WO2009075891A3 - Magnetoelastic sensor element having a liquid-solid interface with a roughened nano/microstructure - Google Patents

Magnetoelastic sensor element having a liquid-solid interface with a roughened nano/microstructure Download PDF

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Publication number
WO2009075891A3
WO2009075891A3 PCT/US2008/013677 US2008013677W WO2009075891A3 WO 2009075891 A3 WO2009075891 A3 WO 2009075891A3 US 2008013677 W US2008013677 W US 2008013677W WO 2009075891 A3 WO2009075891 A3 WO 2009075891A3
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WO
WIPO (PCT)
Prior art keywords
quantifying
sensor element
platelet
liquid
clot
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Application number
PCT/US2008/013677
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French (fr)
Other versions
WO2009075891A2 (en
Inventor
Craig A Grimes
Original Assignee
Craig A Grimes
Kmg2 Sensors Corp Kmg2
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Craig A Grimes, Kmg2 Sensors Corp Kmg2 filed Critical Craig A Grimes
Publication of WO2009075891A2 publication Critical patent/WO2009075891A2/en
Publication of WO2009075891A3 publication Critical patent/WO2009075891A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Ecology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)

Abstract

An analyzer-unit and method that uses information obtained from at least one, yet adapted for a plurality of, magnetoelastic sensor element in contact with a liquid sample (e.g., blood from a patient) for automatically quantifying one or more parameters thereof. The sensor element compriese a liquid-solid interface having a roughened nano/ micro-structure. Information obtained from emissions measured from each sensor element is uniquely processed to determine a quantification about a patient's blood, such as, quantifying platelet aggregation to determine platelet contribution toward clot formation; quantifying fibrin network contribution toward clot formation; quantifying platelet-fibrin clot interactions; quantifying kinetics of thrombin clot generation; quantifying platelet-fibrin clot strength; etc. Structural aspects of unit include: a cartridge having at least one bay within which a sensor element is positioned; each bay in fluid communication with an entry port for injecting a first blood sample, and a gas vent.
PCT/US2008/013677 2007-12-12 2008-12-12 Magnetoelastic sensor element having a liquid-solid interface with a roughened nano/microstructure WO2009075891A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US749507P 2007-12-12 2007-12-12
US61/007,495 2007-12-12

Publications (2)

Publication Number Publication Date
WO2009075891A2 WO2009075891A2 (en) 2009-06-18
WO2009075891A3 true WO2009075891A3 (en) 2009-08-13

Family

ID=40365559

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/013677 WO2009075891A2 (en) 2007-12-12 2008-12-12 Magnetoelastic sensor element having a liquid-solid interface with a roughened nano/microstructure

Country Status (1)

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WO (1) WO2009075891A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108169467A (en) * 2017-11-27 2018-06-15 中国科学院苏州生物医学工程技术研究所 A kind of thrombelastogram instrument quality-control product and its preparation method and application

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009040881A1 (en) 2009-09-09 2011-05-05 Andreas Hettich Gmbh & Co. Kg Method for determining platelet function with a resonator
DE102012202336A1 (en) * 2012-02-16 2013-08-22 Siemens Aktiengesellschaft Apparatus and method for determining a biochemical function of a fluid
AU2014227711B2 (en) * 2013-03-15 2020-04-09 Haemonetics Corporation Apparatus, cartridge and method for hemostasis testing
CN105004868B (en) * 2014-04-17 2016-08-31 北京乐普医疗科技有限责任公司 A kind of multichannel thrombelastogram instrument and using method
CN105092864A (en) * 2014-05-15 2015-11-25 北京乐普医疗科技有限责任公司 3-level thrombelastogram quality control product and application thereof
CN105652022B (en) * 2015-12-31 2017-10-10 浙江盛域医疗技术有限公司 Thrombelastogram instrument quality-control product and preparation method thereof
CN113203661B (en) * 2021-04-08 2022-05-06 浙江大学 Device and method for rapidly detecting blood viscosity based on ultrasonic guided waves of fine metal tubes

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Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
US5629209A (en) * 1995-10-19 1997-05-13 Braun, Sr.; Walter J. Method and apparatus for detecting viscosity changes in fluids
US20030219904A1 (en) * 1999-02-22 2003-11-27 Eli Cohen Protocol for monitoring platelet inhibition
EP1162457A2 (en) * 2000-06-09 2001-12-12 GOLDSTEIN, Sheldon Multiple coagulation test system and method of using a multiple coagulation test system
WO2001096879A2 (en) * 2000-06-09 2001-12-20 Haemoscope Corporation Method and apparatus for monitoring anti-platelet agents
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US20050267569A1 (en) * 2004-03-27 2005-12-01 Gary Barrett Non-invasive detection of in-stent stenosis and drug elution

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Title
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108169467A (en) * 2017-11-27 2018-06-15 中国科学院苏州生物医学工程技术研究所 A kind of thrombelastogram instrument quality-control product and its preparation method and application

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