WO2009095452A8 - Crystal structure of the atpase domain of proteins of the hsp70 family - Google Patents

Crystal structure of the atpase domain of proteins of the hsp70 family Download PDF

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Publication number
WO2009095452A8
WO2009095452A8 PCT/EP2009/051032 EP2009051032W WO2009095452A8 WO 2009095452 A8 WO2009095452 A8 WO 2009095452A8 EP 2009051032 W EP2009051032 W EP 2009051032W WO 2009095452 A8 WO2009095452 A8 WO 2009095452A8
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
hsp70 family
proteins
atpase domain
crystal structure
Prior art date
Application number
PCT/EP2009/051032
Other languages
French (fr)
Other versions
WO2009095452A1 (en
Inventor
Montserrat SOLER LÓPEZ
Irena Bonin
Marc Martinell Pedemonte
Juan AYMAMÍ BOFARULL
Original Assignee
Crystax Pharmaceuticals, S.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crystax Pharmaceuticals, S.L. filed Critical Crystax Pharmaceuticals, S.L.
Publication of WO2009095452A1 publication Critical patent/WO2009095452A1/en
Publication of WO2009095452A8 publication Critical patent/WO2009095452A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

A mutant protein of the Hsp70 family, which comprises the amino acid sequence from amino acid 1 to amino acid 380 that corresponds to an ATPase domain, wherein at positions 60 and 261 the amino acid residues have been mutated to cysteines, being all the positions defined from the initiation of the translation of the protein. The invention also relates to a crystal of the mutant protein of the Hsp70 family, and to methods of identifying potential ligand compounds able to be further used in the preparation of medicaments for the treatment of cancer and some related diseases.
PCT/EP2009/051032 2008-01-31 2009-01-29 Crystal structure of the atpase domain of proteins of the hsp70 family WO2009095452A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08150915 2008-01-31
EP08150915.0 2008-01-31

Publications (2)

Publication Number Publication Date
WO2009095452A1 WO2009095452A1 (en) 2009-08-06
WO2009095452A8 true WO2009095452A8 (en) 2009-12-03

Family

ID=40430019

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/051032 WO2009095452A1 (en) 2008-01-31 2009-01-29 Crystal structure of the atpase domain of proteins of the hsp70 family

Country Status (1)

Country Link
WO (1) WO2009095452A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2728363C (en) 2008-06-26 2019-02-19 Orphazyme Aps Use of hsp70 as a regulator of enzymatic activity
AU2011335545A1 (en) 2010-11-30 2013-06-13 Orphazyme Aps Methods for increasing intracellular activity of Hsp70
PT3193840T (en) 2014-09-15 2021-08-10 Orphazyme Aps Arimoclomol formulation
EP3442530A1 (en) 2016-04-13 2019-02-20 Orphazyme A/S Heat shock proteins and cholesterol homeostasis
KR102254140B1 (en) 2016-04-29 2021-05-24 오르파짐 에이/에스 Arimoclomol for the treatment of glucocerebrosidase-related disorders
EP4247792A1 (en) 2020-11-19 2023-09-27 Zevra Denmark A/S Processes for preparing arimoclomol citrate and intermediates thereof

Also Published As

Publication number Publication date
WO2009095452A1 (en) 2009-08-06

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