WO2009044273A2 - Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response - Google Patents
Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response Download PDFInfo
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- WO2009044273A2 WO2009044273A2 PCT/IB2008/002653 IB2008002653W WO2009044273A2 WO 2009044273 A2 WO2009044273 A2 WO 2009044273A2 IB 2008002653 W IB2008002653 W IB 2008002653W WO 2009044273 A2 WO2009044273 A2 WO 2009044273A2
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- Prior art keywords
- protein
- derivative
- recombinant lag
- use according
- lag
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
Description
Claims
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
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EP12196314.4A EP2601961B1 (en) | 2007-10-05 | 2008-10-03 | Compositions comprising LAG-3 and therapeutic antibodies and their uses in the treatment of cancer |
DK08836333.8T DK2205257T3 (en) | 2007-10-05 | 2008-10-03 | Dosage prescriptions for LAG-3Ig (IMP321) for use in the treatment of cancer |
JP2010527565A JP5908210B2 (en) | 2007-10-05 | 2008-10-03 | Use of recombinant LAG-3 protein or derivative thereof to elicit a monocyte immune response |
ES08836333.8T ES2437333T3 (en) | 2007-10-05 | 2008-10-03 | Dosage regimens of LAG-3Ig (IMP321) for use in cancer treatment |
PL12196314T PL2601961T3 (en) | 2007-10-05 | 2008-10-03 | Compositions comprising LAG-3 and therapeutic antibodies and their uses in the treatment of cancer |
EP19189911.1A EP3586863A1 (en) | 2007-10-05 | 2008-10-03 | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
CN202111358413.3A CN114159548A (en) | 2007-10-05 | 2008-10-03 | Use of recombinant LAG-3 or derivatives thereof for inducing a monocyte immune response |
AU2008306576A AU2008306576B2 (en) | 2007-10-05 | 2008-10-03 | Use of recombinant LAG-3 or the derivatives thereof for eliciting monocyte immune response |
US12/681,068 US9579382B2 (en) | 2007-10-05 | 2008-10-03 | Use of recombinant LAG-3 or the derivatives thereof for eliciting monocyte immune response |
PL12196316T PL2601962T3 (en) | 2007-10-05 | 2008-10-03 | LAG-3 dosage regime for use in the treatment of cancer |
CN200880117476A CN101873864A (en) | 2007-10-05 | 2008-10-03 | Be used to bring out the application of the reconstitution cell LAG-3 or derivatives thereof of mononuclear cell immunne response |
EP12196316.9A EP2601962B1 (en) | 2007-10-05 | 2008-10-03 | LAG-3 dosage regime for use in the treatement of cancer |
EP08836333.8A EP2205257B8 (en) | 2007-10-05 | 2008-10-03 | LAG-3Ig (IMP321) dosage regimes for use in the treatment of cancer |
US15/407,864 US10232038B2 (en) | 2007-10-05 | 2017-01-17 | Use of recombinant LAG-3 or the derivatives thereof for eliciting monocyte immune response |
US16/274,466 US11583582B2 (en) | 2007-10-05 | 2019-02-13 | Use of recombinant LAG-3 or the derivatives thereof for eliciting monocyte immune response |
US18/098,199 US20230149541A1 (en) | 2007-10-05 | 2023-01-18 | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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EP07291214.0 | 2007-10-05 | ||
EP07291214A EP2044949A1 (en) | 2007-10-05 | 2007-10-05 | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
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US12/681,068 A-371-Of-International US9579382B2 (en) | 2007-10-05 | 2008-10-03 | Use of recombinant LAG-3 or the derivatives thereof for eliciting monocyte immune response |
US15/407,864 Continuation US10232038B2 (en) | 2007-10-05 | 2017-01-17 | Use of recombinant LAG-3 or the derivatives thereof for eliciting monocyte immune response |
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WO2009044273A2 true WO2009044273A2 (en) | 2009-04-09 |
WO2009044273A3 WO2009044273A3 (en) | 2009-09-24 |
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PCT/IB2008/002653 WO2009044273A2 (en) | 2007-10-05 | 2008-10-03 | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
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US (4) | US9579382B2 (en) |
EP (7) | EP2044949A1 (en) |
JP (3) | JP5908210B2 (en) |
CN (3) | CN101873864A (en) |
AU (1) | AU2008306576B2 (en) |
DK (4) | DK2601962T3 (en) |
ES (4) | ES2744700T3 (en) |
NO (1) | NO2604275T3 (en) |
PL (3) | PL2604275T3 (en) |
PT (3) | PT2604275T (en) |
TR (1) | TR201900764T4 (en) |
WO (1) | WO2009044273A2 (en) |
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