WO2008051326A3 - Identification of contactins and l1- cams as ligands for the amyloid precursor protein - Google Patents
Identification of contactins and l1- cams as ligands for the amyloid precursor protein Download PDFInfo
- Publication number
- WO2008051326A3 WO2008051326A3 PCT/US2007/018428 US2007018428W WO2008051326A3 WO 2008051326 A3 WO2008051326 A3 WO 2008051326A3 US 2007018428 W US2007018428 W US 2007018428W WO 2008051326 A3 WO2008051326 A3 WO 2008051326A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- contactins
- cams
- ligands
- identification
- precursor protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention relates to APP regulation by extracellular binding partners. More specifically, the invention porvides methods and compositions for treating or preventing diseases, such as Alzheimer's disease, mediated by Contactins and/or Ll family of proteins. The invention further provides methods for identifying molecules that modulate the binding and/or processing of APP and other related molecules.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83911406P | 2006-08-21 | 2006-08-21 | |
US60/839,114 | 2006-08-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008051326A2 WO2008051326A2 (en) | 2008-05-02 |
WO2008051326A3 true WO2008051326A3 (en) | 2009-04-02 |
Family
ID=39325090
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/018428 WO2008051326A2 (en) | 2006-08-21 | 2007-08-21 | Identification of contactins and l1- cams as ligands for the amyloid precursor protein |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008051326A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10303974A1 (en) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid β (1-42) oligomers, process for their preparation and their use |
KR101434935B1 (en) | 2005-11-30 | 2014-10-01 | 애브비 인코포레이티드 | Monoclonal antibodies against amyloid beta protein and uses thereof |
JP5475994B2 (en) | 2005-11-30 | 2014-04-16 | アッヴィ・インコーポレイテッド | Anti-Aβ globulomer antibody, antigen-binding portion thereof, corresponding hybridoma, nucleic acid, vector, host cell, method for producing said antibody, composition comprising said antibody, use of said antibody and method of using said antibody. |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
US20100311767A1 (en) | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
CN104744591B (en) | 2010-04-15 | 2022-09-27 | Abbvie德国有限责任两合公司 | Amyloid beta binding proteins |
CA2808187A1 (en) | 2010-08-14 | 2012-02-23 | Abbvie Inc. | Amyloid-beta binding proteins |
PL2825553T3 (en) * | 2012-03-14 | 2018-12-31 | Regeneron Pharmaceuticals, Inc. | Multispecific antigen-binding molecules and uses thereof |
JP7088572B2 (en) * | 2018-04-05 | 2022-06-21 | ゲノム アンド カンパニー | New targets for anti-cancer and immune enhancement |
US20210230256A1 (en) * | 2018-04-05 | 2021-07-29 | Genome And Company | Novel target for anti-cancer and immune-enhancing |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050027109A1 (en) * | 2003-05-06 | 2005-02-03 | Mezo Adam R. | Methods for chemically synthesizing immunoglobulin chimeric proteins |
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2007
- 2007-08-21 WO PCT/US2007/018428 patent/WO2008051326A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050027109A1 (en) * | 2003-05-06 | 2005-02-03 | Mezo Adam R. | Methods for chemically synthesizing immunoglobulin chimeric proteins |
Non-Patent Citations (2)
Title |
---|
MARETZKY, MOLECULAR AND CELLULAR BIOLOGY, vol. 25, no. 20, 2005, pages 9040 - 9053 * |
RUSH, EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 22, 2005, pages 39 - 49 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008051326A2 (en) | 2008-05-02 |
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