WO2009015180A3 - Novel compounds and methods of using them - Google Patents

Novel compounds and methods of using them Download PDF

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Publication number
WO2009015180A3
WO2009015180A3 PCT/US2008/070828 US2008070828W WO2009015180A3 WO 2009015180 A3 WO2009015180 A3 WO 2009015180A3 US 2008070828 W US2008070828 W US 2008070828W WO 2009015180 A3 WO2009015180 A3 WO 2009015180A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
novel compounds
relates
present
sirtuins
Prior art date
Application number
PCT/US2008/070828
Other languages
French (fr)
Other versions
WO2009015180A2 (en
Inventor
John F W Keana
Peter Ordentlich
Robert Goodenow
Original Assignee
Syndax Pharmaceuticals Inc
John F W Keana
Peter Ordentlich
Robert Goodenow
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syndax Pharmaceuticals Inc, John F W Keana, Peter Ordentlich, Robert Goodenow filed Critical Syndax Pharmaceuticals Inc
Publication of WO2009015180A2 publication Critical patent/WO2009015180A2/en
Publication of WO2009015180A3 publication Critical patent/WO2009015180A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel compounds and their pharmaceutically acceptable salts, prodrugs, solvates, polymorphs, tautomers and isomers. In some embodiments, the compounds described herein may be used to modulate sirtuins (SIRT). The present invention also relates to methods for modulating sirtuins. The present invention also relates to methods useful in the treatment of diseases.
PCT/US2008/070828 2007-07-23 2008-07-23 Novel compounds and methods of using them WO2009015180A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95143007P 2007-07-23 2007-07-23
US60/951,430 2007-07-23

Publications (2)

Publication Number Publication Date
WO2009015180A2 WO2009015180A2 (en) 2009-01-29
WO2009015180A3 true WO2009015180A3 (en) 2009-03-05

Family

ID=40282125

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/070828 WO2009015180A2 (en) 2007-07-23 2008-07-23 Novel compounds and methods of using them

Country Status (1)

Country Link
WO (1) WO2009015180A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2367563A4 (en) 2008-12-08 2012-12-19 Univ Northwestern Method of modulating hsf-1
EP2838881B1 (en) * 2012-04-20 2018-08-08 AbbVie Inc. Isoindolone derivatives

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4798901A (en) * 1984-08-14 1989-01-17 Roussel Uclaf Novel pyrrole derivatives
WO2001074950A2 (en) * 2000-04-03 2001-10-11 Sun Chemical Corporation Mono- and bis-hydrazone pigments
US20020119972A1 (en) * 2000-02-11 2002-08-29 Katerina Leftheris Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases
US6737429B2 (en) * 2000-07-04 2004-05-18 Hoffmann-La Roche Inc. Pyrrole derivatives
US20050032693A1 (en) * 1999-10-07 2005-02-10 Genentech, Inc. Novel polypeptides, their nucleic acids, and methods for their use in angiogenesis and vascularization

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4798901A (en) * 1984-08-14 1989-01-17 Roussel Uclaf Novel pyrrole derivatives
US20050032693A1 (en) * 1999-10-07 2005-02-10 Genentech, Inc. Novel polypeptides, their nucleic acids, and methods for their use in angiogenesis and vascularization
US20020119972A1 (en) * 2000-02-11 2002-08-29 Katerina Leftheris Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases
WO2001074950A2 (en) * 2000-04-03 2001-10-11 Sun Chemical Corporation Mono- and bis-hydrazone pigments
US6737429B2 (en) * 2000-07-04 2004-05-18 Hoffmann-La Roche Inc. Pyrrole derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANDERSON ET AL.: "The preparation and some reactions of brominated pyrrole derivatives", CANADIAN JOURNAL OF CHEMISTRY, vol. 43, 1965, pages 409 - 414 *

Also Published As

Publication number Publication date
WO2009015180A2 (en) 2009-01-29

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