WO2009057137A4 - A process for the purification of levetiracetam - Google Patents
A process for the purification of levetiracetam Download PDFInfo
- Publication number
- WO2009057137A4 WO2009057137A4 PCT/IN2008/000523 IN2008000523W WO2009057137A4 WO 2009057137 A4 WO2009057137 A4 WO 2009057137A4 IN 2008000523 W IN2008000523 W IN 2008000523W WO 2009057137 A4 WO2009057137 A4 WO 2009057137A4
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- levetiracetam
- purification
- filtering
- iii
- residue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Present invention relates to an improved process for the purification of Levetiracetam of formula (I).
Claims
AMENDED CLAIMS received by the International Bureau on 26 August 2009 (26.08.2009); original claims 6-10 deleted; remaining claims unchanged-
5. A process for the purification of Levetiracetam comprising steps of:
(i) treating substantially impure Levetiracetam with acetic acid and activated carbon in a methyl tertiary butyl ether, (ii) stirring and filtering the mixture obtained in step (i)
(iii) evaporating the filtrate of step (ii) to obtain a residue (iv) adding ethyl acetate to the residue obtained in step (iii) to obtain solution (v) refluxing and cooling the solution obtained in step (iv)
(vi) filtering and drying a solid obtained in step (v) to obtain Levetiracetam (I) having purity at least 99.5 %.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1610/MUM/2007 | 2007-08-22 | ||
| IN1610MU2007 | 2007-08-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2009057137A2 WO2009057137A2 (en) | 2009-05-07 |
| WO2009057137A3 WO2009057137A3 (en) | 2009-08-06 |
| WO2009057137A4 true WO2009057137A4 (en) | 2009-10-22 |
Family
ID=40591605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IN2008/000523 WO2009057137A2 (en) | 2007-08-22 | 2008-08-21 | A process for the purification of levetiracetam |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2009057137A2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101885696A (en) * | 2009-05-14 | 2010-11-17 | 上海华理生物医药有限公司 | Method for synthesizing high-purity levetiracetam |
| CN103922988A (en) * | 2014-04-29 | 2014-07-16 | 苏州天马精细化学品股份有限公司 | Method for purifying levetiracetam crude product |
| CN114560800A (en) * | 2022-03-03 | 2022-05-31 | 吉林省博大制药股份有限公司 | Production method of levetiracetam bulk drug |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1517893A2 (en) * | 2003-02-03 | 2005-03-30 | Teva Pharmaceutical Industries Limited | Process for producing levetiracetam |
| EP1663968A1 (en) * | 2003-09-05 | 2006-06-07 | Ranbaxy Laboratories Limited | Process for the preparation of pure levetiracetam |
| WO2007080470A2 (en) * | 2006-01-16 | 2007-07-19 | Orchid Chemicals & Pharmaceuticals Limited | A method for the purification of levetiracetam |
-
2008
- 2008-08-21 WO PCT/IN2008/000523 patent/WO2009057137A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009057137A3 (en) | 2009-08-06 |
| WO2009057137A2 (en) | 2009-05-07 |
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