WO2009069608A1 - マイクロ流体による平面脂質二重膜アレイ及びその平面脂質二重膜を用いた分析方法 - Google Patents

マイクロ流体による平面脂質二重膜アレイ及びその平面脂質二重膜を用いた分析方法 Download PDF

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WO2009069608A1
WO2009069608A1 PCT/JP2008/071368 JP2008071368W WO2009069608A1 WO 2009069608 A1 WO2009069608 A1 WO 2009069608A1 JP 2008071368 W JP2008071368 W JP 2008071368W WO 2009069608 A1 WO2009069608 A1 WO 2009069608A1
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bilayer membrane
planar lipid
microfluid
analysis method
lipid
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PCT/JP2008/071368
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English (en)
French (fr)
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Shoji Takeuchi
Hiroaki Suzuki
Sadao Ota
Wei-Heong Tan
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The University Of Tokyo
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Priority to US12/744,794 priority Critical patent/US8513165B2/en
Priority to EP08854712.0A priority patent/EP2219032B1/en
Publication of WO2009069608A1 publication Critical patent/WO2009069608A1/ja

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    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
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    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
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    • B01L2200/0605—Metering of fluids
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    • B01L2200/0642—Filling fluids into wells by specific techniques
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    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
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    • G01—MEASURING; TESTING
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    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides

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Abstract

　携帯性、分析時間の短縮、求められる試薬の少量化、及び高い再現性をもつ並行自動化といった利点を有するマイクロ流体による平面脂質二重膜アレイ及びその平面脂質二重膜を用いた分析方法を提供する。 　マイクロ流体による平面脂質二重膜アレイにおいて、予め水中に浸して水で飽和させたマイクロ流体による平面脂質二重膜アレイ（ＰＤＭＳ装置）１であって、この平面脂質二重膜アレイ１が、送液口に接続され、並列に配置されるマイクロチャネル２と、このマイクロチャネル２の両側部に開口を有するマイクロチャンバー３とを具備する。
PCT/JP2008/071368 2007-11-26 2008-11-26 マイクロ流体による平面脂質二重膜アレイ及びその平面脂質二重膜を用いた分析方法 WO2009069608A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/744,794 US8513165B2 (en) 2007-11-26 2008-11-26 Planar lipid bilayer array formed by microfluidic technique and method of analysis using planar lipid bilayer
EP08854712.0A EP2219032B1 (en) 2007-11-26 2008-11-26 Planar lipid-bilayer membrane array using microfluid and analysis method with the use of the planar lipid-bilayer membrane

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JP2007304126A JP5441142B2 (ja) 2007-11-26 2007-11-26 マイクロ流体による平面脂質二重膜アレイ及びその平面脂質二重膜を用いた分析方法
JP2007-304126 2007-11-26

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EP (1) EP2219032B1 (ja)
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WO (1) WO2009069608A1 (ja)

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JP2011002385A (ja) * 2009-06-19 2011-01-06 Univ Of Tokyo 人工脂質二重膜を用いた電流計測装置
DE102010022929A1 (de) 2010-06-07 2011-12-08 Albert-Ludwigs-Universität Freiburg Verfahren zum Herstellen einer Bilipidschicht sowie Mikrostruktur und Messanordnung
JP2012103055A (ja) * 2010-11-08 2012-05-31 Kanagawa Acad Of Sci & Technol 標的物質の検出方法及び装置
WO2018159795A1 (ja) * 2017-03-03 2018-09-07 国立大学法人 東京大学 マイクロリアクタチップおよびその製造方法
JP7038700B2 (ja) 2016-08-24 2022-03-18 アモーレパシフィック コーポレーション サイトカラシンｄを含む皮膚美白用組成物

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WO2013002339A1 (ja) * 2011-06-28 2013-01-03 株式会社フジクラ 脂質膜を形成するための基体、及び前記基体の製造方法
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
US9850534B2 (en) * 2012-02-16 2017-12-26 Genia Technologies, Inc. Methods for creating bilayers for use with nanopore sensors
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011002385A (ja) * 2009-06-19 2011-01-06 Univ Of Tokyo 人工脂質二重膜を用いた電流計測装置
DE102010022929A1 (de) 2010-06-07 2011-12-08 Albert-Ludwigs-Universität Freiburg Verfahren zum Herstellen einer Bilipidschicht sowie Mikrostruktur und Messanordnung
WO2011154114A2 (de) 2010-06-07 2011-12-15 Albert-Ludwigs-Universität Freiburg Verfahren zum herstellen einer bilipidschicht sowie mikrostruktur und messanordnung
JP2012103055A (ja) * 2010-11-08 2012-05-31 Kanagawa Acad Of Sci & Technol 標的物質の検出方法及び装置
JP7038700B2 (ja) 2016-08-24 2022-03-18 アモーレパシフィック コーポレーション サイトカラシンｄを含む皮膚美白用組成物
WO2018159795A1 (ja) * 2017-03-03 2018-09-07 国立大学法人 東京大学 マイクロリアクタチップおよびその製造方法
JPWO2018159795A1 (ja) * 2017-03-03 2019-12-12 国立大学法人 東京大学 マイクロリアクタチップおよびその製造方法

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EP2219032B1 (en) 2013-06-26
EP2219032A4 (en) 2010-12-15
JP5441142B2 (ja) 2014-03-12
US20100304980A1 (en) 2010-12-02
EP2219032A1 (en) 2010-08-18
JP2009128206A (ja) 2009-06-11
US8513165B2 (en) 2013-08-20

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