WO2009032665A2 - Articles médicaux poreux pour une administration d'agent thérapeutique - Google Patents

Articles médicaux poreux pour une administration d'agent thérapeutique Download PDF

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Publication number
WO2009032665A2
WO2009032665A2 PCT/US2008/074387 US2008074387W WO2009032665A2 WO 2009032665 A2 WO2009032665 A2 WO 2009032665A2 US 2008074387 W US2008074387 W US 2008074387W WO 2009032665 A2 WO2009032665 A2 WO 2009032665A2
Authority
WO
WIPO (PCT)
Prior art keywords
solvent
medical article
therapeutic agent
solution
porous
Prior art date
Application number
PCT/US2008/074387
Other languages
English (en)
Other versions
WO2009032665A3 (fr
Inventor
David Mcmorrow
Anthony Malone
Tim O'connor
Barry J O'brien
Original Assignee
Boston Scientific Scimed, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Scimed, Inc. filed Critical Boston Scientific Scimed, Inc.
Publication of WO2009032665A2 publication Critical patent/WO2009032665A2/fr
Publication of WO2009032665A3 publication Critical patent/WO2009032665A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus

Definitions

  • non-metallic inorganic materials may be selected, for example, from materials containing one or more of the following: metal oxides, including aluminum oxides and transition metal oxides (e.g., oxides of titanium, zirconium, hafnium, tantalum, molybdenum, tungsten, rhenium, iron, niobium, and iridium); silicon; silicon-based ceramics, such as those containing silicon nitrides, silicon carbides and silicon oxides (sometimes referred to as glass ceramics); calcium phosphate ceramics (e.g., hydroxyapatite); carbon; and carbon-based, ceramic-like materials such as carbon nitrides.
  • metal oxides including aluminum oxides and transition metal oxides (e.g., oxides of titanium, zirconium, hafnium, tantalum, molybdenum, tungsten, rhenium, iron, niobium, and iridium); silicon; silicon-based ceramics, such as those containing silicon ni
  • the therapeutic agent may be soluble T
  • alcohols including (i) phenols such as phenol, 1,3-benzenediol, m-cresol, o-methoxyphenol, methyl salicylate and nonylphenol, (ii) polyhydric alcohols such as ethylene glycol, glycerol, propylene glycol, 1,3-butanediol, diethylene glycol, triethylene glycol, hexylene glycol and dipropylene glycol, and (iii) other alcohols such as methanol, ethanol, ethylene cyanohydrin, allyl alcohol, 1-propan

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un aspect de la présente invention porte sur un procédé, selon lequel un article médical poreux est mis en contact avec une solution qui contient un agent thérapeutique et un solvant afin de charger les pores de l'article médical, après quoi le solvant est sublimé.
PCT/US2008/074387 2007-08-31 2008-08-27 Articles médicaux poreux pour une administration d'agent thérapeutique WO2009032665A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/897,808 2007-08-31
US11/897,808 US7901726B2 (en) 2007-08-31 2007-08-31 Porous medical articles for therapeutic agent delivery

Publications (2)

Publication Number Publication Date
WO2009032665A2 true WO2009032665A2 (fr) 2009-03-12
WO2009032665A3 WO2009032665A3 (fr) 2010-03-25

Family

ID=40336387

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/074387 WO2009032665A2 (fr) 2007-08-31 2008-08-27 Articles médicaux poreux pour une administration d'agent thérapeutique

Country Status (2)

Country Link
US (1) US7901726B2 (fr)
WO (1) WO2009032665A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013542754A (ja) * 2010-09-17 2013-11-28 メドトロニック ヴァスキュラー インコーポレイテッド 薬剤溶出型医療器具に装填するための装置及び方法
CN107943126A (zh) * 2017-11-30 2018-04-20 吉林大学 一种基于气压变压器调节的仿生血管测试系统

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EP1404297B1 (fr) 2001-06-12 2011-04-27 The Johns Hopkins University School Of Medicine Dispositif a reservoir pour administration intra-oculaire de medicaments
US7169178B1 (en) * 2002-11-12 2007-01-30 Advanced Cardiovascular Systems, Inc. Stent with drug coating
US9693841B2 (en) 2007-04-02 2017-07-04 Ension, Inc. Surface treated staples, sutures and dental floss and methods of manufacturing the same
EP2179752B1 (fr) * 2008-10-06 2014-08-13 Biotronik VI Patent AG Implant et son procédé de fabrication
CN104887389B (zh) 2009-01-29 2017-06-23 弗赛特影像4股份有限公司 后段给药
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
EP2413985B8 (fr) 2009-03-31 2015-02-25 Enbio Limited Procédé de revêtement d'implants métalliques avec des mélanges thérapeutiques
US9283305B2 (en) 2009-07-09 2016-03-15 Medtronic Vascular, Inc. Hollow tubular drug eluting medical devices
US20110070358A1 (en) 2009-09-20 2011-03-24 Medtronic Vascular, Inc. Method of forming hollow tubular drug eluting medical devices
US8828474B2 (en) 2009-09-20 2014-09-09 Medtronic Vascular, Inc. Apparatus and methods for loading a drug eluting medical device
US8678046B2 (en) 2009-09-20 2014-03-25 Medtronic Vascular, Inc. Apparatus and methods for loading a drug eluting medical device
US8460745B2 (en) * 2009-09-20 2013-06-11 Medtronic Vascular, Inc. Apparatus and methods for loading a drug eluting medical device
EP3960134A1 (fr) 2010-08-05 2022-03-02 ForSight Vision4, Inc. Dispositif thérapeutique implantable
PT2600930T (pt) 2010-08-05 2021-03-22 Forsight Vision4 Inc Aparelho injetor e método para distribuição de fármacos
US8333801B2 (en) 2010-09-17 2012-12-18 Medtronic Vascular, Inc. Method of Forming a Drug-Eluting Medical Device
US8616040B2 (en) 2010-09-17 2013-12-31 Medtronic Vascular, Inc. Method of forming a drug-eluting medical device
US20120067455A1 (en) * 2010-09-17 2012-03-22 Medtronic Vascular, Inc. Apparatus and Methods for Loading a Drug Eluting Medical Device
US8927047B2 (en) 2011-02-25 2015-01-06 Abbott Cardiovascular Systems Inc. Methods of drug loading a hollow stent with a high viscosity formulation
US9585780B2 (en) 2011-02-25 2017-03-07 Abbott Cardiovascular Systems Inc. Pressure chamber and apparatus for loading material into a stent strut
US8936827B2 (en) 2011-02-25 2015-01-20 Abbott Cardiovascular Systems Inc. Methods of loading a hollow stent with a drug or drug formulation
US9238514B2 (en) * 2011-02-25 2016-01-19 Abbott Cardiovascular Systems Inc. Vacuum chamber and apparatus for loading material into a stent strut
US8757219B2 (en) * 2011-02-25 2014-06-24 Abbott Cardiovascular Systems Inc. Suction pump and apparatus for loading material into a stent strut
US20120216908A1 (en) 2011-02-25 2012-08-30 Abbott Cardiovascular Systems Inc. Methods Of Drug Loading A Hollow Stent By Immersion
SI2755600T1 (sl) 2011-09-16 2021-08-31 Forsight Vision4, Inc. Naprava za izmenjavo tekočine
US20140248372A1 (en) * 2011-09-19 2014-09-04 Emory University Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto
US9549832B2 (en) * 2012-04-26 2017-01-24 Medtronic Vascular, Inc. Apparatus and methods for filling a drug eluting medical device via capillary action
US11167063B2 (en) * 2013-03-14 2021-11-09 W. L. Gore & Associates, Inc. Porous composites with high-aspect ratio crystals
EP2967938B1 (fr) 2013-03-14 2017-03-01 Medtronic Vascular Inc. Procédé pour fabriquer une endoprothèse, et endoprothèse fabriquée par ce procédé
ES2972168T3 (es) 2013-03-28 2024-06-11 Forsight Vision4 Inc Implante oftálmico para administración de sustancias terapéuticas
WO2014182542A1 (fr) 2013-05-06 2014-11-13 Abbott Cardiovascular Systems Inc. Endoprothèse creuse remplie avec une formulation d'agent thérapeutique
US9474834B2 (en) * 2014-04-11 2016-10-25 Abbott Cardiovascular Systems Inc. Stent with albumin coating for enhanced thromboresistance
CA3005238A1 (fr) 2015-11-20 2017-05-26 Forsight Vision4, Inc. Structures poreuses pour dispositifs d'administration de medicament a liberation prolongee
WO2017214432A1 (fr) 2016-06-10 2017-12-14 Medtronic Vascular Inc. Personnalisation du profil d'élution d'un stent
WO2017218354A1 (fr) * 2016-06-13 2017-12-21 Nano Precision Medical, Inc. Dispositif de distribution de médicament
US10226367B2 (en) 2016-12-19 2019-03-12 Medtronic Vascular, Inc. Apparatus and methods for filling a drug eluting medical device via capillary action
BR112020010053A2 (pt) 2017-11-21 2020-11-03 Forsight Vision4, Inc. aparelho para troca de fluido para sistema de liberação de porta expansível e métodos de uso do mesmo

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FR2840547B1 (fr) 2002-06-11 2005-03-04 Commissariat Energie Atomique Procede et dispositif d'incorporation d'un compose dans les pores d'un materiau poreux et leurs utilisations
WO2004112751A1 (fr) 2003-06-18 2004-12-29 Ltt Bio-Pharma Co., Ltd. Microparticule a liberation prolongee contenant un medicament, procede de production correspondant et preparation contenant ladite microparticule
US7744644B2 (en) 2004-03-19 2010-06-29 Boston Scientific Scimed, Inc. Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release
US20060127443A1 (en) 2004-12-09 2006-06-15 Helmus Michael N Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery
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ITRM20050153A1 (it) 2005-04-01 2006-10-02 Consiglio Nazionale Ricerche Procedimento di riempimento di strutture a nanotubo, in particolare nanotubi di carbonio.

Patent Citations (3)

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US5969020A (en) * 1993-08-13 1999-10-19 Poly-Med, Inc. Microporous polymeric foams and microtextured surfaces
WO2007142738A2 (fr) * 2006-05-31 2007-12-13 Abbott Cardiovascular Systems Inc. Couches de revêtement pour dispositifs médicaux et procédés de fabrication de celles-ci
EP1891995A1 (fr) * 2006-08-08 2008-02-27 Debiotech S.A. Chargement de médicaments dans un revêtement poreux

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013542754A (ja) * 2010-09-17 2013-11-28 メドトロニック ヴァスキュラー インコーポレイテッド 薬剤溶出型医療器具に装填するための装置及び方法
CN107943126A (zh) * 2017-11-30 2018-04-20 吉林大学 一种基于气压变压器调节的仿生血管测试系统
CN107943126B (zh) * 2017-11-30 2020-11-10 吉林大学 一种仿生血管测试系统

Also Published As

Publication number Publication date
US20090061071A1 (en) 2009-03-05
WO2009032665A3 (fr) 2010-03-25
US7901726B2 (en) 2011-03-08

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