WO2009097397A3 - Metalloproteinase binding proteins - Google Patents

Metalloproteinase binding proteins Download PDF

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Publication number
WO2009097397A3
WO2009097397A3 PCT/US2009/032384 US2009032384W WO2009097397A3 WO 2009097397 A3 WO2009097397 A3 WO 2009097397A3 US 2009032384 W US2009032384 W US 2009032384W WO 2009097397 A3 WO2009097397 A3 WO 2009097397A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding proteins
metalloproteinase binding
metalloproteinase
protein
drug conjugates
Prior art date
Application number
PCT/US2009/032384
Other languages
French (fr)
Other versions
WO2009097397A2 (en
Inventor
Clive R. Wood
Daniel T. Dransfield
Original Assignee
Dyax Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dyax Corp. filed Critical Dyax Corp.
Publication of WO2009097397A2 publication Critical patent/WO2009097397A2/en
Publication of WO2009097397A3 publication Critical patent/WO2009097397A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

Protein-drug conjugates that bind to membrane type matrix metalloproteinases and methods of using such protein-drug conjugates are described.
PCT/US2009/032384 2008-01-30 2009-01-29 Metalloproteinase binding proteins WO2009097397A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2470308P 2008-01-30 2008-01-30
US61/024,703 2008-01-30

Publications (2)

Publication Number Publication Date
WO2009097397A2 WO2009097397A2 (en) 2009-08-06
WO2009097397A3 true WO2009097397A3 (en) 2010-01-07

Family

ID=40913493

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/032384 WO2009097397A2 (en) 2008-01-30 2009-01-29 Metalloproteinase binding proteins

Country Status (1)

Country Link
WO (1) WO2009097397A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2382993A1 (en) 2010-04-19 2011-11-02 KTB Tumorforschungsgesellschaft mbH Combination of drugs with protein-binding prodrugs
WO2013059439A2 (en) 2011-10-21 2013-04-25 Dyax Corp. Combination therapy comprising an mmp-14 binding protein
GB2538023A (en) * 2014-02-03 2016-11-02 Philochem Ag Targeted drug conjugates
CA3009484A1 (en) * 2015-12-22 2017-06-29 Abbvie Stemcentrx Llc Novel anti-mmp16 antibodies and methods of use
CN110687216A (en) * 2018-07-06 2020-01-14 山西医科大学第一医院 Application of endogenous serum micromolecules in evaluation of laryngeal cancer tumor cell differentiation degree

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060036076A1 (en) * 2003-11-19 2006-02-16 Dyax Corp. Metalloproteinase-binding proteins
WO2006065533A2 (en) * 2004-11-29 2006-06-22 Seattle Genetics, Inc. Engineered antibodies and immunoconjugates
US20070217997A1 (en) * 2005-12-30 2007-09-20 Laetitia Devy Metalloproteinase binding proteins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060036076A1 (en) * 2003-11-19 2006-02-16 Dyax Corp. Metalloproteinase-binding proteins
WO2006065533A2 (en) * 2004-11-29 2006-06-22 Seattle Genetics, Inc. Engineered antibodies and immunoconjugates
US20070217997A1 (en) * 2005-12-30 2007-09-20 Laetitia Devy Metalloproteinase binding proteins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LIU ET AL.: "Eradication of large colon tumor xenogràfts by targeted delivery of maytansinoids.", PROC. NATL. ACAD. SCI. USA, vol. 93, August 1996 (1996-08-01), pages 8618 - 8623 *

Also Published As

Publication number Publication date
WO2009097397A2 (en) 2009-08-06

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