WO2009062198A2 - Système orthétique et prothétique à moteur commandé de manière neuromorphique - Google Patents

Système orthétique et prothétique à moteur commandé de manière neuromorphique Download PDF

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Publication number
WO2009062198A2
WO2009062198A2 PCT/US2008/083065 US2008083065W WO2009062198A2 WO 2009062198 A2 WO2009062198 A2 WO 2009062198A2 US 2008083065 W US2008083065 W US 2008083065W WO 2009062198 A2 WO2009062198 A2 WO 2009062198A2
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WIPO (PCT)
Prior art keywords
foot
false
user
controller
walking
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PCT/US2008/083065
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English (en)
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WO2009062198A3 (fr
Inventor
Ranu Jung
Shah Vikram Jung
Brundavani Srimattirumalaparle
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Advensys, Llc
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Publication of WO2009062198A2 publication Critical patent/WO2009062198A2/fr
Publication of WO2009062198A3 publication Critical patent/WO2009062198A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/50—Prostheses not implantable in the body
    • A61F2/68—Operating or control means
    • A61F2/70—Operating or control means electrical
    • A61F2/72—Bioelectric control, e.g. myoelectric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H3/00—Appliances for aiding patients or disabled persons to walk about
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/50—Prostheses not implantable in the body
    • A61F2/60—Artificial legs or feet or parts thereof
    • A61F2/66—Feet; Ankle joints
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/50—Prostheses not implantable in the body
    • A61F2/60—Artificial legs or feet or parts thereof
    • A61F2002/607—Lower legs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H3/00—Appliances for aiding patients or disabled persons to walk about
    • A61H2003/005—Appliances for aiding patients or disabled persons to walk about with knee, leg or stump rests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H3/00—Appliances for aiding patients or disabled persons to walk about
    • A61H2003/007—Appliances for aiding patients or disabled persons to walk about secured to the patient, e.g. with belts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/01—Constructive details
    • A61H2201/0103—Constructive details inflatable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/12—Driving means
    • A61H2201/1238—Driving means with hydraulic or pneumatic drive
    • A61H2201/1246—Driving means with hydraulic or pneumatic drive by piston-cylinder systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/50—Control means thereof
    • A61H2201/5007—Control means thereof computer controlled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/50—Control means thereof
    • A61H2201/5058—Sensors or detectors
    • A61H2201/5069—Angle sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2230/00—Measuring physical parameters of the user
    • A61H2230/08—Other bio-electrical signals

Definitions

  • the present application provides a powered orthotic device with integrated computer control system for use by individuals with a transtibial (below knee) injury that prevents active control of the foot, ankle or for use by a transtibial amputee.
  • BACKGROUND OF THE INVENTION [0004]
  • military personnel are provided with better body protection, faster evacuation and improved medical technology and assistance.
  • the arms and legs of military personnel remain vulnerable to the ammunition used in today's war zones.
  • Combat trauma to an unprotected arm or leg is often caused by high energy impact resulting in extensive soft tissue damage.
  • Lower leg, foot and ankle injuries in the battlefield can also put soldiers at increased risk of further harm by limiting their mobility.
  • Some of the major everyday living injuries include: automobile accidents, where 16% of occupants of passenger vehicles who were hospitalized following motor vehicle crash injuries, were diagnosed with a serious lower extremity injury and the injuries; workplace injuries, occurring at a rate of nearly 400 foot injury cases a day; and sports injuries and other activity related injuries, where the ankle is the most commonly injured joint among athletes. Such every day living injuries are further exacerbated by demographic trends such as an active aging population, diabetes and obesity.
  • Mobility impairment is the most frequent reason for using an assistive device.
  • Assistive devices include crutches, canes, walkers, medical shoes and wheel chairs.
  • the system and device of the present application provides improved locomotor function by mimicking the control of the uninjured system, and integrally linking the system and device with the neurophysiological control of the intact musculature.
  • the present system and device substantially enhances existing technology for both military and civilian applications.
  • the device of the present system includes a custom or universal fit fixed-ankle orthosis, with an optional above the knee attachment, to stabilize or immobilize an injured lower limb or act as an ankle prosthesis ("AFO"), and an actuated or powered articulated false-foot connected to the fixed-ankle orthosis or prosthesis to form an actuated articulated false-foot orthosis ("AAFO").
  • AFO ankle prosthesis
  • AAFO actuated articulated false-foot orthosis
  • the AAFO includes sensors associated with or mounted on the actuated articulated false-foot , or on or in the body, for sensing the intent of the subject to move, and the movement range of the articulating false-foot or AAFO and an environmental perturbation.
  • the sensors are located in-body, they may be one or more implanted intrafascicular electrodes, nerve sieve electrodes, nerve cuffs, epimysial electrodes, intramuscular electrodes or electromyogram electrodes, that communicate the neurophysiological intent to move to the outside of the body through wireless technology.
  • An actuator is used to drive the articulated false-foot orthosis.
  • the system and device further includes a controller having a neural network pattern generator electronic circuit. This biomimetic design of the pattern generator circuit is based on knowledge of connectivity of neurons within the spinal cord of a primitive vertebrate, which makes it a "neuromorphic" design, or a design that mimics neuro-biological architectures present in the nervous system.
  • the system and device include an electronic circuit made from analog very large scale integrated ("VLSI") components and discrete electronic components capable of autonomously generating cyclic voltage output.
  • a power supply serves the controller and AAFO.
  • the AFO interconnected with the actuator and false-foot to form the AAFO, together with a controller and power supply, form a neuromorphic controlled powered orthotic and prosthetic system or "NOCS,” of the present application.
  • the present portable system and device provide "crutchless walking" to a person with an injured lower limb, which, using the sensors and controller, automatically initiates and terminates cyclic actuation of the AAFO.
  • the system and device also automatically adjusts the speed of the cyclic control of the AAFO to match the users self selected walking velocity.
  • the system and device minimizes the load during walking on the foot that is being supported.
  • the system can further be utilized to provide rhythmic control of an artificial knee or ankle (or prostheses), bilateral artificial knee or ankle (or prostheses), bilateral AAFOs or to control a knee orthosis or if one hip is injured, control based signals from the other good leg may be used to control an external hip, knee or ankle orthosis or prosthesis.
  • Figure 1 is a schematic perspective view of the actuated articulated false- foot orthosis of the neuromorphic controlled powered orthotic device of the present application
  • Figure 2 is a schematic perspective view of the actuated articulated false- foot orthosis of the neuromorphic controlled powered orthotic device of the present application
  • Figure 3 is a schematic perspective view of the neuromorphic controlled powered orthotic device of the present application shown worn on a user;
  • Figure 4 is a schematic perspective view of the false-foot and actuator of the actuated articulated false-foot orthosis of the neuromorphic controlled powered orthotic device of the present application;
  • Figure 5 is a rear view of the device of Figure 4.
  • Figure 6 is a front view of the device of Figure 4.
  • Figure 7 is a bottom view of the device of Figure 4.
  • Figure 8 is a side view of the device of Figure 4;
  • Figures 9, 10, 12 and 13 are schematic representations of alternative actuators for use in the neuromorphic controlled powered orthotic device of the present application;
  • Figures 11a, l ib and l ie are side and front/rear views of schematic representations of alternative actuator positions mounted in the neuromorphic controlled powered orthotic device of the present application;
  • Figures 14-18 are side views of schematic representations of alternative energy saving mechanisms for use in the neuromorphic controlled powered orthotic device of the present application;
  • Figures 20 and 21 are flow charts schematically representing the sensor inputs and pattern generator used in the neuromorphic controlled powered orthotic device of the present application;
  • Figure 22 is a schematic representation of the electronic circuit of the pattern generator used in the neuromorphic controlled powered orthotic device of the present application;
  • Figure 23 is a schematic representation of the electronic circuitry within the system controller of the neuromorphic controlled powered orthotic device of the present application.
  • Figure 24a is a graphical representation of the sensed movement during walking of a normal limb and a limb with a non-operable/passive NOCS;
  • Figure 24b is a graphical representation of the sensed movement during walking of a normal limb and a limb with an operable/active NOCS;
  • Figures 25a and 25b are graphical representations of the sensed movement during walking using the NOCS.
  • Figure 26 is a graphical representation of the forces on the feet of a user during walking with the NOCS of the present application. DETAILED DESCRIPTION OF THE INVENTION
  • the present invention provides an integrated control system, based on principles of architecture and functions of the spinal cord of primitive vertebrates for control of rhythmic movement, to sense and control an actuated powered orthotic splint or prosthetic system for the lower limb.
  • the system is generally referenced here as a neuromorphic controlled powered orthotic and prosthetic system or "NOCS.”
  • the NOCS portable system and device of the present application includes a custom or universal fit fixed-ankle orthosis 12 ("AFO"), with an optional above the knee attachment 14, to stabilize or immobilize an injured lower limb L or act as an ankle prosthesis, and an actuated or powered articulated false-foot 16 connected to the fixed-ankle orthosis or the prosthesis 12 to form an actuated articulated false-foot orthosis 18 ("AAFO").
  • AFO fixed-ankle orthosis
  • AAFO actuated articulated false-foot orthosis
  • sensors 20 for sensing the intent of the subject S to move, and the movement range of the articulating false-foot 16 or AAFO 18 with respect to an environmental perturbation E.
  • An actuator 22 interconnects the fixed-ankle orthosis 12 and the articulated false-foot orthosis 18, and is used to drive the articulated false-foot orthosis.
  • a controller 24 having the neural network unit pattern generator 26 or PG provided by electronic circuitry to initiate and terminate movement of the AAFO as indicated by the sensors 20.
  • the electronic circuitry uses analog components 28 and discrete electronic components 30 capable of autonomously generating cyclic voltage output.
  • a conventional power supply 32 such as a 24 V standard battery, serves the controller 24 and the actuator 22 of the AAFO 18.
  • a fixed-ankle orthosis or AFO 12 is provided which may also be a passive ankle prosthesis.
  • the fixed-ankle orthosis 12 allows lower limb L and ankle A immobilization and forms a housing for the injured lower leg of the user or subject S.
  • Such an AFO 12 can be fit to the user S, and universally shaped to accommodate a shoe B on a foot.
  • the AFO 12 can be a universal, non-custom fit bilateral application, so that the device can be readily deployed under combat conditions, and a combat boot B of any size, right or left boot, can remain on the user S within the AFO until evacuation from the battlefield.
  • the AFO can also be custom fit to the lower limb L, ankle and foot F.
  • the AFO 12 is preferably of a material having sufficient strength to bear loads of up to approximately 90 Kg. Examples of such construction materials include cast polypropylene or other material with similar properties, between approximately 0.2 to 0.5 inches thick.
  • the AFO has a universal anatomical shape of an open foot and calf support 13, for cradling the injured limb L.
  • the AFO 12 may be reinforced in particular locations, at the back of the calf and heel, for example, to allow connection with the articulated false-foot 16 to form the actuated, powered orthosis or AAFO 18.
  • Velcro or other attachment straps 40 are provided to secure the user's boot B or foot without the boot or prostheses within the support 13, and to the false-foot, and a calf liner 42 with a conventional air bladder 43 to reduce the forces on the foot, ankle and calf.
  • the AFO 12 is provided with a thigh support, not shown, which is interconnected with the calf support 13 at a rigid articulated knee connection, all secured to the user via Velcro straps 40 or other flexible attachments.
  • the universal fixed-ankle orthosis, AFO 12 is secured to the articulating false-foot 16.
  • the articulating false-foot may be custom made or of off the shelf components.
  • the shape of the AFO 12 enables it to be integrated with a variety of ankle prostheses which may serve as the false-foot 16, for example, commercially available ankle orthoses, or cam boots, such as OMNI LifeScience, the BREG Pin cam walker, DONJOY MAXTRAX ROM AIR WALKER, DONJOY ULTRA-4 ROM
  • the AAFO 18 is capable of load bearing of up to a 90 Kg person, and supports and is interconnected with the support 13 of the fixed-ankle orthosis 12.
  • the AAFO false-foot 16 includes a base 14 having upwardly extending opposing side brackets 17, each interconnected with the base at a rotating pivot joint P.
  • the side brackets 17 are secured to the support 13 via conventional fasteners as shown, and the brackets 17 are also surrounded by the straps 40 or other attachments securing the foot F and/or boot B within the support 13.
  • the base 14 of the false-foot 16 and support 13 of the AFO 12 are each secured to the actuator 22, which operates to move the support 13 with respect to the base of the false-foot 16 at the pivot point.
  • the AAFO 18 is preferably lightweight and allows one degree of freedom of movement.
  • the AAFO preferably operates to provide plantar-flexion between approximately 0 and 30 degrees, and less than 35 degrees at a maximum, and the user S may actively control this angle.
  • the dorsi-flexion of the AAFO during operation is preferably between approximately 0 and 18 degrees during operation, and less than 30 degrees at a maximum, also with active control allowed.
  • the range of motion provided by the AAFO 18 is shown by the difference in position between the support 13 and base of the false-foot 16 in Figure 1 and Figure 2.
  • Eversion and inversion of the foot F is preferably less than 5 degrees, and is a passive movement of the device 18.
  • an orthosis can also be utilized in a trans-tibial amputee with the articulated false- foot 16 acting as ankle prosthesis.
  • a scree gaiter, a skirt, or dense foam can be used as a debris guard (not shown).
  • a metal debris guard 44 is used to provide a protective cover for the actuator 22.
  • the actuator 14 consists of a motor 46, a motor controller 47, and, optionally, energy storage elements 49.
  • the actuator 14 provides a peak power of at least 225 Watts and a peak force of at least 100ON.
  • the actuator weighs approximately 5-7 lbs, such that the overall weight of the AFO and AAFO is approximately 15 lbs.
  • One form of actuator secured to the acute AAFO 18 includes a direct rotary drive, as shown in Figure 9, or a linear drive is shown in Figure 10, and of the type shown in the preferred embodiment of the present application.
  • actuators within the category of linear drive actuators, there are a variety of places that the actuator could be attached to produce the desired ankle motion, as shown in Figures 1 Ia-I Ic. Additional examples of types of actuators include a hydraulic linear actuator, consisting of conventional off the shelf components, such as a cylinder and piston driven by a working fluid. The flow of fluid is controlled by a high performance electrically controlled valve.
  • a pneumatic actuator could be used, such as a commercially available pneumatic actuator.
  • the McKibben artificial muscle pneumatic actuator may be used, which has a cylindrical flexible bladder which is covered by a braided mesh of non-stretching fibers. Both ends of the bladder are connected to the mesh.
  • a worm gear may also be used for the actuator, as in Figure 13.
  • a worm gear provides a small package that generates sufficient mechanical advantage to provide the required ankle moment.
  • a rotary motor gains mechanical advantage through a planetary gear as well as the worm gear itself.
  • a still further actuator, shown in Figure 12 could make use of a conventional roller screw mechanism, which converts rotary torque into a linear motion like an acme screw or ball screws.
  • an electric motor drives a set of helical rollers around a threaded shaft to product linear motion.
  • energy storage may be utilized in conjunction with the actuator as it is connected to the false-foot 16 to reduce energy required by the mechanical actuators in the system.
  • Examples of methods for storing and transferring kinetic energy back into the false-foot to reduce demands for peak force and peak power include elastomeric top or bottom mounted bumpers, shown in Figures 14-15; a servo-saver concept, Figure 16, is also provided in which rotational energy is reacted through a coiled spring element; a tapered leaf spring may be used, as in Figure 17, in which a leaf spring is deformed during the heel strike of the false-foot; and pre-tensioned elastomeric bands of the type shown in Figure 19.
  • a coil spring is configured to wrap around elements of the actuator.
  • This type of spring is commercially available in a variety of sizes and tensions, and typically of a steel alloy material.
  • the springs are compressed as the actuator moves up/down and thus store energy during compression.
  • the springs work in series with the direction of the actuator movement. Adding bungee cords mounted in parallel can further enhance the ability to store and release energy.
  • a non-custom fixed universal ankle foot orthosis or AFO 16 is interconnected with an actuated articulated false- foot orthosis or AAFO using a linear actuator 22 having a roller screw mechanism 45.
  • the AFO is capable of use in a combat zone for stabilizing the leg of an injured soldier without removing the boot B.
  • the AFO 16 is shown in a toe up/dorsi-flexed position
  • Figure 2 shows the AFO in a toe down/plantar-flexed position, indicating a range of motion provided by the AAFO 18.
  • the actuator 22 includes a conventional rotary DC Maxon motor 46, having an EPOS 70/10 motor controller which converts force to linear action through the lead screw mechanism 45 shown.
  • the motor 46 is shown within a housing mounted on the top of the actuator 22.
  • McMaster-Carr tie rods support a sliding carriage moved on ball bearings using the ball screw mechanism shown.
  • Linear springs 49 shown in Figures 1-2, mounted on the tie rods, and in series with the lead screw mechanism, provide the energy storage previously mentioned during dorsi- flexion and plantar-flexion.
  • Detachable flexible cord or bungee cord may be provided as parallel energy storage elements.
  • the bungee cord or flexible material (shown schematically in Figure 5) can be secured at the top of the AFO and the bottom of the AAFO on posts or hook 50 shown in Figures 4-8.
  • Quick disconnect mechanisms 51 are provided between the actuator 22 at the upper attachment location on the AFO, and the lower attachment location between the actuator and the false-foot 16, so that the actuator may be quickly removed or attached from the AAFO 18 on the user S.
  • sensors 20 may be used to transmit position information for components of the NOCS 10.
  • the sensors 20 are interconnected with the system controller 24 or motor controller 47 and provide accurate information about the angular excursion of the false-foot 16, sense initiation, respond to continuous movement of the user, and termination of a gait event cycle, provide feedback to the controller about the self selected walking speeds of the user S, provide information about external disturbances and perturbations and help reset the locomotor rhythm.
  • a first type of sensor is provided in or adjacent the pivot point P of the AAFO or in the motor 46 of the actuator 22. As shown in Figure 2, the sensor 20a is illustrated mounted adjacent the pivot point P of the false-foot 16.
  • the sensor 20a which may be a potentiometer at the pivot point P, indicates the change in angle of the false-foot 16, or the degree of plantar-flexion or dorsi-flexion of the AAFO 18, and uses local proportional integrative derivative feedback control of the actuator motor 46 that results in linear movement of the lead screw shaft of the actuator 22.
  • Such linear movement results in rotational movement of the false- foot 16 about the pivot point P, and a calibration process indicates linear movement in millimeters, or turns of the lead screw, relative to the angular movement in degrees.
  • a second type of sensor 20b is provided to sense initiation and termination of a gait event cycle, as well as continuous movement of the uninjured limb or the contralateral leg, thereby providing real-time output at the self-selected walking speed of the user S.
  • This second sensor type may be mounted anywhere along the AAFO or AFO bracket front, back or side, an in-body sensor, on the uninjured swinging limb, on the intact portion of the injured limb or on any body part that moves at the self-selected walking pace.
  • the output of the second sensor 20b can be a continuous signal or a periodic discrete pulse-like signal, where the pulse is generated when the sensor output goes above a predefined threshold.
  • the output of the second sensor 20b provides feedforward input to the PG 26 of the NOCS via the auxiliary neuron as described below.
  • the PG provides trajectory timing for driving the actuator motor 46.
  • the illustrated sensor 20b shown mounted laterally on the AAFO 18, is a gyroscope type sensor, and specifically a MEMS based gyroscope from Analog Devices, product ADXRS300, multiple sensors may be used, and multiple types of sensors may be used. Alternatively, this sensor 20b, which senses the initiation and termination of the user S may be the sole sensor used.
  • a third type of sensor 20c may provide information about the episodic external disturbances and perturbations and helps reset the locomotor rhythm by providing a brief input signal to the PG.
  • the sensor 20c may be mounted on a sensor board of the controller.
  • the rotational velocity signal provided by sensor 20a may also be used to provide information to the neuromorphic orthotic controller, for detection of key gait events or to provide a continuous estimate of rotational velocity or orientation if the signal is integrated. While only a single second type of sensor is required, additional first and third types are also advantageous to improve the feedback control provided by the system 10.
  • Sensors may alternatively be located on or in the user's body, or mounted on either leg.
  • hip-angle sensors commercial goniometers
  • tilt- sensors mounted on the shank of un-injured leg surface electromyogram sensors may be mounted on a thigh of the injured leg or thigh or shank of un-injured leg
  • accelerometers force sensitive resistors
  • potentiometers operational in the range 0-35 degrees, with 180 degrees maximum
  • Intramuscular Implanted in the muscle multistranded Teflon coated stainless steel wire, monopolar and bipolar configurations, good tensile strength, and flexibility
  • Epimysial Implanted under the skin on the muscle, monopolar and bipolar configurations, less prone to mechanical failure
  • LIFE Stable suitable for stimulating and recording
  • Intraspinal Microwires Near to normal recruitment, reduced fatigue, highly selective stimulation
  • the NOCS 10 system controller 24 includes an electronic pattern generating circuit 26 which was developed based on the simplified connectivity pattern of neurons forming a neural network within the spinal cord of a primitive vertebrate, specifically a lamprey eel, to produce a rhythmic pattern for signaling the actuator 22 to move the AAFO 18, and associated electronic circuitry to receive inputs from sensors, provide 24 V DC to 5 V DC voltage converter from the power source and to provide impedance matching between the controller 24 and the actuator motor controller 47.
  • the neural network design within the electronic pattern generating circuit, together with the other discrete electronic components are provided as the NOCS system controller, which are enabled in a portable unit capable of being worn by a user S are as shown in Figure 3, and hereafter referred to as a pattern generator PG.
  • This controller 24 and the power supply 32 fit within a belt pouch or back pack C, as shown schematically in Figure 3.
  • the basic connectivity pattern employed by the pattern generator is shown in Figures 20-21.
  • the neural network structure of the PG is based upon a 9-neuron network mimicking the simplified connectivity pattern of spinal cord neurons in primitive vertebrates to produce rhythmic movement output.
  • the 4 types of neurons on each side of the body, or 8 in total, are the excitatory E, lateral L, crossed C and motor M.
  • An auxiliary neuron A is also used.
  • An auxiliary neuron (A) was added to the PG circuit to provide input to the constituent neurons for entrainment of the PG output to an external signal.
  • the external signal will be a voltage proportional to one of the continuous gait measure signals.
  • the A neuron modifies this voltage to a current to be injected into one of the other eight neurons.
  • the number of neurons used to form a network can be modified to fewer neurons, or a single neuron on each side, or the 8-neuron network may be replaced by a single neuron.
  • the network oscillator 60 shown schematically in Figure 20, may consist of two or more neurons.
  • the neurons may or may not be arranged in a symmetric pattern.
  • a non- symmetric pattern would mimic networks found in invertebrates.
  • a single neuron that is capable of producing rhythmic output could replace the network of 8 or fewer neurons. In the latter case the mathematical model used for defining the neuron itself must include pacemaker currents, not shown.
  • Each neuron provides a periodic output signal that can be utilized to provide the periodic drive signal to the actuator motor controller 47. All neurons of the PG 26 are driven by a constant tonic input and one or more neurons of the PG are driven by a phasic input, obtained from signal data capturing from the sensors 20 during walking movement.
  • the dynamic activity of each neuron is described by the following differential equations. [0057] In the preferred embodiment, each neuron is described by the following differential equation example:
  • G 1 R is the maximum conductance across the membrane for passive currents flowing at rest
  • V R is the resting potential for neuron i
  • G ⁇ is the maximum conductance for tonic synaptic input into the neuron i
  • V T is the reversal potential for the tonic current input
  • G j1 is the maximal synaptic conductance for phasic synaptic input from neuron j to neuron i
  • V syn is the synaptic reversal potential for the synaptic current from neuron j to i
  • G'e x t is the maximal synaptic conductance for external input
  • Ve x t is the reversal potential for the conductance on the external input.
  • This external input is the output of one or more sensors.
  • Ipm are other pacemaker currents that allow a single neuron to produce cyclic voltage output and may or may not be used.
  • Iext are injected currents in proportion to the sensor outputs.
  • Each neuron's output represents the firing frequency and is assumed to be related to its membrane voltage by a nonlinear function given by a seventh order polynomial h(v) with a strict threshold and saturation.
  • the preferred embodiment of the PG of the present application under appropriate constant tonic drive the preferred embodiment of the PG of the present application generates: a left-right alternating oscillatory rhythm; stable oscillations over a range of frequencies spanning normal human walking, or approximately 0.1Hz to 3Hz; and has a capacitive membrane with transmembrane conductances that provide pathways for passive leakage current, tonic drive current, synaptic current from other PG neurons and external current from sensor 20a, 20b, 20c derived signals.
  • the output voltages of the PG are scaled to lie between 0 and 5 volts.
  • the cyclic output from the PG 26 provides feedforward or open loop input to the motor controller 47 of the actuator 22 connected to the AAFO 18.
  • Descending voluntary control of the user S which is determined based upon rhythmic lower limb L movement detected by sensors 20, such as the sensor on the injured limb or the in-body or on-body sensors on the injured or uninjured (opposite) limb, provides an input signal to the PG to initiate or terminate the rhythmic control of the AAFO 18 using the motor controller 47 of the actuator 22, thereby capturing the user's intent to move.
  • sensors 20 such as the sensor on the injured limb or the in-body or on-body sensors on the injured or uninjured (opposite) limb
  • Such analog cycle-to-cycle control or entrainment of the PG rhythm through an electronic auxiliary neuronal circuit is used to match AAFO 18 motion or rhythm to a self-selected walking speed.
  • Sensors 20b on AAFO provide feedback FB to the PG for phase dependent resetting, or adjustment of the cycle period, which is dependent on the phase of the cyclic movement or of the cyclic output of the PG, in response to external disturbance. During such phase dependent resetting, the actuator 20 causes the AAFO 18 to plantar- flex and/or dorsi- flex.
  • the PG 26 can work as an autonomous oscillator, meaning that it does not need periodic drive signal input from the sensors 20a, 20b, 20c, to enable oscillation.
  • the PG oscillations can be suppressed if there is a constant external signal input to the PG.
  • the NOCS speed of operation can be entrained to an external signal input from the sensors 20 to the PG.
  • the PG responds to external changes in speed within a cycle of perturbation.
  • the PG could also be programmed to respond to simultaneous inputs from more than one entrainment and/or perturbation signal, and thus can be entrained and respond to brief perturbations at the same time. If more than one PG is used, and were provided in appropriate phase relationship, a knee and ankle prosthesis could both be controlled at the same time.
  • the PG may be desired to use the PG to drive other cyclic processes, which maybe physiological or not, and which are not locomotor related. Still other examples of locomotor related applications, involve use of the PG to control an articulated actuated ankle foot orthosis, where the powered articulated false- foot 16 connects to an ankle and acts as a robotic assist device for therapy of the injured ankle.
  • the PG could be used without any input from the user S in a passive mode of exercise or could be entrained by signals from on-body sensors or in-body sensors, such as neural cuff, as the person is walking, to entrain the PG to provide active control of the articulated actuated ankle-foot orthosis.
  • the PG is simulated for oscillation, and has the ability to be entrained at a variety of frequencies that would be within the range of human walking speed. Current in proportion to the amplitude of a simulated phasic input was provided and the PG oscillation frequency monitored. Under default conditions, the PG oscillates at a pre-entrainment default frequency (f pre ) of 0.75 Hz. Once entrainment begins, the PG circuit quickly assumes the frequency (f pos t) of the current input. The PG circuit can thus be entrained to a 1 : 1 ratio (f pos t/ f pr e). For example, the PG circuit 30 produces an oscillatory signal in response to movement sensor input, which signal follows the frequency of the movement sensor.
  • FIGS. 22 and 23 show schematic components of a preferred circuit with the synaptic interconnects between the 8 neurons in the PG implemented using a 28 pin, analog VLSI chip 28 and discrete components and other circuitry provided on a circuit board 30 made from components as described and shown.
  • the frequency of oscillations of all the neurons of PG circuit is ideally 0.75Hz, but within a range of approximately 0.1 - 4 Hz.
  • the analog VLSI chip 28 is manufactured using an AMI 0.5 ⁇ m complementary metal-oxide- semiconductor process of the type processed by MOSIS, but could be implemented in other analog VLSI technology processes ranging from 0.13 to 1.5 ⁇ m or in nanometer technology processes such as 90nm.
  • the supply voltage can range up to 5 volts depending on the process used.
  • the sub-circuits of the system include differential circuits, p-MOS, n-MOS, current mirrors and wide range amplifiers.
  • the PG circuit uses 467 transistors and the VLSI circuit layout size is just 6.071 sq millimeters. [0067] Noise is important in all analog circuits because it limits dynamic range.
  • the PG 26 design operates using a voltage of approximately 5V, but which can range from about 1.2V to 5 V, and is capable of battery operation.
  • the design operating temperature range is approximately -55deg C to +125 deg C.
  • the chip 28 is packaged using commercially available techniques but preferably uses a ceramic DIP package that when plugged into a DIP socket, can be replaced, stored, or transferred from one board to another.
  • the current chip utilizes ceramic DIP packaging.
  • Figure 25b shows transition from passive to active control while the subject was walking at a self-selected speed.
  • the potentiometer recording shows the excessive dorsi-flexion before push-off which is converted to the appropriate plantar-flexion by the active/on NOCS.
  • the controller responds immediately with appropriate adjustment of the step cycle.
  • Figure 26 shows the pressure distribution under the feet during walking with the active NOCS.
  • the left foot F is immobilized using the NOCS while the right foot F is in direct contact with the walking surface.
  • the pressure distribution indicates that the transmission of force from the false-foot 16 to the immobilized foot F is reduced under the heel and forces are not transmitted to the ball of the foot.
  • load bearing of the immobilized foot during the gait cycle is lower.
  • operation of the NOCS 10 may be further enhanced where an commercially available boot is also worn on the non-injured limb.

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Rehabilitation Therapy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Prostheses (AREA)
  • Rehabilitation Tools (AREA)

Abstract

L'invention concerne un système et un dispositif orthétique et prothétique à moteur commandé de manière neuromorphique, comprenant une orthèse de cheville fixe à agencement personnalisé ou universel, pour stabiliser ou immobiliser un membre inférieur blessé ou pour agir en tant que prothèse de cheville, et un faux pied articulé actionné ou à moteur relié à l'orthèse de cheville fixe ou à la prothèse pour former une orthèse de faux pied articulée actionnée. Il existe des capteurs associés ou montés sur le faux pied articulé actionné, ou dans ou sur le corps pour détecter l'intention de déplacement du sujet, et la plage de déplacement du faux pied d'articulation ou AAFO et une perturbation environnementale. Un actionneur est utilisé pour entraîner l'orthèse de faux pied articulé. Le système et le dispositif comprennent en outre un dispositif de commande ayant un circuit électronique d'une conception biomimétique basée sur une connaissance de la connectivité de neurones avec la moelle épinière de vertébrés primitifs. Le système et le dispositif comprennent un circuit électronique réalisé à partir de composants intégrés et de composants électroniques distincts analogiques à très grande échelle capables de générer de manière autonome une sortie de tension cyclique. Une source d'alimentation intégrée sert le dispositif de commande portable et l'AAFO.
PCT/US2008/083065 2007-11-08 2008-11-10 Système orthétique et prothétique à moteur commandé de manière neuromorphique WO2009062198A2 (fr)

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WO2009062198A3 (fr) 2016-05-26

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