WO2006105338A3 - Fc VARIANTS WITH OPTIMIZED PROPERTIES - Google Patents
Fc VARIANTS WITH OPTIMIZED PROPERTIES Download PDFInfo
- Publication number
- WO2006105338A3 WO2006105338A3 PCT/US2006/011752 US2006011752W WO2006105338A3 WO 2006105338 A3 WO2006105338 A3 WO 2006105338A3 US 2006011752 W US2006011752 W US 2006011752W WO 2006105338 A3 WO2006105338 A3 WO 2006105338A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- variants
- optimized properties
- optimized
- properties
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008504389A JP2008537941A (en) | 2005-03-31 | 2006-03-31 | Fc variants with optimized properties |
EP06748967A EP1871808A2 (en) | 2005-03-31 | 2006-03-31 | Fc VARIANTS WITH OPTIMIZED PROPERTIES |
CA002602663A CA2602663A1 (en) | 2005-03-31 | 2006-03-31 | Fc variants with optimized properties |
AU2006230413A AU2006230413B8 (en) | 2005-03-31 | 2006-03-31 | Fc variants with optimized properties |
IL186145A IL186145A0 (en) | 2005-03-31 | 2007-09-20 | Fc VARIANTS WITH OPTIMIZED PROPERTIES |
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66719705P | 2005-03-31 | 2005-03-31 | |
US60/667,197 | 2005-03-31 | ||
US11/124,620 | 2005-05-05 | ||
US11/124,620 US8188231B2 (en) | 2002-09-27 | 2005-05-05 | Optimized FC variants |
US70537805P | 2005-08-03 | 2005-08-03 | |
US60/705,378 | 2005-08-03 | ||
US72333505P | 2005-10-03 | 2005-10-03 | |
US72329405P | 2005-10-03 | 2005-10-03 | |
US60/723,294 | 2005-10-03 | ||
US60/723,335 | 2005-10-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006105338A2 WO2006105338A2 (en) | 2006-10-05 |
WO2006105338A3 true WO2006105338A3 (en) | 2007-03-29 |
Family
ID=37054149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/011752 WO2006105338A2 (en) | 2005-03-31 | 2006-03-31 | Fc VARIANTS WITH OPTIMIZED PROPERTIES |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1871808A2 (en) |
AU (1) | AU2006230413B8 (en) |
CA (1) | CA2602663A1 (en) |
IL (1) | IL186145A0 (en) |
WO (1) | WO2006105338A2 (en) |
Cited By (5)
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US8101720B2 (en) | 2004-10-21 | 2012-01-24 | Xencor, Inc. | Immunoglobulin insertions, deletions and substitutions |
US8158760B2 (en) | 2000-10-06 | 2012-04-17 | Kyowa Hakko Kirin Co., Ltd | Glycoengineered, recombinant antibody |
US8852586B2 (en) | 2004-11-12 | 2014-10-07 | Xencor, Inc. | Fc variants with altered binding to FcRn |
US9200079B2 (en) | 2004-11-12 | 2015-12-01 | Xencor, Inc. | Fc variants with altered binding to FcRn |
US11851476B2 (en) | 2011-10-31 | 2023-12-26 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain |
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EP4055055B1 (en) | 2020-12-18 | 2023-11-22 | LamKap Bio beta AG | Bispecific antibodies against ceacam5 and cd47 |
CA3221735A1 (en) | 2021-06-18 | 2022-12-22 | F. Hoffmann-La Roche Ag | Bispecific anti-ccl2 antibodies |
WO2023242351A1 (en) | 2022-06-16 | 2023-12-21 | Lamkap Bio Beta Ag | Combination therapy of bispecific antibodies against ceacam5 and cd47 and bispecific antibodies against ceacam5 and cd3 |
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US8852586B2 (en) | 2004-11-12 | 2014-10-07 | Xencor, Inc. | Fc variants with altered binding to FcRn |
US8883973B2 (en) | 2004-11-12 | 2014-11-11 | Xencor, Inc. | Fc variants with altered binding to FcRn |
US9200079B2 (en) | 2004-11-12 | 2015-12-01 | Xencor, Inc. | Fc variants with altered binding to FcRn |
US11851476B2 (en) | 2011-10-31 | 2023-12-26 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain |
Also Published As
Publication number | Publication date |
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CA2602663A1 (en) | 2006-10-05 |
IL186145A0 (en) | 2008-01-20 |
AU2006230413A1 (en) | 2006-10-05 |
AU2006230413B8 (en) | 2011-01-20 |
EP1871808A2 (en) | 2008-01-02 |
WO2006105338A2 (en) | 2006-10-05 |
AU2006230413B2 (en) | 2010-09-23 |
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