WO2009053256A3 - Process for the production of beta lactam crystals - Google Patents

Process for the production of beta lactam crystals Download PDF

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Publication number
WO2009053256A3
WO2009053256A3 PCT/EP2008/063604 EP2008063604W WO2009053256A3 WO 2009053256 A3 WO2009053256 A3 WO 2009053256A3 EP 2008063604 W EP2008063604 W EP 2008063604W WO 2009053256 A3 WO2009053256 A3 WO 2009053256A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
beta lactam
crystals
lactam crystals
giving
Prior art date
Application number
PCT/EP2008/063604
Other languages
French (fr)
Other versions
WO2009053256A2 (en
Inventor
Joan Cabre
Rafael Garcia
Pere Lloveras
Original Assignee
Sandoz Ag
Joan Cabre
Rafael Garcia
Pere Lloveras
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag, Joan Cabre, Rafael Garcia, Pere Lloveras filed Critical Sandoz Ag
Publication of WO2009053256A2 publication Critical patent/WO2009053256A2/en
Publication of WO2009053256A3 publication Critical patent/WO2009053256A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/14—Preparation of salts
    • C07D499/16—Preparation of salts of alkali or alkaline earth metals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

An improved process for the production of Sulbactam Sodium characterised in that aqueous Isopropyl Alcohol is used as crystallisation medium. The crystals thus obtained can be smoothly dried, giving a content of residual solvent lower than 0.1%.
PCT/EP2008/063604 2007-10-22 2008-10-10 Process for the production of beta lactam crystals WO2009053256A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07118997 2007-10-22
EP07118997.1 2007-10-22

Publications (2)

Publication Number Publication Date
WO2009053256A2 WO2009053256A2 (en) 2009-04-30
WO2009053256A3 true WO2009053256A3 (en) 2009-07-09

Family

ID=39272408

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/063604 WO2009053256A2 (en) 2007-10-22 2008-10-10 Process for the production of beta lactam crystals

Country Status (1)

Country Link
WO (1) WO2009053256A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103113390B (en) * 2013-03-12 2014-10-08 四川省惠达药业有限公司 Sulbactam sodium compound and medical composition of sulbactam sodium compound and mezlocillin sodium
CN103127114B (en) * 2013-03-12 2014-02-26 四川省惠达药业有限公司 Medicinal composition including piperacillin sodium and sulbactam sodium
CN104876946A (en) * 2015-04-30 2015-09-02 王雪雁 Sulbactam compound for treating infectious diseases, and preparation method therefor
CN104958318A (en) * 2015-08-04 2015-10-07 青岛蓝盛洋医药生物科技有限责任公司 Medicinal sulbactam sodium composition for treating infectious diseases
CN111233893A (en) * 2020-03-13 2020-06-05 山东二叶制药有限公司 Preparation process of sulbactam sodium

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2461949A (en) * 1944-06-13 1949-02-15 Squibb & Sons Inc Method of obtaining a crystalline sodium penicillin
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
PL163690B1 (en) * 1990-07-02 1994-04-29 Inst Farmaceutyczny Method of obtaining sodium salt of penicillanic acid 1,1-dioxide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2461949A (en) * 1944-06-13 1949-02-15 Squibb & Sons Inc Method of obtaining a crystalline sodium penicillin
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
PL163690B1 (en) * 1990-07-02 1994-04-29 Inst Farmaceutyczny Method of obtaining sodium salt of penicillanic acid 1,1-dioxide

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1 April 1998 (1998-04-01), XP002476497, retrieved from STN Database accession no. 128:257257(DN) *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 12 October 2006 (2006-10-12), XP002476499, retrieved from STN Database accession no. 146:487109(DN) *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 15 July 1995 (1995-07-15), XP002476498, retrieved from STN Database accession no. 123:55588(DN) *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 28 February 2007 (2007-02-28), XP002476501, retrieved from STN Database accession no. 148:191748(DN) *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 5 April 1987 (1987-04-05), XP002476500, retrieved from STN Database accession no. 106:101926(DN) *
LIST, P.H., HÖRHAMMER, L., EDITORS: "HAGERS HANDBUCH DER PHARMAZEUTISCHEN PRAXIS", 1971, SPRINGER-VERLAG, BERLIN, XP002476496 *
LU, YE ET AL: "IMPROVEMENT OF CRYSTALIZATION OF SULBACTAM SODIUM", HEILONGJIANG YIYAO, vol. 19, no. 3, 2006, pages 185 - 186, XP008090259 *
QIU, FANG-LI ET AL, HUAXUE SHIJIE, vol. 47, no. 2, 2006, pages 99 - 101, XP008090122 *
VLASE CRISTINA ET AL, REVISTA DE CHIMIE, BUCHAREST, RO, vol. 49, no. 2, 1998, pages 96 - 101, XP008090123, ISSN: 0034-7752 *
YOU, JINYING ET AL, KANGSHENGSU, vol. 11, no. 4, 1986, pages 363 - 365, XP008090204 *

Also Published As

Publication number Publication date
WO2009053256A2 (en) 2009-04-30

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