WO2009074883A3 - Improved process for preparing duloxetine - Google Patents

Improved process for preparing duloxetine Download PDF

Info

Publication number
WO2009074883A3
WO2009074883A3 PCT/IB2008/003875 IB2008003875W WO2009074883A3 WO 2009074883 A3 WO2009074883 A3 WO 2009074883A3 IB 2008003875 W IB2008003875 W IB 2008003875W WO 2009074883 A3 WO2009074883 A3 WO 2009074883A3
Authority
WO
WIPO (PCT)
Prior art keywords
improved process
preparing duloxetine
duloxetine
preparing
provides
Prior art date
Application number
PCT/IB2008/003875
Other languages
French (fr)
Other versions
WO2009074883A2 (en
Inventor
Stephen Benedict David Winter
Original Assignee
Medichem Sa
Stephen Benedict David Winter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa, Stephen Benedict David Winter filed Critical Medichem Sa
Publication of WO2009074883A2 publication Critical patent/WO2009074883A2/en
Publication of WO2009074883A3 publication Critical patent/WO2009074883A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Abstract

The invention provides an improved process for preparing duloxetine. The invention provides an improved process for preparing duloxetine, efficiently and with good reaction rate, which is carried out in a homogeneous mixture, at a temperature lower than 80 °C, in which chiral integrity is preserved, and neither sodium hydride nor potassium hydroxide is required.
PCT/IB2008/003875 2007-11-06 2008-11-06 Improved process for preparing duloxetine WO2009074883A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98588207P 2007-11-06 2007-11-06
US60/985,882 2007-11-06

Publications (2)

Publication Number Publication Date
WO2009074883A2 WO2009074883A2 (en) 2009-06-18
WO2009074883A3 true WO2009074883A3 (en) 2009-08-06

Family

ID=40671400

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/003875 WO2009074883A2 (en) 2007-11-06 2008-11-06 Improved process for preparing duloxetine

Country Status (1)

Country Link
WO (1) WO2009074883A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8530674B2 (en) * 2010-05-06 2013-09-10 Sci Pharmtech, Inc. Process for preparing (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine by using optically active methylhydroxylaminopropanol compound as intermediate
ES2471133T3 (en) * 2010-05-10 2014-06-25 Sci Pharmatech, Inc. Process for preparing (S) - (+) - N-methyl-3- (1-naphthyloxy) -3- (2-thienyl) propylamine by using an optically active methylhydroxylaminopropanol compound as intermediate
GR1007725B (en) 2011-10-17 2012-10-18 Φαρματεν Αβεε, Process for the preparation of highly pure duloxetine hydrochloride

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006126213A1 (en) * 2005-05-24 2006-11-30 Matrix Laboratories Ltd An improved process for the preparation of duloxetine
US20070167636A1 (en) * 2006-01-19 2007-07-19 Butchko Mark A Improved process for the asymmetric synthesis of duloxetine
WO2007095200A2 (en) * 2006-02-13 2007-08-23 Teva Pharmaceutical Industries Ltd. A process for the preparation of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a duloxetine intermediate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006126213A1 (en) * 2005-05-24 2006-11-30 Matrix Laboratories Ltd An improved process for the preparation of duloxetine
US20070167636A1 (en) * 2006-01-19 2007-07-19 Butchko Mark A Improved process for the asymmetric synthesis of duloxetine
WO2007095200A2 (en) * 2006-02-13 2007-08-23 Teva Pharmaceutical Industries Ltd. A process for the preparation of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a duloxetine intermediate

Also Published As

Publication number Publication date
WO2009074883A2 (en) 2009-06-18

Similar Documents

Publication Publication Date Title
ZA200902558B (en) Process for producing modified polymer, modified polymer obtained by the process, and rubber composition containing the same
EP1857520A4 (en) Composition for heat-storage object formation, heat-storage object, and process for producing heat-storage object
WO2006105338A3 (en) Fc VARIANTS WITH OPTIMIZED PROPERTIES
WO2008002499A3 (en) Tetrafluoropropene production processes
MX2009008662A (en) Method for producing 2,3,3,3-tetrafluoropropene.
WO2008021256A3 (en) Nanoplatelet metal hydroxides and methods of preparing same
UA97382C2 (en) Rasagiline tannate
TW200704699A (en) Resin composition for cleaning
PL2193173T3 (en) Carbon black, method for the production thereof, and use thereof
EP1877520B8 (en) Method for steam reforming carbonaceous material
IL189309A0 (en) Process for producing fullerene dispersion liquid, and fullerene dispersion liquid
CA2687645C (en) Method for making a highly exfoliated vermiculite without using any organic binder or additive for forming the same
EP1976046A4 (en) Fuel cell separator, process for producing the same, and fuel cell including the separator
IL197708A0 (en) Process for the fabrication of manometric, zonodispersed and stable magnesium hydroxide and product obtained
WO2007109060A3 (en) Meat brines
WO2008054522A3 (en) Room temperature synthesis of gan nanopowder
EP2135889A4 (en) Fluorinated polyether compound, process for producing the same, and curable composition containing the same
MX2009008352A (en) Method for lithium exchange reactions.
IL202831A (en) Process for performing an endothermic reaction, reactors for performing the process and their uses
WO2008144200A3 (en) Process for the production of highly graphitizable carbon foam
WO2008133962A3 (en) Thermal insulative product and related methods
WO2008007279A3 (en) Method of content substitution
ZA201004031B (en) Dehydrohalagenation process for the preparation of intermediates useful in providing 6,6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds
WO2009022108A3 (en) Hydrogen storage material
WO2007100546A3 (en) Composite fuels for hydrogen generation

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008860363

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08860363

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 08860363

Country of ref document: EP

Kind code of ref document: A2