WO2009070291A1 - Composition d'aliment pour animaux avec des caractéristiques nutritionnelles améliorées - Google Patents

Composition d'aliment pour animaux avec des caractéristiques nutritionnelles améliorées Download PDF

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Publication number
WO2009070291A1
WO2009070291A1 PCT/US2008/013123 US2008013123W WO2009070291A1 WO 2009070291 A1 WO2009070291 A1 WO 2009070291A1 US 2008013123 W US2008013123 W US 2008013123W WO 2009070291 A1 WO2009070291 A1 WO 2009070291A1
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WIPO (PCT)
Prior art keywords
pectin
animal feed
supplement
degree
feed
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PCT/US2008/013123
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English (en)
Inventor
Guillermo Schroeder
Ignacio R. Ipharraguerre
Michael A. Messman
Kevin J. Touchette
Jason L. Shelton
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Cargill, Incorporated
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Publication of WO2009070291A1 publication Critical patent/WO2009070291A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/20—Animal feeding-stuffs from material of animal origin
    • A23K10/26—Animal feeding-stuffs from material of animal origin from waste material, e.g. feathers, bones or skin
    • A23K10/28—Animal feeding-stuffs from material of animal origin from waste material, e.g. feathers, bones or skin from waste dairy products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87—Re-use of by-products of food processing for fodder production

Definitions

  • Antibiotics are commonly given by mouth for prophylaxis and growth promotion.
  • the widespread use of antibiotics to treat calf scours and improve performance is being discouraged or banned in many countries to avoid potential resistance of human pathogens.
  • researchers suggest that the overall effect of oral antibiotics can be detrimental to calves' health.
  • Common diarrhea agents are either not affected by antibiotics or are highly resistant.
  • antibiotics given orally can alter the normal population of organisms in the gut and may sometimes predispose the calf to super infections or fungal infections.
  • Some antibiotics used for scours can actually inhibit glucose absorption and alter the cells that line the gut wall. In such cases, the continuing use of antibiotics can prolong diarrhea.
  • the impact that complex carbohydrates have on the intestinal function and gastrointestinal microflora in humans and non-ruminant animals has received considerable attention.
  • the present application is directed to the use of animal feeds and animal feed supplements, which include pectin as a prebiotic compound in diets for growing farm animals.
  • Pectin can be used to reduce scours in neonatal growing ruminants and pigs with potential positive effects on overall animal performance.
  • pectin can be effective in reducing cholesterol levels in plasma, but may reduce animal growth in some instances.
  • doses of pectin between about 1 to 5% of the total diet are typically quite suitable.
  • the pectin can either be mixed with solid feed (e.g. pellets, starters, etc) or incorporated into a liquid feed (e.g., a liquid milk replacer).
  • the pectin included in the present feed compositions and supplements may act as a prebiotic in the diet of neonatal animals to improve gut health (e.g., reduce fecal scours).
  • the inclusion of pectin as a prebiotic in the diet of neonatal animals may reduce cholesterol levels as well as increase animal growth.
  • the present feed compositions and supplements may be particularly beneficial when fed to young animals. Examples would include but are not limited to growing ruminants before their rumen is functionally developed (typically the first four weeks of age), neonatal mammals receiving supplemental milk or feed, young animals experiencing a food transition from liquid to solid, and others.
  • pectin can be mixed into a milk replacer and/or a solid feed (e.g., a starter feed).
  • the pectin to be included in milk replacer may desirably be a low calcium form, which typically has a higher solubility in water than higher calcium forms.
  • Pectin is a polymer of methyl D-galacturonate and is found in plant cell walls, e.g., in the cell walls in citrus peel. Natural biological complex oligosaccharides of these types may be difficult to digest in the upper gastrointestinal tract (upper GIT) and are mostly fermented in the lower GIT. Due to the type and site of fermentation of pectin in the gastrointestinal tract, its supplementation in the diet can alter and potentially improve the balance between beneficial and pathogenic bacteria population in the GIT. Such a change in the gastrointestinal bacteria population can result in improved gut health and overall animal performance. In addition, pectin may alter the viscosity and flow of digesta through the intestine which may help to reduce the absorption of cholesterol, thereby reducing the plasma level of that compound.
  • One embodiment of the present feed composition is a starter feed for young animals, which includes (a) a protein-based component; and (b) pectin.
  • feeds may include a non- fiber carbohydrate source, such as corn, and/or an essential amino acid supplement.
  • Other additives may be included in the feed composition as well.
  • the feed composition may also include other nutrient additives, such as fat, a calcium source, vitamin(s) supplements and/or mineral sources.
  • the present feed composition includes at least about 20 wt.% of a protein source and pectin.
  • the feed composition is substantially free of egg product, e.g., contains no more than about 0.5 wt.% egg product.
  • the protein source commonly includes a substantial amount of a dairy-based protein source, such as milk-protein or whey- protein (e.g., in the form of dried whey and/or whey protein concentrate), protein derived from an oilseed, such as soybean and/or sunflower, protein derived from cereals, such as wheat, and/or protein derived from animal source(s).
  • the pectin employed in producing the present feed compositions commonly has a galacturonic acid content of at least about 65 wt.% and a degree of esterification (DE) of at least about 50 %.
  • the pectin may be modified, e.g., through derivatization by reaction with a modifying agent such as an amine.
  • a modifying agent such as an amine.
  • pectin may be treated with ammonia to convert at least a portion of the ester group into amide groups.
  • the pectins used in the present compositions have a degree of amidation of no more than about 50 % and more commonly, have a very low degree of amidation, e.g., a degree of amidation of no more than about 5 %.
  • the pectin employed in the present feed compositions has a low calcium sensitivity and a low calcium content, e.g., includes no more than about 10,000 ppm calcium and more desirably, no more than about 5,000 ppm calcium.
  • the pectin may be a rapid setting pectin and suitably may be derived from a fruit source, e.g., citrus pectin and/or apple pectin.
  • Pectins derived from sugar beet may also suitably be employed in the present feed compositions.
  • the pectins employed in the present feeds may have a gel strength of at least about 150 SAG.
  • a 1 wt.% solution of the pectin in distilled water at 25°C commonly has a viscosity of at least 15 cPs and, often, about 30 cPs or higher.
  • the methods include feeding the young mammal an animal feed which includes a prebiotically effective amount of pectin and a protein source.
  • the feed generally includes about 1 to 5 wt.% pectin, such as a rapid setting low calcium pectin which has a degree of esterification of at least about 50% and a galacturonic acid content of at least about 65 wt.%.
  • the feed typically includes at least about 20 wt.% and, often, 40 wt.% or more of the protein source.
  • the protein source commonly includes a dairy protein source, e.g., milk protein and/or whey protein.
  • Other protein sources that may be suitably employed include protein materials derived from oilseeds and/or cereals, such as protein-enriched materials derived from soy, sunflower and/or wheat.
  • an animal feed supplement e.g., a supplement which is capable of use as a milk extender.
  • the supplement may include at least about 20 wt.% (solids basis) of a protein source; a fat source; lactose; an essential amino acid additive; and a prebiotically effective amount of pectin.
  • Such supplements typically contain about 20 to 30 wt.% (solids basis) of the protein source and about 3 to 7 wt.% (solids basis) fat.
  • an electrolyte supplement e.g., a supplement which may be used to treat non-ruminating calves suffering from scours.
  • the supplement suitably includes sodium salt, a potassium salt, a calcium salt, glycine; dextrose; a magnesium salt; and a prebiotically effective amount of pectin.
  • the electrolyte supplement contains about 2 to 10 wt.% (solids basis) of the pectin.
  • FIG. 1 is a graph showing the evolution of body weight during the first six weeks of age of neonatal dairy calves fed the diets described in Example 1.
  • FIG. 2 is a graph showing the total bacteria count in feces from neonatal dairy calves fed the diets described in Example 1.
  • FIG. 3 is a graph showing the concentration of Escherichia coli, Lactobacillus,
  • One embodiment of the present method relates to feeding pectin, a polymer comprising a substantial percentage of methyl D-galacturonate, to neonatal animals as a prebiotic.
  • pectin a polymer comprising a substantial percentage of methyl D-galacturonate
  • the inclusion of pectin in such feeds is believed to be associated with an improved gut health (e.g., reduced fecal scours) as well as enhanced animal growth.
  • gut health e.g., reduced fecal scours
  • supplementation of feeds with pectin potentially may have one or more of the following effects on neonatal animals consuming such a pectin containing feed:
  • Pectin having a degree of esterification (“DE") of at least about 50, more suitably at least about 60, and more desirably at least about 65 are particularly suitable for use in the present feed compositions.
  • High molecular weight pectins with a DE of about 65 to 75 are commonly used in the present feed compositions.
  • Such pectins are desirably not highly modified, e.g., may be pectins with a relatively high molecular weight and have a degree of amidation (DA) which is quite low, e.g., no more than about 5% and, more suitably, no more than about 1 %.
  • DA degree of amidation
  • pectin from a citrus source e.g., orange, grapefruit, lime and/or lemon.
  • Other suitable sources of pectin include apple pectin and pectin derived from sugar beets.
  • the pectin employed in the present compositions is preferably a low calcium sensitivity pectin.
  • the pectin also preferably has a low calcium content, e.g., a pectin having a calcium content of no more than about 10,000 ppm, suitably no more than about 5,000 ppm, desirably no more than about 2,500 ppm and, in some instances, has a calcium content of about 1 ,000 ppm or lower.
  • the pectin employed in the present compositions generally has a relatively high galacturonic acid content. Materials with a galacturonic acid content of at least about 65 wt.% are suitable for use in the present compositions.
  • the pectin may have galacturonic acid content of at least about 75 wt.% and, in some instances, pectins with a galacturonic acid content of about 80 wt.% or higher may be employed.
  • the pectin employed in the present feeds may have a viscosity of at least about
  • pectins with a viscosity at least about 20 cPs, desirably at least about 25 cPs, and in some embodiments about 30 to 50 cPs (as determined from a 1 wt.% aqueous solution of the pectin in distilled water at 25°C) may be employed in the present feeds.
  • a pectin with a viscosity at least about 100 cPs e.g., about 130 to 140 cPs
  • a viscosity at least about 100 cPs e.g., about 130 to 140 cPs
  • a pectin with a viscosity at least about 100 cPs e.g., about 130 to 140 cPs
  • a 1.8 wt.% aqueous solution of the pectin in distilled water at 25°C may be employed.
  • the pectin employed in the present feeds may be chemically modified to include amide functional groups in place of a portion of the galacturonic ester groups, which are naturally present (e.g., by reacting the pectin material with ammonia).
  • Such pectins desirably have a degree of amidation of no more than about 50 %. More commonly, pectins with a substantially lower degree of amidation, e.g., a degree of amidation of no more than about 5 %, are employed in the present feeds.
  • the pectin is substantially unmodified to include such amide groups, e.g., pectins with a degree of amidation of no more than about 1 %.
  • the present feed compositions may include other nutrient additives, such as essential amino acid(s); a calcium source; vitamin and/or mineral sources; and/or a non-fiber carbohydrate source(s).
  • the feed composition may include an essential amino acid(s) additive, which includes one or more of isoleucine, leucine, lysine, threonine, tryptophan, methionine, histidine, valine and phenylalanine.
  • suitable calcium sources include calcium carbonate and/or dicalcium phosphate.
  • suitable non-fiber carbohydrate sources include corn starch, cereal grains, molasses, dextrose, lactose and/or glycerol.
  • suitable vitamin(s) include of vitamin A, vitamin C, vitamin D, vitamin E and/or vitamin B complex.
  • suitable mineral supplement(s) include NaCl and/or sources of Mn, Fe, Mg, Cu, Zn, iodine, selenium, and/or cobalt (Co).
  • the present animal feed may be a starter feed, e.g., for use in feeding neonatal animals, such as neonatal ruminants and pigs.
  • the starter feed may include at least about 20 wt.% of a protein source and at least about 1 wt.% pectin.
  • a protein source which includes a dairy-based protein source (e.g., dried whey and/or whey protein concentrate), cereal-based protein source (e.g., a wheat protein source), oilseed-based protein source (e.g., soybean meal and/or soy protein concentrate) and/or protein derived from an animal source.
  • the animal feed may also include a non-fiber carbohydrate source, such as corn, and/or an essential amino acid supplement.
  • a non-fiber carbohydrate source such as corn
  • an essential amino acid supplement such as an essential amino acid supplement.
  • Other nutrient additives such as fat, a calcium source, vitamin(s) supplements and/or mineral sources, may be included in the feed composition as well.
  • the pectins employed in the present feed compositions may have a galacturonic acid content of at least about 65 wt.%, a degree of esterification of at least about 50 % and a viscosity of at least about 15 cPs, as determined from a 1 wt.% aqueous solution of said liquid milk replacer in distilled water at 25 0 C.
  • Such pectins may desirably have a calcium content of no more than about 5,000 ppm.
  • the pectins may have a galacturonic acid content of at least about 75 wt.%, a degree of esterification of at least about 60 % and a viscosity of at least about 20 cPs, as determined from a 1 wt.% aqueous solution of said liquid milk replacer in distilled water at 25°C.
  • the pectins employed in the present feed compositions may have a galacturonic acid content of at least about 75 wt.%, a degree of esterification of at least about 65 to 75% and a viscosity of at least about 30 cPs, as determined from a 1 wt.% aqueous solution of said liquid milk replacer in distilled water at 25°C.
  • the present animal feed may be a liquid milk replacer which comprises (a) a dairy-based protein component; and (b) a prebiotically effective amount of pectin.
  • the pectin may have a galacturonic acid content of at least about 65 wt.%; a calcium content of no more than about 10,000 ppm; a degree of esterification of at least about 50 %; and a 1 wt.% aqueous solution of the pectin in distilled water at 25 0 C has a viscosity of at least about 15 cPs.
  • a liquid milk replacer which may include at least about 20 wt.% dairy-based protein component; and at least about 1 wt.% pectin.
  • the pectin may have a galacturonic acid content of at least about 65 wt.%, a degree of esterification of at least about 50 % and a viscosity of at least about 15 cPs, as determined from a 1 wt.% aqueous solution of the pectin in distilled water at 25°C.
  • Another embodiment provides an animal feed for young mammals comprising a dairy-based protein source; and pectin; wherein the animal feed is substantially free of egg product.
  • Another embodiment provides a liquid milk replacer for young mammals comprising a dairy-based protein component; and a prebiotically effective amount of pectin; wherein the liquid milk replacer is substantially free of egg product.
  • Another embodiment provides an animal feed for young mammals comprising at least about 20 wt.% of a protein source; an essential amino acid(s) supplement; a calcium source; a non-fiber carbohydrate source; and a prebiotically effective amount of pectin.
  • the animal feed may include about 1 to 5 wt.% of the pectin.
  • the present animal feed may be a liquid milk replacer comprising at least about 20 wt.% dairy-based protein component; and at least about 1 wt.% pectin.
  • the pectin may have a galacturonic acid content of at least about 65 wt.%, a degree of esterification of at least about 50 % and a viscosity of at least about 15 cPs, as determined from a 1 wt.% aqueous solution of the pectin in distilled water at 25°C.
  • a method of enhancing gut health in a young mammal is also provided herein.
  • the method includes feeding the young mammal an animal feed, which comprises pectin and a protein source.
  • the animal feed may be substantially free of egg product.
  • Another embodiment provides an animal feed supplement, which is capable of use as a milk extender.
  • the supplement may be in dry solid form or in aqueous liquid.
  • the supplement includes at least about 20 wt.% (solids basis) of a protein source (typically about 20 to 30 wt.%); about 3 to 7 wt.% (solids basis) fat; lactose; an essential amino acid additive; and a prebiotically effective amount of pectin.
  • the animal feed supplement commonly contains about 2 to 10 wt.% (solids basis) of the pectin.
  • the essential amino acid additive commonly includes lysine and/or methionine.
  • the animal feed supplement may also include a vitamin additive, which includes one or more of vitamin A, vitamin C, vitamin D, vitamin E and vitamin B complex.
  • the pectin desirably has a galacturonic acid content of at least about 75 wt.%; a degree of esterif ⁇ cation of at least about 65 %; and a 1 wt.% aqueous solution of the pectin in distilled water at 25°C has a viscosity of at least about 25 cPs.
  • the protein source may include powdered skim milk, casein, dried whey and/or whey protein concentrate.
  • the animal feed supplement may also include propionic acid, acetic acid and/or citric acid, which may be present in acid and/or salt form.
  • the organic acid(s) is present as a mixture of acid and salt forms so as to buffer an aqueous liquid form of the supplement at a pH of about 3.5 to 5.5.
  • the supplement suitably has a minimum sodium content of at least about 5.5 wt.%, a minimum potassium content of at least about 0.3 wt.%, a calcium content of about 0.1 to 0.3 wt.%, a minimum magnesium content of at least about 0.05 wt.%.
  • the supplement may also contain lactic acid bacteria, e.g., about 3 to 10 mill cfu / gram of such bacteria.
  • an electrolyte supplement e.g., a supplement which may be used to treat non-ruminating calves suffering from scours.
  • the supplement suitably includes sodium chloride and/or monosodium phosphate; potassium chloride and/or monopotassium phosphate; calcium chloride; glycine; dextrose; a magnesium salt; and a prebiotically effective amount of pectin.
  • the supplement suitably has a sodium content of about 4 to 5.5 wt.% and a potassium content of about 1 to 2 wt.%.
  • the electrolyte supplement contains about 2 to 10 wt.% (solids basis) of the pectin.
  • the pectin may desirably have a galacturonic acid content of at least about 75 wt.%; a degree of esterification of at least about 65 %; and a 1 wt.% aqueous solution of the pectin in distilled water at 25°C has a viscosity of at least about 25 cPs.
  • Example 1 Feed For Neonatal Calves
  • the objective of this study was to evaluate the effect of supplementing pectin to neonatal dairy calves compared with a negative control (non-medicated milk replacer) and with two other potential sources of prebiotic (ActistarTM and ⁇ -Glucan). Fifty calves were randomly assigned to one of five dietary treatments from birth to 14 weeks of age. The 5 treatments were:
  • ActistarTM control milk replacer + 10 g/d of ActistarTM
  • Fecal samples taken at 3 days (no effects of treatments) and 4 week after calving (maximum differences in body weight; Figure 1) were analyzed for bacteria account. The first determination was used as covariable to analyze the bacteria concentration at 4 week of age. Total bacteria count in feces was lower in those calves receiving pectin, Actistar or the mix of both (see Table 3).
  • E. coli Escherichia coli
  • pectin and ActistarTM body weight gain
  • pectin is an natural alternative to improve body weight gain during the first 3 weeks of age (148% improvement respect to control), increase solid (starter) intake (38% improvement), allowing accelerating weaning (13% improvement), without affecting gain to feed ratio and helping to maintain a better fecal score (appearance and odor), which agreed with a lower E. coli concentration.
  • the objective of this study was to evaluate the effect of pectin feeding on cholesterol levels in broilers.
  • a total of 486 male broilers of the Ross 308 strain (WeIp Hatchery, Bancroft, IA) were used for a 9-treatment study.
  • the diets were formulated to be adequate in all nutrients.
  • the positive control (PC) diet contained 1% cholesterol.
  • the test ingredients included different pectin sources and cellulose as another control.
  • the different pectin sources included in this trial were from apple (DE 70 and DE 35) and citrus (DE 70, DE 35, and DE 0) and a low molecular weight pectin.
  • This reduction in ADG was mainly due to a reduction in feed intake but there also was a reduction (P ⁇ 0.05) in gain:feed in those chicks fed the diets with citrus pectin or apple pectin (DE 70) or with apple pectin (DE 35).
  • the goal in this trial was to feed a high enough level to affect cholesterol without affecting performance. This data indicated the addition of 3% of these pectin types was too high to obtain optimal growth performance.
  • Example 3 Feed containing Pectin as Prebiotic for Neonatal Pigs.
  • a feed ration suitable for use in young swine may be formulated using the ingredient listed below in Table 4 with 1.0 wt.% to 5.0 wt.% added pectin material.
  • An exemplary formulation for a baby swine ration is (Ingredient Percent (w/w) of Formulation):
  • a feed ration suitable for use in neonatal calves and pigs may be formulated using the ingredients listed below together with 1.0 wt.% to 5.0 wt.% added pectin material.
  • Exemplary formulations for calf milk replacers with ranges of primary ingredients are shown in Table 5 below. These formulations will typically be milk and/or wheat based. Table 5.
  • Example 6 Exemplary dry starter feed for calves
  • a feed ration suitable for use in neonatal calves may be formulated using the ingredient listed below including 1.0 wt.% to 5.0 wt.% added pectin material.
  • Exemplary formulations for calf dry starter feeds with ranges of primary ingredients are shown in Table 6 below. These formulations will typically be milk and/or wheat based. Table 6.
  • a feed ration suitable for use in young swine may be formulated using the ingredient listed below in Table 7 Other variations with similar nutrient profiles will be suitable as well
  • An exemplary formulation for a baby swine ration is (Ingredient Percent (w/w) of Formulation, as-is basis) Table 7.
  • the physical characteristics of an exemplary pectin material are summarized in Table 9.
  • the material is a low calcium, rapid setting citrus pectin with a relatively high degree of esterification (DE) and galacturonic acid content (GaIA).

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Abstract

L'invention porte sur l'utilisation d'aliments pour animaux qui contiennent de la pectine comme composé prébiotique dans des régimes pour le développement d'animaux de ferme. Les aliments contiennent couramment au moins environ 20 % en poids d'une source de protéine et une quantité prébiotiquement efficace de pectine. L'invention porte également sur des procédés d'amélioration de la santé intestinale chez un jeune mammifère. Les procédés incluent l'alimentation du jeune mammifère avec des aliments pour animaux, tels que des aliments de départ ou un substitut de lait liquide, qui contiennent une quantité prébiotiquement efficace de pectine et une source de protéine.
PCT/US2008/013123 2007-11-28 2008-11-25 Composition d'aliment pour animaux avec des caractéristiques nutritionnelles améliorées WO2009070291A1 (fr)

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CN103636943A (zh) * 2013-11-26 2014-03-19 大连创达技术交易市场有限公司 一种饲料添加剂
WO2017009257A3 (fr) * 2015-07-10 2017-02-23 Nutrition Sciences N.V. Compositions alimentaires pour prévenir et traiter des maladies inflammatoires
IT201600115007A1 (it) * 2016-11-15 2018-05-15 Frabes S P A Composizioni alimentari, loro usi e procedimenti per la loro preparazione

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US6428837B1 (en) * 2000-06-09 2002-08-06 Cp Kelco Aps Deesterified pectins, processes for producing such pectins, and stabilized acidic liquid systems comprising the same
US20040086491A2 (en) * 2002-02-05 2004-05-06 Corpak Medsystems, Inc. Probiotic/Prebiotic Composition and Delivery Method
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103636943A (zh) * 2013-11-26 2014-03-19 大连创达技术交易市场有限公司 一种饲料添加剂
WO2017009257A3 (fr) * 2015-07-10 2017-02-23 Nutrition Sciences N.V. Compositions alimentaires pour prévenir et traiter des maladies inflammatoires
CN107921057A (zh) * 2015-07-10 2018-04-17 营养科学股份有限公司 用于预防和治疗炎性疾病的果胶组合物
US10639323B2 (en) 2015-07-10 2020-05-05 Nutrition Sciences N.V. Feed compositions for preventing and treating inflammatory diseases
EP3939598A1 (fr) * 2015-07-10 2022-01-19 Nutrition Sciences N.V. Compositions alimentaires permettant de prévenir et de traiter des maladies inflammatoires
IT201600115007A1 (it) * 2016-11-15 2018-05-15 Frabes S P A Composizioni alimentari, loro usi e procedimenti per la loro preparazione
EP3320786A1 (fr) * 2016-11-15 2018-05-16 Frabes S.p.A. Composition alimentaire, utilisation et procede de preparation

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