WO2009048532A3 - Formation of particles for ultrasound application, drug release, and other uses, and microfluidic methods of preparation - Google Patents

Formation of particles for ultrasound application, drug release, and other uses, and microfluidic methods of preparation Download PDF

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Publication number
WO2009048532A3
WO2009048532A3 PCT/US2008/011456 US2008011456W WO2009048532A3 WO 2009048532 A3 WO2009048532 A3 WO 2009048532A3 US 2008011456 W US2008011456 W US 2008011456W WO 2009048532 A3 WO2009048532 A3 WO 2009048532A3
Authority
WO
WIPO (PCT)
Prior art keywords
emulsions
particles
formation
preparation
drug release
Prior art date
Application number
PCT/US2008/011456
Other languages
French (fr)
Other versions
WO2009048532A2 (en
Inventor
Howard A. Stone
Jiandi Wan
Matthew Sullivan
Original Assignee
President And Fellows Of Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by President And Fellows Of Harvard College filed Critical President And Fellows Of Harvard College
Publication of WO2009048532A2 publication Critical patent/WO2009048532A2/en
Publication of WO2009048532A3 publication Critical patent/WO2009048532A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying

Abstract

The present invention generally relates to emulsions and, in particular, to systems and methods for forming multiple emulsions and emulsions produced therefrom. A multiple emulsion generally describes a larger droplet that contains one or more smaller droplets therein which, in some cases, can contain even smaller droplets therein, etc. Multiple emulsions can be formed in certain embodiments with generally precise repeatability, and can be tailored to include any number of inner droplets, in any desired nesting arrangement, within a single outer droplet. In some cases, one (or more) of the fluids can be a gas. In addition, in some embodiments, the size of the multiple emulsion can be varied.
PCT/US2008/011456 2007-10-05 2008-10-03 Formation of particles for ultrasound application, drug release, and other uses, and microfluidic methods of preparation WO2009048532A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99799407P 2007-10-05 2007-10-05
US60/997,994 2007-10-05

Publications (2)

Publication Number Publication Date
WO2009048532A2 WO2009048532A2 (en) 2009-04-16
WO2009048532A3 true WO2009048532A3 (en) 2009-09-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/011456 WO2009048532A2 (en) 2007-10-05 2008-10-03 Formation of particles for ultrasound application, drug release, and other uses, and microfluidic methods of preparation

Country Status (1)

Country Link
WO (1) WO2009048532A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN102892704A (en) * 2010-03-30 2013-01-23 巴黎综合理工学院 Device for forming drops in microfluidic circuit

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EP1861194A2 (en) 2005-03-04 2007-12-05 The President and Fellows of Harvard College Method and apparatus for forming multiple emulsions
FR2948024B1 (en) * 2009-07-17 2020-01-10 Centre National De La Recherche Scientifique - Cnrs - ULTRASOUND ACTIVABLE EMULSION AND MANUFACTURING METHOD THEREOF.
JP5869482B2 (en) 2009-09-02 2016-02-24 プレジデント アンド フェローズ オブ ハーバード カレッジ Multiple emulsions produced using jetting and other techniques
BR112012004715A2 (en) * 2009-09-02 2017-05-23 Basf Se multiple emulsions created by using joints
WO2011046443A1 (en) * 2009-10-15 2011-04-21 Vivid As Ultrasound triggered controlled release drug delivery
WO2011056389A2 (en) * 2009-11-03 2011-05-12 Manuel Marquez Method of making an artificial micro-gland using taxis
AR080405A1 (en) * 2010-03-17 2012-04-04 Basf Se EMULSIFICATION TO FOUND
KR20140034242A (en) 2011-05-23 2014-03-19 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Control of emulsions, including multiple emulsions
US20140220350A1 (en) 2011-07-06 2014-08-07 President And Fellows Of Harvard College Multiple emulsions and techniques for the formation of multiple emulsions
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
MX364957B (en) 2012-08-14 2019-05-15 10X Genomics Inc Microcapsule compositions and methods.
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US20150376609A1 (en) 2014-06-26 2015-12-31 10X Genomics, Inc. Methods of Analyzing Nucleic Acids from Individual Cells or Cell Populations
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2894694C (en) 2012-12-14 2023-04-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2900481A1 (en) 2013-02-08 2014-08-14 10X Genomics, Inc. Polynucleotide barcode generation
CN103240043B (en) * 2013-05-09 2014-08-13 四川大学 Preparation method of monodisperse multicomponent multiple emulsion
AU2015243445B2 (en) 2014-04-10 2020-05-28 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
US11065348B2 (en) 2014-06-19 2021-07-20 The Trustees Of The University Of Pennsylvania Apparatus and methods for making recombinant protein-stabilized monodisperse microbubbles
US20160122817A1 (en) 2014-10-29 2016-05-05 10X Genomics, Inc. Methods and compositions for targeted nucleic acid sequencing
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
US10551610B2 (en) 2014-12-24 2020-02-04 National Research Council Of Canada Alignment and rotation of Janus microparticles in response to acceleration
EP3237556B1 (en) 2014-12-24 2023-06-07 National Research Council of Canada Microparticles and apparatus for smart ink production
SG11201705615UA (en) 2015-01-12 2017-08-30 10X Genomics Inc Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
EP3262407B1 (en) 2015-02-24 2023-08-30 10X Genomics, Inc. Partition processing methods and systems
EP3262188B1 (en) 2015-02-24 2021-05-05 10X Genomics, Inc. Methods for targeted nucleic acid sequence coverage
SG11201804086VA (en) 2015-12-04 2018-06-28 10X Genomics Inc Methods and compositions for nucleic acid analysis
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
EP3481540B1 (en) * 2016-07-08 2022-12-21 President and Fellows of Harvard College Formation of colloids or gels within droplets
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP4029939B1 (en) 2017-01-30 2023-06-28 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US10400235B2 (en) 2017-05-26 2019-09-03 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
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CN102892704A (en) * 2010-03-30 2013-01-23 巴黎综合理工学院 Device for forming drops in microfluidic circuit

Also Published As

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