WO2009037432A1 - Dispositif et procédé pour localiser des veines ou des artères - Google Patents

Dispositif et procédé pour localiser des veines ou des artères Download PDF

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Publication number
WO2009037432A1
WO2009037432A1 PCT/GB2008/003132 GB2008003132W WO2009037432A1 WO 2009037432 A1 WO2009037432 A1 WO 2009037432A1 GB 2008003132 W GB2008003132 W GB 2008003132W WO 2009037432 A1 WO2009037432 A1 WO 2009037432A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
patient
vein
artery
infrared
Prior art date
Application number
PCT/GB2008/003132
Other languages
English (en)
Inventor
Farhad Bybordi
Original Assignee
Talley Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Talley Group Limited filed Critical Talley Group Limited
Publication of WO2009037432A1 publication Critical patent/WO2009037432A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4887—Locating particular structures in or on the body
    • A61B5/489—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array

Definitions

  • the present invention relates to a device and method for locating veins or arteries.
  • the invention relates to a portable device for locating a vein or artery in tissue beneath the skin of a human or animal patient .
  • a medical care-giver can sometimes be difficult for a medical care-giver to locate a patient ' s vein or artery for the purpose of drawing blood, giving blood, or giving an intravenous injection.
  • Such injections might include injections of any medicated fluid into the vein or artery, such as simple saline solution, or complex antidotes and the like.
  • Visual location of a vein or artery using the human eye can be particularly difficult in patients with dark-coloured skin or in children, infants or others who have particularly thick layers of fat above their veins and arteries.
  • Abnormal skin masses can also lead to more difficulty in locating a vein or artery under the skin mass.
  • US 2006/0020212 describes a portable vein locating device which includes one or more infrared illuminators for transmission of infrared light through a patient's skin, and a vein imaging module for determining the location of a vein beneath the skin by detecting the absence of backscattered infrared light. As the device is passed over a patient's skin, infrared light from the infrared illuminators penetrates through the patient's skin and is absorbed by veins under the skin but scattered by the fat and other tissues surrounding the veins.
  • the vein imaging module which includes a number of infrared light detectors, for detecting the backscattered light, and a display, for indicating to the medical caregiver the location beneath the skin of detected veins.
  • the present invention seeks to provide an improved device for locating veins or arteries which provides various advantages over currently known devices .
  • a portable device for locating a vein or artery in tissue beneath the skin of a human or animal patient.
  • the device comprises: an infrared emitter for transmitting infrared radiation through the skin of the patient; an infrared detector for detecting reflected infrared radiation so as to identify a vein or artery location beneath the patient's skin; an indicator for indicating the identified vein or artery location; and an opening in the device arranged to allow marking of the patient's skin at the identified vein or artery location.
  • the infrared detector detects infrared radiation reflected from the patient's tissue. In contrast, infrared radiation is absorbed rather than reflected by the patient's veins and/or arteries.
  • the device assists a care giver by providing a quick approach to find any usable vein/artery which may not be detectable via touch or visual inspection.
  • the claimed device is particularly beneficial for those with dark skin, or having a high fat content, where standard techniques for vein/artery location are less successful .
  • the device uses non-invasive infrared technology to locate veins or arties in human or animal tissue. The location of a vein or artery is indicated to the user visually and/or audibly.
  • the device has an associated location marking means for marking the location of a viable vein or artery identified by the device.
  • This location marking means is in the form of an opening in the device at a suitable location relative to the infrared emitter/receiver that it can be used to insert a pen through to mark a vein/artery location directly onto the patient's skin. This makes it easy for a user to know exactly where to insert the needle/syringe. Alternatively, marking of veins/arteries could be used to allow a technician or surgeon to make a precision incision in a patient's skin without risking cutting through a major vein/artery and potentially causing unwanted bleeding.
  • the device is intended for use by professionals or other caregivers, such as home carers.
  • the indicator is operable to indicate an amount of reflected infrared radiation detected by the infrared detector such that a location which reflects a reduced amount of infrared radiation may be identified as a vein or artery location.
  • the opening comprises one or more of a notch, a slot and a hole.
  • the opening comprises a hole for marking a point location of the identified vein or artery on the patient's skin.
  • the opening comprises an elongate slot for marking a direction of the identified vein or artery on the patient's skin.
  • the slot may be an open slot.
  • the indicator comprises an audible indicator operable to sound when the amount of reflected infrared radiation detected by the infrared detector is below a predetermined threshold value.
  • the indicator comprises a visual indicator.
  • the visual indicator comprises a light emitting diode operable to illuminate when the amount of reflected infrared radiation detected by the infrared detector is below a predetermined threshold value.
  • the infrared detector comprises an array of infrared detector elements. More advantageously, the visual indicator comprises a display for displaying a spatial distribution of reflected infrared radiation- detected by the array of infrared detector elements.
  • the device further comprises a magnifying lens for enhanced visibility of the patient's skin by a user.
  • a method for locating a vein or artery in tissue beneath the skin of a human or animal patient comprises : providing a portable device having an infrared emitter, an infrared detector, an indicator and an opening; moving the device across the patient's skin; transmitting infrared radiation through the patient's skin with the infrared emitter; detecting reflected infrared radiation with the infrared detector so as to identify a vein or artery location beneath the patient's skin; indicating an identified vein or artery location with the indicator; and marking the patient's skin at the identified vein or artery location by inserting a marking device through the opening.
  • the marking device may be a pen or the like.
  • the indicator may be an audio indicator such as an alarm tone, or may be a visual indicator such as an LED or two-dimensional display screen.
  • the opening may include a hole and/or a slot.
  • the method comprises : providing a portable device having an infrared emitter, an infrared detector, an indicator and an opening; moving the device across the patient's skin; transmitting infrared radiation through the patient's skin with the infrared emitter; detecting reflected infrared radiation with the infrared detector so as to identify a vein or artery location beneath the patient's skin; indicating an identified vein or artery location with the indicator; and injecting the patient at the identified vein or artery location by inserting a needle or syringe into the patient's skin through the opening.
  • a fourth aspect of the present invention there is provided a method for locating an area of tissue free of veins or arteries beneath the skin of a human or animal patient.
  • the method comprises: providing a portable device having an infrared emitter, an infrared detector, an indicator and an opening; moving the device across the patient's skin; transmitting infrared radiation through the patient's skin with the infrared emitter; detecting reflected infrared radiation with the infrared detector so as to identify any vein or artery locations beneath the patient's skin; indicating any identified vein or artery location with the indicator; moving the device to an area of tissue free of veins or arteries beneath the patient's skin; and making an incision in the patient's skin in the area free of veins or arteries by inserting a cutting implement into the patient's skin through the opening.
  • the opening comprises a slot. More advantageously, the opening comprises an open slot.
  • Figure 1 shows top and bottom perspective views of a device in accordance with a first embodiment of the present invention.
  • Figure 2 shows top and bottom perspective views of a device in accordance with a second embodiment of the present invention.
  • Figures Ia and Ib show top and bottom perspective views respectively of a hand-held device 10 in accordance with a first embodiment of the invention.
  • the device 10 is portable and is ergonomically designed for ease of holding by the user.
  • the device generally approximates a pen or stylus in shape, being generally elongate and having a rounded tip 16.
  • the device is comprised of metallic or plastics injection-moulded parts which make it easy to manufacture, light-weight and also provide a high level of ruggedness.
  • the device 10 will continue to function after a drop of Im onto a concrete surface.
  • the device 10 comprises very few sub-assemblies, which makes it cheaper and easier to manufacture.
  • the device can be seen to have a top face 12 and a bottom face 14.
  • the terms “top” and “bottom” used herein are relative terms which are used for ease of description of the Figures. However, it will be appreciated that the device 10 could be stored or used in an alternative orientation such that the "top” face 12 of Figure Ia does not face substantially upwards. Thus, the terms “top” and “bottom” should not be construed to be limiting.
  • the device 10 extends in an elongate manner between first and second ends 16 and 18 respectively.
  • the first end 16 is _ the tip of the device 10. Between the two ends 16 and 18, the device comprises three consecutive portions 20, 22 and 24, as described below.
  • the first portion 20 includes the first end 16.
  • the first portion 20 comprises an infrared emitter/receiver 26.
  • the infrared emitter/receiver 26 includes two elongate arrays of emitter/receivers 26a and 26b disposed on the bottom face 14 of the device 10.
  • the two elongate arrays of emitter/receivers 26a and 26b extend substantially along the elongate axis of the device 10.
  • Such infrared ray technology has been used in many other medical and non-medical devices (e.g. TV remote controls, car remote locking devices) over the past 30 years. It is used in all manner of product applications and is harmless to humans/animals so is safe for human/animal use. Due to the low frequencies, the infrared technology is also very economical and draws low power from a battery.
  • the infrared emitter/receiver 26 comprises a plurality of emitting and receiving sensors which are configured to enable depth measurement to be achieved.
  • the first portion 20 further comprises a hole 28 and a slot 30 which each extend through the device 10 from the top face 12 to the bottom face 14.
  • the hole 28 is a relatively small aperture which is shown as being circular in Figure 1.
  • the hole is located close to the infrared emitter/receiver 26 on the bottom face 14 of the device 10.
  • the slot 30 is an elongate triangular shape which extends from first end 16 of the device 10 towards the hole 28.
  • the slot 30 is also located close to or in the vicinity of the infrared emitter/receiver 26.
  • the hole 28 lies on the lengthwise axis of the elongate slot 30.
  • the lengthwise axis of the slot 30 extends substantially along the elongate axis of the device 10 (i.e. it extends in the same direction as each of the elongate arrays of emitter/receivers 26a and 26b) .
  • the triangular slot 30 effectively forms an elongate arrow head pointing towards the hole 28 which identifies the vein location.
  • the hole 28 and the slot 30 allow and assist the user to mark or guide a syringe tip to the appropriate vein or artery location as discussed further below.
  • the second portion 22 includes visual and/or audio indicators which are responsive to the amount of infrared radiation received by the infrared emitter/receiver 26.
  • a single visual indicator is shown on the top face 12 of the device 10 in the form of an LED 32 which illuminates when a reduced amount of radiation is detected by the infrared emitter/receiver 26.
  • the illumination may be constant or flashing.
  • An audible tone may also sound from a microphone (not shown) on the device 10 when a reduced amount of radiation is detected by the infrared emitter/receiver 26.
  • the illumination may get brighter and/or the alarm tone may get louder as the device 10 gets closer to a viable vein, which is indicated by a decreasing overall amount of reflected radiation being detected by the infrared emitter/receiver 26.
  • the third portion 24 includes the second end 18.
  • the third portion 24 is essentially a handle portion to enable a user to easily grip or hold the device 10 by hand, but a user may alternatively/additionally hold the device using the second portion 22.
  • a clip 34 may optionally be provided for ease of storage of the device 10 in a pocket or the like.
  • the third portion 24 also has a panel 36 which may be removed to insert a battery (not shown) for powering the device 10.
  • the power source of the device 10 is a DC battery.
  • the panel 36 may be simply clipped in and out of place without the need for specialist tool .
  • a user holds the device 10 by hand using the second and/or third portions 22 and 24 as a handle. Being a hand-held device 10, the device 10 is easily portable by a user in a pocket or the like.
  • the user orients the device 10 such that the bottom face 14 is placed in contact with or just above the skin of a patient. In this way, the device 10 is oriented such that infrared emitter/receiver 26 is able to transmit infrared radiation through the skin of the patient. Tissue and blood have different absorption properties with respect to infrared radiation. Thus, in effect, the emitted infrared radiation is either reflected (i.e.
  • the infrared emitter/receiver 26 is operable to detect the amount of infrared radiation that has been reflected back by the patient's tissue. Therefore, when the device 10 is appropriately positioned above a vein or artery, there is relatively less infrared reflected infrared radiation detected by the infrared emitter/receiver 26 than when the device 10 is positioned above tissue only.
  • the LED 32 is operable to illuminate and an audible tone may also sound so as to indicate to the user a likely position of a vein or artery of the patient .
  • a marking device e.g. a pen
  • a pen may be inserted from above (i.e. from the top face 12 towards the bottom face 14) into the hole 28 to draw a point mark on the patient's skin.
  • the hole 28 enables the patient's skin to be marked at a suitable point location for inserting a syringe/needle into a vein or artery.
  • the device 10 may also be used to find the direction of the vein or artery beneath the patient's skin. This is accomplished by moving the device 10 across the patient's skin in the region of the identified vein location point. The device should be moved in a direction indicated by the arrow X in Figure Ia. In particular, the device should be moved in a direction corresponding to the primary axis of the elongate slot 30. If the LED 32 stops flashing, it is likely that the device 10 is being moved in a direction transverse to the direction of the vein or artery. In contrast, if the LED remains illuminated, it is likely that the device 10 is being moved in a direction along the identified vein or artery. In this case, the user may use - li ⁇
  • the pen to mark the vein or artery direction on the patient's skin.
  • the pen may be inserted from above (i.e. from the top face 12 towards the bottom face 14) into the slot 30 to draw a directional mark on the patient's skin.
  • the device 10 may then be put to one side and a needle or syringe may be inserted into the identified vein or artery of the patient by making use of the marks on the skin.
  • the needle or syringe may be inserted directly through the hole 28 or the slot 30 of the device 10 and into the patient's skin.
  • the hole 28 and/or the slot 30 are arranged to guide a syringe needle to the targeted vein location.
  • FIG. 2a A further embodiment of the device of the present invention is shown in the top and bottom perspective views in Figure 2a and 2b respectively. Similar reference numerals are used in Figure 2 as were used in Figure 1. Differences between the two embodiments are described below.
  • the slot 30 in Figure 2 is an open slot. In other words, the slot 30 is open at the tip end 16 of the device
  • the second portion 22 of the second embodiment includes visual and/or audio indicators which are responsive to the amount of infrared radiation received by the infrared emitter/receiver 26.
  • the same audible alarm may be provided to sound when a reduced overall amount of radiation is detected by the infrared emitter/receiver 26.
  • the embodiment of Figure 2 comprises a display 38 in the form of a liquid crystal display (LCD) .
  • a control PCB is also provided within the device. The control PCB receives and processes signals from the infrared emitter/receiver 26 so as to provide associated image data to be displayed on the display 38.
  • the display 38 provides a two-dimensional display of reflected infrared radiation. In the image shown on the display 38 there is therefore a contrast between the patient ' s tissue areas and any veins/arteries. Since a two-dimensional representation is provided, the display 38 enables the vein/artery direction to be ascertained. In other words, the display 38 depicts both vein/artery location and vein/artery direction in one simple image. As for the previous • embodiment , the vein/artery location may be marked on the patient ' s skin by inserting a pen through hole 28, and the vein/artery direction may be marked on the patient's skin by inserting a pen through slot 30 when the vein/artery on the display is aligned with the slot 30.
  • the user can view the physical shape of an identified vein/artery in terms of either its diameter or flow rate, and can thereby determine whether the particular vein/artery is suitable for needle puncture.
  • a technician or surgeon could make a precision incision into a patient's skin by inserting a cutting instrument through the slot 30 when the display 38 indicates that there is not a major vein/artery in the vicinity. This would prevent the possibility of unwanted bleeding of the patient due to the incision.
  • the display 38 can be either color or monochrome (e.g. black and white) .
  • An on/off switch 40 is also provided on the top face 12 of the second portion 22 of the device 10 in Figure 2a.
  • the third portion 24 is formed as a ring 42 with a central aperture 44 for receiving a magnifying glass or lens (not shown) .
  • the magnifying glass When inserted, the magnifying glass enables the user to magnify any skin type so as to more clearly see the skin surface, particularly in difficult lighting conditions. In other words, the magnifying lens provides improved visibility of the patient's skin for the user.
  • the device of the present invention in terms of location of veins/arteries beneath the surface of human/animal tissue.
  • the device could be used by fire fighters, paramedics, students, technicians, phlebotomists, nurses, doctors, veterinarians, and so on. Some such applications of the device are described further below.
  • Veterinary applications of the device are envisaged when the patient is an animal. In such cases, it may be necessary for the veterinarian to shave the animal ' s fur or hair before using the device. Alternatively, constructional changes could be incorporated to suit the presence of furry tissue .
  • a clinical/hospital variant is also envisaged. Such a variant would include the two-dimensional display feature as described above with reference to Figure 2. This variant would also include an interface for acceptance of invasive surgical devices. For example, differently shaped openings may be provided in addition to or instead of the hole 28 and the slot 30 described above.
  • a data export port could also be included to enable the display to be shown on a separate display device. This would enable the display to be larger in cases where fine resolution is required.
  • a military variant is also contemplated. This would be similar to the hospital version, but with more rugged construction.
  • a paediatric variant is also envisaged. Such a device would be similar to those described above, but with a higher degree of precision.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention décrit un dispositif portatif (10) destiné à localiser une veine ou une artère dans un tissu sous-cutané d'un sujet humain ou animal. Le dispositif comporte un émetteur infrarouge (26), un détecteur infrarouge (26), un indicateur (32) et une ouverture (28, 30). L'émetteur infrarouge émet un rayonnement infrarouge à travers la peau du patient. Le détecteur infrarouge détecte un rayonnement infrarouge réfléchi de façon à identifier l'emplacement de la veine ou de l'artère sous-cutanée du sujet. L'indicateur (32) indique l'emplacement identifié de la veine ou de l'artère. L'ouverture (28, 30) dans le dispositif est agencée pour permettre le marquage de la peau du patient à l'emplacement identifié de la veine ou de l'artère. L'invention décrit également des procédés de localisation d'une veine ou d'une artère dans un tissu sous-cutané d'un sujet humain ou animal.
PCT/GB2008/003132 2007-09-18 2008-09-16 Dispositif et procédé pour localiser des veines ou des artères WO2009037432A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85682607A 2007-09-18 2007-09-18
US11/856,826 2007-09-18

Publications (1)

Publication Number Publication Date
WO2009037432A1 true WO2009037432A1 (fr) 2009-03-26

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012126915A1 (fr) * 2011-03-22 2012-09-27 Novartis Ag Capteur
WO2013108209A1 (fr) * 2012-01-19 2013-07-25 Technion Research & Development Foundation Ltd. Système et méthode d'imagerie de vaisseau
US8780176B2 (en) 2008-08-15 2014-07-15 Technion Research & Development Foundation Limited Vessel imaging system and method
CN104068830A (zh) * 2014-07-24 2014-10-01 天津市鹰泰利安康医疗科技有限责任公司 一种双光血管显像仪
CN110269632A (zh) * 2019-06-17 2019-09-24 北京大学第一医院 一种动脉标注方法及医用动脉标注器
US20200230365A1 (en) * 2019-01-18 2020-07-23 Becton, Dickinson And Company Intravenous therapy system for blood vessel detection
US10962490B2 (en) 2015-12-28 2021-03-30 University Of Washington Methods for aligning a spectrometer
US20220031232A1 (en) * 2020-07-30 2022-02-03 Novotec Llc Vessel location assistance device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02172473A (ja) * 1988-12-26 1990-07-04 Akai Electric Co Ltd 静脈探査装置
JP2006102029A (ja) * 2004-10-04 2006-04-20 Matsushita Electric Ind Co Ltd 血管位置提示装置
US20070161909A1 (en) * 2006-01-10 2007-07-12 Ron Goldman Micro Vein Enhancer
US20080147147A1 (en) * 2006-12-18 2008-06-19 Medrad, Inc. Vein locating device for vascular access procedures

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02172473A (ja) * 1988-12-26 1990-07-04 Akai Electric Co Ltd 静脈探査装置
JP2006102029A (ja) * 2004-10-04 2006-04-20 Matsushita Electric Ind Co Ltd 血管位置提示装置
US20070161909A1 (en) * 2006-01-10 2007-07-12 Ron Goldman Micro Vein Enhancer
US20080147147A1 (en) * 2006-12-18 2008-06-19 Medrad, Inc. Vein locating device for vascular access procedures

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8780176B2 (en) 2008-08-15 2014-07-15 Technion Research & Development Foundation Limited Vessel imaging system and method
WO2012126915A1 (fr) * 2011-03-22 2012-09-27 Novartis Ag Capteur
US9415167B2 (en) 2011-03-22 2016-08-16 Novartis Ag Infrared skin detection sensor
WO2013108209A1 (fr) * 2012-01-19 2013-07-25 Technion Research & Development Foundation Ltd. Système et méthode d'imagerie de vaisseau
US10646160B2 (en) 2012-01-19 2020-05-12 Technion Research & Development Foundation Limited Vessel imaging system and method
US11850065B2 (en) 2012-01-19 2023-12-26 Technion Research & Development Foundation Limited Vessel imaging system and method
CN104068830A (zh) * 2014-07-24 2014-10-01 天津市鹰泰利安康医疗科技有限责任公司 一种双光血管显像仪
US10962490B2 (en) 2015-12-28 2021-03-30 University Of Washington Methods for aligning a spectrometer
US20200230365A1 (en) * 2019-01-18 2020-07-23 Becton, Dickinson And Company Intravenous therapy system for blood vessel detection
US11707603B2 (en) * 2019-01-18 2023-07-25 Becton, Dickinson And Company Intravenous therapy system for blood vessel detection
CN110269632A (zh) * 2019-06-17 2019-09-24 北京大学第一医院 一种动脉标注方法及医用动脉标注器
US20220031232A1 (en) * 2020-07-30 2022-02-03 Novotec Llc Vessel location assistance device

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