WO2009048073A1 - Method of coating granules - Google Patents
Method of coating granules Download PDFInfo
- Publication number
- WO2009048073A1 WO2009048073A1 PCT/JP2008/068291 JP2008068291W WO2009048073A1 WO 2009048073 A1 WO2009048073 A1 WO 2009048073A1 JP 2008068291 W JP2008068291 W JP 2008068291W WO 2009048073 A1 WO2009048073 A1 WO 2009048073A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- water
- coating
- organic solvent
- active substance
- physiologically active
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Abstract
It is intended to provide a coating method wherein the elution profile of the principle agent from granules containing a physiologically active substance is controlled by coating cores containing the physiologically active substance by spraying thereto a coating solution which contains a water-insoluble polymer, an organic solvent having a boiling point of 50oC or higher and water and in which the content ratio by weight of the organic solvent to the water is about 89/11 to about 50/50.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007263185 | 2007-10-09 | ||
JP2007-263185 | 2007-10-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009048073A1 true WO2009048073A1 (en) | 2009-04-16 |
Family
ID=40549217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/068291 WO2009048073A1 (en) | 2007-10-09 | 2008-10-08 | Method of coating granules |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009048073A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010280589A (en) * | 2009-06-03 | 2010-12-16 | Ohara Yakuhin Kogyo Kk | Method for producing particles containing bioactive substance |
JP2012046454A (en) * | 2010-08-27 | 2012-03-08 | Lion Corp | Tablet for internal use and method for producing the same |
WO2018045103A1 (en) * | 2016-08-30 | 2018-03-08 | Allergan, Inc. | Method of manufacturing coated beads |
US11078085B2 (en) | 2016-05-26 | 2021-08-03 | Allergan, Inc. | Production of rounded salt particles |
WO2023209606A1 (en) * | 2022-04-29 | 2023-11-02 | Illumina Cambridge Limited | Methods and systems for encapsulating lyophilised microspheres |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH021405A (en) * | 1988-03-31 | 1990-01-05 | Tanabe Seiyaku Co Ltd | Preparation of release control type and production thereof |
JPH05194225A (en) * | 1991-11-07 | 1993-08-03 | Yoshitomi Pharmaceut Ind Ltd | Stabilized antiulcer agent-containing preparation |
WO1994010983A1 (en) * | 1992-11-06 | 1994-05-26 | Hisamitsu Pharmaceutical Co., Inc. | Peroral pharmaceutical preparation releasable in lower digestive tract |
JPH08109126A (en) * | 1994-10-07 | 1996-04-30 | Amano Pharmaceut Co Ltd | Impact-resistant enteric granule and tablet containing the same |
JPH08259446A (en) * | 1995-01-24 | 1996-10-08 | Mitsui Toatsu Chem Inc | Sustained action pharmaceutical preparation |
JPH09295933A (en) * | 1996-03-07 | 1997-11-18 | Takeda Chem Ind Ltd | Composition for controlling release purpose |
JPH10231242A (en) * | 1997-02-20 | 1998-09-02 | Taiyo Yakuhin Kogyo Kk | Long-acting diclofenac sodium composition |
JP2002363080A (en) * | 2001-06-08 | 2002-12-18 | Towa Yakuhin Kk | Method for producing stable oral anti-ulcer preparation |
JP2007519741A (en) * | 2004-01-29 | 2007-07-19 | ヤマノウチ・ファーマ・テクノロジーズ・インク | Gastrointestinal specific multiple drug release system |
-
2008
- 2008-10-08 WO PCT/JP2008/068291 patent/WO2009048073A1/en active Application Filing
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH021405A (en) * | 1988-03-31 | 1990-01-05 | Tanabe Seiyaku Co Ltd | Preparation of release control type and production thereof |
JPH05194225A (en) * | 1991-11-07 | 1993-08-03 | Yoshitomi Pharmaceut Ind Ltd | Stabilized antiulcer agent-containing preparation |
WO1994010983A1 (en) * | 1992-11-06 | 1994-05-26 | Hisamitsu Pharmaceutical Co., Inc. | Peroral pharmaceutical preparation releasable in lower digestive tract |
JPH08109126A (en) * | 1994-10-07 | 1996-04-30 | Amano Pharmaceut Co Ltd | Impact-resistant enteric granule and tablet containing the same |
JPH08259446A (en) * | 1995-01-24 | 1996-10-08 | Mitsui Toatsu Chem Inc | Sustained action pharmaceutical preparation |
JPH09295933A (en) * | 1996-03-07 | 1997-11-18 | Takeda Chem Ind Ltd | Composition for controlling release purpose |
JPH10231242A (en) * | 1997-02-20 | 1998-09-02 | Taiyo Yakuhin Kogyo Kk | Long-acting diclofenac sodium composition |
JP2002363080A (en) * | 2001-06-08 | 2002-12-18 | Towa Yakuhin Kk | Method for producing stable oral anti-ulcer preparation |
JP2007519741A (en) * | 2004-01-29 | 2007-07-19 | ヤマノウチ・ファーマ・テクノロジーズ・インク | Gastrointestinal specific multiple drug release system |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010280589A (en) * | 2009-06-03 | 2010-12-16 | Ohara Yakuhin Kogyo Kk | Method for producing particles containing bioactive substance |
JP2012046454A (en) * | 2010-08-27 | 2012-03-08 | Lion Corp | Tablet for internal use and method for producing the same |
US11078085B2 (en) | 2016-05-26 | 2021-08-03 | Allergan, Inc. | Production of rounded salt particles |
WO2018045103A1 (en) * | 2016-08-30 | 2018-03-08 | Allergan, Inc. | Method of manufacturing coated beads |
WO2023209606A1 (en) * | 2022-04-29 | 2023-11-02 | Illumina Cambridge Limited | Methods and systems for encapsulating lyophilised microspheres |
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