WO2009024901A3 - Dispositif de détecteur - Google Patents

Dispositif de détecteur Download PDF

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Publication number
WO2009024901A3
WO2009024901A3 PCT/IB2008/053248 IB2008053248W WO2009024901A3 WO 2009024901 A3 WO2009024901 A3 WO 2009024901A3 IB 2008053248 W IB2008053248 W IB 2008053248W WO 2009024901 A3 WO2009024901 A3 WO 2009024901A3
Authority
WO
WIPO (PCT)
Prior art keywords
sensor device
target moieties
amount
sensor
sample fluid
Prior art date
Application number
PCT/IB2008/053248
Other languages
English (en)
Other versions
WO2009024901A2 (fr
Inventor
Mark T Johnson
Hendrik Roelof Stapert
Murray F Gillies
Erik R Vossenaar
Original Assignee
Koninkl Philips Electronics Nv
Mark T Johnson
Hendrik Roelof Stapert
Murray F Gillies
Erik R Vossenaar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninkl Philips Electronics Nv, Mark T Johnson, Hendrik Roelof Stapert, Murray F Gillies, Erik R Vossenaar filed Critical Koninkl Philips Electronics Nv
Publication of WO2009024901A2 publication Critical patent/WO2009024901A2/fr
Publication of WO2009024901A3 publication Critical patent/WO2009024901A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Cleaning Or Drying Semiconductors (AREA)

Abstract

La présente invention concerne un dispositif de détecteur (10) permettant de déterminer la présence et/ou la quantité de fractions cibles (5) dans un premier fluide d'échantillon (4). Le dispositif de détecteur (10) comprend des moyens de déplacement de fluide pour déplacer de façon régulée le premier fluide d'échantillon (4) comprenant les fractions cibles (5) et un deuxième fluide de lavage (6). Le dispositif de détecteur (10) selon des modes de réalisation de l'invention permet le lavage et la détection répétés de la présence et/ou de la quantité de fractions cibles (7) attachées à une surface de substrat de détecteur (3). La présente invention concerne également un procédé permettant de former de tels dispositifs de détecteur (10) et un procédé permettant de déterminer la présence et/ou la quantité de fractions cibles (5) dans un premier fluide d'échantillon (4) à l'aide de ces dispositifs de détecteur (10).
PCT/IB2008/053248 2007-08-17 2008-08-13 Dispositif de détecteur WO2009024901A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07114503 2007-08-17
EP07114503.1 2007-08-17

Publications (2)

Publication Number Publication Date
WO2009024901A2 WO2009024901A2 (fr) 2009-02-26
WO2009024901A3 true WO2009024901A3 (fr) 2009-05-07

Family

ID=40282331

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/053248 WO2009024901A2 (fr) 2007-08-17 2008-08-13 Dispositif de détecteur

Country Status (1)

Country Link
WO (1) WO2009024901A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002021568A2 (fr) * 2000-09-01 2002-03-14 Mcnc Dispositif de pompage electrostatique a structure de systeme mecanique microelectrique de type reparti
US20050266582A1 (en) * 2002-12-16 2005-12-01 Modlin Douglas N Microfluidic system with integrated permeable membrane
WO2008020374A2 (fr) * 2006-08-14 2008-02-21 Koninklijke Philips Electronics N.V. Dispositif microfluidique électrique utilisant un principe de matrice active
WO2008035293A2 (fr) * 2006-09-20 2008-03-27 Koninklijke Philips Electronics N.V. Appareil microfluidique destiné à être employé dans des biopuces ou des biosystèmes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002021568A2 (fr) * 2000-09-01 2002-03-14 Mcnc Dispositif de pompage electrostatique a structure de systeme mecanique microelectrique de type reparti
US20050266582A1 (en) * 2002-12-16 2005-12-01 Modlin Douglas N Microfluidic system with integrated permeable membrane
WO2008020374A2 (fr) * 2006-08-14 2008-02-21 Koninklijke Philips Electronics N.V. Dispositif microfluidique électrique utilisant un principe de matrice active
WO2008035293A2 (fr) * 2006-09-20 2008-03-27 Koninklijke Philips Electronics N.V. Appareil microfluidique destiné à être employé dans des biopuces ou des biosystèmes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DU Z ET AL: "Recognition and capture of breast cancer cells using an antibody-based platform in a microelectromechanical systems device", BIOMEDICAL MICRODEVICES, KLUWER ACADEMIC PUBLISHERS, BO, vol. 9, no. 1, 11 November 2006 (2006-11-11), pages 35 - 42, XP019464057, ISSN: 1572-8781 *
YOO ET AL: "Fabrication of a bio-MEMS based cell-chip for toxicity monitoring", BIOSENSORS & BIOELECTRONICS, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 22, no. 8, 2 February 2007 (2007-02-02), pages 1586 - 1592, XP005870749, ISSN: 0956-5663 *

Also Published As

Publication number Publication date
WO2009024901A2 (fr) 2009-02-26

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