WO2009072361A1 - インビボ蛍光検査用組成物、それを用いた乳癌組織の検査方法、及び生体疾患組織のイメージング観察方法 - Google Patents

インビボ蛍光検査用組成物、それを用いた乳癌組織の検査方法、及び生体疾患組織のイメージング観察方法 Download PDF

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Publication number
WO2009072361A1
WO2009072361A1 PCT/JP2008/069524 JP2008069524W WO2009072361A1 WO 2009072361 A1 WO2009072361 A1 WO 2009072361A1 JP 2008069524 W JP2008069524 W JP 2008069524W WO 2009072361 A1 WO2009072361 A1 WO 2009072361A1
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WIPO (PCT)
Prior art keywords
composition
body tissue
vivo fluorescence
diseased body
fluorescence test
Prior art date
Application number
PCT/JP2008/069524
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English (en)
French (fr)
Inventor
Kazuya Tsukada
Kazuyoshi Goan
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Konica Minolta Medical & Graphic, Inc.
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Publication date
Application filed by Konica Minolta Medical & Graphic, Inc. filed Critical Konica Minolta Medical & Graphic, Inc.
Publication of WO2009072361A1 publication Critical patent/WO2009072361A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4312—Breast evaluation or disorder diagnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0091—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0065—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle
    • A61K49/0067—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle quantum dots, fluorescent nanocrystals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nanotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Endocrinology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

　耐光性、検出精度に優れ、かつ非侵襲性が高く、毒性懸念がない腫瘍等の生体疾患組織の検査を可能とする、近赤外波長領域で蛍光を発するIV族量子ドットを光学的検出用標識剤として含むインビボ蛍光検査用組成物を提供する。更に、それを用いた乳癌組織の検査方法、及び生体疾患組織のイメージング観察方法を提供する。本発明のインビボ蛍光検査用組成物は、生体疾患組織のインビボ蛍光検査に使用されるインビボ蛍光検査用組成物であって、３５０～１２００ｎｍから選択される励起波長の電磁波照射による局部励起に基づき、近赤外波長領域で蛍光を発するIV族量子ドットを、光学的検出用標識剤として、含有することを特徴とする。
PCT/JP2008/069524 2007-12-05 2008-10-28 インビボ蛍光検査用組成物、それを用いた乳癌組織の検査方法、及び生体疾患組織のイメージング観察方法 WO2009072361A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-314742 2007-12-05
JP2007314742 2007-12-05

Publications (1)

Publication Number Publication Date
WO2009072361A1 true WO2009072361A1 (ja) 2009-06-11

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PCT/JP2008/069524 WO2009072361A1 (ja) 2007-12-05 2008-10-28 インビボ蛍光検査用組成物、それを用いた乳癌組織の検査方法、及び生体疾患組織のイメージング観察方法

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102851021A (zh) * 2012-09-26 2013-01-02 中国科学技术大学 一种高亮度无毒性荧光量子点纳米复合探针及其制备方法
CN106492236A (zh) * 2016-11-22 2017-03-15 上海师范大学 一种多功能纳米探针及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005172429A (ja) * 2003-12-05 2005-06-30 Sony Corp 生体物質蛍光標識剤及び生体物質蛍光標識方法、並びにバイオアッセイ方法及び装置
JP2007178239A (ja) * 2005-12-27 2007-07-12 Kenji Yamamoto 親水性量子ドット

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005172429A (ja) * 2003-12-05 2005-06-30 Sony Corp 生体物質蛍光標識剤及び生体物質蛍光標識方法、並びにバイオアッセイ方法及び装置
JP2007178239A (ja) * 2005-12-27 2007-07-12 Kenji Yamamoto 親水性量子ドット

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LI, X. ET AL.: "Process for Preparing Macroscopic Quantities of Brightly Photoluminescent Silicon Nanoparticles with Emission Spanning the Visible Spectrum", LANGMUIR, vol. 19, no. 20, 30 September 2003 (2003-09-30), pages 8490 - 8496 *
MICHALET, X. ET AL.: "Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics", SCIENCE, vol. 307, 28 January 2005 (2005-01-28), pages 538 - 544 *
MITSURU ISHIKAWA: "Ryoshi Dot no Seimei Kagaku Ryoiki eno Oyo", August 2007, CMC PUBLISHING CO., LTD./KENJI TSUJI, article "2. Ryoshi Dot Gijutsu Bio Oyo no Doko", pages: 28 - 30 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102851021A (zh) * 2012-09-26 2013-01-02 中国科学技术大学 一种高亮度无毒性荧光量子点纳米复合探针及其制备方法
CN102851021B (zh) * 2012-09-26 2014-06-25 中国科学技术大学 一种无毒性荧光量子点纳米复合探针及其制备方法
CN106492236A (zh) * 2016-11-22 2017-03-15 上海师范大学 一种多功能纳米探针及其制备方法和应用

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