WO2009036925A1 - Procédé pour réduire les taches de vieillesse - Google Patents

Procédé pour réduire les taches de vieillesse Download PDF

Info

Publication number
WO2009036925A1
WO2009036925A1 PCT/EP2008/007483 EP2008007483W WO2009036925A1 WO 2009036925 A1 WO2009036925 A1 WO 2009036925A1 EP 2008007483 W EP2008007483 W EP 2008007483W WO 2009036925 A1 WO2009036925 A1 WO 2009036925A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
product applicator
active ingredient
product
spray head
Prior art date
Application number
PCT/EP2008/007483
Other languages
German (de)
English (en)
Other versions
WO2009036925A8 (fr
Inventor
Margaret Horton
Nils Hoffmann
Sören JASPERS
Stefan Heuser
Thomas Blatt
Cathrin Scherner
Ludger Kolbe
Original Assignee
Beiersdorf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE200710043698 external-priority patent/DE102007043698A1/de
Application filed by Beiersdorf Ag filed Critical Beiersdorf Ag
Publication of WO2009036925A1 publication Critical patent/WO2009036925A1/fr
Publication of WO2009036925A8 publication Critical patent/WO2009036925A8/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/445—Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • A61M15/025—Bubble jet droplet ejection devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0468—Liquids non-physiological
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers

Definitions

  • the present invention relates to a method for the selective application of cosmetic or pharmaceutical formulations to the skin and to a selective product applicator for cosmetic or pharmaceutical formulations.
  • US 2006/0016999 A1 discloses a device which indicates to the user the type of cosmetic sunscreen preparation required.
  • the intensity of the UVA and UVB radiation of the sunlight is detected by corresponding sensors.
  • the preparation needed to protect the skin is calculated on the basis of appropriately preselected data on the individual skin properties and displayed to the user via optical or acoustic signals.
  • an automatic application of the corresponding preparation does not take place.
  • WO 04/039255 A1 discloses methods for the noninvasive analysis of the skin structure by means of optical methods. In particular, the methods shown are used to determine the melanin density.
  • WO 02/087681 a method for the administration of therapeutic agents is known, in which a device implanted to the patient generates a signal which controls the delivery of an active ingredient from an adhesive plaster applied to the skin of the patient.
  • a device implanted to the patient generates a signal which controls the delivery of an active ingredient from an adhesive plaster applied to the skin of the patient.
  • no substances acting on or only in the upper layers of the skin can be used, since they do not or only in very small, ineffective amounts enter the body of a patient.
  • the method of skin care or skin treatment is not suitable because only relatively small areas of skin can be covered with a patch. It is therefore an object of the present invention to provide a method and a suitable device which enable a selective application of cosmetic or pharmaceutical preparations for skin care or skin treatment, in particular for the treatment of age spots.
  • the object is achieved in a first aspect by a method in which first the coloration of the skin, the skin relief or both over the entire surface of a selected skin surface is optically detected, the areas are determined within which the data deviate from target values, and then the cosmetic or pharmaceutical preparations are released on these surfaces.
  • Preferred embodiments of the method are the subject of the subclaims.
  • Age spots are in contrast to birthmarks in the skin level or are stored as melanin accumulations in the skin layers.
  • moles have a skin profile, which means that birthmarks often stand out from the surrounding skin as elevation.
  • birthmarks are skin lesions that should not be treated with active ingredients. The treatment of birthmarks should not be done without medical consultation, as this may put you at risk for uterine cancer 1 and 'melanoma'.
  • Age spots on the other hand represent a disproportionate melanin deposition, whereby the pronounced staining is depth-dependent and melanin-dependent. It is therefore important and readily possible to distinguish age spots of birthmarks with profile in the inventive method.
  • the amount of active substance applied must therefore, and this is the great advantage of the process according to the invention, be adapted to the depth and density of the deposited melanin.
  • the object of the method is therefore to apply the active ingredients only to the age spots so that they bring about a uniform reduction effect.
  • An advantage of the method is the rapid success and a saving of active ingredients through targeted treatment.
  • a higher concentration of the active ingredient can be applied locally.
  • the application of a high amount of active ingredient or high volume of active ingredient can lead to a diffusion of the active ingredient beyond the edge of the age spot, which can result in unsightly bright diffusion edges.
  • the application of the pharmaceutical or cosmetic preparation is also corrected on the basis of the theological and diffusion properties of the preparation in such a way that leakage of the preparation from the specific area is avoided. For example, a very fluid solution might migrate beyond the age spot, since the goal is to treat only the area, the thin solution with a defined edge is
  • the age spot would otherwise be more noticeable and stressed if around him a brighter edge arises.
  • Measurements of the roughness of the skin by measuring the shadows of an obliquely illuminated skin area are known. The higher the elevations or deeper the grooves in the considered skin section, the longer shadows they cast.
  • the light reflected on the skin surface is detected via corresponding sensors.
  • the change in intensity, the change in the wavelength of the reflected light or both in comparison to the incident light are detected.
  • the values obtained are compared with setpoints or setpoint ranges.
  • the setpoint values can, for example, be determined in advance by appropriate measurements on wrinkle-free Skin areas with a lower relief depth or uniformly pigmented skin areas are determined.
  • Another method for determining the setpoint values is, for example, to determine mean values from the measured values during the measurement itself, which values are used as setpoint values or setpoint range. It is important to be able to record the structure of the skin surface, either line-by-line (line scanner) or flat (CCD camera).
  • Preparations which contain active ingredients are preferably used according to the invention.
  • the choice of active ingredients depends on the type of skin change and the desired effect. For example, lightening, toning or anti-inflammatory agents are suitable for alleviating undesirable color changes.
  • the inventive method is preferably used for targeted pigment whitening or staining. Furthermore, the method according to the invention can be used for targeted treatment of acne, inflammations, redness and irritation as well as insect bites.
  • the pharmaceutical or cosmetic preparations used in the process according to the invention comprise active substances, individually or in combination, which are suitable for the particular application.
  • Suitable active ingredients are, for example, the following active substances selected from the group of biochinones, in particular ubiquinone (Q10), ubiquinol, folic acid and its derivatives, in particular tetrahydrofolic acid and dihydrofolic acid, niacin and its derivatives i ⁇ , in particular niacinamide, creatine and creatinine, camitin, biotin, isoflavone, Cardiolipin, lipoic acid, anti-freezing proteins, pimpinella-anis-fruit-extract, hop and hop malt extracts, active ingredients that promote the restructuring of connective tissue such as natural and synthetic isoflavonoids and isoflavonoid-containing plant extracts such as soybean and clover Extracts, active ingredients to support skin functions in dry ner skin such as vitamin C, biotin, carnitine, propionic acid, green tea extracts, eucalyptus oil, urea and mineral salts such as NaCl, marine minerals and osmolytes
  • Active substances in encapsulated form can also be used in the process according to the invention, the encapsulating materials being, for example, collagen matrices, cyclic oligosaccharides, in particular alpha-, beta-, HP-beta-, domed-Me-beta, gamma-cyclodextrin, cellulose, gelatin, wax or liposomes.
  • the encapsulating materials being, for example, collagen matrices, cyclic oligosaccharides, in particular alpha-, beta-, HP-beta-, domed-Me-beta, gamma-cyclodextrin, cellulose, gelatin, wax or liposomes.
  • whitening or skin-colored pigments UV protection agents
  • rucinol (4-butylresorcinol) hexylresorcinol kojic acid, dioic acid.
  • the present object is achieved by selective Fernapplika- gate, which at least one optoelectronic sensor, at least one product reservoir, a data processing unit and at least one electrically triggered Device for releasing liquids.
  • Preferred embodiments of the product applicator are the subject of the subclaims.
  • the opto-electronic sensors and the liquid-dispensing devices connected to the product reservoirs are connected to the data processing unit.
  • the product applicator according to the invention has the form of a pin which can be actuated or applied with one hand. All components are chosen so that they can be arranged in a housing which can be held in one hand.
  • the electrically triggered device for releasing liquids has a spray head.
  • the spray head can be a
  • Micro diaphragm pumps often use the piezo effect (piezo diaphragm micropumps) mentioned below.
  • a preferred embodiment of the present invention is the use of overpressure containers and microvalves (corresponding to the technique used in the airbrush method).
  • the spray head comprises a bubble jet spray head or a piezo spray head.
  • a spray head according to the bubble jet method which is referred to below as a bubble jet spray head, tiny drops of liquid are produced by means of a heating element.
  • explosive a spray head according to the bubble jet method
  • the active ingredients and / or preparations are introduced by microinjections (microneedle system) directly into the Melaninansammlungen.
  • microinjections microneedle system
  • application types such as thermal inkjet, Mirkoventil and spraying using a Venturi nozzle (airbrush principle)
  • the preparation to be released must not be too hot, so that the active ingredients are not destroyed.
  • the viscosity, the maximum particle size and the agglomeration behavior of the particles of the preparation to be released must also be matched to the pumping power and the nozzle geometry of the device used in order to enable targeted release.
  • CCD Charge Coupled Device
  • the measured value acquisition according to the present invention is an evaluation of the light intensity distribution.
  • a special optical arrangement e.g. Angle between the optical axes of the light source and the recording unit to better determine the wrinkle expression is to pay attention to the exact location assignment between the intensity signal and the application target area.
  • the light intensity can be recorded as a sum signal or spectrally differentiating via optical or electronic filters.
  • the trigger signal for the application can be obtained via a threshold value of the intensity or from threshold value combinations of different spectral intensities.
  • the threshold value or the threshold value combinations must be determined individually for each skin in a "training mode.”
  • optical iris may be required in order to focus the training particularly selectively on specific skin characteristics.
  • the present object is achieved by the use of the product applicator according to the invention for the selective application of cosmetic or pharmaceutical preparations on the skin.
  • the applicator according to the invention is preferred for the application of pharmaceutical and cosmetic preparations for the treatment of acne, wrinkles and other signs of aging as well as pigmentation disorders.
  • Preparations suitable according to the invention are solutions, for example aqueous and / or alcoholic solutions (concentrates), emulsions, gels, melts, serums and make-up.

Abstract

La présente invention concerne un procédé d'application sélective de formulations cosmétiques ou pharmaceutiques sur la peau ainsi qu'un dispositif d'application sélective de produit destiné à des formulations cosmétiques ou pharmaceutiques.
PCT/EP2008/007483 2007-09-13 2008-09-11 Procédé pour réduire les taches de vieillesse WO2009036925A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102007043698.1 2007-09-13
DE200710043698 DE102007043698A1 (de) 2007-09-13 2007-09-13 Selektiver Produktapplikator
DE102008041971.0 2008-09-10
DE102008041971A DE102008041971A1 (de) 2007-09-13 2008-09-10 Verfahren zur Reduktion von Altersflecken

Publications (2)

Publication Number Publication Date
WO2009036925A1 true WO2009036925A1 (fr) 2009-03-26
WO2009036925A8 WO2009036925A8 (fr) 2009-07-09

Family

ID=40010886

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/007483 WO2009036925A1 (fr) 2007-09-13 2008-09-11 Procédé pour réduire les taches de vieillesse

Country Status (2)

Country Link
DE (1) DE102008041971A1 (fr)
WO (1) WO2009036925A1 (fr)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016191217A1 (fr) * 2015-05-22 2016-12-01 L'oreal Applicateurs pour le traitement d'affections cutanées
US10004885B2 (en) 2015-05-22 2018-06-26 L'oreal Imaging applicator for treating skin conditions
US10071233B2 (en) 2015-05-22 2018-09-11 L'oreal Point applicator for treating skin conditions
US10076646B2 (en) 2015-05-22 2018-09-18 L'oreal Rolling applicator for treating skin conditions
CN109125106A (zh) * 2018-08-06 2019-01-04 上海优萃生物科技有限公司 一种祛皱原液及其在皮肤促渗技术上的应用
US10933156B2 (en) 2018-02-01 2021-03-02 The Procter & Gamble Company System and method for dispensing material
US10945515B2 (en) 2017-06-16 2021-03-16 The Procter & Gamble Company Personal care device with audible feedback
US11077689B2 (en) 2015-12-07 2021-08-03 The Procter & Gamble Company Systems and methods for providing a service station routine
US11076675B2 (en) 2017-06-16 2021-08-03 The Procter & Gamble Company Method for camouflaging tonal imperfections
US11083672B2 (en) 2018-02-01 2021-08-10 The Procter & Gamble Company Cosmetic ink composition comprising a surface tension modifier
US11090238B2 (en) 2017-06-16 2021-08-17 The Procter & Gamble Company Array of cosmetic compositions for camouflaging tonal imperfections
US11116302B2 (en) 2015-06-11 2021-09-14 The Procter & Gamble Company Apparatus and methods for modifying keratinous surfaces
USRE49230E1 (en) 2015-06-11 2022-10-04 The Procter & Gamble Company Cartridges for use in an apparatus for modifying keratinous surfaces
US11590782B2 (en) 2015-12-07 2023-02-28 The Procter & Gamble Company Systems and methods for providing a service station routine
US11833236B2 (en) 2018-02-01 2023-12-05 The Procter And Gamble Company Heterogenous cosmetic ink composition for inkjet printing applications
US11857665B2 (en) 2018-02-01 2024-01-02 The Procter And Gamble Company Stable cosmetic ink composition

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017114423A1 (de) 2017-06-28 2019-01-03 Schülke & Mayr GmbH Verwendung von Alkylresorcinolen zur Verbesserung der Wirksamkeit von Kosmetikkonservierungsstoffen

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US20030065294A1 (en) * 2001-09-28 2003-04-03 Pickup Ray L. Cutaneous administration system
EP1459782A2 (fr) * 2003-03-21 2004-09-22 Hewlett-Packard Development Company, L.P. Méthode et dispositif pour délivrer de manière visée des agents médiceaux où similaires
WO2007022095A1 (fr) * 2005-08-12 2007-02-22 Yeager Rick B Systeme et procede d'application d'un agent modifiant la reflectance pour ameliorer l'attrait visuel de la peau humaine

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AU2002305313A1 (en) 2001-04-30 2002-11-11 Medtronic, Inc. Implantable medical device and patch system
GB0225060D0 (en) 2002-10-29 2002-12-04 Astron Clinica Ltd Methods and apparatus for measuring tissue histology
DE202004003148U1 (de) * 2004-03-01 2005-03-24 Merlaku Kastriot Schmink-Gerät
US20060016999A1 (en) 2004-07-26 2006-01-26 Angelfun Enterprises Co., Ltd. Apparatus for displaying the necessary suntan lotion and the skin care
WO2008098235A2 (fr) * 2007-02-11 2008-08-14 Yeager Rick B Système et procédé pour la fourniture d'images simulées via surveillance cosmétique
DE102007007612A1 (de) * 2007-02-13 2008-08-14 Beiersdorf Ag Verfahren zur Depigmentierung der Haut
DE102007043698A1 (de) * 2007-09-13 2009-03-19 Beiersdorf Ag Selektiver Produktapplikator

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030065294A1 (en) * 2001-09-28 2003-04-03 Pickup Ray L. Cutaneous administration system
EP1459782A2 (fr) * 2003-03-21 2004-09-22 Hewlett-Packard Development Company, L.P. Méthode et dispositif pour délivrer de manière visée des agents médiceaux où similaires
WO2007022095A1 (fr) * 2005-08-12 2007-02-22 Yeager Rick B Systeme et procede d'application d'un agent modifiant la reflectance pour ameliorer l'attrait visuel de la peau humaine

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107847720A (zh) * 2015-05-22 2018-03-27 欧莱雅 用于治疗皮肤状况的涂抹器
US10004885B2 (en) 2015-05-22 2018-06-26 L'oreal Imaging applicator for treating skin conditions
US10071233B2 (en) 2015-05-22 2018-09-11 L'oreal Point applicator for treating skin conditions
US10076646B2 (en) 2015-05-22 2018-09-18 L'oreal Rolling applicator for treating skin conditions
EP3310425B1 (fr) * 2015-05-22 2021-01-20 L'Oréal Applicateurs pour le traitement d'affections cutanées
WO2016191217A1 (fr) * 2015-05-22 2016-12-01 L'oreal Applicateurs pour le traitement d'affections cutanées
US11116302B2 (en) 2015-06-11 2021-09-14 The Procter & Gamble Company Apparatus and methods for modifying keratinous surfaces
USRE49230E1 (en) 2015-06-11 2022-10-04 The Procter & Gamble Company Cartridges for use in an apparatus for modifying keratinous surfaces
US11590782B2 (en) 2015-12-07 2023-02-28 The Procter & Gamble Company Systems and methods for providing a service station routine
US11077689B2 (en) 2015-12-07 2021-08-03 The Procter & Gamble Company Systems and methods for providing a service station routine
US10945515B2 (en) 2017-06-16 2021-03-16 The Procter & Gamble Company Personal care device with audible feedback
US11090238B2 (en) 2017-06-16 2021-08-17 The Procter & Gamble Company Array of cosmetic compositions for camouflaging tonal imperfections
US11076675B2 (en) 2017-06-16 2021-08-03 The Procter & Gamble Company Method for camouflaging tonal imperfections
US11083672B2 (en) 2018-02-01 2021-08-10 The Procter & Gamble Company Cosmetic ink composition comprising a surface tension modifier
US11090239B2 (en) 2018-02-01 2021-08-17 The Procter & Gamble Company Cosmetic ink composition comprising a surface tension modifier
US10933156B2 (en) 2018-02-01 2021-03-02 The Procter & Gamble Company System and method for dispensing material
US11833236B2 (en) 2018-02-01 2023-12-05 The Procter And Gamble Company Heterogenous cosmetic ink composition for inkjet printing applications
US11857665B2 (en) 2018-02-01 2024-01-02 The Procter And Gamble Company Stable cosmetic ink composition
CN109125106A (zh) * 2018-08-06 2019-01-04 上海优萃生物科技有限公司 一种祛皱原液及其在皮肤促渗技术上的应用

Also Published As

Publication number Publication date
DE102008041971A1 (de) 2010-03-11
WO2009036925A8 (fr) 2009-07-09

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