WO2009077436A3 - Method for preparing protein conjugates - Google Patents

Method for preparing protein conjugates Download PDF

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Publication number
WO2009077436A3
WO2009077436A3 PCT/EP2008/067376 EP2008067376W WO2009077436A3 WO 2009077436 A3 WO2009077436 A3 WO 2009077436A3 EP 2008067376 W EP2008067376 W EP 2008067376W WO 2009077436 A3 WO2009077436 A3 WO 2009077436A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
protein conjugates
preparing protein
group
preparing
Prior art date
Application number
PCT/EP2008/067376
Other languages
French (fr)
Other versions
WO2009077436A2 (en
Inventor
Ralph Leon Biemans
Pierre Duvivier
Original Assignee
Glaxosmithkline Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Publication of WO2009077436A2 publication Critical patent/WO2009077436A2/en
Publication of WO2009077436A3 publication Critical patent/WO2009077436A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

Abstract

An improved method for preparing protein conjugates comprises reacting primary amino groups of a first protein with a one group of a bifunctional linker and reacting a second protein with a second group on te same bifuntional linker to form a protein conjugate.
PCT/EP2008/067376 2007-12-14 2008-12-12 Method for preparing protein conjugates WO2009077436A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0724357A GB0724357D0 (en) 2007-12-14 2007-12-14 Method for preparing protein conjugates
GB0724357.9 2007-12-14

Publications (2)

Publication Number Publication Date
WO2009077436A2 WO2009077436A2 (en) 2009-06-25
WO2009077436A3 true WO2009077436A3 (en) 2009-09-17

Family

ID=39016540

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/067376 WO2009077436A2 (en) 2007-12-14 2008-12-12 Method for preparing protein conjugates

Country Status (2)

Country Link
GB (1) GB0724357D0 (en)
WO (1) WO2009077436A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY34073A (en) 2011-05-17 2013-01-03 Glaxosmithkline Biolog Sa IMPROVED VACCINE OF STREPTOCOCCUS PNEUMONIAE AND PREPARATION METHODS.
MX2020013466A (en) * 2018-06-26 2021-04-19 Immunogen Inc Immunoconjugates targeting adam9 and methods of use thereof.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002060937A1 (en) * 2001-02-01 2002-08-08 Institut Curie Universal carrier for targeting molecules to gb3 receptor expressing cells
US6602507B1 (en) * 1988-03-25 2003-08-05 The Rockefeller University Synthetic peptides from streptococcal M protein and vaccines prepared therefrom
WO2005112991A2 (en) * 2004-05-21 2005-12-01 Glaxosmithkline Biologicals Sa Vaccines
EP1844788A1 (en) * 2006-04-13 2007-10-17 Bio Life Science Forschungs- und Entwicklungsges.m.b.H. HER-2/neu multi-peptide vaccine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6602507B1 (en) * 1988-03-25 2003-08-05 The Rockefeller University Synthetic peptides from streptococcal M protein and vaccines prepared therefrom
WO2002060937A1 (en) * 2001-02-01 2002-08-08 Institut Curie Universal carrier for targeting molecules to gb3 receptor expressing cells
WO2005112991A2 (en) * 2004-05-21 2005-12-01 Glaxosmithkline Biologicals Sa Vaccines
EP1844788A1 (en) * 2006-04-13 2007-10-17 Bio Life Science Forschungs- und Entwicklungsges.m.b.H. HER-2/neu multi-peptide vaccine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HAICHEUR NACILLA ET AL: "The B subunit of Shiga toxin coupled to full-size antigenic protein elicits humoral and cell-mediated immune responses associated with a Th1-dominant polarization", INTERNATIONAL IMMUNOLOGY, OXFORD UNIVERSITY PRESS, GB, vol. 15, no. 10, 1 October 2003 (2003-10-01), pages 1161 - 1171, XP002353584, ISSN: 0953-8178 *
O'DOWD A M ET AL: "Novel modifications to the C-terminus of LTB that facilitate site-directed chemical coupling of antigens and the development of LTB as a carrier for mucosal vaccines", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 17, no. 11-12, 1 March 1999 (1999-03-01), pages 1442 - 1453, XP004158272, ISSN: 0264-410X *
TAKAHASHI I ET AL: "IMMUNOGENICITY AND PROTECTIVE EFFECT AGAINST ORAL COLONIZATION BY STREPTOCOCCUS-MUTANS OF SYNTHETIC PEPTIDES OF A STREPTOCOCCAL SURFACE PROTEIN ANTIGEN", JOURNAL OF IMMUNOLOGY, vol. 146, no. 1, 1991, pages 332 - 336, XP002535536, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
GB0724357D0 (en) 2008-01-23
WO2009077436A2 (en) 2009-06-25

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