WO2009071912A3 - Material comprising nm23 linked to a substrate for use in treating neuron disorders - Google Patents

Material comprising nm23 linked to a substrate for use in treating neuron disorders Download PDF

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Publication number
WO2009071912A3
WO2009071912A3 PCT/GB2008/004030 GB2008004030W WO2009071912A3 WO 2009071912 A3 WO2009071912 A3 WO 2009071912A3 GB 2008004030 W GB2008004030 W GB 2008004030W WO 2009071912 A3 WO2009071912 A3 WO 2009071912A3
Authority
WO
WIPO (PCT)
Prior art keywords
linked
substrate
materials
neuron growth
neuron disorders
Prior art date
Application number
PCT/GB2008/004030
Other languages
French (fr)
Other versions
WO2009071912A2 (en
Inventor
William Eustace Basil Johnson
Christopher Martin Bunce
Original Assignee
The University Of Birmingham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Of Birmingham filed Critical The University Of Birmingham
Publication of WO2009071912A2 publication Critical patent/WO2009071912A2/en
Publication of WO2009071912A3 publication Critical patent/WO2009071912A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Abstract

Provided are materials for promoting neuron growth, the materials comprising Nm23 protein, or a biologically effective fragment or derivative thereof, linked to a substrate capable of supporting neuron growth. The Nm23 may preferably be immobilised on the substrate. The materials provided may be suitable for implantation at a site of neuronal disruption. The materials may be adapted to guide neuron growth. The invention also provides an Nm23 protein, or a therapeutically effective fragment or derivative thereof, linked to a substrate capable of supporting neuron growth, for use as a medicament, as well as corresponding methods of treatment.
PCT/GB2008/004030 2007-12-05 2008-12-05 Materials for neuron growth WO2009071912A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0723819.9 2007-12-05
GBGB0723819.9A GB0723819D0 (en) 2007-12-05 2007-12-05 Materials for neuron growth

Publications (2)

Publication Number Publication Date
WO2009071912A2 WO2009071912A2 (en) 2009-06-11
WO2009071912A3 true WO2009071912A3 (en) 2010-03-11

Family

ID=38983049

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/004030 WO2009071912A2 (en) 2007-12-05 2008-12-05 Materials for neuron growth

Country Status (2)

Country Link
GB (1) GB0723819D0 (en)
WO (1) WO2009071912A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007026355A2 (en) * 2005-08-29 2007-03-08 Yeda Research And Development Co. Ltd. Modulators of cell migration and methods of identifying same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007026355A2 (en) * 2005-08-29 2007-03-08 Yeda Research And Development Co. Ltd. Modulators of cell migration and methods of identifying same

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
AMENDOLA ROBERTO ET AL: "DR-nm23 gene expression in neuroblastoma cells: Relationship to integrin expression, adhesion characteristics, and differentiation", JOURNAL OF THE NATIONAL CANCER INSTITUTE (BETHESDA), vol. 89, no. 17, 1997, pages 1300 - 1310, XP002562616, ISSN: 0027-8874 *
BACKER MARINA V ET AL: "Overexpression of NM23-1 enhances responsiveness of IMR-32 human neuroblastoma cells to differentiation stimuli", ANTICANCER RESEARCH, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 20, no. 3A, 1 May 2000 (2000-05-01), pages 1743 - 1749, XP009127648, ISSN: 0250-7005 *
GERVASI F ET AL: "NM23 INFLUENCES PROLIFERATION AND DIFFERENTIATION OF PC12 CELLS IN RESPONSE TO NERVE GROWTH FACTOR", CELL GROWTH AND DIFFERENTIATION, THE ASSOCIATION, PHILADELPHIA, PA, US, vol. 7, no. 12, 1 December 1996 (1996-12-01), pages 1689 - 1695, XP008031890, ISSN: 1044-9523 *
JUNG SHIN ET AL: "Expression of Nm23 in gliomas and its effect on migration and invasion in vitro", ANTICANCER RESEARCH, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 26, no. 1A, 1 January 2006 (2006-01-01), pages 249 - 258, XP009127638, ISSN: 0250-7005 *
JUNKO OKABE-KADO ET AL: "Physiological and Pathological Relevance of Extracellular NM23/NDP Kinases", JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 35, no. 1, 1 February 2003 (2003-02-01), pages 89 - 93, XP019280496, ISSN: 1573-6881 *
LOMBARDI D ET AL: "NM23: UNRAVELING ITS BIOLOGICAL FUNCTION IN CELL DIFFERENTIATION", JOURNAL OF CELLULAR PHYSIOLOGY, WILEY LISS, NEW YORK, NY, US, vol. 182, no. 2, 1 February 2000 (2000-02-01), pages 144 - 149, XP008031851, ISSN: 0021-9541 *
NEGRONI A ET AL: "NEUROBLASTOMA SPECIFIC EFFECTS OF DR-NM23 AND ITS MUTANT FORMS ON DIFFERENTIATION AND APOPTOSIS", CELL DEATH AND DIFFERENTIATION, NATURE PUBLISHING GROUP, GB, vol. 7, no. 9, 1 January 2000 (2000-01-01), pages 843 - 850, XP008031853, ISSN: 1350-9047 *

Also Published As

Publication number Publication date
WO2009071912A2 (en) 2009-06-11
GB0723819D0 (en) 2008-01-16

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