WO2009048027A1 - Probe for detecting polymorphism in gene involved in immunity, and use thereof - Google Patents

Probe for detecting polymorphism in gene involved in immunity, and use thereof Download PDF

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Publication number
WO2009048027A1
WO2009048027A1 PCT/JP2008/068090 JP2008068090W WO2009048027A1 WO 2009048027 A1 WO2009048027 A1 WO 2009048027A1 JP 2008068090 W JP2008068090 W JP 2008068090W WO 2009048027 A1 WO2009048027 A1 WO 2009048027A1
Authority
WO
WIPO (PCT)
Prior art keywords
probe
seq
gene
polymorphism
detect
Prior art date
Application number
PCT/JP2008/068090
Other languages
French (fr)
Japanese (ja)
Inventor
Mitsuharu Hirai
Satoshi Majima
Original Assignee
Arkray, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arkray, Inc. filed Critical Arkray, Inc.
Priority to EP08837768A priority Critical patent/EP2130917A4/en
Priority to KR1020097005150A priority patent/KR101192008B1/en
Priority to CN2008800116369A priority patent/CN101652478B/en
Priority to US12/594,519 priority patent/US9157118B2/en
Priority to JP2009504927A priority patent/JP5290957B2/en
Publication of WO2009048027A1 publication Critical patent/WO2009048027A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/107—Temperature of melting, i.e. Tm
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

Disclosed is a polymorphism detection probe which can detect a polymorphism having a difference only by one nucleotide. At least one oligonucleotide selected from the group consisting of the sequences depicted in SEQ ID NO:4, SEQ ID NO:23, SEQ ID NO:30, SEQ ID NO:47, SEQ ID NO:57 and SEQ ID NO:64 is used as a probe for Tm analysis. The Tm analysis using the probe can detect a specific polymorphism in each of FCGR3A gene, FCGR2A gene, IL-10 gene, TNFα gene and TNFβ gene which are involved in the pharmacological effect of an antibody medicine or the like in a simple manner. When two or more types of the probe are allowed to co-exist in a reaction system, it becomes possible to detect two or more types of polymorphism in a single reaction system.
PCT/JP2008/068090 2007-10-09 2008-10-03 Probe for detecting polymorphism in gene involved in immunity, and use thereof WO2009048027A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08837768A EP2130917A4 (en) 2007-10-09 2008-10-03 Probe for detecting polymorphism in gene involved in immunity, and use thereof
KR1020097005150A KR101192008B1 (en) 2007-10-09 2008-10-03 Probe to detect of polymorphism of immunity-related gene and use thereof
CN2008800116369A CN101652478B (en) 2007-10-09 2008-10-03 Probe for detecting polymorphism in gene involved in immunity, and use thereof
US12/594,519 US9157118B2 (en) 2007-10-09 2008-10-03 Probes for detecting immune-related gene polymorphisms and applications of the same
JP2009504927A JP5290957B2 (en) 2007-10-09 2008-10-03 Probes for detecting polymorphisms in immune-related genes and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007263713 2007-10-09
JP2007-263713 2007-10-09

Publications (1)

Publication Number Publication Date
WO2009048027A1 true WO2009048027A1 (en) 2009-04-16

Family

ID=40549173

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/068090 WO2009048027A1 (en) 2007-10-09 2008-10-03 Probe for detecting polymorphism in gene involved in immunity, and use thereof

Country Status (6)

Country Link
US (1) US9157118B2 (en)
EP (1) EP2130917A4 (en)
JP (1) JP5290957B2 (en)
KR (1) KR101192008B1 (en)
CN (1) CN101652478B (en)
WO (1) WO2009048027A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120124029A (en) * 2011-05-02 2012-11-12 아크레이 가부시키가이샤 Probe for detecting polymorphism, method of detecting polymorphism, method of evaluating drug efficacy and reagent kit for detecting polymorphism

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WO2012061814A1 (en) * 2010-11-05 2012-05-10 Transgenomic, Inc. Pcr primers and methods for rapid and specific genotyping
CN103276078B (en) * 2013-05-28 2014-11-05 中国人民解放军第三军医大学第三附属医院 Cytokine gene SNP genetic marker detection kit and using method thereof
EP3415636B1 (en) * 2016-02-09 2020-11-25 Eiken Kagaku Kabushiki Kaisha Method for detecting target nucleic acid and nucleic acid probe used therein
CN106399582B (en) * 2016-12-20 2019-12-24 上海杏园瑞民生物工程有限公司 Kit for detecting polymorphism of gene related to treatment sensitivity of targeted drug cetuximab for colorectal cancer and application of kit
WO2019013613A2 (en) * 2017-07-09 2019-01-17 Hakken Enterprise Sa De Cv Methods and kids for determining a risk of cancer
CN108330180A (en) * 2017-10-25 2018-07-27 广州和康医疗技术有限公司 A kind of method and kit carrying out genotype detection to the sites FCGR3A

Citations (1)

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WO2005123947A1 (en) 2004-06-15 2005-12-29 Universite Francois Rabelais Methods of assessing susceptibility to drug-induced thrombocytopenia

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JP4181232B2 (en) * 1997-07-18 2008-11-12 帝國製薬株式会社 Diclofenac sodium-containing oily external patch preparation
ATE493121T1 (en) * 1999-07-15 2011-01-15 Hisamitsu Pharmaceutical Co PERCUTANE ABSORBABLE PREPARATIONS
US20060051353A1 (en) * 2004-05-14 2006-03-09 Jean-Frederic Colombel Methods and compositions to evaluate antibody treatment response
JP2008500832A (en) * 2004-06-01 2008-01-17 サントル・オスピタリエ・レジオナル・エ・ユニヴェルシタイル・ドゥ・トゥール Methods for assessing treatment response to FCGR3A Gebotype (GEBOTYPE) and non-depleting antibodies
AU2006205571B2 (en) * 2005-01-13 2012-03-22 Progenika Biopharma, S.A. Methods and products for in vitro genotyping
GB0510790D0 (en) 2005-05-26 2005-06-29 Syngenta Crop Protection Ag Anti-CD16 binding molecules
EP1801234A1 (en) * 2005-12-22 2007-06-27 Stichting Sanquin Bloedvoorziening Diagnostic methods involving determining gene copy numbers and use thereof

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WO2005123947A1 (en) 2004-06-15 2005-12-29 Universite Francois Rabelais Methods of assessing susceptibility to drug-induced thrombocytopenia

Non-Patent Citations (7)

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Title
"Dai 28 Kai Annual Meeting of the Molecular Biology Society of Japan Koen Yoshishu", 2005, article YUKARI KUREBAYASHI ET AL.: "Zenjido Idenshi Kaiseki Sochi o Mochiita Hito CYP2C19 no Iden Takei Kaiseki to Shinki Kaiseki System o Mochiita Databese no Kaihat", pages: 742, XP008116988 *
BUILLAUME CARTRON ET AL., BLOOD, vol. 99, no. 3, 1 February 2002 (2002-02-01)
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HATJIHARISSI E. ET AL: "Increased natural killer cell expression of CD16, augmented binding and ADCC activity to rituximab among individuals expressing the Fc?gamma? RIIIa-158 V/V and V/F polymorphism.", BLOOD, vol. 110, no. 7, 1 October 2007 (2007-10-01), pages 2561 - 2564, XP008117815 *
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120124029A (en) * 2011-05-02 2012-11-12 아크레이 가부시키가이샤 Probe for detecting polymorphism, method of detecting polymorphism, method of evaluating drug efficacy and reagent kit for detecting polymorphism
KR101581388B1 (en) 2011-05-02 2015-12-30 아크레이 가부시키가이샤 Probe for detecting polymorphism, method of detecting polymorphism, method of evaluating drug efficacy and reagent kit for detecting polymorphism

Also Published As

Publication number Publication date
EP2130917A4 (en) 2010-09-01
EP2130917A1 (en) 2009-12-09
KR101192008B1 (en) 2012-11-02
JP5290957B2 (en) 2013-09-18
JPWO2009048027A1 (en) 2011-02-17
CN101652478A (en) 2010-02-17
CN101652478B (en) 2013-03-27
US20100047806A1 (en) 2010-02-25
KR20090052353A (en) 2009-05-25
US9157118B2 (en) 2015-10-13

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