WO2009072830A3 - Hollow microneedle array - Google Patents

Hollow microneedle array Download PDF

Info

Publication number
WO2009072830A3
WO2009072830A3 PCT/KR2008/007195 KR2008007195W WO2009072830A3 WO 2009072830 A3 WO2009072830 A3 WO 2009072830A3 KR 2008007195 W KR2008007195 W KR 2008007195W WO 2009072830 A3 WO2009072830 A3 WO 2009072830A3
Authority
WO
WIPO (PCT)
Prior art keywords
needle
upper portion
diameter
skin
hollow microneedle
Prior art date
Application number
PCT/KR2008/007195
Other languages
French (fr)
Other versions
WO2009072830A2 (en
Inventor
Woo Sung Nam
Sin Kil Cho
Original Assignee
Incyto Co Ltd
Woo Sung Nam
Sin Kil Cho
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyto Co Ltd, Woo Sung Nam, Sin Kil Cho filed Critical Incyto Co Ltd
Publication of WO2009072830A2 publication Critical patent/WO2009072830A2/en
Publication of WO2009072830A3 publication Critical patent/WO2009072830A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles

Abstract

A hollow microneedle array includes a needle part having a plurality of hollow microneedle and a substrate part supporting the needle part. The needle includes an upper portion inserted into ski and a base portion communicated with the upper portion and supporting the upper portion. An upper end of the upper portion has such an outer diameter that reduces pain upon penetration into the skin. A diameter of the upper portion smoothly increases as it goes to the other end thereof so as to reduce pain upon penetration into the skin. An aspect ratio of the diameter of the upper end of the upper portion to a length of the needle is high to enable deep penetration into the skin. A diameter of the base portion generally exponentially increases as it goes to a lower end of the base portion so as to increase total strength of the needle in both longitudinal and lateral directions. Further, the needle is made of biocompatible metal having good mechanical properties.
PCT/KR2008/007195 2007-12-07 2008-12-05 Hollow microneedle array WO2009072830A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2007-0127085 2007-12-07
KR1020070127085A KR20090059971A (en) 2007-12-07 2007-12-07 Hollow microneedle

Publications (2)

Publication Number Publication Date
WO2009072830A2 WO2009072830A2 (en) 2009-06-11
WO2009072830A3 true WO2009072830A3 (en) 2009-07-23

Family

ID=40718359

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2008/007195 WO2009072830A2 (en) 2007-12-07 2008-12-05 Hollow microneedle array

Country Status (2)

Country Link
KR (1) KR20090059971A (en)
WO (1) WO2009072830A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101136739B1 (en) * 2009-06-15 2012-04-19 주식회사 라파스 Multi-functional Hybrid Microstructure and Process for Preparing the Same
KR101386442B1 (en) * 2010-04-01 2014-04-18 주식회사 라파스 Process for Preparing Solid Microstructures by Blowing and Solid Microstructures Prepared by the Same
US8545741B2 (en) 2010-04-01 2013-10-01 Nurim Wellness Co. Ltd. Method of manufacturing microstructure
KR101254240B1 (en) * 2010-12-17 2013-04-12 주식회사 라파스 Process for preparing microstructures
KR101180032B1 (en) 2010-07-12 2012-09-05 인싸이토(주) Method for manufacturing Hollow Microneedle with Controlled External Appearance Characteristics
KR101254245B1 (en) * 2011-02-01 2013-04-12 주식회사 라파스 Stent delivery device having stent wire conjugated with microstructure
KR101412535B1 (en) * 2011-11-29 2014-06-26 연세대학교 산학협력단 Hollow Microneedle for Intravitreal Drug Delivery
US20150112282A1 (en) * 2012-04-09 2015-04-23 Industry-Academic Cooperation Foundation, Yonsei University Hollow microneedle and subretinal syringe for subretinal injection or extraction
ITRM20130079A1 (en) * 2013-02-12 2014-08-13 Consiglio Nazionale Ricerche METHOD FOR THE PRODUCTION OF A MICRO-NEEDLE LAYER
KR101488397B1 (en) * 2013-02-22 2015-02-03 연세대학교 산학협력단 Process for Preparing Microstructures by Negative Pressure and Microstructures Prepared by the Same
KR20160019944A (en) 2013-06-13 2016-02-22 마이크로데믹스 인코퍼레이티드 Metallic microneedles
CN108430564B (en) * 2015-12-04 2022-01-11 艾希莱恩公司 Microneedle and chip
WO2017150824A1 (en) 2016-03-03 2017-09-08 가천대학교 산학협력단 Microneedle and manufacturing method therefor
WO2017198872A1 (en) 2016-05-20 2017-11-23 Uprax System and method for applying microneedles
KR101834317B1 (en) * 2016-07-13 2018-03-05 영남대학교 산학협력단 Apparatus and method for fabricating of micro niddle
KR101947624B1 (en) * 2016-12-29 2019-02-14 랩앤피플주식회사 Multi type micro-needle
US20220218237A1 (en) * 2019-06-19 2022-07-14 Lg Electronics Inc. Needle-type biosensor

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002239014A (en) * 2001-02-19 2002-08-27 Sumitomo Precision Prod Co Ltd Needle-like body and method for manufacturing needle- like body
JP2005021678A (en) * 2003-06-10 2005-01-27 Medorekkusu:Kk Pad base for percutaneous admistration and its manufacturing method
KR100612891B1 (en) * 2005-02-24 2006-08-14 삼성전자주식회사 Microneedle and method of fabricating the same
KR100781702B1 (en) * 2006-07-21 2007-12-03 연세대학교 산학협력단 A hollow type microneedle and methods for preparing it

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002239014A (en) * 2001-02-19 2002-08-27 Sumitomo Precision Prod Co Ltd Needle-like body and method for manufacturing needle- like body
JP2005021678A (en) * 2003-06-10 2005-01-27 Medorekkusu:Kk Pad base for percutaneous admistration and its manufacturing method
KR100612891B1 (en) * 2005-02-24 2006-08-14 삼성전자주식회사 Microneedle and method of fabricating the same
KR100781702B1 (en) * 2006-07-21 2007-12-03 연세대학교 산학협력단 A hollow type microneedle and methods for preparing it

Also Published As

Publication number Publication date
KR20090059971A (en) 2009-06-11
WO2009072830A2 (en) 2009-06-11

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