WO2009058800A3 - Synthèse de nucléosides - Google Patents

Synthèse de nucléosides Download PDF

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Publication number
WO2009058800A3
WO2009058800A3 PCT/US2008/081499 US2008081499W WO2009058800A3 WO 2009058800 A3 WO2009058800 A3 WO 2009058800A3 US 2008081499 W US2008081499 W US 2008081499W WO 2009058800 A3 WO2009058800 A3 WO 2009058800A3
Authority
WO
WIPO (PCT)
Prior art keywords
synthesis
nucleosides
processes
nucleoside analogues
nucleoside
Prior art date
Application number
PCT/US2008/081499
Other languages
English (en)
Other versions
WO2009058800A2 (fr
Inventor
Gregory L Verdine
Seongmin Lee
Original Assignee
Harvard College
Gregory L Verdine
Seongmin Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Gregory L Verdine, Seongmin Lee filed Critical Harvard College
Publication of WO2009058800A2 publication Critical patent/WO2009058800A2/fr
Publication of WO2009058800A3 publication Critical patent/WO2009058800A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur un procédé de synthèse d'analogues de nucléosides.
PCT/US2008/081499 2007-10-29 2008-10-29 Synthèse de nucléosides WO2009058800A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98355007P 2007-10-29 2007-10-29
US60/983,550 2007-10-29

Publications (2)

Publication Number Publication Date
WO2009058800A2 WO2009058800A2 (fr) 2009-05-07
WO2009058800A3 true WO2009058800A3 (fr) 2009-07-16

Family

ID=40591723

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/081499 WO2009058800A2 (fr) 2007-10-29 2008-10-29 Synthèse de nucléosides

Country Status (1)

Country Link
WO (1) WO2009058800A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2861611T (pt) 2012-05-25 2016-10-11 Janssen Sciences Ireland Uc Nucleósidos de espirooxetano de uracilo
WO2014099941A1 (fr) 2012-12-19 2014-06-26 Idenix Pharmaceuticals, Inc. 4'-fluoro-nucléosides pour le traitement du vhc
BR112015014457A2 (pt) 2012-12-21 2017-11-21 Alios Biopharma Inc composto ou sal farmaceuticamente aceitável do mesmo e composição farmacêutica e respectivos usos e processos para melhorar ou tratar infecção de hcv, para inibir a atividade da ns5b polimerase do vírus da hepatite c e a replicação de vírus da hepatite c
CN105705511A (zh) 2013-04-12 2016-06-22 艾其林医药公司 用于治疗hcv的氘化核苷前药
BR112017013858A2 (pt) 2014-12-26 2018-02-27 Univ Emory n4-hidroxicitidina e derivados e usos antivirais relacionados aos mesmos
BR112020010581A2 (pt) 2017-12-07 2020-11-10 Emory University composição farmacêutica, recipiente pressurizado, e, métodos para tratar ou prevenir uma infecção viral e de tratamento ou prevenção de coronavírus humano, sars, coronavírus mers, vírus da encefalite equina oriental, vírus da encefalite equina ocidental, vírus da encefalite equina venezuelana, vírus chikungunya e infecção por infecção de ross river, vírus orthomyxoviridae ou vírus paramyxoviridae ou vírus rsv, ou infecção pelo vírus influenza a e vírus influenza b ou vírus filoviridae ou vírus ebola.
KR20200140274A (ko) * 2018-03-07 2020-12-15 에모리 유니버시티 4'-할로겐 함유 뉴클레오티드 및 뉴클레오시드 치료 조성물 및 이와 관련된 용도
CN113929724B (zh) * 2021-11-02 2024-05-31 周雨恬 一种核苷类化合物及其药物组合物和用途
CN114891048B (zh) * 2022-05-16 2024-03-26 浙江晟格生物科技有限公司 一种制备4-氟基-2,3,5-三-氧-苯甲酰基-β-L-呋喃核糖的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999043691A1 (fr) * 1998-02-25 1999-09-02 Emory University 2'-fluoronucleosides
US20050130274A1 (en) * 2001-09-05 2005-06-16 O'hagan David Enzymatic process for the synthesis of organo-fluorine compounds
WO2007053869A2 (fr) * 2005-11-09 2007-05-18 Saischek Und Partner Meg Dérives de furanose à substitution 2,2-dithio, procédé de production et leur utilisation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999043691A1 (fr) * 1998-02-25 1999-09-02 Emory University 2'-fluoronucleosides
US20050130274A1 (en) * 2001-09-05 2005-06-16 O'hagan David Enzymatic process for the synthesis of organo-fluorine compounds
WO2007053869A2 (fr) * 2005-11-09 2007-05-18 Saischek Und Partner Meg Dérives de furanose à substitution 2,2-dithio, procédé de production et leur utilisation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JUNG, M. E. ET AL.: "Preparation of 4'-substituted thymidines by substitution of the thymidine 5'-esters.", J. ORG. CHEM., vol. 66, 2001, pages 2624 - 2635 *

Also Published As

Publication number Publication date
WO2009058800A2 (fr) 2009-05-07

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