WO2009024834A3 - Acides nucléiques impliques dans les infections virales - Google Patents

Acides nucléiques impliques dans les infections virales Download PDF

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Publication number
WO2009024834A3
WO2009024834A3 PCT/IB2007/004718 IB2007004718W WO2009024834A3 WO 2009024834 A3 WO2009024834 A3 WO 2009024834A3 IB 2007004718 W IB2007004718 W IB 2007004718W WO 2009024834 A3 WO2009024834 A3 WO 2009024834A3
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WO
WIPO (PCT)
Prior art keywords
viral infection
nucleic acids
acids involved
hiv
methods
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PCT/IB2007/004718
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English (en)
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WO2009024834A2 (fr
WO2009024834A8 (fr
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Rosetta Genomics Ltd
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Filing date
Publication date
Application filed by Rosetta Genomics Ltd filed Critical Rosetta Genomics Ltd
Priority to US12/517,760 priority Critical patent/US8481506B2/en
Publication of WO2009024834A2 publication Critical patent/WO2009024834A2/fr
Publication of WO2009024834A8 publication Critical patent/WO2009024834A8/fr
Publication of WO2009024834A3 publication Critical patent/WO2009024834A3/fr
Priority to US13/986,802 priority patent/US20140179757A1/en
Priority to US14/796,112 priority patent/US20160002639A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1133—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against herpetoviridae, e.g. HSV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2330/00—Production
    • C12N2330/10—Production naturally occurring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised
    • C12N2330/31—Libraries, arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Abstract

L'invention concerne des acides nucléiques humains viraux isolés, associés aux infections virales, ainsi que diverses molécules d'acides nucléiques connexes ou dérivées de ceux-ci. Les acides nucléiques selon l'invention peuvent être utiles dans la prévention, le diagnostic et le traitement des infections virales.
PCT/IB2007/004718 2006-12-05 2007-12-05 Acides nucléiques impliques dans les infections virales WO2009024834A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/517,760 US8481506B2 (en) 2006-12-05 2007-12-05 Nucleic acids involved in viral infection
US13/986,802 US20140179757A1 (en) 2006-12-05 2013-06-06 Nucleic acids involved in viral infection
US14/796,112 US20160002639A1 (en) 2006-12-05 2015-07-10 Nucleic acids involved in viral infection

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86866606P 2006-12-05 2006-12-05
US60/868,666 2006-12-05
US97126507P 2007-09-11 2007-09-11
US60/971,265 2007-09-11

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/517,760 A-371-Of-International US8481506B2 (en) 2006-12-05 2007-12-05 Nucleic acids involved in viral infection
US13/986,802 Division US20140179757A1 (en) 2006-12-05 2013-06-06 Nucleic acids involved in viral infection

Publications (3)

Publication Number Publication Date
WO2009024834A2 WO2009024834A2 (fr) 2009-02-26
WO2009024834A8 WO2009024834A8 (fr) 2009-10-01
WO2009024834A3 true WO2009024834A3 (fr) 2011-12-29

Family

ID=40378751

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/004718 WO2009024834A2 (fr) 2006-12-05 2007-12-05 Acides nucléiques impliques dans les infections virales

Country Status (2)

Country Link
US (3) US8481506B2 (fr)
WO (1) WO2009024834A2 (fr)

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WO2009111493A1 (fr) * 2008-03-03 2009-09-11 Duke University Microarn viraux
EP2631240A1 (fr) * 2009-05-22 2013-08-28 Intelligent Medical Devices, Inc. Sondes et amorces optimisées et leurs procédés d'utilisation pour la détection, le criblage, la quantification, l'isolement et le séquençage de Cytomégalovirus et de virus Epstein-Barr
EP2630241B1 (fr) 2010-10-22 2018-10-17 CuRNA, Inc. Traitement de maladies associées à l'alpha-l-iduronidase (idua) par inhibition du transcrit antisens endogène de idua
EP2546358A1 (fr) * 2011-07-15 2013-01-16 Laboratorios Del. Dr. Esteve, S.A. Procédés et réactifs pour un contrôle efficace de la progression du VIH
WO2013067873A1 (fr) * 2011-11-09 2013-05-16 南京森楠生物技术研究有限公司 Acide nucléique, ou acide nucléique peptidique dirigé contre le virus de la grippe et formulation de ceux-ci
CA2867420A1 (fr) * 2012-03-19 2013-09-26 Prestizia Procedes de determination du tropisme et de l'utilisation d'un recepteur d'un virus, en particulier du vih, dans des echantillons corporels preleves a partir de la circulation
WO2013173774A2 (fr) * 2012-05-18 2013-11-21 Pathogenica, Inc. Sondes d'inversion moléculaire
CN103589721A (zh) * 2012-08-15 2014-02-19 北京命码生科科技有限公司 植物微小核糖核酸的提取、制备及其应用
CN104694541A (zh) * 2013-12-09 2015-06-10 江苏命码生物科技有限公司 禽流感病毒miRNA及其鉴定、检测和应用
CA2949710A1 (fr) * 2014-05-30 2015-12-03 The Board Of Trustees Of The Leland Stanford Junior University Compositions et methodes pour traiter des infections virales latentes
MA41349A (fr) * 2015-01-14 2017-11-21 Univ Temple Éradication de l'herpès simplex de type i et d'autres virus de l'herpès associés guidée par arn
KR101652806B1 (ko) * 2015-08-21 2016-09-01 주식회사 엠모니터 Lamp를 이용한 인플루엔자 검출용 프라이머 및 그 용도
WO2017075475A1 (fr) * 2015-10-30 2017-05-04 Editas Medicine, Inc. Méthodes et compositions liées à crispr/cas pour le traitement du virus de l'herpès simplex
EP3525816A4 (fr) * 2016-10-11 2020-08-05 Yale University Méthodes de détection d'infection virale respiratoire
WO2021011493A1 (fr) * 2019-07-12 2021-01-21 Duke University Système d'ingénierie 3'utr crispr-dcas 13 et ses procédés d'utilisation
WO2024026418A1 (fr) * 2022-07-28 2024-02-01 New York University Ciblage d'arn chromr non codant long dans une inflammation médiée par l'interféron chez l'homme

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Also Published As

Publication number Publication date
WO2009024834A2 (fr) 2009-02-26
WO2009024834A8 (fr) 2009-10-01
US8481506B2 (en) 2013-07-09
US20140179757A1 (en) 2014-06-26
US20160002639A1 (en) 2016-01-07
US20100184205A1 (en) 2010-07-22

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