WO2009097480A2 - Libération de médicament déclenchée par un laser pulsé à infrarouge proche à partir de vésicules et vésosomes rompus à nanoenveloppe creuse - Google Patents

Libération de médicament déclenchée par un laser pulsé à infrarouge proche à partir de vésicules et vésosomes rompus à nanoenveloppe creuse Download PDF

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Publication number
WO2009097480A2
WO2009097480A2 PCT/US2009/032534 US2009032534W WO2009097480A2 WO 2009097480 A2 WO2009097480 A2 WO 2009097480A2 US 2009032534 W US2009032534 W US 2009032534W WO 2009097480 A2 WO2009097480 A2 WO 2009097480A2
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WO
WIPO (PCT)
Prior art keywords
nanostructure
gold
template
silver
metallic
Prior art date
Application number
PCT/US2009/032534
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English (en)
Other versions
WO2009097480A3 (fr
Inventor
Joseph A. Zasadzinski
Guohui Wu
Brian Prevo
Original Assignee
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Priority to US12/863,010 priority Critical patent/US20110052671A1/en
Publication of WO2009097480A2 publication Critical patent/WO2009097480A2/fr
Publication of WO2009097480A3 publication Critical patent/WO2009097480A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0065—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0084—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion liposome, i.e. bilayered vesicular structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Definitions

  • Suitable noble metals that can be employed include platinum, palladium, platinum-ruthenium alloys, rhodium, gold, iridium, osmium and the like.
  • Noble metal salts are known in the art and include metals salts comprising chlorides, nitrates, acetates or others and combinations of these salts .
  • Ligands can be linked to metallic nanostructures. Such caps can be non-functionalized, polyhomo- or polyhetero-functionalized. Nanostructures (e.g., nanospheres or nanoparticles) are capped, in one aspect, by long-chain alkyl thiols (e.g., dodecanethiol) and soluble in organic solvents (e.g., chloroform, dichloromethane, toluene, hexanes) .
  • Ligands or caps of various chemical classes are suitable for use. Ligands include, but are not limited to, alkanethiols having alkyl chain lengths of about C 1 -C30. In Attorney Docket No 00017-009WO1
  • Chemical moieties suitable for functional modification include, but are not limited to, bromo, chloro, iodo, fluoro, amino, hydroxyl, thio, phosphino, alkylthio, cyano, nitro, amido, carboxyl, aryl, heterocyclyl, ferrocenyl or heteroaryl .
  • the ligands can be attached to the central core by various methods including, but not limited to, covalent attachment, and electrostatic attachment .
  • a hollow nanoshell is mixed with, or attached to, liposomes or vesosomes via ligand-receptor tethering, or encapsulated within lipid bilayer vesicles or vesosomes that contain a drug to be released.
  • Nanosecond to femtosecond pulses of electromagnetic radiation e.g., near infrared ⁇ 800 nm wavelength
  • causes the nanostructure to adsorb sufficient energy to heat or to cause vibrational energy or pressure fluctuations in the surrounding media e.g., water, buffer, or physiological fluids
  • the heat or pressure fluctuations cause mechanical disruption of the lipid membranes in the vesicles or vesosomes (similar to ultrasound generated cavitation or pressure fluctuations) , causing an encapsulated drug or agent to be rapidly released.
  • Both temporal and spatial control of drug release can be controlled via the application of electromagnetic irradiation external to the cell, tissue or organism.
  • the nanoparticles that are useful in metal nanoparticle compositions according to the disclosure will typically have a certain degree of purity.
  • the particles (without capping ligands) may include not more than about 1-10 atomic percent impurities, e.g., not more than about 0.1-1 atomic percent impurities, typically not more than about 0.01-0.1 atomic percent impurities.
  • Impurities are those materials that are not intended in the final product and that adversely affect the properties of the final product .
  • a wavelength or wavelength spectrum of electromagnetic radiation is chosen to match the maximum of absorption for at least partially metallic spherical and non-spherical nanostructures which may be at least partially coated with organic or inorganic dielectric material or conjugated with biological molecules.
  • the methods of disclosure can be performed with irradiation with electromagnetic irradiation of any frequency or wavelength to cause a nanostructure to generate acoustic or pressure waves. Wavelengths in the visible or infrared range from about 200 to about 3000 nm can be used. Typically irradiation in the near-infrared wavelength range from 650 to 1200 nm is used.
  • nanostructures i.e., silica core/gold nanoshells, gold nanorods, and hollow gold nanoshells (HGN) are effective at absorbing NIR light and converting this energy into heat.
  • HGNs are similar to silica core/gold nanoshells that have been used both in vitro and in vivo to accumulate NIR light, except that HGNs have a hollow core, which allows easier synthesis and smaller overall dimensions.
  • Gold nanoshells and nanorods illuminated with NIR light have been successfully used to non-invasively heat cells and tissues in vivo and in vi tro .
  • X-ray photoelectron spectroscopy verified that silver was present with the gold metal after the galvanic replacement took place, but not the chemical state, Ag +1 or Ag 0 , of the silver. The silver signature was present even after the samples had been dialyzed in 5mM citrate solutions for several days, indicating that the silver was insoluble and associated with the nanoshells.
  • XPS provides a means for mapping the chemical composition of the first several nanometers of a surface.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Manufacture Of Metal Powder And Suspensions Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention porte sur des procédés d'administration de médicament et sur des compositions. Plus particulièrement, l'invention porte sur des compositions à administration liposomale comprenant une nanostructure.
PCT/US2009/032534 2008-01-30 2009-01-30 Libération de médicament déclenchée par un laser pulsé à infrarouge proche à partir de vésicules et vésosomes rompus à nanoenveloppe creuse WO2009097480A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/863,010 US20110052671A1 (en) 2008-01-30 2009-01-30 Near infra-red pulsed laser triggered drug release from hollow nanoshell disrupted vesicles and vesosomes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2469008P 2008-01-30 2008-01-30
US61/024,690 2008-01-30

Publications (2)

Publication Number Publication Date
WO2009097480A2 true WO2009097480A2 (fr) 2009-08-06
WO2009097480A3 WO2009097480A3 (fr) 2009-10-29

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Country Status (2)

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US (1) US20110052671A1 (fr)
WO (1) WO2009097480A2 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102298055A (zh) * 2011-07-21 2011-12-28 南京博天科智生物技术有限公司 一种人血液h-fabp纳米金标检测试纸条及其制备方法
GB2505401A (en) * 2012-08-31 2014-03-05 Uni Heidelberg Transferring nanoparticles into eukaryotic cells
CN104031266A (zh) * 2014-06-25 2014-09-10 吉林大学 一种导电高分子/贵金属复合纳米环、制备方法及应用
WO2015088042A1 (fr) * 2013-12-11 2015-06-18 Okinawa Institute Of Science And Technology School Corporation Procédé pour une libération contrôlée à l'aide d'impulsions laser femtoseconde
RU2646441C1 (ru) * 2016-12-21 2018-03-05 Федеральное государственное бюджетное образовательное учреждение высшего образования "Сибирский государственный университет геосистем и технологий" Способ упорядочения расположения наночастиц на поверхности подложки
CN110586003A (zh) * 2019-07-30 2019-12-20 上海匡宇科技股份有限公司 一种复合微球及其制备方法

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US8808733B2 (en) * 2009-03-31 2014-08-19 The Board Of Trustees Of The University Of Arkansas Method of controlled drug release from a liposome carrier
WO2013070872A1 (fr) 2011-11-08 2013-05-16 The Board Of Trustees Of The University Of Arkansas Procédés et compositions pour la libération induite par rayons x de liposomes sensibles au ph
US20130261444A1 (en) 2012-03-28 2013-10-03 The Uab Research Foundation Photothermal nanostructures in tumor therapy
US9789154B1 (en) 2012-05-04 2017-10-17 Duke University Plasmonics-active metal nanostar compositions and methods of use
US9561292B1 (en) * 2012-08-20 2017-02-07 Duke University Nanostars and nanoconstructs for detection, imaging, and therapy
US10358680B2 (en) 2012-09-11 2019-07-23 Duke University Nano-plasmonic molecular probes for plasmonics coupling interference
BR112015006873A2 (pt) 2012-09-27 2017-07-04 Rhodia Operations processo para produzir nanoestruturas de prata e copolímero útil em tal processo
US20140094383A1 (en) * 2012-10-02 2014-04-03 Ohio State Innovation Foundation Tethered Lipoplex nanoparticle Biochips And Methods Of Use
WO2014100379A1 (fr) * 2012-12-19 2014-06-26 The Research Foundation For The State University Of New York Compositions et procédé pour libération déclenchée par lumière de matières depuis des nanovésicules
US10633695B2 (en) 2013-03-22 2020-04-28 Duke University Nano-plasmonic molecular probes and methods of use
EP2990139B1 (fr) * 2013-06-07 2019-02-20 LG Chem, Ltd. Nanoparticules de métal
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
KR101768275B1 (ko) 2014-08-14 2017-08-14 주식회사 엘지화학 금속 나노입자의 제조방법
US11486047B2 (en) 2017-06-22 2022-11-01 Aalto University Foundation Sr Method of recovering Pt or Ag or Pt and Ag from sulfate based metal solutions
WO2019195858A1 (fr) * 2018-04-06 2019-10-10 Cornell University Nanocages inorganiques et procédés de préparation et d'utilisation de celles-ci
CN114849039A (zh) * 2022-05-26 2022-08-05 华中科技大学同济医学院附属协和医院 一种肠道药物递送的仿生机器人系统及其制备方法和应用
WO2024038181A1 (fr) * 2022-08-18 2024-02-22 Katholieke Universiteit Leuven Analyse de particules

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US20050056118A1 (en) * 2002-12-09 2005-03-17 Younan Xia Methods of nanostructure formation and shape selection
US20060141268A1 (en) * 2003-01-21 2006-06-29 The Penn State Research Foundation Nanoparticle coated nanostructured surfaces for detection, catalysis and device applications
US20060177660A1 (en) * 2005-02-09 2006-08-10 Challa Kumar Core-shell nanostructures and microstructures
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US20080003130A1 (en) * 2006-02-01 2008-01-03 University Of Washington Methods for production of silver nanostructures

Patent Citations (5)

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US20050056118A1 (en) * 2002-12-09 2005-03-17 Younan Xia Methods of nanostructure formation and shape selection
US20060141268A1 (en) * 2003-01-21 2006-06-29 The Penn State Research Foundation Nanoparticle coated nanostructured surfaces for detection, catalysis and device applications
US20060177660A1 (en) * 2005-02-09 2006-08-10 Challa Kumar Core-shell nanostructures and microstructures
US20080003130A1 (en) * 2006-02-01 2008-01-03 University Of Washington Methods for production of silver nanostructures
US20070292495A1 (en) * 2006-06-15 2007-12-20 Ludwig Florian N Nanoshells for drug delivery

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102298055A (zh) * 2011-07-21 2011-12-28 南京博天科智生物技术有限公司 一种人血液h-fabp纳米金标检测试纸条及其制备方法
GB2505401A (en) * 2012-08-31 2014-03-05 Uni Heidelberg Transferring nanoparticles into eukaryotic cells
WO2015088042A1 (fr) * 2013-12-11 2015-06-18 Okinawa Institute Of Science And Technology School Corporation Procédé pour une libération contrôlée à l'aide d'impulsions laser femtoseconde
JP2016540012A (ja) * 2013-12-11 2016-12-22 学校法人沖縄科学技術大学院大学学園 フェムト秒レーザーパルスを用いた制御放出のための方法
CN104031266A (zh) * 2014-06-25 2014-09-10 吉林大学 一种导电高分子/贵金属复合纳米环、制备方法及应用
RU2646441C1 (ru) * 2016-12-21 2018-03-05 Федеральное государственное бюджетное образовательное учреждение высшего образования "Сибирский государственный университет геосистем и технологий" Способ упорядочения расположения наночастиц на поверхности подложки
CN110586003A (zh) * 2019-07-30 2019-12-20 上海匡宇科技股份有限公司 一种复合微球及其制备方法

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Publication number Publication date
US20110052671A1 (en) 2011-03-03
WO2009097480A3 (fr) 2009-10-29

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