WO2009072002A3 - Bisphenols in cancer therapy - Google Patents

Bisphenols in cancer therapy Download PDF

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Publication number
WO2009072002A3
WO2009072002A3 PCT/IB2008/003818 IB2008003818W WO2009072002A3 WO 2009072002 A3 WO2009072002 A3 WO 2009072002A3 IB 2008003818 W IB2008003818 W IB 2008003818W WO 2009072002 A3 WO2009072002 A3 WO 2009072002A3
Authority
WO
WIPO (PCT)
Prior art keywords
bisphenols
cancer therapy
topoisomerase
anticancer agents
anticancer
Prior art date
Application number
PCT/IB2008/003818
Other languages
French (fr)
Other versions
WO2009072002A2 (en
Inventor
Brian B. Hasinoff
Hong Liang
Original Assignee
University Of Manitoba
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Manitoba filed Critical University Of Manitoba
Publication of WO2009072002A2 publication Critical patent/WO2009072002A2/en
Publication of WO2009072002A3 publication Critical patent/WO2009072002A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention generally relates to anticancer agents and methods of treating cancer. The anticancer agents described herein comprise a bisphenol core and generally act as topoisomerase II inhibitors, though their anticancer activity may be related to other mechanisms as well. The bisphenols discussed therein may also protect certain cells against detrimental effects of topoisomerase II poisons.
PCT/IB2008/003818 2007-09-14 2008-09-15 Bisphenols in cancer therapy WO2009072002A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99375707P 2007-09-14 2007-09-14
US60/993,757 2007-09-14

Publications (2)

Publication Number Publication Date
WO2009072002A2 WO2009072002A2 (en) 2009-06-11
WO2009072002A3 true WO2009072002A3 (en) 2011-05-05

Family

ID=40718274

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/003818 WO2009072002A2 (en) 2007-09-14 2008-09-15 Bisphenols in cancer therapy

Country Status (1)

Country Link
WO (1) WO2009072002A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103922979B (en) * 2013-01-11 2016-05-25 卫生福利部国家中医药研究所 Compound and composition for skin for skin-whitening

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043313A (en) * 1989-04-03 1991-08-27 Ricoh Company, Ltd. Thermosensitive recording material
US5238768A (en) * 1992-06-15 1993-08-24 Xerox Corporation Toner compositions with sulfone charge enhancing additives
CA2463724A1 (en) * 2001-10-16 2003-04-24 Structural Bioinformatics Inc. Organosulfur inhibitors of tyrosine phosphatases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043313A (en) * 1989-04-03 1991-08-27 Ricoh Company, Ltd. Thermosensitive recording material
US5238768A (en) * 1992-06-15 1993-08-24 Xerox Corporation Toner compositions with sulfone charge enhancing additives
CA2463724A1 (en) * 2001-10-16 2003-04-24 Structural Bioinformatics Inc. Organosulfur inhibitors of tyrosine phosphatases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HONG, L. ET AL.: "A three-Dimensional Quantitative Structure-Activity Analysis of a New Class of Bisphenol Topoisomerase Iia Inhibitors", MOLECULAR PHARMACOLOGY, vol. 73, 28 November 2007 (2007-11-28), pages 686 - 696 *
QUISTAD, G. B. ET AL.: "Plant metabolism of fluvinate [a-cyano-3- phenocybenzyl-2-[2-chloro-4trifluoromethylnilino]-3-methylbutanoate]", J. AGRIC. FOOD CHEM., vol. 30, no. 5, 1982, pages 888 - 895 *

Also Published As

Publication number Publication date
WO2009072002A2 (en) 2009-06-11

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