WO2009067530A1 - Digestion accrue d'énergie ou de protéine résultant de l'inclusion de chélates d'acide aminé métalliques dans l'alimentation animale - Google Patents

Digestion accrue d'énergie ou de protéine résultant de l'inclusion de chélates d'acide aminé métalliques dans l'alimentation animale Download PDF

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Publication number
WO2009067530A1
WO2009067530A1 PCT/US2008/084054 US2008084054W WO2009067530A1 WO 2009067530 A1 WO2009067530 A1 WO 2009067530A1 US 2008084054 W US2008084054 W US 2008084054W WO 2009067530 A1 WO2009067530 A1 WO 2009067530A1
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Prior art keywords
feed
amino acid
reduced protein
animal
protein feed
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PCT/US2008/084054
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English (en)
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Dewayne H. Ashmead
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Albion International Inc.
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Publication of WO2009067530A1 publication Critical patent/WO2009067530A1/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/20—Feeding-stuffs specially adapted for particular animals for horses
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry

Definitions

  • waste In many types of livestock production operations, particularly those where livestock are kept in confinement, animal waste must be actively managed. In these cases, the waste is commonly collected from the animals' living space and gathered at a designated location. For example, large-scale swine production facilities often utilize large "lagoons" in which to collect liquid and solid wastes from the animals. Gathering waste in these ways has the effect of concentrating the waste, as well as the odors, ammonia, and pathogens that may accompany it. Nitrogen, phosphorus, and heavy metals from animal feces may accumulate in the adjacent soil, disrupting the nutrient balance and decreasing its arability. Nitrates in the soil may in turn be carried to local streams and rivers via runoff, fostering excessive algal growth and increasing fish mortality. Therefore, waste accumulations associated with livestock operations have the potential to adversely affect surrounding air, soil, and water. DETAILED DESCRIPTION
  • metal and “mineral” may be used interchangeably. Each refers particularly to any divalent or trivalent metal that, when in ionic form, can form one or more coordinate bonds with a ligand, and is substantially non-toxic when administered in traditional amounts as known in the art.
  • the metal can be selected from the group consisting of Cu, Mn, Mg, Fe, Zn, Cr, Se 1 and Ca.
  • amino acids or "naturally occurring amino acids” shall mean ⁇ - amino acids that are known to be used for forming the basic constituents of proteins, including alanine, arginine, asparagine, aspartic acid, cysteine, cystine, glutamine, glutamic acid, glycine, histidine, hydroxyproline, isoleucine, leucine, lysine, methionine, ornithine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, including dipeptides and tripeptides thereof, as well as combinations thereof.
  • metal salts or “salts,” it is recognized that oxides and hydroxides are not technically salts in the classic sense. However, in accordance with embodiments of the present invention, metal oxides and hydroxides are considered to be salts along with any other metal salts as more typically defined. Chelates are not considered to be salts.
  • chelate metal amino acid chelate
  • metal amino acid chelate or the like can be used interchangeably herein, and refer to a product resulting from the reaction of one or more amino acid ligands with a metal ion at a molar ratio of 1 :1 to 4:1 , and typically 1 :1 to 3:1. In one specific embodiment, the molar ratio can about 2:1.
  • Each amino acid of the chelate bonds to the metal both at the ⁇ -amino nitrogen and the carboxyl oxygen of the amino acid to form a ring structure.
  • each chelate features one or more five-member heterocyclic rings, each ring comprising the metal atom, as well as an amino acid's ⁇ -amino nitrogen, ⁇ -carbon, carbonyl carbon, and carboxyl oxygen.
  • the bond formed by the ⁇ -amino nitrogen is typically a coordinate bond, where both electrons of the bond are donated by the nitrogen.
  • the bond formed by the carboxyl oxygen may be coordinate, covalent, or ionic, though preferably it is a coordinate bond.
  • the term "chelate” requires that a ring structure be formed which includes both the amino acid ligand and the metal.
  • livestock includes warm-blooded animals kept or raised for use or pleasure.
  • livestock refers to animals selected from the group consisting of swine, ruminants, poultry, equines, and any combination thereof.
  • growth may refer to an increase in the height, length, width, mass, or weight of the animal's own body, or any combination of these measurements. Such increases may occur in an animal that has reached sexual maturity as well as in developing animals that are still sexually immature.
  • supply shall mean any foodstuff, composition, or compound that contains a substance intended to benefit an animal, and is provided to the animal in order to increase the amount of that substance ingested by the animal above the amount it receives by its normal dietary behavior.
  • orally administer means delivering a compound or composition to a living animal so that the compound, composition, or a component thereof may be taken in orally and ingested by the animal.
  • Some typical methods of administering substances to livestock animals include presenting the animal with a compound or composition in an edible form either alone or with the animal's feed or water, or injecting a liquid or a bolus of solid directly into the animal's mouth.
  • the term "about” is used to provide flexibility to a numerical range endpoint by providing that a given value may be "a little above” or “a little below” the endpoint.
  • the degree of flexibility of this term can be dictated by the particular variable and would be within the knowledge of those skilled in the art to determine based on experience and the associated description herein.
  • metals are administered to livestock animals in the form of inorganic metal salts, such as metal oxides, metal hydroxides, metal sulfates, metal phosphates, metal carbonates, and/or metal chlorides.
  • Metals are also commonly administered to livestock in the form of other metal complexes, such as metal complex proteinates, metal propionates, and yeast derivative complexes. Supplementation of this kind has been shown to increase growth rates in livestock animals. However, the efficiency with which ingested inorganic metals are absorbed into the blood is quite low. It has been recognized that such poor absorption can impact the efficiency of feed conversion in an animal.
  • a method of increasing feed conversion in an animal can comprise orally co-administering a metal amino acid chelate and a protein to the animal in the form of a reduced protein feed, such that the reduced protein feed has a protein content of at least 5 wt% less than a comparative non- reduced protein feed where the administration of the reduced protein feed can contribute to stimulating growth of the animal to at least the same degree as administration of the comparative non-reduced protein feed.
  • the comparative non-reduced protein feed can be devoid of metal amino acid chelates.
  • a reduced protein feed having a metal amino acid chelate that increases feed conversion in an animal can comprise one or more metal amino acid chelates and a protein, such that the reduced protein feed has a protein content of at least 5 wt% less than a comparative non-reduced protein feed where the administration of the reduced protein feed can contribute to stimulating growth of the animal to at least the same degree as administration of the comparative non-reduced protein feed.
  • the comparative non-reduced protein feed can be devoid of metal amino acid chelates.
  • non-reduced protein feed When discussing a comparative non-reduced protein feed in the embodiments described herein, such a comparative non-reduced protein feed is referred to for the purposes of comparison.
  • a feed is not necessarily administered to animals in a regular basis in general, but is used for the purposes of quantifying on a smaller scale the results achieved by the reduced protein feed compositions and methods as described herein.
  • the non-reduced protein feeds may contain the additives, components, and other elements described herein for reduced protein feed compositions.
  • non-reduced protein feeds described herein generally are devoid of the metal amino acid chelate, even though they may contain metals and amino acids that are not chelated.
  • a non-reduced protein feed may contain inorganic metal salts and amino acid supplements.
  • the term "non-reduced protein feed” can be used interchangeably with the term "conventional feed” throughout the application.
  • the present invention encompasses a feed composition that includes metal amino acid chelates and protein (and optionally other energy sources, such as phospholipids, mono-, di-, and triglycerides, fatty acids, and/or simple and complex carbohydrates), and may be fed to a livestock animal so as to provide a metal to the animal in a highly bioavailable form.
  • the metal amino acid chelates provided by the present invention can be absorbed rapidly and efficiently in the intestine. Therefore, by feeding an animal a feed composition in accordance with this invention, more of the metal it ingests can be absorbed into the bloodstream. As a result, the animal will attain a higher blood fevel of the metal than it would from ingesting the same number of moles of metal from other sources such as an inorganic metal salt. While not intending to be bound by any particular theory, it is thought that increased bioavailability of the metal can increase enzymatic activity as many enzymes require metals as cofactors.
  • coadministering metal amino acid chelates with a protein can allow a more efficient feed conversion of the feed's energy sources, such as protein and other energy sources such as phospholipids, mono-, di-, and triglycerides, fatty acids, and/or simple and complex carbohydrates.
  • the animal can absorb more metal and protein as compared to feeds devoid of metal amino acid chelates.
  • the animal typically will also excrete less of the protein, nitrate, and/or metal in its feces.
  • the present methods and compositions provide a reduced protein feed having a metal amino acid chelate that increase feed conversion in an animal that provide stimulation of the growth of the animal to the same degree as a non-reduced protein feed devoid of metal amino acid chelates.
  • the methods described herein can further comprise a preliminary step of determining an amount of protein needed to promote efficient growth of the animal. This preliminary step can provide the ability to supply a feed that generates acceptable animal growth with less protein as would otherwise be necessary because of the presence of the amino acid chelate.
  • stimulating growth of the animal can be measured as weight gain.
  • metal amino acid chefates e.g., copper, zinc, or manganese
  • metal amino acid chefates may be administered to the animal.
  • other nutritionally relevant metals that can bind with an amino acid to form a chelate, e.g., iron, calcium, magnesium, chromium, etc.
  • the metal can be a member selected from the group consisting of copper, zinc, manganese, calcium, magnesium, chromium, selenium, iron, and combinations thereof.
  • Members of the group of naturally occurring amino acids can be used as the ligand(s), binding to the metal to be administered via coordinate, covalent, or ionic bonds.
  • the amino acid can be a member selected from the group consisting of: alanine, arginine, aparagine, aspartic acid, cysteine, cystine, glutamine, glutamic acid, glycine, histidine, hydroxyproline, isoleucine, leucine, lysine, methionine, ornithine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, and dipeptides and tripeptides formed by any combination thereof.
  • Metals having a sufficient number of free coordination sites may in fact bind one, two, or three amino acid molecules (and sometimes four).
  • the same amino acid may constitute all of its ligands, or any combination of different amino acids may also bind to a particular metal ion.
  • the metal amino acid chelate can have an amino acid to metal molar ratio from about 1 :1 to about 4:1. It will be apparent to those skilled in the art that a large number of metal/amino acid combinations are in accordance with embodiments of the present invention. It is also to be understood that the present invention is intended to encompass all possible combinations that include naturally occurring amino acids chelated to metals which may be administered to an animal in order to promote growth. Different practices exist in the art for the keeping of livestock, each depending on the kind of animal kept, the size of the livestock operation, and the amount of space available.
  • Some livestock farming methods involve keeping livestock animals confined in buildings or other restricted spaces. Confined livestock animals may obtain their feed from troughs or feed dispensers, or their feed may be scattered on the floor or ground of their confinement area. Under other practices, livestock animals are allowed to roam freely over a wide area of land, and may obtain most of their food from foraging. Accordingly, different embodiments of the present invention may be employed in administering chelates to animals.
  • a metal amino acid chelate may be administered to an animal in accordance with this invention by combining the chelate with the animal's feed.
  • the metal amino acid chelate can be in a particulate form within the reduced protein feed.
  • the chelate may be intermixed with the feed before presenting the mixture to the animal.
  • the metal amino acid chelate can be added to the feed during processing and then administered to the animal as a fortified feed.
  • the feed can include a food fortified with the one or more metal amino acid chelates.
  • the amino acid chelate can be in a liquid or solid form.
  • the chelate may be shaped (with a foodstuff or a carrier) into a pellet or bolus and delivered directly into the animal's mouth with a bolusing gun.
  • a chelate may be dissolved or suspended in the drinking water provided to the animal.
  • a chelate may be dissolved or suspended in a potable liquid.
  • the feed can be a liquid feed which can also include a solution or suspension of one or more metal amino acid chelates. A common way known in the art for administering such a liquid is to deliver it directly into the mouth of the animal with a drench gun.
  • a chelate may be also administered to free-roaming animals in accordance with this invention by mixing the chelate with feed or liquid and placing the feed or liquid at one or more locations within the animals' foraging range.
  • the chelate may be included in a solid composition.
  • the composition may be provided in a cube, block, or tub, or in a feeder and then placed at one or more locations within the animal's foraging range.
  • the methods and compositions described herein can be used with any animal.
  • the methods and compositions can be used with livestock.
  • the methods and compositions can be used with swine.
  • the methods and compositions can be used with ruminants.
  • the methods and compositions can be used with poultry.
  • the methods and compositions can be used with equines.
  • Reduced protein feeds may further comprise any grain or mixture of grains that are edible by livestock animals, such as corn, wheat, rye, barley, sorghum, oats, rice, cottonseed meal, and canola, as well as other foodstuffs such as soybeans, milk products, meat, bone meal, feather meal, and byproducts from food processing.
  • the feed may further comprise an additive or mixture of additives selected from the group consisting of vitamins, flavor enhancers, aroma enhancers, colorings, fiber, yeast, ground limestone, potassium chloride, stabilizers, emulsifiers, sequestrants, preservatives, antioxidants, and anti-caking agents.
  • the reduced protein feed can include inorganic metal salts and/or vitamins or can be co administered with inorganic metal salts and/or vitamins.
  • the feed can be an admixture of the one or more metal amino acid chelates and a food. It is notable that the metal amino acid chelates can be blended with foods, incorporated into foods, suspended in feed liquids, or dissolved in feed liquids. In one embodiment, the metal amino acid chelate can be fortified liquid.
  • the metal amino acid chelate can be co administered with a liquid or can be administered as a fortified liquid.
  • Feeding metal amino acid chelates to animals in accordance with the present invention can, in addition to providing essential dietary minerals, serve as a dietary source of amino acids. Furthermore, providing amino acids in this form can result in more amino acids being available to the animal for digestion when compared to feeding with only protein. Therefore, feeding an metal animal amino acid chelates can allow for one to decrease the amount of protein in the animal's diet due to the supplement of amino acids provided by the chelate as well as the increased enzymatic activity associated with the increased bioavailability of the metal, as previously discussed. An additional result is that the animal will excrete a lower amount of protein, nitrate, and metals in its waste compared to an animal on a conventional diet.
  • the methods of the present invention provide a way to minimize the nitrate content of animal waste (including feces and/or urine) by coadministering metal amino acid chelates and protein to the animal as compared to administering conventional feed or non- reduced protein feed.
  • the methods of the present invention provide a way to minimize the protein content of animal waste (including feces and/or urine) by coadministering metal amino acid chelates and protein to the animal as compared to administering conventional feed or non- reduced protein feed.
  • the methods of the present invention provide a way to minimize the metal content of animal waste (including feces and/or urine) by coadministering metal amino acid chelates and protein to the animal as compared to administering conventional feed or non-reduced protein feed.
  • the protein, metal, and/or nitrate content of the feces can be reduced by 1 wt% to 70 wt% as compared to administration of the non-reduced protein feed.
  • the protein, nitrate, and/or metal content of the feces is reduced by 3 wt% to 50 wt% as compared to administration of the non-reduced protein feed.
  • the Minerals were provided as either amino acid chelates (AAC) or as inorganic metal sulfates (IM).
  • AAC amino acid chelates
  • IM inorganic metal sulfates
  • the AAC were fed to the treated groups and the IM to the control groups. Additionally all feeds contained C ⁇ O 2 as marker to determine digestibility of the feed. Feed and water were provided ad libitum for 60 days. Prior to study initiation all feeds were analyzed for amino acid content by an auto analyzer, for energy by a calorimetric bomb, and Cr by Inductively Coupled Plasma - Atomic Emission Spectroscopy (ICP-AES).
  • ICP-AES Inductively Coupled Plasma - Atomic Emission Spectroscopy
  • Table 1 shows the apparent increased digestibility of the energy (protein and other forms of energy) and amino acids when the diets were supplemented with AAC compared to IM.
  • the percent increase is significant (PO.05).
  • the apparent digestibility of the amino acids changed with the source of the base diet indicating that the amino acids are more available to the birds from certain base diets compared to other base diets. Nevertheless, regardless of the base diet, the broiler feed ration could be formulated to contain less protein without compromising broiler performance.
  • the control group Group 2 received equivalent amounts of the same supplemental minerals but in the form of sulfates (IM). Diet 1 was divided into two equal parts. One half was blended with AAC while the other half was blended with IM prior to initiating the trial and Fe, Zn, Mn and Cu presences from either source (AAC or IM) confirmed by ICP- AES. The two feeds were labeled Treatment Group or Control Group so that Group 1 received the AAC supplement and Group 2 received the (M supplement.
  • IM sulfates
  • Chromic oxide (Cr 2 ⁇ 3 ) was used as an external marker to allow calculations for apparent nutrient digestibility. It was blended with the feeds concurrently with the mineral supplements. The presence of Cr 2 O 3 in the two feeds was confirmed by ICP-AES prior to study initiation. Amino acids in the feeds were determined using an auto-analyzer. Gross energy values from the feeds were determined via a bomb calorimeter. Both the amino acids and gross energy values in the feeds were ascertained prior to commencement of the study. Fresh fortified feed was supplied daily for 14 days between 1700 and 1800 hours. Since apparent nutrient digestibility evaluations were based on comparative concentrations of Cr 2 O 3 in the feed and feces, no records were maintained on daily feed intake.
  • fecal samples were obtained rectally from each pig and analyzed for gross energy, amino acid content and Cr 2 Oe.
  • the Cr 2 ⁇ 3 assays were performed by ICP-AES, the amino acids by an auto-analyzer, and the gross energy by a bomb calorimeter. Each assay was performed on each of the fecal samples.
  • Each group of pigs received its assigned feed daily ad libitum for 14 days.
  • Group 1 received the feed containing the AAC supplement and
  • Group 2 received the feed containing IM supplement. All feed was provided daily between 1700 and 1800 hours. Water was provided ad libitum.
  • the percent increase is significant (P ⁇ 0.05). Increased absorption of the AAC form of minerals appears to augment delivery of minerals required for metabolic production and activation of gastric hydrolytic enzymes in the mucosal tissue. This increased enzymatic production can result in greater enzymatic activity in the gastrointestinal tract manifested as increased apparent digestion of amino acids and gross energy.
  • mice Sixteen albino rats were divided into two groups of 8 animals each. Both groups received the same rat chow for 10 days. One group, however, received supplemental Fe, Cu, Zn and Mn AAC at the same levels (g/Kg) described in the swine study. On day 11 , all rats were sacrificed. Each animal's duodenum and an equal length of the upper jejunum were removed. The excised intestinal samples were cut along the mesenteric line and subsequently rinsed with distilled and deionized water.
  • the mucus membrane from each intestinal segment was scraped and put in a labeled container with 4 ml_ distilled and deionized water where it was homogenized for 20 minutes and subsequently centrifuged for an additional 20 minutes.
  • electrophoreses the enzymatic activities of 5 membrane bound hydrolytic enzymes were determined. As shown in the Table 5, when AAC were supplemented in the rats' diet, the hydrolytic activities of the measured membrane bound digestive enzymes significantly increased (P ⁇ 0.05).
  • Table 5 Mean enzymatic activity of several intestinal mucus membrane bond enzymes in rats with and without amino acid chelate supplements.
  • the percent increase is significant (PO.05).
  • Diets A through E had crude protein analysis of 11.7%, 10.0%, 9/7%, 8.8%, and 8.6% respectively. All of the calves receiving B and D diets were first fed Diet B for the first 84 days of the trial and then half of them had their protein intakes reduced to Diet D for the remainder of the study. The calves in the C and E groups were first fed Diet C for 84 days and then half of the calves were given Diet E for the remainder of the trial.
  • Each steer was weighed on two consecutive days at the beginning and end of the experiment, and each steer's weight averaged for the two days. Each animal was also weighed one time every 28 days throughout the experiment. Hip heights were measured on days 0, 56, 84, and the day before termination of the study. Termination occurred when the projected weight of the steers reached 1150 pounds (523 Kg).
  • the weight gains and performance of the steers are shown in Table 7.
  • Daily feed intake was almost the same for each group except C - E which was slightly higher. This is reflected in larger animals and a greater average daily gain.
  • the actual feed consumed per pound of gain was lower than any of the other groups except C.
  • the significance of these observations is that the calves in the C - E group received less crude protein in their diet than any of the other groups and yet they performed as well as or better than the other animals. This shows that when protein is co-administered with the metal amino acid chelates, a lower amount of dietary protein is optimally utilized by the cattle.
  • CM milk replacer described in Table 10
  • IMZ Amino Acid Chelate Albion Advanced Nutrition, Clearfield, UT; Product 1 10)/1 ,000 kg (as-fed basis) to supply 20 gm iron, 10 gm zinc, 4gm manganese and 0.5 gm copper/1 , 000 kg of milk replacer.
  • Group 2 (IO) was fed the milk replacer described in Table 10 plus inorganic minerals in the sulfate form to supply an equal amount of added mineral in the inorganic form.
  • calves were allotted to treatment by birth order with the first calf born being placed on CM, the second calf being placed on IO, etc. Calves were paired for treatment observation by pairing calf 1 with calf 2, etc. until all calves were allocated to treatment. This method of allotment to trial was chosen to ensure that each treatment pairing was composed of calves of the closest possible age that each pair was exposed to similar conditions of weather, etc. All calves were maintained in individual wooden crates throughout the trial with water available free choice in addition to the milk replacer provided. Shade was provided for all calves at all times. Water was removed, buckets cleaned and fresh water replaced daily for each calf prior to feeding milk replacer in the evening.
  • Calves were provided milk replacer in nipple-buckets twice daily at 0630-0730 hours and 1700-1800 hours. All calves were provided 454 gm of milk replacer with sufficient water to extend the volume of milk replacer to 1 ,750 ml for each feeding. Calves were allowed 30 minutes to consume the milk replacer and then buckets used to supply the milk replacer were removed. On day 30, fecal samples were obtained from each calf and used to determine differences in the apparent digestibility due to supplemental trace mineral source. Apparent digestibility of gross energy and selected amino acids from the diet were calculated by comparing nutrient content of milk replacer as outlined in Table 11 with nutrient content of fecal collections. Digestibility was determined using chromic oxide as an indigestible external marker.
  • CM Group 1 calves
  • IO calves in Group 2

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Abstract

L'invention concerne des procédés et des compositions permettant d'accroître la conversion des aliments chez un animal. Un procédé d'augmentation de la conversion des aliments chez un animal peut comprendre une co-administration orale d'un chélate d'acide aminé métallique et d'une protéine à l'animal sous la forme d'une alimentation appauvrie en protéines, l'alimentation appauvrie en protéines ayant une teneur en protéines d'au moins 5 % en poids inférieure à une alimentation de comparaison non appauvrie en protéines. L'alimentation de comparaison non appauvrie en protéines peut être exempte de chélates d'acide aminé métalliques. L'administration de l'alimentation appauvrie en protéines peut contribuer à stimuler la croissance de l'animal au moins au même degré que l'administration de l'alimentation de comparaison non appauvrie en protéines.
PCT/US2008/084054 2007-11-20 2008-11-19 Digestion accrue d'énergie ou de protéine résultant de l'inclusion de chélates d'acide aminé métalliques dans l'alimentation animale WO2009067530A1 (fr)

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CN111718272A (zh) * 2020-07-14 2020-09-29 安徽华恒生物科技股份有限公司 一种丙氨酸金属螯合物的制备方法和其应用
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EP3155904B1 (fr) * 2008-07-18 2024-09-18 Hill's Pet Nutrition, Inc. Compositions d'amélioration de la qualité de vie d'un animal adulte

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US20100090158A1 (en) * 2008-10-09 2010-04-15 Kanto Kagaku Kabushiki Kaisha Alkaline aqueous solution composition for treating a substrate
KR20190041739A (ko) * 2017-10-13 2019-04-23 주식회사 소프트아쿠아 아미노산-미네랄 복합체를 포함하는 액상 보조사료 조성물
KR102000135B1 (ko) 2017-10-13 2019-10-01 주식회사 소프트아쿠아 아미노산-미네랄 복합체를 포함하는 액상 보조사료 조성물
CN111248353A (zh) * 2020-03-17 2020-06-09 南宁市泽威尔饲料有限责任公司 一种微乳型液体有机微量元素饲料添加剂及其制备方法
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CN111718272B (zh) * 2020-07-14 2023-09-19 安徽华恒生物科技股份有限公司 一种丙氨酸金属螯合物的制备方法和其应用
US12036286B2 (en) 2021-03-18 2024-07-16 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds
CN115191517A (zh) * 2022-07-21 2022-10-18 湖北省联投生物科技股份有限公司 一种氨基酸螯合组合物、饲料及其制备方法与应用

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