the component are switched, so that via the electrical conductive plasma a transmitted arc can be adjusted. It is also possible to generate the arc, not to produce it from the plasmatron or the spray gun, but by means of a provided counter electrode.
  • the use of an arc during or after the application of titanium or compound particles on a raw surface of an implant has the significant advantage of a JouPschen heating high resistance resistances, ie in this case at the contact points between the titanium or compound grains, respectively - on particles because these are constricted areas and thus an increased electrical resistance.
  • a JouPschen heating high resistance resistances ie in this case at the contact points between the titanium or compound grains, respectively - on particles because these are constricted areas and thus an increased electrical resistance.
  • Tensile layer of the sintering aid to the thus coated titanium particles is a higher ohmic resistance, as the titanium particles themselves, so that here Joule heat is produced, resulting in a limited local only to the points of contact of the grains heating, especially in the coating layer, through which the sintering necks connecting the particles are reinforced.
  • this heat released on the spot leads to additional local sintering and thereby to reinforcement of sintered necks between the titanium granules, without at the same time causing sintering and / or smoothening of the remaining regions of the particles and of the substrate surface.
  • This advantageous effect causes in the coating a strong increase of their shear strength by a factor of 2 to 3 compared to the same coating parameters in the production, but without transferred arc.
  • the joint use of a sintering aid and a transferred arc can achieve a six- to seven-fold increased shear strength compared to a pure, open-pored titanium layer.
  • the arc is understood to be any type of energy action, in particular electrical, by means of which a JouFscher thermal effect can be achieved at narrowed points.
  • a major advantage of using an arc is that this immediately during the application of Titan13. Compound particles can be applied, so that the coating process ultimately runs in one stage and requires no additional process step, although a subsequent reinforcement of the sintering necks through the use of an arc is conceivable.
  • the part of the contact resistance which is due to the sintering aid, can be influenced by the choice of Sinterangesffens and the thickness thereof according to the invention, so that a targeted very high solidification of the open-pore surface layer can be achieved with a contiguous pore network
  • Silicon or cobalt are preferably used according to the invention as sintering aid, if titanium is used as the material for producing the framework structure, silicon particles preferably containing silicon particles in an amount in the range from 0.5% by weight to 8.5% by weight. % ⁇ 1.5 wt%, preferably 0.5 wt% to 3.0 wt%, and more preferably 1.0 wt% ⁇ 0.5 wt%.
  • the silicon particles used are silicon powder having a particle size ⁇ 80 ⁇ m, preferably ⁇ 40 ⁇ m and particularly preferably ⁇ 20 ⁇ m. With regard to the particle size distribution, reference is made to the above statements.
  • the titanium particles are coated with silicon particles in such a way that the coated titanium particles, which are now referred to as compound particles, have a particle size ⁇ 90 ⁇ m, preferably ⁇ 150 ⁇ m, again taking into account the predefined particle size distribution.
  • titanium particles Because of these size ratios, it is possible to coat the titanium particles with silicon particles and thus to provide a high surface area which, in the event of subsequent melting during a vacuum plasma coating process, for bonding particles or for connecting particles to a substrate is available. Furthermore, it is possible to coat titanium particles with silicon particles in compliance with the abovementioned particle sizes so that an edged periphery of the coated titanium particles, ie the compound particles, is substantially retained and the compound particles have an axial ratio of ⁇ 5: 2.
  • the vacuum plasma injection process parameters are adjusted so that the compound particles are only superficially melted and compacted when hitting the raw surface of the implant, respectively on the intermediate layer, if present, only slightly, so that their original geometry, in particular with respect to the axial ratio , largely preserved.
  • the angular particles which impinge on a substrate surface to form a structure which is connected to each other substantially only over points and edges of the individual angular particles, so that a kind of cage is created in the form of a framework structure. from which the contiguous pore network is formed and through whose cavities bone substance can grow and grow.
  • the raw surface of the implant prior to a coating process with compound particles having a base layer i. H. is coated with an intermediate layer, which may be formed depending on the base material of a raw implant body and preferably made of pure titanium and / or silicon-coated titanium.
  • the application of the intermediate layer takes place in the same vacuum plasma spray coating process as the application of the actual surface layer, with the self-explanatory application of the intermediate layer before the surface layer is applied.
  • the base or intermediate layer is produced with a layer thickness of ⁇ 200 ⁇ m, preferably of ⁇ 100 ⁇ m, and particularly preferably in the range of 30 ⁇ m to 50 ⁇ m.
  • a surface layer or three-dimensional open-porous framework structure produced according to the above statements on preferably metallic implant materials brings three major advantages, which consist on the one hand that the micro roughness of the surface structure produced stimulating effect on ingrowing bone tissue. Furthermore, a macroroughness and the open-pored framework structure itself ensure a very good bond between ingrown bone and implant material, and moreover, the material thickness of the surface layer, respectively the framework structure, provides an optimally suitable thickness which is optimized as an integration zone for the ingrowth of bone material and a firm, resilient and secure hold of the bone on the implant, respectively, vice versa, ensures.
  • step b) is carried out by immersing the framework structure in a bath, preferably a sol bath, which contains the substances which serve as filling material for filling the pores of the surface layer. These substances are either dissolved in the bath and / or, preferably homogeneously, dispersed. In this way, a filling of the pores of the surface layer or the framework structure with the filler materials is easily possible because they can penetrate together with the liquid bath medium in the pores and cavities of the framework structure.
  • substances which are selected from a group comprising: calcium phosphate, in particular hydroxylapatite and / or tricalcium phosphate, calcium sulfate, silicon oxide, in particular in the form of silica gel, preferably pebble xerogel , Titanium oxide, gelatin, collagen, extracellular matrix proteins, growth factor (s), bone-forming protein (s), hydrogel (s), substance (s) with antibiotic activity, optionally pharmacologically active substances, in particular inflammatory and / or or analgesic substances, as well as mixtures of the aforementioned substances.
  • this liquid matrix can penetrate the pores of the surface layer or the framework structure well and completely so that for filling the pores of the surface layer or the framework structure only a it is necessary to immerse the surface layer or the framework structure or the entire implant in the bath containing the filler substance baths.
  • the penetration of the silica-hydroxyapatite matrix together with the filler substances into the pores of the surface layer or the framework structure can be assisted by auxiliary measures known from the prior art, which can be mechanical and / or electrical in nature. It is also conceivable that surface tension reducing agents are used to achieve, as far as possible, complete and rapid filling of the pores.
  • the SoI i. in particular the silica-hydroxyapatite matrix, which is present in the form of a mixture, heat-treated and dried, the silica initially solidifying to a gel in which the disperse silicas are arranged net, leaf or honeycomb with a surface-rich structure and by another Drying to a xerogel solidifies.
  • this xerogel possesses micro- and nano-pores, which favor bone cell ingrowth and ingrowth, and provide good support due to the large surface area of the micropores.
  • filler materials are not exhaustive at this point, but it should be emphasized that substances which are suitable, bone ingrowth and growth, as well as optional adjuvants and additives, may also be used as filler materials, with a selection of those to be used Substances and their respective concentration in the silica hydroxyapatite matrix, depending on the condition of the bone, in particular bone type and bone age, can be varied.
  • these Sleeping material substances are at least partially replaced, preferably for the most part, by this bone substance, so that in the optimal final state only more bone substance is present within the pore volume of the surface layer or the framework structure after the filling substance substances have been dissolved and / or absorbed and rebuilt by the bone cells and / or were taken up or removed via blood vessels also ingrown into the framework structure.
  • an implant in particular joint replacement implant, which has a surface layer corresponding to the above specification and / or is produced by a method according to one of claims 14 to 18.
  • the object according to the invention is achieved by the use of a surface layer according to the above specification and / or the aforementioned manufacturing method, wherein the surface layer for hip shanks, shells for hip joints, femoral components for a knee replacement, tibial components for a knee replacement, components for a shoulder joint replacement, components for an elbow joint replacement, components for a toe joint replacement, components for a finger joint replacement, for a component for fusion of vertebrae of the lumbar spine, for components for a disc replacement, transgingival implant systems, for orthodontic implant systems and tooth replacement implants is suitable.
  • the surface layer according to the invention with its filled with filling pores for the above-mentioned areas of application in a very good manner, since a cementless anchoring of bone to the implants due to the excellent properties of the surface layer according to the invention, Namely, due to the micropores present in the filling material, is ensured, which ensure an optimized ingrowth and growth of bone on the surface layer and thus on the implant.
  • edged titanium powder produced via the hydride stage it is compounded in a first step with a small amount of a fine silicon powder.
  • the titanium powder has a particle size of less than 350 microns and the silicon powder such a maximum of 65 microns.
  • the resulting spray powder or the resulting compound particles consist of still edged particles with a maximum axial ratio of 5: 2.
  • this compounded powder is applied to the implant surface as an open-pored structure.
  • the open-pore layer itself has a layer thickness of 0.5 mm to 1.5 mm and a porosity of 40% to 50%.
  • the size of the pores, determined as the maximum diameter is 150 ⁇ m to 400 ⁇ m.
  • the opening of these pores against the outside is in the range of 150 microns to 500 microns.
  • This layer is applied by means of a vacuum plasma spraying method and using a simultaneous arc.
  • the plasma spray parameters are adjusted in this process so that the titanium particles are slightly melted, but are only slightly compacted upon impact with the substrate, namely the raw surface of the implant and already applied particles.
  • the applied arc additionally bonds the deposited titanium particles together as well as the sintering necks connecting them and their connection to the substrate, i. the surface of the implant, reinforced. It creates a coherent network of mutually connected titanium particles and at the same time a coherent, internal porosity.
  • the porosity of the titanium layer applied by means of a vacuum plasma spraying method according to the invention is continuous up to an intermediate layer which is arranged above the raw surface of the implant.
  • the intermediate layer serves an improved Adhesion of the surface layer, or the framework structure on the substrate and is formed as a thin dense titanium layer which has been deposited on the raw surface of the implant.
  • This intermediate layer has a thickness of about 50 microns.
  • this substrate serves as an electrode or grounding.
  • a JouPsche heating is generated at their junctions with each other and with the substrate, which represent a high-ohmic contact resistance, which causes a local sintering of these joints without the porosity and roughness in other areas of both the substrate and the applied particles is affected.
  • the roughness and continuous porosity which is optimally suited for ingrowth of bone tissue, sustained while the strength and cohesion of the particles with each other and with the substrate due to the application of the arc process is sustainably improved.
  • the vacuum plasma-sprayed layers in particular in combination with the arc process, have a good adhesion to the substrate and with respect to the particles with one another and a good shear resistance within the layer.
  • a filling of the pores of this surface layer or of the framework structure with a bioactive resorbable pore filling material is subsequently carried out.
  • This consists of a silica xerogel with embedded hydroxyapatite particles having a size of 10 nm to 500 nm.
  • This filling material also has extracellular matrix proteins, growth factors, bone-forming proteins, antibiotics, as well as gelatin and collagen. These substances are present in a liquid silica-hydroxyapatite matrix.
  • a bath which is formed by the silica-hydroxyapatite matrix and the other ingredients.
  • the surface layer or the framework structure is removed from the bath, the silica-hydroxyapatite matrix is dried and crosslinked by means of a thermal treatment.
  • This thermal treatment forms a nanoporous xerogel matrix that has a loose network of polysilicic acid molecules and hydroxylapatite particles. This loose network is ideal for ingrowth of osteoblasts.
  • the scaffold structure according to the invention together with the filling material filling the pores of this scaffold structure can be used not only in connection with implants but also as bone filling material, if a scaffold structure filled with filling material is introduced, for example, into bone cavities, bone cracks or otherwise damaged bones , Also in this case filled with filling material framework structure is ideal for ingrowth of bone cells, the latter can grow from all sides in the framework structure or the filler, provided that it is freely accessible. This is the case if the framework structure is not arranged on a raw surface of an implant or on another surface, but is present as such.
  • the highly porous scaffold structure can be of any size and shape that is suitable, with rods, cylinders, blocks, and wedge-shaped scaffold structures being explicitly advantageous.
  • both the open-pore biocompatible surface layer according to the invention for an implant, an implant produced from this surface layer and the method according to the invention for producing the same constitute a new and advantageous technology compared with the prior art, by which a rapid and effective ingrowth of Bone cells in one open-porous surface layer is ensured. This is accomplished by providing within the pores of the open cell surface layer a matrix to which bone cells can adhere well and within which these bone cells can spread, divide and propagate well.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Molecular Biology (AREA)
  • Ceramic Engineering (AREA)
  • Dentistry (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

Couche de surface biocompatible à pores ouverts pour un implant, qui est située sur une surface brute de l'implant, et implant comportant une couche de surface biocompatible à pores ouverts, les pores de la couche de surface étant remplis au moins partiellement, de préférence à au moins 80% et idéalement complètement d'une matière de charge bioactive, de préférence résorbable. La présente invention concerne en outre un procédé de fabrication d'une telle couche de surface ainsi que d'un tel implant, et un implant pourvu d'une couche de surface de ce type, ainsi que l'utilisation d'une telle couche de surface selon l'invention pour un implant ou en tant qu'implant.
PCT/EP2009/000386 2008-02-05 2009-01-22 Couche de surface biocompatible à pores ouverts pour un implant, procédé de fabrication de ladite couche et son utilisation WO2009097968A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09707895A EP2237808A2 (fr) 2008-02-05 2009-01-22 Couche de surface biocompatible à pores ouverts pour un implant, procédé de fabrication de ladite couche et son utilisation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102008007562 2008-02-05
DE102008007562.0 2008-02-05
DE102008044951A DE102008044951A1 (de) 2008-02-05 2008-08-29 Offenporige biokompatible Oberflächenschicht für ein Implantat, Verfahren zur Herstellung und Verwendung
DE102008044951.2 2008-08-29

Publications (2)

Publication Number Publication Date
WO2009097968A2 true WO2009097968A2 (fr) 2009-08-13
WO2009097968A3 WO2009097968A3 (fr) 2010-04-29

Family

ID=40822277

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/000386 WO2009097968A2 (fr) 2008-02-05 2009-01-22 Couche de surface biocompatible à pores ouverts pour un implant, procédé de fabrication de ladite couche et son utilisation

Country Status (3)

Country Link
EP (1) EP2237808A2 (fr)
DE (1) DE102008044951A1 (fr)
WO (1) WO2009097968A2 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102012005293A1 (de) * 2012-03-15 2013-09-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Implantat und Verfahren zur Herstellung desselben
US8888860B2 (en) 2010-02-04 2014-11-18 Finsbury (Development) Limited Prosthesis
CN104606716A (zh) * 2014-12-31 2015-05-13 上海杰视医疗科技有限公司 一种超高分子量聚乙烯复合材料及其制备方法
DE102017111784A1 (de) 2017-05-30 2018-12-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Beschichtetes Substrat mit titanhaltiger Beschichtung und modifizierter Titanoxidbeschichtung
CN109498845A (zh) * 2018-12-05 2019-03-22 湖南顶立科技有限公司 多孔口腔种植体及其制备方法
CN110038170A (zh) * 2019-04-04 2019-07-23 凯斯蒂南京医疗器械有限公司 一种可降解聚氨酯复合物及其用途
CN110251182A (zh) * 2019-06-14 2019-09-20 凯斯蒂南京医疗器械有限公司 一种伞型组织封堵器
CN114732944A (zh) * 2022-04-07 2022-07-12 北京大学 一种复合结构锌基棒材及其制备方法
CN115105641A (zh) * 2022-06-20 2022-09-27 四川大学 一种可骨性愈合连接的皮下植入材料

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009023239A1 (de) * 2009-05-30 2011-01-13 John, Hendrik, Dipl.-Ing. Verfahren zur Herstellung und Bearbeitung eines medizinischen Implantats sowie gemäß dem Verfahren hergestelltes Implantat
FR2993171B1 (fr) * 2012-07-11 2015-09-04 Rv Finances Cotyle pour prothese de hanche
WO2014060591A1 (fr) * 2012-10-19 2014-04-24 Thomas Gerber Revêtement ostéoconducteur pour implants en matière plastique
FR3038831B1 (fr) 2015-07-16 2017-07-21 Spineart Sa Cage intervertebrale pour arthrodese
CN111840647B (zh) * 2019-04-25 2022-10-21 深圳兰度生物材料有限公司 可吸收屏障膜及其制备方法
DE102020116929A1 (de) 2020-06-26 2021-12-30 Universität Rostock Endoprothese, Verfahren zu deren Herstellung und Verwendung einer Endoprothese

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999016479A1 (fr) * 1997-10-01 1999-04-08 Phillips-Origen Ceramic Technology, Llc. Materiaux pour substituts osseux
DE10022162A1 (de) * 2000-05-09 2001-11-22 Deutsch Zentr Luft & Raumfahrt Zementfreies Implantat und Verfahren zur Herstellung eines zementfreien Implantats
US6451059B1 (en) * 1999-11-12 2002-09-17 Ethicon, Inc. Viscous suspension spinning process for producing resorbable ceramic fibers and scaffolds
WO2006020090A2 (fr) * 2004-07-19 2006-02-23 Smith & Nephew, Inc. Frittage par courant pulse de surfaces d'implants medicaux
US20060121084A1 (en) * 2004-12-08 2006-06-08 Borden Mark D Continuous phase composite for musculoskeletal repair

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005052354A1 (de) 2005-11-02 2007-05-03 Plus Orthopedics Ag Offenporige biokompatible Oberflächenschicht für ein Implantat sowie Verfahren zur Herstellung und Verwendung

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999016479A1 (fr) * 1997-10-01 1999-04-08 Phillips-Origen Ceramic Technology, Llc. Materiaux pour substituts osseux
US6451059B1 (en) * 1999-11-12 2002-09-17 Ethicon, Inc. Viscous suspension spinning process for producing resorbable ceramic fibers and scaffolds
DE10022162A1 (de) * 2000-05-09 2001-11-22 Deutsch Zentr Luft & Raumfahrt Zementfreies Implantat und Verfahren zur Herstellung eines zementfreien Implantats
WO2006020090A2 (fr) * 2004-07-19 2006-02-23 Smith & Nephew, Inc. Frittage par courant pulse de surfaces d'implants medicaux
US20060121084A1 (en) * 2004-12-08 2006-06-08 Borden Mark D Continuous phase composite for musculoskeletal repair

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8888860B2 (en) 2010-02-04 2014-11-18 Finsbury (Development) Limited Prosthesis
US9393121B2 (en) 2010-02-04 2016-07-19 Finsbury (Development) Limited Prosthesis
EP3308747A3 (fr) * 2010-02-04 2018-05-30 Finsbury (Development) Limited Méthode pour fabrication d`une prothèse
DE102012005293A1 (de) * 2012-03-15 2013-09-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Implantat und Verfahren zur Herstellung desselben
CN104606716A (zh) * 2014-12-31 2015-05-13 上海杰视医疗科技有限公司 一种超高分子量聚乙烯复合材料及其制备方法
WO2018220002A1 (fr) 2017-05-30 2018-12-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Substrat revêtu présentant un revêtement contenant du titane et revêtement d'oxyde de titane modifié
DE102017111784A1 (de) 2017-05-30 2018-12-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Beschichtetes Substrat mit titanhaltiger Beschichtung und modifizierter Titanoxidbeschichtung
CN109498845A (zh) * 2018-12-05 2019-03-22 湖南顶立科技有限公司 多孔口腔种植体及其制备方法
CN110038170A (zh) * 2019-04-04 2019-07-23 凯斯蒂南京医疗器械有限公司 一种可降解聚氨酯复合物及其用途
CN110251182A (zh) * 2019-06-14 2019-09-20 凯斯蒂南京医疗器械有限公司 一种伞型组织封堵器
CN114732944A (zh) * 2022-04-07 2022-07-12 北京大学 一种复合结构锌基棒材及其制备方法
CN114732944B (zh) * 2022-04-07 2023-01-13 北京大学 一种复合结构锌基棒材及其制备方法
CN115105641A (zh) * 2022-06-20 2022-09-27 四川大学 一种可骨性愈合连接的皮下植入材料
CN115105641B (zh) * 2022-06-20 2023-06-02 四川大学 一种可骨性愈合连接的皮下植入材料

Also Published As

Publication number Publication date
EP2237808A2 (fr) 2010-10-13
WO2009097968A3 (fr) 2010-04-29
DE102008044951A1 (de) 2009-08-06

Similar Documents

Publication Publication Date Title
WO2009097968A2 (fr) Couche de surface biocompatible à pores ouverts pour un implant, procédé de fabrication de ladite couche et son utilisation
Pei et al. 3D printed titanium scaffolds with homogeneous diamond-like structures mimicking that of the osteocyte microenvironment and its bone regeneration study
EP0204786B1 (fr) Materiau de remplacement d'os et son utilisation
EP1515758B1 (fr) Revetement metallique a pores ouverts pour implants d'articulation artificielle et procede pour le realiser
DE69825911T2 (de) Knochersatzmaterial
EP0984745B1 (fr) Structures pour le remplacement de l'os ou du cartilage
EP0006544B1 (fr) Matériau de remplacement des os pour implantation à base de céramique de phosphate de calcium dans une matrice et procédé pour sa fabrication
DE3106917C2 (de) Verfahren zur Herstellung eines Implantates als Knochenersatz
DE112007003309B4 (de) Knochenimplantat sowie Set zur Herstellung von Knochenimplantaten und seine Verwendung
EP1942961B1 (fr) Procédé de fabrication d'une couche de surface biocompatible à pores ouverts destinée à un implant.
EP0366018B1 (fr) Structure cellulaire métallique et son procédé de fabrication
DE102004045410A1 (de) Knochenersatzimplantat für human- und veterinärmedizinische Anwendungen
EP3538029B1 (fr) Implant articulaire pour la régénération tissulaire au niveau de l'articulation
WO2014202685A1 (fr) Composants en céramique pour le remplacement de surfaces articulaires
WO2010097413A1 (fr) Implant constitué au moins en partie d'un matériau composite, produit composite intermédiaire et procédé de fabrication d'un implant
DE2905647A1 (de) Als knochenimplantat ausgebildetes verankerungselement
EP3801395A1 (fr) Procédé et dispositif de fabrication d'un implant
EP3801394B1 (fr) Implant articulaire pour la néoformation tissulaire au niveau de l'articulation
DE102010028430B4 (de) Implantat als Knochenersatz mit einer seine Oberfläche zumindest teilweise bedeckenden offenmaschigen, dreidimensionalen Raumnetzstruktur
EP3946165A1 (fr) Implant en un matériau de support entrecoupé de matériau donneur biologiquement actif et procédé de sa fabrication
EP4331634A2 (fr) Implant osseux à structure poreuse revêtue
WO2015144760A1 (fr) Procédé d'application de particules chargées sur un implant
DD300262A7 (de) Metallspongiosa

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09707895

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2009707895

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE