WO2009049961A3 - Nouveaux dérivés d'aspirine donneurs no - Google Patents

Nouveaux dérivés d'aspirine donneurs no Download PDF

Info

Publication number
WO2009049961A3
WO2009049961A3 PCT/EP2008/061596 EP2008061596W WO2009049961A3 WO 2009049961 A3 WO2009049961 A3 WO 2009049961A3 EP 2008061596 W EP2008061596 W EP 2008061596W WO 2009049961 A3 WO2009049961 A3 WO 2009049961A3
Authority
WO
WIPO (PCT)
Prior art keywords
new
aspirin derivatives
donor
derivatives
donor aspirin
Prior art date
Application number
PCT/EP2008/061596
Other languages
English (en)
Other versions
WO2009049961A2 (fr
Inventor
Roberta Fruttero
Alberto Gasco
Loretta Lazzarato
Monica Donnola
Barbara Rolando
Stefano Biondi
Original Assignee
Nicox Sa
Roberta Fruttero
Alberto Gasco
Loretta Lazzarato
Monica Donnola
Barbara Rolando
Stefano Biondi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa, Roberta Fruttero, Alberto Gasco, Loretta Lazzarato, Monica Donnola, Barbara Rolando, Stefano Biondi filed Critical Nicox Sa
Priority to JP2010529313A priority Critical patent/JP2011500619A/ja
Priority to EP08803567A priority patent/EP2200967A2/fr
Priority to CA2700243A priority patent/CA2700243A1/fr
Priority to US12/679,594 priority patent/US20100210694A1/en
Publication of WO2009049961A2 publication Critical patent/WO2009049961A2/fr
Publication of WO2009049961A3 publication Critical patent/WO2009049961A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La présente invention concerne des dérivés d'aspirine donneurs NO, un procédé destiné à leur préparation et des compositions pharmaceutiques les contenant.
PCT/EP2008/061596 2007-10-19 2008-09-03 Nouveaux dérivés d'aspirine donneurs no WO2009049961A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2010529313A JP2011500619A (ja) 2007-10-19 2008-09-03 新規なｎｏ−供与アスピリン誘導体
EP08803567A EP2200967A2 (fr) 2007-10-19 2008-09-03 Nouveaux derives d'aspirine donneurs no
CA2700243A CA2700243A1 (fr) 2007-10-19 2008-09-03 Nouveaux derives d'aspirine donneurs no
US12/679,594 US20100210694A1 (en) 2007-10-19 2008-09-03 New no-donor aspirin derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96091207P 2007-10-19 2007-10-19
US60/960,912 2007-10-19

Publications (2)

Publication Number Publication Date
WO2009049961A2 WO2009049961A2 (fr) 2009-04-23
WO2009049961A3 true WO2009049961A3 (fr) 2009-06-25

Family

ID=40428035

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/061596 WO2009049961A2 (fr) 2007-10-19 2008-09-03 Nouveaux dérivés d'aspirine donneurs no

Country Status (6)

Country Link
US (1) US20100210694A1 (fr)
EP (1) EP2200967A2 (fr)
JP (1) JP2011500619A (fr)
AR (1) AR071638A1 (fr)
CA (1) CA2700243A1 (fr)
WO (1) WO2009049961A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20111818A1 (it) * 2011-10-06 2013-04-07 Nicox Sa Derivati dell'aspirina donatori di ossido nitrico
CN103687843B (zh) * 2011-10-24 2016-11-16 尼科斯科学爱尔兰公司 醌基一氧化氮供体化合物
CN104350052B (zh) 2012-05-31 2017-05-31 施万生物制药研发Ip有限责任公司 一氧化氮供体脑啡肽酶抑制剂
CN104119289B (zh) * 2014-07-16 2016-08-17 成都丽凯手性技术有限公司 一种合成氧化呋咱化合物的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2359110A1 (fr) * 1976-07-21 1978-02-17 Rohm & Haas Derives de l'acide salicylique, leur obtention et compositions pharmaceutiques les contenant
US5859053A (en) * 1995-05-02 1999-01-12 Bayer Aktiengesellschaft Acetylsalicylic acid nitrates

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2359110A1 (fr) * 1976-07-21 1978-02-17 Rohm & Haas Derives de l'acide salicylique, leur obtention et compositions pharmaceutiques les contenant
US5859053A (en) * 1995-05-02 1999-01-12 Bayer Aktiengesellschaft Acetylsalicylic acid nitrates

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHIROLI V ET AL: "Nitric oxide-donating non-steroidal anti-inflammatory drugs: the case of nitroderivatives of aspirin", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 38, no. 4, 1 April 2003 (2003-04-01), pages 441 - 446, XP004425019, ISSN: 0223-5234 *
CLARA CENA AND CO, JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, 2003, pages 747 - 754, XP002520872 *
GILMER ET AL: "Evaluation of nitrate-substituted pseudocholine esters of aspirin as potential nitro-aspirins", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 17, no. 11, 10 May 2007 (2007-05-10), pages 3217 - 3220, XP022068425, ISSN: 0960-894X *
NIELSEN N M ET AL: "EVALUATION OF GLYCOLAMIDE ESTERS AND VARIOUS OTHER ESTERS OF ASPIRIN AS TRUE ASPIRIN PRODRUGS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON.; US, vol. 3, no. 32, 1 January 1989 (1989-01-01), pages 727 - 734, XP001076610, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
WO2009049961A2 (fr) 2009-04-23
US20100210694A1 (en) 2010-08-19
JP2011500619A (ja) 2011-01-06
CA2700243A1 (fr) 2009-04-23
EP2200967A2 (fr) 2010-06-30
AR071638A1 (es) 2010-07-07

Similar Documents

Publication Publication Date Title
AP2384A (en) 1,2,4,5-tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them.
WO2009084024A3 (fr) Procédé pour la préparation de r-sitagliptine et de ses sels pharmaceutiquement acceptables
WO2008037716A3 (fr) Compositions pharmaceutiques
WO2007093627A3 (fr) Composition biocide
IL216171A (en) Lipidic Compound, Method for Preparing the Compound, Pharmaceutical and Lipid Preparations Containing Their Composition and Uses
WO2010015657A3 (fr) Nouveaux alcoxypyrazoles
WO2010031720A3 (fr) Nouvelle formulation d’anticorps
IL184562A (en) Polymorph ivandront a, a process for its preparation and pharmaceutical preparations containing it
AP2011005935A0 (en) New Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions comprising them.
WO2006134021A3 (fr) Procede de preparation de nouveaux sels de tiotropium, nouveaux sels de tiotropium en tant que tels et compositions pharmaceutiques associees
WO2008129501A3 (fr) Compositions pharmaceutiques de duloxetine
HK1096386A1 (en) Indanyl-piperazine compounds, a process for their preparation and pharmaceutical compositions containing them
WO2009022327A3 (fr) Nouveau procédé de préparation de lévocétirizine de pureté élevée et de ses sels
AP2007004223A0 (en) Novel phenyl-pyridinyl-piperazine derivatives, a method for the production thereof and pharmaceutical compositions containing said derivatives
WO2010012459A3 (fr) Procédé de préparation de sels de solifénacine et inclusion de ces derniers dans des formes pharmaceutiques
SI2231598T1 (sl) Novi derivati diazeniumdiolata postopek pripravele teh in njihovi farmacevtski sestavki
WO2009051417A3 (fr) Dérivés de lactame phénanthrène présentant une activité anticancéreuse et procédé de préparation de ceux-ci
WO2009049961A3 (fr) Nouveaux dérivés d'aspirine donneurs no
WO2008034912A3 (fr) Procédé de synthèse du clopidogrel et nouvelles formes de sels pharmaceutiquement acceptables de celui-ci
ZA200902414B (en) Indole derivatives, process for the preparation thereof and pharmaceutical compositions containing them
HK1126190A1 (en) Novel pyridinylaminoalkylene- and pyridinyloxyalkylene-cyclopropanamines, process for the preparation thereof and pharmaceutical compositions containing them
ZA200706067B (en) Production process for NSAID-containing lozenges, their compositions, their medicinal use
ZA200603809B (en) Phenylpyridylpiperazine compounds, a process for their preparation and pharmaceutical compositions containing them
WO2009013594A3 (fr) Procédé de préparation de compositions solides à libération contrôlée contenant de l'oxcarbazépine, et compositions obtenues par ce procédé
WO2009007747A3 (fr) Nouveaux composés

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08803567

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2700243

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 12679594

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2010529313

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008803567

Country of ref document: EP