WO2009053091A3 - Method and test kit for investigating biological processes at the interface between an implant and bone/soft tissues - Google Patents

Method and test kit for investigating biological processes at the interface between an implant and bone/soft tissues Download PDF

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Publication number
WO2009053091A3
WO2009053091A3 PCT/EP2008/009023 EP2008009023W WO2009053091A3 WO 2009053091 A3 WO2009053091 A3 WO 2009053091A3 EP 2008009023 W EP2008009023 W EP 2008009023W WO 2009053091 A3 WO2009053091 A3 WO 2009053091A3
Authority
WO
WIPO (PCT)
Prior art keywords
implant
bone
interface
test kit
soft tissues
Prior art date
Application number
PCT/EP2008/009023
Other languages
French (fr)
Other versions
WO2009053091A2 (en
Inventor
Felicia Suska
Peter Thomsen
M M Omar Omar
Christer Slotte
Ulf Nannmark
Jan Hall
Stina Wigren
Neven Zorics
Maria Lenneras
Original Assignee
Nobel Biocare Services Ag
Felicia Suska
Peter Thomsen
M M Omar Omar
Christer Slotte
Ulf Nannmark
Jan Hall
Stina Wigren
Neven Zorics
Maria Lenneras
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobel Biocare Services Ag, Felicia Suska, Peter Thomsen, M M Omar Omar, Christer Slotte, Ulf Nannmark, Jan Hall, Stina Wigren, Neven Zorics, Maria Lenneras filed Critical Nobel Biocare Services Ag
Publication of WO2009053091A2 publication Critical patent/WO2009053091A2/en
Publication of WO2009053091A3 publication Critical patent/WO2009053091A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to a method for investigating cellular and molecular processes at the interface between an implant and bone/soft tissues. A preferred embodiment comprises the steps of a) collecting crevicular fluid from sulcus around a tooth or an implant, b) extracting RNA from the fluid, c) means for generating cDNA using RNA as template and d) providing a gene expression analysis, preferably by means of qPCR technique. The invention also comprises a test kit for carrying out the method.
PCT/EP2008/009023 2007-10-24 2008-10-24 Method and test kit for investigating biological processes at the interface between an implant and bone/soft tissues WO2009053091A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0702379 2007-10-24
SESE0702379-9 2007-10-24

Publications (2)

Publication Number Publication Date
WO2009053091A2 WO2009053091A2 (en) 2009-04-30
WO2009053091A3 true WO2009053091A3 (en) 2009-07-02

Family

ID=40266128

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/009023 WO2009053091A2 (en) 2007-10-24 2008-10-24 Method and test kit for investigating biological processes at the interface between an implant and bone/soft tissues

Country Status (1)

Country Link
WO (1) WO2009053091A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102895652B (en) * 2011-07-27 2014-07-09 东北师范大学 Method for promoting osteoblast differentiation by using Runx2 and Osterix and application thereof
GB201302257D0 (en) * 2013-02-08 2013-03-27 Nobel Biocare Services Ag Method for measuring bone loss rate
RU2554229C1 (en) * 2014-01-24 2015-06-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации Method for diagnostic tissue biopsy in dental implant
CN117169521A (en) * 2023-08-25 2023-12-05 暨南大学附属第一医院（广州华侨医院） Mass spectrum negative ion mode metabonomics biomarker for peri-implant inflammation and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050170369A1 (en) * 2004-02-02 2005-08-04 Hitomi Shimpuku-Nosaka Methods for diagnosing a genetic risk for bone loss
WO2005098032A1 (en) * 2004-04-08 2005-10-20 Lutz-Henning Block Method of diagnosing osseointegration of artificial dental implants by means of gene arrays

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050170369A1 (en) * 2004-02-02 2005-08-04 Hitomi Shimpuku-Nosaka Methods for diagnosing a genetic risk for bone loss
WO2005098032A1 (en) * 2004-04-08 2005-10-20 Lutz-Henning Block Method of diagnosing osseointegration of artificial dental implants by means of gene arrays

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ATAOGLU HANIFE ET AL: "Interleukin-1beta, tumor necrosis factor-alpha levels and neutrophil elastase activity in peri-implant crevicular fluid.", CLINICAL ORAL IMPLANTS RESEARCH OCT 2002, vol. 13, no. 5, October 2002 (2002-10-01), pages 470 - 476, XP002512829, ISSN: 0905-7161 *
CORNELINI ROBERTO ET AL: "Transforming growth factor-beta 1 expression in the peri-implant soft tissues of healthy and failing dental implants.", JOURNAL OF PERIODONTOLOGY, vol. 74, no. 4, April 2003 (2003-04-01), pages 446 - 450, XP008101250, ISSN: 0022-3492 *
DU C ET AL: "Apatite/amelogenin coating on titanium promotes osteogenic gene expression", JOURNAL OF DENTAL RESEARCH, vol. 84, no. 11, November 2005 (2005-11-01), pages 1070 - 1074, XP002512458, ISSN: 0022-0345 *
OGAWA T ET AL: "Genes differentially expressed in titanium implant healing", JOURNAL OF DENTAL RESEARCH, vol. 85, no. 6, June 2006 (2006-06-01), pages 566 - 570, XP002512459, ISSN: 0022-0345 *
OGAWA TAKAHIRO ET AL: "Different bone integration profiles of turned and acid-etched implants associated with modulated expression of extracellular matrix genes.", THE INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS 2003 MAR-APR, vol. 18, no. 2, March 2003 (2003-03-01), pages 200 - 210, XP008101263, ISSN: 0882-2786 *
OGAWA TAKAHIRO ET AL: "Modulated bone matrix-related gene expression is associated with differences in interfacial strength of different implant surface roughness.", JOURNAL OF PROSTHODONTICS : OFFICIAL JOURNAL OF THE AMERICAN COLLEGE OF PROSTHODONTISTS DEC 2002, vol. 11, no. 4, December 2002 (2002-12-01), pages 241 - 247, XP008101156, ISSN: 1059-941X *
SUGITA NORIKO ET AL: "Characterization of complement receptor type 1 and type 3 mRNA expression on polymorphonuclear leucocytes (neutrophils) in gingival crevicular fluid from periodontitis-affected patients", ARCHIVES OF ORAL BIOLOGY, vol. 42, no. 2, 1997, pages 113 - 120, XP002512460, ISSN: 0003-9969 *
ZHANG TING ET AL: "Gene expression of four adhesive proteins in the early healing of bone defect and bone-implant interface.", CONFERENCE PROCEEDINGS : ... ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. CONFERENCE 2006, vol. 1, 2006, pages 2087 - 2090, XP002512457, ISSN: 1557-170X *

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Publication number Publication date
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