WO2009037342A3 - Formulation comprenant des agents de contraste pour irm contenant une polybase organique - Google Patents

Formulation comprenant des agents de contraste pour irm contenant une polybase organique Download PDF

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Publication number
WO2009037342A3
WO2009037342A3 PCT/EP2008/062550 EP2008062550W WO2009037342A3 WO 2009037342 A3 WO2009037342 A3 WO 2009037342A3 EP 2008062550 W EP2008062550 W EP 2008062550W WO 2009037342 A3 WO2009037342 A3 WO 2009037342A3
Authority
WO
WIPO (PCT)
Prior art keywords
formulation
mri
contrast agents
polybase
organic
Prior art date
Application number
PCT/EP2008/062550
Other languages
English (en)
Other versions
WO2009037342A2 (fr
Inventor
Marc Port
Original Assignee
Guerbet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet filed Critical Guerbet
Publication of WO2009037342A2 publication Critical patent/WO2009037342A2/fr
Publication of WO2009037342A3 publication Critical patent/WO2009037342A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

L'invention concerne une formulation d'agents de contraste qui contient un chélate formant un complexe avec un ion métallique paramagnétique et au moins une polybase organique.
PCT/EP2008/062550 2007-09-20 2008-09-19 Formulation comprenant des agents de contraste pour irm contenant une polybase organique WO2009037342A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0757716A FR2921271A1 (fr) 2007-09-20 2007-09-20 Formulation d'agents de contraste pour l'irm contenant une polybase organique
FR0757716 2007-09-20
US97422707P 2007-09-21 2007-09-21
US60/974,227 2007-09-21

Publications (2)

Publication Number Publication Date
WO2009037342A2 WO2009037342A2 (fr) 2009-03-26
WO2009037342A3 true WO2009037342A3 (fr) 2009-10-01

Family

ID=39204019

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/062550 WO2009037342A2 (fr) 2007-09-20 2008-09-19 Formulation comprenant des agents de contraste pour irm contenant une polybase organique

Country Status (2)

Country Link
FR (1) FR2921271A1 (fr)
WO (1) WO2009037342A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2786768A1 (fr) * 2013-04-04 2014-10-08 Agfa Healthcare Procédé de préparation d'un matériau comprenant un ligand macrocyclique et de production d'une formulation pharmaceutique comprenant ledit ligand avec un lanthanide
GB201421161D0 (en) * 2014-11-28 2015-01-14 Ge Healthcare As Metal complex formulations

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0263861B1 (fr) * 1986-04-11 1990-08-01 Guerbet S.A. Sel de lysine du complexe gadolinium-dota et ses applications au diagnostic
EP1106186A2 (fr) * 1999-12-08 2001-06-13 Mallinckrodt Inc. Bioconjugués non-covalents pour application dans la IRM
WO2006027244A2 (fr) * 2004-09-10 2006-03-16 Bracco Imaging S.P.A. Complexes metalliques paramagnetiques pour la visualisation en irm de polynucleotides internalises
WO2006088958A2 (fr) * 2005-02-15 2006-08-24 Dendritic Nanotechnologies, Inc. Polymeres dendritiques (chelate ou ligand) encapsules

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0263861B1 (fr) * 1986-04-11 1990-08-01 Guerbet S.A. Sel de lysine du complexe gadolinium-dota et ses applications au diagnostic
EP1106186A2 (fr) * 1999-12-08 2001-06-13 Mallinckrodt Inc. Bioconjugués non-covalents pour application dans la IRM
WO2006027244A2 (fr) * 2004-09-10 2006-03-16 Bracco Imaging S.P.A. Complexes metalliques paramagnetiques pour la visualisation en irm de polynucleotides internalises
WO2006088958A2 (fr) * 2005-02-15 2006-08-24 Dendritic Nanotechnologies, Inc. Polymeres dendritiques (chelate ou ligand) encapsules

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BELLIN M.-F.: "MR contrast agents, the old and the new", EUROPEAN JOURNAL OF RADIOLOGY, vol. 60, no. 3, December 2006 (2006-12-01), pages 314 - 323, XP002474466 *
CARAVAN P ET AL: "GADOLINIUM(III) CHELATES AS MRI CONTRAST AGENTS: STRUCTURE, DYNAMICS, AND APPLICATIONS", CHEMICAL REVIEWS, ACS,WASHINGTON, DC, US, vol. 99, 20 August 1999 (1999-08-20), pages 2293 - 2352, XP002375825, ISSN: 0009-2665 *
CHAN ET AL: "Small molecular gadolinium(III) complexes as MRI contrast agents for diagnostic imaging", COORDINATION CHEMISTRY REVIEWS, ELSEVIER SCIENCE, AMSTERDAM, NL, vol. 251, no. 17-20, 14 September 2007 (2007-09-14), pages 2428 - 2451, XP022247748, ISSN: 0010-8545 *
ZHANG Z ET AL: "GADOLINIUM MEETS MEDICINAL CHEMISTRY: MRI CONTRAST AGENT DEVELOPMENT", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 12, no. 7, 2005, pages 751 - 778, XP008051693, ISSN: 0929-8673 *

Also Published As

Publication number Publication date
FR2921271A1 (fr) 2009-03-27
WO2009037342A2 (fr) 2009-03-26

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