WO2009066291A3 - Micrornas expression signature for determination of tumors origin - Google Patents

Micrornas expression signature for determination of tumors origin Download PDF

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Publication number
WO2009066291A3
WO2009066291A3 PCT/IL2008/001525 IL2008001525W WO2009066291A3 WO 2009066291 A3 WO2009066291 A3 WO 2009066291A3 IL 2008001525 W IL2008001525 W IL 2008001525W WO 2009066291 A3 WO2009066291 A3 WO 2009066291A3
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WO
WIPO (PCT)
Prior art keywords
determination
expression signature
tumors
origin
specific
Prior art date
Application number
PCT/IL2008/001525
Other languages
French (fr)
Other versions
WO2009066291A2 (en
Inventor
Nitzan Rosenfeld
Shai Rosenwald
Iris Barshack
Dvora Nass
Original Assignee
Rosetta Genomics Ltd
Tel Hashomer Medical Res Infrastructure & Services Ltd
Nitzan Rosenfeld
Shai Rosenwald
Iris Barshack
Dvora Nass
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosetta Genomics Ltd, Tel Hashomer Medical Res Infrastructure & Services Ltd, Nitzan Rosenfeld, Shai Rosenwald, Iris Barshack, Dvora Nass filed Critical Rosetta Genomics Ltd
Publication of WO2009066291A2 publication Critical patent/WO2009066291A2/en
Publication of WO2009066291A3 publication Critical patent/WO2009066291A3/en
Priority to IL205559A priority Critical patent/IL205559A0/en
Priority to US12/782,067 priority patent/US20100273172A1/en
Priority to US14/284,256 priority patent/US9803247B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides a process for classification of specific cancers and tumors origin through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA expression framework allows optimization of treatment, and determination of specific therapy.
PCT/IL2008/001525 2007-03-27 2008-11-20 Micrornas expression signature for determination of tumors origin WO2009066291A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IL205559A IL205559A0 (en) 2007-11-21 2010-05-05 Micrornas expression signature for determination of tumors origin
US12/782,067 US20100273172A1 (en) 2007-03-27 2010-05-18 Micrornas expression signature for determination of tumors origin
US14/284,256 US9803247B2 (en) 2007-03-27 2014-05-21 MicroRNAs expression signature for determination of tumors origin

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US98945807P 2007-11-21 2007-11-21
US60/989,458 2007-11-21
US4340708P 2008-04-09 2008-04-09
US61/043,407 2008-04-09
US7377408P 2008-06-19 2008-06-19
US61/073,774 2008-06-19

Related Child Applications (3)

Application Number Title Priority Date Filing Date
PCT/IL2008/000396 Continuation-In-Part WO2008117278A2 (en) 2007-03-27 2008-03-20 Gene expression signature for classification of cancers
US53294009A Continuation-In-Part 2007-03-27 2009-09-24
US12/782,067 Continuation-In-Part US20100273172A1 (en) 2007-03-27 2010-05-18 Micrornas expression signature for determination of tumors origin

Publications (2)

Publication Number Publication Date
WO2009066291A2 WO2009066291A2 (en) 2009-05-28
WO2009066291A3 true WO2009066291A3 (en) 2009-07-09

Family

ID=40329114

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2008/001525 WO2009066291A2 (en) 2007-03-27 2008-11-20 Micrornas expression signature for determination of tumors origin

Country Status (1)

Country Link
WO (1) WO2009066291A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10150999B2 (en) * 2010-11-17 2018-12-11 Interpace Diagnostics, Llc miRNAs as biomarkers for distinguishing benign from malignant thyroid neoplasms
FR2968674A1 (en) * 2010-12-08 2012-06-15 Univ Joseph Fourier IN VITRO INTER-TISSUE DIAGNOSIS METHOD FOR DIAGNOSING BRAIN TUMORS
EP2505663A1 (en) 2011-03-30 2012-10-03 IFOM Fondazione Istituto Firc di Oncologia Molecolare A method to identify asymptomatic high-risk individuals with early stage lung cancer by means of detecting miRNAs in biologic fluids
CN103898219A (en) * 2014-04-01 2014-07-02 镇江市第三人民医院 Serum miRNA marker for detecting primary biliary cirrhosis, marker composition and application thereof
WO2022019326A1 (en) * 2020-07-22 2022-01-27 国立大学法人広島大学 Method for providing assistance in detecting brain tumor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JAY CHRIS ET AL: "miRNA profiling for diagnosis and prognosis of human cancer", DNA AND CELL BIOLOGY MAY 2007,, vol. 26, no. 5, 1 May 2007 (2007-05-01), pages 293 - 300, XP002510058 *
LADEIRO Y ET AL: "23 MICRORNA (MIRNA) PROFILING IN HEPATOCELLULAR TUMORS IS ASSOCIATED TO CLINICAL FEATURES AND ONCOGENE/TUMOR SUPPRESSOR GENE MUTATION", JOURNAL OF HEPATOLOGY, MUNKSGAARD INTERNATIONAL PUBLISHERS, COPENHAGEN, DK, vol. 48, 1 January 2008 (2008-01-01), pages S11, XP022626179, ISSN: 0168-8278, [retrieved on 20080101] *
LU J ET AL: "MicroRNA expression profiles classify human cancers", NATURE, NATURE PUBLISHING GROUP, LONDON, UK, vol. 435, no. 7043, 9 June 2005 (2005-06-09), pages 834 - 838, XP002339403, ISSN: 0028-0836 *
ROSENFELD NITZAN ET AL: "MicroRNAs accurately identify cancer tissue origin", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 26, no. 4, 1 April 2008 (2008-04-01), pages 462 - 469, XP002492655, ISSN: 1087-0156 *
VOLINIA STEFANO ET AL: "A microRNA expression signature of human solid tumors defines cancer gene targets", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, vol. 103, no. 7, 14 February 2006 (2006-02-14), pages 2257 - 2261, XP002460699, ISSN: 0027-8424 *
WIEMER ERIK ET AL: "miRNA expression profiling in cancer cell lines and tumor samples using LNA (TM) oligonucleotide arrays", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, NEW YORK, NY, vol. 47, 1 April 2006 (2006-04-01), pages 980 - 981, XP001538067, ISSN: 0197-016X *

Also Published As

Publication number Publication date
WO2009066291A2 (en) 2009-05-28

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