WO2009057763A1 - 新規アジュバント - Google Patents

新規アジュバント Download PDF

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Publication number
WO2009057763A1
WO2009057763A1 PCT/JP2008/069919 JP2008069919W WO2009057763A1 WO 2009057763 A1 WO2009057763 A1 WO 2009057763A1 JP 2008069919 W JP2008069919 W JP 2008069919W WO 2009057763 A1 WO2009057763 A1 WO 2009057763A1
Authority
WO
WIPO (PCT)
Prior art keywords
vaccine
infection
allergen
mucosal
tumor
Prior art date
Application number
PCT/JP2008/069919
Other languages
English (en)
French (fr)
Inventor
Toshihiro Tsukui
Ken Ishii
Shizuo Akira
Cevayir Coban
Original Assignee
Nippon Zenyaku Kogyo Co., Ltd.
Osaka University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Zenyaku Kogyo Co., Ltd., Osaka University filed Critical Nippon Zenyaku Kogyo Co., Ltd.
Priority to US12/740,899 priority Critical patent/US9056094B2/en
Priority to JP2009539133A priority patent/JP5292303B2/ja
Priority to EP08845024.2A priority patent/EP2221062B1/en
Publication of WO2009057763A1 publication Critical patent/WO2009057763A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

　アレルゲンワクチン、感染症ワクチン、粘膜ワクチン又は腫瘍ワクチンと併用するワクチンアジュバント組成物の提供。ヘモゾイン又はβヘマチンを含むアレルゲンワクチン、感染症ワクチン、粘膜ワクチン又は腫瘍ワクチンと併用するアジュバント組成物並びに該アジュバント組成物並びにアレルゲンワクチン、感染症ワクチン、粘膜ワクチン若しくは腫瘍ワクチンを含むワクチン組成物。
PCT/JP2008/069919 2007-11-02 2008-10-31 新規アジュバント WO2009057763A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/740,899 US9056094B2 (en) 2007-11-02 2008-10-31 Adjuvant
JP2009539133A JP5292303B2 (ja) 2007-11-02 2008-10-31 新規アジュバント
EP08845024.2A EP2221062B1 (en) 2007-11-02 2008-10-31 Novel adjuvant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007285737 2007-11-02
JP2007-285737 2007-11-02

Publications (1)

Publication Number Publication Date
WO2009057763A1 true WO2009057763A1 (ja) 2009-05-07

Family

ID=40591143

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/069919 WO2009057763A1 (ja) 2007-11-02 2008-10-31 新規アジュバント

Country Status (4)

Country Link
US (1) US9056094B2 (ja)
EP (1) EP2221062B1 (ja)
JP (1) JP5292303B2 (ja)
WO (1) WO2009057763A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011074711A1 (ja) 2009-12-18 2011-06-23 国立大学法人大阪大学 βヘマチンを含むアジュバント
US8894996B2 (en) 2009-02-27 2014-11-25 Osaka University Immunoadjuvant composition and use thereof
WO2014196657A1 (ja) 2013-06-04 2014-12-11 国立大学法人大阪大学 加熱工程を含むβヘマチン結晶の製造方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1743941B1 (en) 2004-04-09 2014-06-04 Nippon Zenyaku Kogyo Co., Ltd. Novel mite allergen

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849307A (en) 1997-03-26 1998-12-15 The Picower Institute For Medical Research Vaccine adjuvant
WO2006061965A1 (ja) 2004-12-09 2006-06-15 Osaka University ヘモゾイン誘導による自然免疫を利用したマラリア感染症の検出・測定、マラリア感染症の予防又は治療薬のスクリーニング、及び該自然免疫誘導の調節
WO2007147255A1 (en) * 2006-06-22 2007-12-27 Mcgill University Synthetic monodisperse hemozoin crystals preparation and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19601754A1 (de) * 1996-01-19 1997-07-24 Hoechst Ag Dictyocaulus viviparus Antigen zur Diagnose des Lungenwurmbefalls und zur Vakzinierung
US5846735A (en) * 1996-04-18 1998-12-08 University Of Iowa Research Foundation Hepatitis C virus Fc-binding function
BR9714160A (pt) * 1996-12-20 2000-05-02 Univ Texas Antìgenos uspa1 e uspa2 de moraxella catarrhalis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849307A (en) 1997-03-26 1998-12-15 The Picower Institute For Medical Research Vaccine adjuvant
WO2006061965A1 (ja) 2004-12-09 2006-06-15 Osaka University ヘモゾイン誘導による自然免疫を利用したマラリア感染症の検出・測定、マラリア感染症の予防又は治療薬のスクリーニング、及び該自然免疫誘導の調節
WO2007147255A1 (en) * 2006-06-22 2007-12-27 Mcgill University Synthetic monodisperse hemozoin crystals preparation and uses thereof

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
INFECT. IMMUN., vol. 70, 2002, pages 3939 - 3943
INFECT. IMMUN., vol. 70, no. 7, July 2002 (2002-07-01), pages 3939 - 43
J EXP MED., vol. 201, no. 1, 3 January 2005 (2005-01-03), pages 19 - 25
J. IMMUNOL., vol. 172, pages 3101 - 3110
PROC. NATL. ACAD. SCI. U.S.A., vol. 88, 1991, pages 325 - 329
PROC. NATL. ACAD. SCI. U.S.A., vol. 88, pages 325 - 329
PROC. NATL. ACAD. SCI. U.S.A., vol. 93, 1996, pages 11865 - 11870
See also references of EP2221062A4 *
SLATER ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 88, 1991, pages 325 - 329

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8894996B2 (en) 2009-02-27 2014-11-25 Osaka University Immunoadjuvant composition and use thereof
WO2011074711A1 (ja) 2009-12-18 2011-06-23 国立大学法人大阪大学 βヘマチンを含むアジュバント
JP5832904B2 (ja) * 2009-12-18 2015-12-16 国立大学法人大阪大学 βヘマチンを含むアジュバント
WO2014196657A1 (ja) 2013-06-04 2014-12-11 国立大学法人大阪大学 加熱工程を含むβヘマチン結晶の製造方法
US9732107B2 (en) 2013-06-04 2017-08-15 Osaka University Method for producing beta-hematin crystal comprising step of heating

Also Published As

Publication number Publication date
EP2221062B1 (en) 2014-05-21
EP2221062A4 (en) 2011-02-09
US9056094B2 (en) 2015-06-16
JPWO2009057763A1 (ja) 2011-03-10
EP2221062A1 (en) 2010-08-25
JP5292303B2 (ja) 2013-09-18
US20100247568A1 (en) 2010-09-30

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