WO2009063484A3 - Stable pharmaceutical composition of lamotrigine - Google Patents

Stable pharmaceutical composition of lamotrigine Download PDF

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Publication number
WO2009063484A3
WO2009063484A3 PCT/IN2008/000463 IN2008000463W WO2009063484A3 WO 2009063484 A3 WO2009063484 A3 WO 2009063484A3 IN 2008000463 W IN2008000463 W IN 2008000463W WO 2009063484 A3 WO2009063484 A3 WO 2009063484A3
Authority
WO
WIPO (PCT)
Prior art keywords
lamotrigine
pharmaceutical composition
stable pharmaceutical
pharmaceutically acceptable
composition
Prior art date
Application number
PCT/IN2008/000463
Other languages
French (fr)
Other versions
WO2009063484A2 (en
Inventor
Ranjan Pradhan Manas
Urankar Manohar
Sathya Narayana Vemula
Singh Samprada
Original Assignee
Alkem Lab Ltd
Ranjan Pradhan Manas
Urankar Manohar
Sathya Narayana Vemula
Singh Samprada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkem Lab Ltd, Ranjan Pradhan Manas, Urankar Manohar, Sathya Narayana Vemula, Singh Samprada filed Critical Alkem Lab Ltd
Publication of WO2009063484A2 publication Critical patent/WO2009063484A2/en
Publication of WO2009063484A3 publication Critical patent/WO2009063484A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to a process for a stable pharmaceutical composition of lamotrigine or a pharmaceutically acceptable salt thereof, comprising pregelatinised starch, wherein the said composition is essentially free of a pharmaceutically acceptable clay or polyvinylpyrrolidone.
PCT/IN2008/000463 2007-08-03 2008-07-18 Stable pharmaceutical composition of lamotrigine WO2009063484A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1499/MUM/2007 2007-08-03
IN1499MU2007 2007-08-03

Publications (2)

Publication Number Publication Date
WO2009063484A2 WO2009063484A2 (en) 2009-05-22
WO2009063484A3 true WO2009063484A3 (en) 2009-07-02

Family

ID=40639274

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000463 WO2009063484A2 (en) 2007-08-03 2008-07-18 Stable pharmaceutical composition of lamotrigine

Country Status (1)

Country Link
WO (1) WO2009063484A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107519141A (en) * 2016-06-21 2017-12-29 北京科信必成医药科技发展有限公司 A kind of Lamotrigine microplate and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992013527A1 (en) * 1991-01-30 1992-08-20 The Wellcome Foundation Limited Water-dispersible tablets
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
WO2004103340A1 (en) * 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited Water dispersible tablets of lamotrigine
WO2005051350A2 (en) * 2003-10-28 2005-06-09 Torrent Pharmaceuticals Limited Water dispersible tablet
WO2008104996A2 (en) * 2007-02-28 2008-09-04 Jubilant Organosys Limited Water dispersible pharmaceutical formulation and process for preparing the same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992013527A1 (en) * 1991-01-30 1992-08-20 The Wellcome Foundation Limited Water-dispersible tablets
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
WO2004103340A1 (en) * 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited Water dispersible tablets of lamotrigine
WO2005051350A2 (en) * 2003-10-28 2005-06-09 Torrent Pharmaceuticals Limited Water dispersible tablet
WO2008104996A2 (en) * 2007-02-28 2008-09-04 Jubilant Organosys Limited Water dispersible pharmaceutical formulation and process for preparing the same

Also Published As

Publication number Publication date
WO2009063484A2 (en) 2009-05-22

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